5-oxo-6-8-11-14-eicosatetraenoic-acid has been researched along with Hypersensitivity* in 1 studies
1 other study(ies) available for 5-oxo-6-8-11-14-eicosatetraenoic-acid and Hypersensitivity
| Article | Year |
|---|---|
The effect of allergen-induced bronchoconstriction on concentration of 5-oxo-ETE in exhaled breath condensate of house dust mite-allergic patients.
Arachidonic acid metabolites regulate several aspects of airway function including inflammation, muscle contraction and mucous secretion.. The aim of this study was to evaluate concentration of selected 5-lipoxygenase- and cyclooxygenase-derived eicosanoids in exhaled breath condensate (EBC) during allergen-induced bronchoconstriction.. The study was performed on 24 allergic rhinitis/asthma patients sensitized to a house dust mite (HDM) Dermatophagoides pteronyssinus (Dp) and 13 healthy controls (HCs). Bronchial challenge with Dp extract was performed only in the allergic patients. EBC samples were collected before (T. Our study demonstrates significant up-regulation of 5-oxo-ETE synthesis in HDM-allergic patients and indicates possible involvement of that mediator in the pathogenesis of allergic asthma. Topics: Adult; Allergens; Animals; Antigens, Dermatophagoides; Arachidonic Acids; Biomarkers; Bronchoconstriction; Eicosanoids; Exhalation; Female; Humans; Hypersensitivity; Male; Nitric Oxide; Pyroglyphidae; Respiratory Function Tests; Skin Tests; Tandem Mass Spectrometry; Young Adult | 2017 |