6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Haas, R; Frambach, SJCM; Russel, FGM; Schirris, TJJ; Smeitink, JAM; van de Wal, MAE; van den Broek, PHH | 1 |
| Beyrath, J; Hankemeier, T; Jiang, X; Pecheritsyna, S; Pennings, B; Renkema, H; Schoeman, JC; Smeitink, J | 1 |
| Beyrath, J; Collin, RWJ; Das, D; de Haas, R; Garanto, A; Greupink, R; Heerschap, A; Pertijs, J; Renkema, HG; Russel, FG; Smeitink, JA; van den Broek, P; Willems, P | 1 |
| Bekel, A; Beyrath, J; Eftekhari, P; Houben, L; Pecheritsyna, S; Pellegrini, M; Renkema, H; Smeitink, JAM; van den Broek, P; van Zandvoort, P | 1 |
| Beukema, R; Beyrath, J; de Laat, P; Groothuis, J; Hemelaar, P; Janssen, MCH; Koene, S; Pickkers, P; Smeitink, J; Spaans, E; Verhaak, C | 1 |
| Beyrath, J; Blanchet, L; Buydens, LM; Jonckheere, AI; Koopman, WJ; Pellegrini, M; Rodenburg, RJ; Smeitink, JA; van Emst-de Vries, SE; Vogels, C; Willems, PH | 1 |
| Distelmaier, F; Koopman, WJ; Mayatepek, E; Smeitink, JA; Visch, HJ; Willems, PH | 1 |
| Dieteren, CE; Koopman, WJ; Nijtmans, LG; Roestenberg, P; Smeitink, JA; Valsecchi, F; Willems, PH | 1 |
1 review(s) available for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation.
Topics: Animals; Biological Transport; Cattle; Chromans; Electron Transport; Electron Transport Complex I; Eukaryotic Cells; Fibroblasts; Humans; Mammals; Membrane Lipids; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; NADH Dehydrogenase; Organ Specificity; Oxidative Phosphorylation; Reactive Oxygen Species; Rotenone; Signal Transduction | 2010 |
1 trial(s) available for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
The KHENERGY Study: Safety and Efficacy of KH176 in Mitochondrial m.3243A>G Spectrum Disorders.
Topics: Administration, Oral; Adult; Antioxidants; Chromans; Cross-Over Studies; DNA, Mitochondrial; Double-Blind Method; Female; Humans; Male; Middle Aged; Mitochondrial Diseases; Mutation; Treatment Outcome | 2019 |
6 other study(ies) available for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice.
Topics: Adenosine Triphosphate; Animals; Bezafibrate; Chromans; Clofibrate; Electron Transport Complex I; Fatty Acids; Humans; Leigh Disease; Longevity; Mice; Mice, Knockout; Mitochondria; Mitochondrial Diseases; Motor Activity; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors | 2020 |
Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE
Topics: Animals; Cells, Cultured; Chromans; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Humans; Inflammation; Interleukin-1beta; Intramolecular Oxidoreductases; Lipopolysaccharides; Mice; Microsomes; Mitochondrial Diseases; Oxidation-Reduction; Prostaglandin-E Synthases; RAW 264.7 Cells | 2021 |
Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease.
Topics: Animals; Brain; Chromans; Diffusion Tensor Imaging; Electron Transport Complex I; Gait; Leigh Disease; Mice; Mice, Knockout; Mitochondrial Diseases; Neuroimaging; Reactive Oxygen Species | 2017 |
KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery.
Topics: Apoptosis; Cell Death; Cell Line; Chromans; Dose-Response Relationship, Drug; Electron Transport Complex I; Glutathione; Humans; Mitochondria; Mitochondrial Diseases; Models, Molecular; Molecular Conformation; Molecular Structure; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Peroxiredoxins; Reactive Oxygen Species; Structure-Activity Relationship; Thioredoxins | 2018 |
Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning.
Topics: Chromans; Citrate (si)-Synthase; Electron Transport Complex I; Fibroblasts; Humans; Leigh Disease; Machine Learning; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; Oxidative Phosphorylation; Reactive Oxygen Species | 2015 |
The antioxidant Trolox restores mitochondrial membrane potential and Ca2+ -stimulated ATP production in human complex I deficiency.
Topics: Adenosine Triphosphate; Antioxidants; Bradykinin; Calcium; Cell Line; Chromans; Dose-Response Relationship, Drug; Electron Transport Complex I; Endoplasmic Reticulum; Fibroblasts; Humans; Membrane Potential, Mitochondrial; Mitochondrial Diseases; Reactive Oxygen Species | 2009 |