6-7-dihydroxyflavone has been researched along with Myocardial-Ischemia* in 1 studies
1 other study(ies) available for 6-7-dihydroxyflavone and Myocardial-Ischemia
| Article | Year |
|---|---|
Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing.
Brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is associated with ischemic heart diseases (IHD). 7,8-dihydroxyflavone (7,8-DHF), BDNF mimetic, is a potent agonist of TrkB. We aimed to investigate the effects and the underlying mechanisms of 7,8-DHF on cardiac ischemia. Myocardial ischemic mouse model was induced by ligation of left anterior descending coronary artery. 7,8-DHF (5 mg/kg) was administered intraperitoneally two days after ischemia for four weeks. Echocardiography, HE staining and transmission electron microscope were used to examine the function, histology and ultrastructure of the heart. H9c2 cells were treated with hydrogen peroxide (H Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Death; Cell Survival; Flavones; GTP Phosphohydrolases; Heart; Humans; Hydrogen Peroxide; Membrane Glycoproteins; Mice; Mitochondria; Mitochondrial Dynamics; Myocardial Ischemia; Neuroprotective Agents; Optic Atrophy, Autosomal Dominant; Protein-Tyrosine Kinases | 2019 |