6-hydroxyindole has been researched along with Uremia* in 1 studies
1 other study(ies) available for 6-hydroxyindole and Uremia
Article | Year |
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6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients.
The hepatic uptake transporter organic anion transporting polypeptide (OATP) 1B1 is inhibited by some uremic toxins; however, direct inhibition can only partially explain the delayed systemic elimination of substrate drugs in renal failure patients. This study aimed to examine the long-lasting inhibition of OATP1B1 by uremic toxins and their metabolites. Preincubation of HEK293/OATP1B1 cells with 21 uremic toxins resulted in almost no change in the uptake of a typical substrate [ Topics: Biological Transport; Dose-Response Relationship, Drug; Estrone; HEK293 Cells; Hepatocytes; Humans; Indoles; Kinetics; Liver-Specific Organic Anion Transporter 1; Renal Insufficiency; Up-Regulation; Uremia | 2020 |