6-hydrazinopyridine-3-carboxylic-acid and Alzheimer-Disease

The authors sought to use radiolabeled annexin V, a marker of phosphatidylserine expression, to image Alzheimer dementia (AD). Four of five patients with AD had multifocal cortical annexin V uptake, whereas all seven non-AD and six control patients had normal SPECT. The mean cortex/cerebellar activity in patients with AD (1.4 +/- 0.6) was higher than that of non-AD dementia patients (0.7 +/- 0.2; p = 0.02). Radiolabeled annexin V may be useful for imaging AD.

Topics: Aged; Aged, 80 and over; Alzheimer Disease; Annexin A5; Dementia; Dementia, Vascular; Female; Humans; Hydrazines; Injections, Intravenous; Lewy Body Disease; Ligands; Magnetic Resonance Imaging; Male; Middle Aged; Nicotinic Acids; Phosphatidylserines; Pilot Projects; Technetium; Tomography, Emission-Computed, Single-Photon