6-chloro-6-deoxyglucose and Nerve-Degeneration

6-chloro-6-deoxyglucose (24 mg/kg/day) produces infertility in male rats and marmosets. In the present study very high doses (480 mg/kg/day) were found not to impair the fertility of male mice. However, such doses induced the formation of vacuolated lesions in specific regions of central nervous system grey matter causing varying degrees of physical disability. A similar response has been obtained in marmosets. Astrocytes appear to be primarily affected with later involvement of nerve cells. The sites of lesions correspond closely to regions of high glucose utilization.

Topics: Animals; Astrocytes; Central Nervous System; Contraceptive Agents, Male; Deoxy Sugars; Deoxyglucose; Fertility; Glucose; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Vacuoles