6-7-dihydroxyflavone and Anxiety-Disorders

6-7-dihydroxyflavone has been researched along with Anxiety-Disorders* in 1 studies

Other Studies

1 other study(ies) available for 6-7-dihydroxyflavone and Anxiety-Disorders

Article	Year
Activation of BDNF signaling prevents the return of fear in female mice. Learning & memory (Cold Spring Harbor, N.Y.), 2013, Apr-15, Volume: 20, Issue:5 There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the development of PTSD. Here we report that female mice are resistant to fear extinction, and exhibit increased DNA methylation of Bdnf exon IV and a concomitant decrease in mRNA expression within the medial prefrontal cortex. Activation of BDNF signaling by the trkB agonist 7,8-dihydroxyflavone blocks the return of fear in female mice after extinction training, and thus represents a novel approach to treating fear-related anxiety disorders that are characterized by a resistance to extinction and increased propensity for renewal. Topics: Animals; Anxiety Disorders; Brain-Derived Neurotrophic Factor; Disease Models, Animal; DNA Methylation; Exons; Extinction, Psychological; Fear; Female; Flavones; Mice; Prefrontal Cortex; RNA, Messenger; Signal Transduction	2013

Article

Year

Activation of BDNF signaling prevents the return of fear in female mice.

Learning & memory (Cold Spring Harbor, N.Y.), 2013, Apr-15, Volume: 20, Issue:5

There are significant sex differences in vulnerability to develop fear-related anxiety disorders. Females exhibit twice the rate of post-traumatic stress disorder (PTSD) as males and sex differences have been observed in fear extinction learning in both humans and rodents, with a failure to inhibit fear emerging as a precipitating factor in the development of PTSD. Here we report that female mice are resistant to fear extinction, and exhibit increased DNA methylation of Bdnf exon IV and a concomitant decrease in mRNA expression within the medial prefrontal cortex. Activation of BDNF signaling by the trkB agonist 7,8-dihydroxyflavone blocks the return of fear in female mice after extinction training, and thus represents a novel approach to treating fear-related anxiety disorders that are characterized by a resistance to extinction and increased propensity for renewal.

Topics: Animals; Anxiety Disorders; Brain-Derived Neurotrophic Factor; Disease Models, Animal; DNA Methylation; Exons; Extinction, Psychological; Fear; Female; Flavones; Mice; Prefrontal Cortex; RNA, Messenger; Signal Transduction

2013