6-chloro-6-deoxyglucose and Nerve-Degeneration

6-chloro-6-deoxyglucose has been researched along with Nerve-Degeneration* in 1 studies

Other Studies

1 other study(ies) available for 6-chloro-6-deoxyglucose and Nerve-Degeneration

ArticleYear
The neurotoxicity and antifertility properties of 6-chloro-6-deoxyglucose in the mouse.
    Neurotoxicology, 1981, Volume: 2, Issue:3

    6-chloro-6-deoxyglucose (24 mg/kg/day) produces infertility in male rats and marmosets. In the present study very high doses (480 mg/kg/day) were found not to impair the fertility of male mice. However, such doses induced the formation of vacuolated lesions in specific regions of central nervous system grey matter causing varying degrees of physical disability. A similar response has been obtained in marmosets. Astrocytes appear to be primarily affected with later involvement of nerve cells. The sites of lesions correspond closely to regions of high glucose utilization.

    Topics: Animals; Astrocytes; Central Nervous System; Contraceptive Agents, Male; Deoxy Sugars; Deoxyglucose; Fertility; Glucose; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Vacuoles

1981