6-cyano-7-nitroquinoxaline-2-3-dione and Tremor
6-cyano-7-nitroquinoxaline-2-3-dione has been researched along with Tremor* in 1 studies
Other Studies
1 other study(ies) available for 6-cyano-7-nitroquinoxaline-2-3-dione and Tremor
Article | Year |
---|---|
Conveyance of cortical pacing for parkinsonian tremor-like hyperkinetic behavior by subthalamic dysrhythmia.
Parkinson's disease is characterized by both hypokinetic and hyperkinetic symptoms. While increased subthalamic burst discharges have a direct causal relationship with the hypokinetic manifestations (e.g., rigidity and bradykinesia), the origin of the hyperkinetic symptoms (e.g., resting tremor and propulsive gait) has remained obscure. Neuronal burst discharges are presumed to be autonomous or less responsive to synaptic input, thereby interrupting the information flow. We, however, demonstrate that subthalamic burst discharges are dependent on cortical glutamatergic synaptic input, which is enhanced by A-type K Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Globus Pallidus; Glutamic Acid; Humans; Hyperkinesis; Male; Membrane Potentials; Mice, Inbred C57BL; Motor Cortex; Muscle, Skeletal; Optogenetics; Parkinson Disease, Secondary; Rats; Rats, Wistar; Subthalamic Nucleus; Synapses; Synaptic Transmission; Tremor | 2021 |