6-hydroxychlorzoxazone and Acute Kidney Failure studies

6-hydroxychlorzoxazone and Acute Kidney Failure

6-hydroxychlorzoxazone: chlorzoxazone metabolite in humans

Research Excerpts

Excerpt	Relevance	Reference
" Thus, the time-dependent pharmacokinetic parameters of CZX and OH-CZX were evaluated after the intravenous administration of CZX (20 mg/kg) to control rats, and the 2 h, 24 h and 96 h KPLPS rats along with the time-dependent changes in the protein expression of hepatic Cyp2e1."	1.35	Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. ( Choi, YH; Jung, HY; Kang, HE; Kim, SH; Lee, MG, 2009)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

3 (100.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Jung, HY	1
Kang, HE	1
Choi, YH	1
Kim, SH	3
Lee, MG	3
Moon, YJ	1
Lee, AK	1
Chung, HC	1
Kim, EJ	2
Lee, DC	1
Lee, I	2
Kim, SG	2
Chung, W	1

Studies

Jung, HY

Kang, HE

Choi, YH

Kim, SH

Lee, MG

Moon, YJ

Lee, AK

Chung, HC

Kim, EJ

Lee, DC

Lee, I

Kim, SG

Chung, W

Other Studies

3 other studies available for 6-hydroxychlorzoxazone and Acute Kidney Failure

Article	Year
Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels. Biopharmaceutics & drug disposition, 2009, Volume: 30, Issue:8 Topics: Acute Kidney Injury; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Disease Models, Animal; Drug I	2009
Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:6 Topics: Acute Kidney Injury; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; C	2003
Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate. Life sciences, 2003, Jun-06, Volume: 73, Issue:3 Topics: Acute Kidney Injury; Animals; Area Under Curve; Blood Proteins; Catalysis; Chlorzoxazone; Chromatogr	2003

Article

Year

Time-dependent effects of Klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in KPLPS rats to control levels.

Biopharmaceutics & drug disposition, 2009, Volume: 30, Issue:8

Topics: Acute Kidney Injury; Animals; Chlorzoxazone; Cytochrome P-450 CYP2E1; Disease Models, Animal; Drug I

2009

Effects of acute renal failure on the pharmacokinetics of chlorzoxazone in rats.

Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:6

Topics: Acute Kidney Injury; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blotting, Northern; C

2003

Effects of recombinant human growth hormone on the pharmacokinetics of intravenous chlorzoxazone in rats with acute renal failure induced by uranyl nitrate.

Life sciences, 2003, Jun-06, Volume: 73, Issue:3

Topics: Acute Kidney Injury; Animals; Area Under Curve; Blood Proteins; Catalysis; Chlorzoxazone; Chromatogr

2003