5-nitro-2-(3-phenylpropylamino)benzoic acid has been researched along with Malaria, Falciparum in 4 studies
5-nitro-2-(3-phenylpropylamino)benzoic acid: structure given in first source; chloride channel antagonist
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For all of the substrates tested the order of potency of these three inhibitors was the same (NPPB > furosemide > niflumate) and dose-response curves for the effect of these inhibitors on malaria-induced choline transport were similar to those for malaria-induced thymidine transport." | 1.29 | Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel. ( Elford, BC; Ellory, JC; Horner, HA; Kirk, K; Newbold, CI, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, ME | 1 |
| Parrott, EE | 1 |
| Singh, R | 1 |
| Nelson, SW | 1 |
| Huber, SM | 2 |
| Lang, C | 1 |
| Lang, F | 2 |
| Duranton, C | 1 |
| Staines, HM | 1 |
| Alkhalil, A | 1 |
| Allen, RJ | 1 |
| De Jonge, HR | 1 |
| Derbyshire, E | 1 |
| Egée, S | 1 |
| Ginsburg, H | 1 |
| Hill, DA | 1 |
| Kirk, K | 2 |
| Lisk, G | 1 |
| Oteng, E | 1 |
| Pillai, AD | 1 |
| Rayavara, K | 1 |
| Rouhani, S | 1 |
| Saliba, KJ | 1 |
| Shen, C | 1 |
| Solomon, T | 1 |
| Thomas, SL | 1 |
| Verloo, P | 1 |
| Desai, SA | 1 |
| Horner, HA | 1 |
| Elford, BC | 1 |
| Ellory, JC | 1 |
| Newbold, CI | 1 |
1 review available for 5-nitro-2-(3-phenylpropylamino)benzoic acid and Malaria, Falciparum
| Article | Year |
|---|---|
Electrophysiological studies of malaria parasite-infected erythrocytes: current status.
Topics: Animals; Anions; Cell Membrane Permeability; Dantrolene; Erythrocytes; Furosemide; Humans; Ion Chann | 2007 |
3 other studies available for 5-nitro-2-(3-phenylpropylamino)benzoic acid and Malaria, Falciparum
| Article | Year |
|---|---|
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
Topics: Antimalarials; Apicoplasts; Chloroplasts; DNA; DNA-Directed DNA Polymerase; Drug Discovery; Exonucle | 2014 |
Organic osmolyte channels in malaria-infected erythrocytes.
Topics: Animals; Cells, Cultured; Erythrocyte Membrane; Erythrocytes; Humans; Ion Channels; Malaria, Falcipa | 2008 |
Transport of diverse substrates into malaria-infected erythrocytes via a pathway showing functional characteristics of a chloride channel.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport, Active; Bumetanide; | 1994 |