5-nitro-2-(3-phenylpropylamino)benzoic acid has been researched along with Cystic Fibrosis in 11 studies
5-nitro-2-(3-phenylpropylamino)benzoic acid: structure given in first source; chloride channel antagonist
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "VX-770 (Ivacaftor) has been approved for clinical usage in cystic fibrosis patients with several CFTR mutations." | 3.83 | Potentiators exert distinct effects on human, murine, and Xenopus CFTR. ( Cui, G; Imhoff, BR; Infield, DT; Khazanov, N; McCarty, NA; Senderowitz, H; Stauffer, BB, 2016) |
| "Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel, which mediates transepithelial Cl- transport in a variety of epithelia, including airway, intestine, pancreas, and sweat duct." | 1.30 | Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells. ( Loffing, J; McCoy, D; Moyer, BD; Stanton, BA, 1998) |
| "Cystic fibrosis has been characterized as a defect in the regulation of cyclic AMP-dependent transepithelial chloride transport." | 1.29 | Cyclic AMP-related and cation-affected human platelet chloride transport regulation. ( Agam, G; Aviram, M; Livne, AA; Rothstein, A; Zilberman-Kaufman, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jeong, JH | 1 |
| Joo, NS | 1 |
| Hwang, PH | 1 |
| Wine, JJ | 1 |
| Stott, JB | 1 |
| deCourcey, F | 1 |
| Ennis, M | 1 |
| Zholos, AV | 1 |
| Cui, G | 1 |
| Khazanov, N | 1 |
| Stauffer, BB | 1 |
| Infield, DT | 1 |
| Imhoff, BR | 1 |
| Senderowitz, H | 1 |
| McCarty, NA | 1 |
| Cho, WK | 1 |
| Siegrist, VJ | 1 |
| Zinzow, W | 1 |
| Agam, G | 1 |
| Aviram, M | 1 |
| Zilberman-Kaufman, M | 1 |
| Rothstein, A | 1 |
| Livne, AA | 1 |
| Jiang, C | 1 |
| Finkbeiner, WE | 1 |
| Widdicombe, JH | 1 |
| Miller, SS | 1 |
| Loffing, J | 1 |
| Moyer, BD | 1 |
| McCoy, D | 1 |
| Stanton, BA | 1 |
| Rückes-Nilges, C | 1 |
| Weber, U | 1 |
| Lindemann, H | 1 |
| Münker, G | 1 |
| Clauss, W | 1 |
| Weber, WM | 1 |
| Gabriel, SE | 1 |
| Makhlina, M | 1 |
| Martsen, E | 1 |
| Thomas, EJ | 1 |
| Lethem, MI | 1 |
| Boucher, RC | 1 |
| Gyömörey, K | 1 |
| Garami, E | 1 |
| Galley, K | 1 |
| Rommens, JM | 1 |
| Bear, CE | 1 |
| Kunzelmann, K | 1 |
| Pavenstädt, H | 1 |
| Greger, R | 1 |
11 other studies available for 5-nitro-2-(3-phenylpropylamino)benzoic acid and Cystic Fibrosis
| Article | Year |
|---|---|
Mucociliary clearance and submucosal gland secretion in the ex vivo ferret trachea.
Topics: Analgesics, Non-Narcotic; Angiogenesis Inhibitors; Animals; Bronchodilator Agents; Bumetanide; Calci | 2014 |
Functional and pharmacological characterization of volume-regulated anion channels in human normal and cystic fibrosis bronchial and nasal epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Bronchi; Cell Line; Chloride Channels; Cyclopentan | 2014 |
Potentiators exert distinct effects on human, murine, and Xenopus CFTR.
Topics: Amino Acid Sequence; Aminophenols; Animals; Cells, Cultured; Chloride Channel Agonists; Cystic Fibro | 2016 |
Impaired regulatory volume decrease in freshly isolated cholangiocytes from cystic fibrosis mice: implications for cystic fibrosis transmembrane conductance regulator effect on potassium conductance.
Topics: 1-Methyl-3-isobutylxanthine; Angiogenesis Inhibitors; Animals; Bile Ducts; Buffers; Colforsin; Cycli | 2004 |
Cyclic AMP-related and cation-affected human platelet chloride transport regulation.
Topics: Adolescent; Alprostadil; Blood Platelets; Cations; Child; Child, Preschool; Chloride Channels; Cycli | 1995 |
Fluid transport across cultures of human tracheal glands is altered in cystic fibrosis.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Biological Transport, Active; Body Flui | 1997 |
Exocytosis is not involved in activation of Cl- secretion via CFTR in Calu-3 airway epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Amiloride; Cell Membrane; Chloride | 1998 |
Minor role of Cl- secretion in non-cystic fibrosis and cystic fibrosis human nasal epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Amiloride; Calcium Channel | 1999 |
Permeabilization via the P2X7 purinoreceptor reveals the presence of a Ca2+-activated Cl- conductance in the apical membrane of murine tracheal epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bromine; Calcium; Calcium Channel Blocker | 2000 |
Non-CFTR chloride channels likely contribute to secretion in the murine small intestine.
Topics: Angiogenesis Inhibitors; Animals; Biological Transport; Calcium Signaling; Chloride Channels; Chlori | 2001 |
Properties and regulation of chloride channels in cystic fibrosis and normal airway cells.
Topics: Calcium; Cell Membrane; Cells, Cultured; Chloride Channels; Chlorides; Cystic Fibrosis; Electric Con | 1989 |