Compounds > 6-cyano-7-nitroquinoxaline-2-3-dione

6-cyano-7-nitroquinoxaline-2-3-dione and Hypotension

6-cyano-7-nitroquinoxaline-2-3-dione has been researched along with Hypotension* in 1 studies

Other Studies

1 other study(ies) available for 6-cyano-7-nitroquinoxaline-2-3-dione and Hypotension

Article	Year
Hypotension to central endothelin-1: effect of glutamate receptor blockade. Biochemical and biophysical research communications, 1994, Nov-30, Volume: 205, Issue:1 Endothelin-1 (ET-1) produces hypotension via an action at glutamate-sensitive medullary cardiovascular sites. Here, we used excitatory amino acid (EAA) receptor antagonists to examine the possible role of an endogenous EAA in this neural action of central ET-1. ET-1 (3 pmol) applied to the IV ventricle of anesthetized, artificially ventilated rats elicited a sustained decrease in blood pressure (27 +/- 6%). Pretreatment with two EAA receptor antagonists, APV and CNQX (or MK-801 and CNQX), significantly attenuated the hypotension to central ET-1 (11 +/- 4%). Since these antagonists do not interact with endothelin receptors, we conclude that release of an endogenous EAA may contribute to the hypotensive action of central ET-1. Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Endothelins; Excitatory Amino Acid Antagonists; Hypotension; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate	1994

Article

Year

Hypotension to central endothelin-1: effect of glutamate receptor blockade.

Biochemical and biophysical research communications, 1994, Nov-30, Volume: 205, Issue:1

Endothelin-1 (ET-1) produces hypotension via an action at glutamate-sensitive medullary cardiovascular sites. Here, we used excitatory amino acid (EAA) receptor antagonists to examine the possible role of an endogenous EAA in this neural action of central ET-1. ET-1 (3 pmol) applied to the IV ventricle of anesthetized, artificially ventilated rats elicited a sustained decrease in blood pressure (27 +/- 6%). Pretreatment with two EAA receptor antagonists, APV and CNQX (or MK-801 and CNQX), significantly attenuated the hypotension to central ET-1 (11 +/- 4%). Since these antagonists do not interact with endothelin receptors, we conclude that release of an endogenous EAA may contribute to the hypotensive action of central ET-1.

Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Endothelins; Excitatory Amino Acid Antagonists; Hypotension; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate

1994