6-hydroxychlorzoxazone has been researched along with Disease Models, Animal in 3 studies
6-hydroxychlorzoxazone: chlorzoxazone metabolite in humans
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thus, the time-dependent pharmacokinetic parameters of CZX and OH-CZX were evaluated after the intravenous administration of CZX (20 mg/kg) to control rats, and the 2 h, 24 h and 96 h KPLPS rats along with the time-dependent changes in the protein expression of hepatic Cyp2e1." | 1.35 | Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. ( Choi, YH; Jung, HY; Kang, HE; Kim, SH; Lee, MG, 2009) |
| "Chlormethiazole inhibited the increase in the ethanol-induced CYP2E1 activity in vivo, as measured by chlorzoxazone 6-hydroxylation, but did not affect the level of CYP2E1 apoprotein." | 1.31 | Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. ( Donohue, TM; Fang, C; French, BA; French, SW; Fu, P; Gouillon, Z; Hagbjork, AL; Ingelman-Sundberg, M; Li, J; Lucas, D, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, HY | 1 |
| Kang, HE | 1 |
| Choi, YH | 1 |
| Kim, SH | 2 |
| Lee, MG | 2 |
| Chung, W | 1 |
| Kim, EJ | 1 |
| Lee, I | 1 |
| Kim, SG | 1 |
| Gouillon, Z | 1 |
| Lucas, D | 1 |
| Li, J | 1 |
| Hagbjork, AL | 1 |
| French, BA | 1 |
| Fu, P | 1 |
| Fang, C | 1 |
| Ingelman-Sundberg, M | 1 |
| Donohue, TM | 1 |
| French, SW | 1 |
3 other studies available for 6-hydroxychlorzoxazone and Disease Models, Animal
| Article | Year |
|---|---|
Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels.
Topics: Acute Kidney Injury; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Disease Models, Animal; Drug I | 2009 |
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.
Topics: Acute Kidney Injury; Animals; Area Under Curve; Blood Proteins; Catalysis; Chlorzoxazone; Chromatogr | 2003 |
Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole.
Topics: Animals; Apoenzymes; Body Weight; Chlormethiazole; Chlorzoxazone; Chymotrypsin; Cysteine Endopeptida | 2000 |