6-anilino-5,8-quinolinedione has been researched along with Muscle Relaxation in 37 studies
6-anilino-5,8-quinolinedione: structure given in first source; SRS-A & guanylate cyclase antagonist
6-anilino-5,8-quinolinedione : A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " BNP inhibited the contractile response produced by CCK-8 in a dose-response manner, with an IC50 value of 8." | 1.31 | Interaction between brain natriuretic peptide and atrial natriuretic peptide in caecal circular smooth muscle cells. ( Chijiiwa, Y; Motomura, Y; Nawata, H; Ochiai, T; Yasuda, O, 2000) |
| "Halothane has been shown to inhibit the action of NO on blood vessels." | 1.30 | Halothane attenuates nitric oxide relaxation of rat aortas by competition for the nitric oxide receptor site on soluble guanylyl cyclase. ( Bina, S; Hart, JL; Jing, M; Ling, GS; Muldoon, SM, 1998) |
| "Clonidine did not increase cGMP levels in vascular preparations with intact endothelia, in the presence or absence of LY83583." | 1.27 | Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation. ( Diamond, J; Harris, KH; MacLeod, KM; Ng, DD, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.11) | 18.7374 |
| 1990's | 27 (72.97) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ryu, CK | 1 |
| Jung, SH | 1 |
| Lee, JA | 1 |
| Kim, HJ | 1 |
| Lee, SH | 1 |
| Chung, JH | 1 |
| Ertuğ, PU | 1 |
| Aydinoglu, F | 1 |
| Goruroglu Ozturk, O | 1 |
| Singirik, E | 1 |
| Ögülener, N | 1 |
| Jun, CH | 1 |
| Lee, TS | 1 |
| Sohn, UD | 1 |
| Matsuda, NM | 1 |
| Lemos, MC | 1 |
| Feitosa, RL | 1 |
| Kannan, MS | 2 |
| Johnson, DE | 2 |
| Martin, W | 1 |
| McAllister, KH | 1 |
| Paisley, K | 1 |
| Kawada, T | 1 |
| Ishibashi, T | 1 |
| Sasage, H | 1 |
| Kato, K | 1 |
| Imai, S | 1 |
| Akiho, H | 2 |
| Chijiiwa, Y | 3 |
| Okabe, H | 1 |
| Harada, N | 1 |
| Nawata, H | 3 |
| Moritoki, H | 1 |
| Hisayama, T | 1 |
| Kondoh, W | 1 |
| Takeuchi, S | 1 |
| Wu, M | 1 |
| Pritchard, KA | 1 |
| Kaminski, PM | 1 |
| Fayngersh, RP | 1 |
| Hintze, TH | 1 |
| Wolin, MS | 1 |
| Jin, JG | 2 |
| Murthy, KS | 2 |
| Grider, JR | 2 |
| Makhlouf, GM | 2 |
| Wong, WS | 1 |
| Roman, CR | 1 |
| Fleisch, JH | 1 |
| Iwakiri, Y | 1 |
| Motomura, Y | 2 |
| Osame, M | 1 |
| Coceani, F | 2 |
| Kelsey, L | 2 |
| Seidlitz, E | 1 |
| Takeuchi, T | 1 |
| Kishi, M | 1 |
| Ishii, T | 1 |
| Nishio, H | 1 |
| Hata, F | 1 |
| Shenberger, JS | 1 |
| Shew, RL | 1 |
| Hernández, M | 1 |
| Elmedal, B | 1 |
| Mulvany, MJ | 1 |
| Simonsen, U | 1 |
| Stuart-Smith, K | 1 |
| Warner, DO | 1 |
| Jones, KA | 1 |
| Jing, M | 1 |
| Ling, GS | 1 |
| Bina, S | 1 |
| Hart, JL | 1 |
| Muldoon, SM | 1 |
| Clyman, RI | 1 |
| Waleh, N | 1 |
| Black, SM | 1 |
| Riemer, RK | 1 |
| Mauray, F | 1 |
| Chen, YQ | 1 |
| Jia, Y | 1 |
| Zacour, M | 1 |
| Tolloczko, B | 1 |
| Martin, JG | 1 |
| Göçmen, C | 1 |
| Seçilmiş, A | 1 |
| Uçar, P | 1 |
| Karataş, Y | 1 |
| Onder, S | 1 |
| Dikmen, A | 1 |
| Baysal, F | 1 |
| Davie, CS | 1 |
| Kubo, M | 1 |
| Standen, NB | 1 |
| Kwan, YW | 1 |
| To, KW | 1 |
| Lau, WM | 1 |
| Tsang, SH | 1 |
| Hernanz, R | 1 |
| Alonso, MJ | 1 |
| Baena, AB | 1 |
| Salaices, M | 1 |
| Alvarez, L | 1 |
| Castillo-Olivares, JL | 1 |
| Marín, J | 1 |
| Yasuda, O | 1 |
| Ochiai, T | 1 |
| Colpaert, EE | 1 |
| Lefebvre, RA | 2 |
| Minhas, S | 1 |
| Eardley, I | 1 |
| Joyce, AD | 1 |
| Morrison, JB | 1 |
| Grser, T | 1 |
| Rubanyi, GM | 1 |
| Barbier, AJ | 1 |
| Triggle, CR | 1 |
| Bieger, D | 1 |
| Torfgård, K | 1 |
| Ahlner, J | 1 |
| Axelsson, KL | 1 |
| Diamond, J | 2 |
| MacLeod, KM | 1 |
| Ng, DD | 1 |
| Harris, KH | 1 |
| Malta, E | 1 |
| Macdonald, PS | 1 |
| Dusting, GJ | 1 |
37 other studies available for 6-anilino-5,8-quinolinedione and Muscle Relaxation
| Article | Year |
|---|---|
6-arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation.
Topics: Animals; Aorta; Endothelium, Vascular; Muscle Relaxation; Quinolines; Rats; Structure-Activity Relat | 1999 |
Comparative study of the quercetin, ascorbic acid, glutathione and superoxide dismutase for nitric oxide protecting effects in mouse gastric fundus.
Topics: Aminoquinolines; Animals; Antioxidants; Ascorbic Acid; Ditiocarb; Female; Gastric Fundus; Glutathion | 2013 |
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response R | 2003 |
The effect of guanylate cyclase inhibitors on non-adrenergic and non-cholinergic neurogenic relaxations of the South American opossum lower esophageal sphincter.
Topics: Aminoquinolines; Animals; Cyclic GMP; Cysteamine; Electric Stimulation; Esophageal Sphincter, Lower; | 2008 |
Modulation of nitric oxide-dependent relaxation of pig tracheal smooth muscle by inhibitors of guanylyl cyclase and calcium activated potassium channels.
Topics: Aminoquinolines; Animals; Calcium; Charybdotoxin; Electric Stimulation; Guanylate Cyclase; Isoproter | 1995 |
NANC neurotransmission in the bovine retractor penis muscle is blocked by superoxide anion following inhibition of superoxide dismutase with diethyldithiocarbamate.
Topics: Aminoquinolines; Animals; Autonomic Nervous System; Cattle; Ditiocarb; Guanylate Cyclase; In Vitro T | 1994 |
Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit.
Topics: Aminoquinolines; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Drug Interactions; | 1994 |
Direct inhibitory effect of atrial natriuretic peptide on isolated caecal circular smooth muscle cells via soluble guanylate cyclase.
Topics: Aminoquinolines; Animals; Atrial Natriuretic Factor; Carbachol; Cecum; Dideoxyadenosine; Guanylate C | 1994 |
Thapsigargin, a Ca(2+)-ATPase inhibitor, relaxes rat aorta via nitric oxide formation.
Topics: Aminoquinolines; Animals; Aorta, Thoracic; Arginine; Calcium; Calcium-Transporting ATPases; Cyclic G | 1994 |
Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite.
Topics: Aminoquinolines; Animals; Cattle; Free Radical Scavengers; Glutathione; In Vitro Techniques; Kinetic | 1994 |
Activation of distinct cAMP- and cGMP-dependent pathways by relaxant agents in isolated gastric muscle cells.
Topics: Aminoquinolines; Animals; Arginine; Cell Separation; Colon; Cyclic AMP; Cyclic GMP; Digestive System | 1993 |
Differential relaxant responses of guinea-pig lung strips and bronchial rings to sodium nitroprusside: a mechanism independent of cGMP formation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aminoquinolines; Analysis of Var | 1995 |
Direct inhibitory effect of corticotropin releasing hormone on isolated caecal circular smooth muscle cells of guinea pig via adenylate cyclase system.
Topics: Adenylyl Cyclase Inhibitors; Aminoquinolines; Animals; Cecum; Corticotropin-Releasing Hormone; Enzym | 1996 |
Carbon monoxide-induced relaxation of the ductus arteriosus in the lamb: evidence against the prime role of guanylyl cyclase.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Monoxide; Cyclic GMP; Cyto | 1996 |
Nitric oxide-mediated relaxation without concomitant changes in cyclic GMP content of rat proximal colon.
Topics: Aminoquinolines; Animals; Colon; Cyclic GMP; Dimethylphenylpiperazinium Iodide; Dose-Response Relati | 1996 |
Relaxation of porcine tracheal smooth muscle by parathyroid hormone-related protein.
Topics: 1-Methyl-3-isobutylxanthine; Aminoquinolines; Animals; Carbachol; Cyclic AMP; Dose-Response Relation | 1997 |
Characterization of PACAP receptors and signaling pathways in rabbit gastric muscle cells.
Topics: Adenylate Cyclase Toxin; Alkaloids; Aminoquinolines; Animals; Calcium; Carbazoles; Cells, Cultured; | 1997 |
Mechanisms of relaxations of bovine isolated bronchioles by the nitric oxide donor, GEA 3175.
Topics: Albuterol; Aminoquinolines; Animals; Apamin; Bronchi; Bronchodilator Agents; Cattle; Charybdotoxin; | 1998 |
The role of cGMP in the relaxation to nitric oxide donors in airway smooth muscle.
Topics: Aminoquinolines; Animals; Antidotes; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors | 1998 |
Halothane attenuates nitric oxide relaxation of rat aortas by competition for the nitric oxide receptor site on soluble guanylyl cyclase.
Topics: Aminoquinolines; Anesthetics, Inhalation; Animals; Aorta, Thoracic; Binding, Competitive; Cyclic GMP | 1998 |
Regulation of ductus arteriosus patency by nitric oxide in fetal lambs: the role of gestation, oxygen tension, and vasa vasorum.
Topics: Aminoquinolines; Animals; Aorta; Calcimycin; Ductus Arteriosus; Ductus Arteriosus, Patent; Enzyme In | 1998 |
Nitric oxide synthesis by tracheal smooth muscle cells by a nitric oxide synthase-independent pathway.
Topics: Aminoquinolines; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Hydrox | 1998 |
A possible role of S-nitrosothiols at the nitrergic relaxations in the mouse corpus cavernosum.
Topics: Acetylcholine; Aminoquinolines; Animals; Chelating Agents; Ditiocarb; Electric Stimulation; Enzyme I | 1998 |
Potassium channel activation and relaxation by nicorandil in rat small mesenteric arteries.
Topics: Aminoquinolines; Animals; Calcium Channels; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Electrophysio | 1998 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxi | 1999 |
Mechanisms involved in relaxation induced by exogenous nitric oxide in pig coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aminoquinolines; Animals; Corona | 1999 |
Interaction between brain natriuretic peptide and atrial natriuretic peptide in caecal circular smooth muscle cells.
Topics: Aminoquinolines; Animals; Atrial Natriuretic Factor; Binding Sites; Cecum; Cyclic AMP; Guinea Pigs; | 2000 |
Influence of bilirubin and other antioxidants on nitrergic relaxation in the pig gastric fundus.
Topics: Aminoquinolines; Animals; Antioxidants; Bilirubin; Biliverdine; Electric Stimulation; Enzyme Inhibit | 2000 |
The effect of cyclic GMP on rabbit corporal smooth muscle tone and its modulation by cyclo-oxygenase products.
Topics: Acetylcholine; Aminoquinolines; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Indometha | 2000 |
Endothelin-1 release from the lamb ductus arteriosus: are carbon monoxide and nitric oxide regulatory agents?
Topics: Aminoquinolines; Animals; Carbon Monoxide; Cyclic AMP; Ductus Arteriosus; Endothelin-1; Endotoxins; | 2000 |
Different mechanisms of hypoxic relaxation in canine coronary arteries and rat abdominal aortas.
Topics: Aminoquinolines; Animals; Aorta, Abdominal; Arginine; Coronary Vessels; Dinoprost; Dogs; Endothelium | 1992 |
Effect of LY 83583 on relaxation induced by non-adrenergic non-cholinergic nerve stimulation and exogenous nitric oxide in the rat gastric fundus.
Topics: Aminoquinolines; Animals; Electric Stimulation; Female; Gastric Fundus; Male; Muscle Relaxation; Mus | 1992 |
Can dihydropyridines enhance photorelaxation of smooth muscle by calcium-independent mechanisms?
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1990 |
Relaxation of bovine mesenteric arteries by glyceryl trinitrate and other nitro-compounds: evidence for partly different mechanisms of action.
Topics: Aminoquinolines; Animals; Cattle; Female; Isosorbide Dinitrate; Mesenteric Arteries; Mice; Muscle Re | 1990 |
Effects of LY83583, nordihydroguaiaretic acid, and quinacrine on cyclic GMP elevation and inhibition of tension by muscarinic agonists in rabbit aorta and left atrium.
Topics: Acetylcholine; Aminoquinolines; Animals; Aorta, Thoracic; Catechols; Cyclic GMP; Epoprostenol; Femal | 1987 |
Evidence that cGMP is the mediator of endothelium-dependent inhibition of contractile responses of rat arteries to alpha-adrenoceptor stimulation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Aminoquinolines; Animals; Aorta; Clonidine; Cyclic GMP; En | 1987 |
Inhibition of vascular smooth muscle relaxation by LY83583.
Topics: Acetylcholine; Adenosine Triphosphate; Aminoquinolines; Animals; Cyclic GMP; Endothelium, Vascular; | 1988 |