6-anilino-5,8-quinolinedione has been researched along with Astrocytoma in 2 studies
6-anilino-5,8-quinolinedione: structure given in first source; SRS-A & guanylate cyclase antagonist
6-anilino-5,8-quinolinedione : A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of 6-anilino-5,8-quinolinedione (LY83583), an inhibitor of guanylyl cyclase (GC), on the growth of human brain tumor cells (U-373 MG astrocytoma and SK-N-MC neuroblastoma) was evaluated." | 3.69 | Mechanism of potentiation of LY83583-induced growth inhibition by sodium nitroprusside in human brain tumor cells. ( Lee, YS; Wurster, RD, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, YS | 1 |
| Wurster, RD | 1 |
| Meini, A | 1 |
| Benocci, A | 1 |
| Frosini, M | 1 |
| Sgaragli, G | 1 |
| Pessina, G | 1 |
| Aldinucci, C | 1 |
| Youmbi, GT | 1 |
| Palmi, M | 1 |
2 other studies available for 6-anilino-5,8-quinolinedione and Astrocytoma
| Article | Year |
|---|---|
Mechanism of potentiation of LY83583-induced growth inhibition by sodium nitroprusside in human brain tumor cells.
Topics: Aminoquinolines; Analysis of Variance; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Calcium; | 1995 |
Nitric oxide modulation of interleukin-1[beta]-evoked intracellular Ca2+ release in human astrocytoma U-373 MG cells and brain striatal slices.
Topics: Aminoquinolines; Animals; Arginine; Astrocytoma; Calcium; Corpus Striatum; Cyclic GMP; Dibutyryl Cyc | 2000 |