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5-methoxypsoralen and Cancer of Skin

5-methoxypsoralen has been researched along with Cancer of Skin in 12 studies

5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.
5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.

Research Excerpts

ExcerptRelevanceReference
" All test groups developed atypical squamous papillomas in direct proportion to the dosage of UVA radiation received."1.27Psoralen-containing sunscreen is tumorigenic in hairless mice. ( Cartwright, LE; Walter, JF, 1983)
"Most of the tumors were rapidly growing squamous cell carcinomas giving metastases in 20% of the animals."1.265-Methoxypsoralen, the melanogenic additive in sun-tan preparations, is tumorigenic in mice exposed to 365 nm u.v. radiation. ( Bisagni, E; Zajdela, F, 1981)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's5 (41.67)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wackernagel, A1
Hofer, A1
Legat, F1
Kerl, H2
Wolf, P2
Magnus, IA3
Young, AR4
Pathak, MA1
Davies, AC1
Smith, NP1
Cartwright, LE1
Walter, JF1
Zajdela, F1
Bisagni, E1
Müllegger, R1
Cerroni, L1
Aigner, R1
Fueger, G1
Höfler, G1
Derbaschnig, J1
Shephard, SE1
Panizzon, RG1
Reeve, VE1
Greenoak, GE1
Boehm-Wilcox, C1
Canfield, PJ1
Gallagher, CH1
Walker, SL1
Kinley, JS1
Plastow, SR1
Averbeck, D1
Morlière, P1
Dubertret, L1
Gibbs, NK1

Reviews

1 review available for 5-methoxypsoralen and Cancer of Skin

ArticleYear
Sunscreens: topical and systemic approaches for protection of human skin against harmful effects of solar radiation.
    Journal of the American Academy of Dermatology, 1982, Volume: 7, Issue:3

    Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; beta Carotene; Carotenoids; Chloro

1982

Other Studies

11 other studies available for 5-methoxypsoralen and Cancer of Skin

ArticleYear
Efficacy of 8-methoxypsoralen vs. 5-methoxypsoralen plus ultraviolet A therapy in patients with mycosis fungoides.
    The British journal of dermatology, 2006, Volume: 154, Issue:3

    Topics: 5-Methoxypsoralen; Adult; Aged; Aged, 80 and over; Epidemiologic Methods; Female; Humans; Male; Meth

2006
Is psoralen-containing sunscreen tumorigenic in hairless mice?
    Journal of the American Academy of Dermatology, 1984, Volume: 10, Issue:2 Pt 1

    Topics: 5-Methoxypsoralen; Animals; Methoxsalen; Mice; Mice, Hairless; Photochemotherapy; PUVA Therapy; Skin

1984
A comparison of the phototumorigenic potential of 8-MOP and 5-MOP in hairless albino mice exposed to solar simulated radiation.
    The British journal of dermatology, 1983, Volume: 108, Issue:5

    Topics: 5-Methoxypsoralen; Animals; Female; Male; Methoxsalen; Mice; Mice, Hairless; Neoplasms, Radiation-In

1983
Psoralen-containing sunscreen is tumorigenic in hairless mice.
    Journal of the American Academy of Dermatology, 1983, Volume: 8, Issue:6

    Topics: 5-Methoxypsoralen; Animals; Cysts; Dose-Response Relationship, Drug; Female; Isomerism; Methoxsalen;

1983
5-Methoxypsoralen, the melanogenic additive in sun-tan preparations, is tumorigenic in mice exposed to 365 nm u.v. radiation.
    Carcinogenesis, 1981, Volume: 2, Issue:2

    Topics: 5-Methoxypsoralen; Animals; Carcinogens; Carcinoma, Squamous Cell; DNA Repair; Female; Male; Methoxs

1981
British Photodermatology Group guidelines for PUVA.
    The British journal of dermatology, 1994, Volume: 130, Issue:2

    Topics: 5-Methoxypsoralen; Cataract; Dermatitis, Atopic; Humans; Methoxsalen; Mycosis Fungoides; Psoriasis;

1994
Photoaccentuated erythroderma associated with CD4+ T lymphocytopenia: successful treatment with 5-methoxypsoralen and UVA, interferon alfa-2b, and extracorporeal photopheresis.
    Journal of the American Academy of Dermatology, 1996, Volume: 35, Issue:2 Pt 2

    Topics: 5-Methoxypsoralen; Dermatitis, Exfoliative; HIV Seronegativity; Humans; Interferon alpha-2; Interfer

1996
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy.
    Dermatology (Basel, Switzerland), 1999, Volume: 199, Issue:2

    Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; Baths; DNA Adducts; Female; Humans

1999
Effect on topical 5-methoxypsoralen on tumorigenesis induced in albino and pigmented hairless mouse skin by UV irradiation.
    Journal of photochemistry and photobiology. B, Biology, 1990, Volume: 5, Issue:3-4

    Topics: 5-Methoxypsoralen; Albinism; Animals; Dose-Response Relationship, Radiation; Isomerism; Methoxsalen;

1990
Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model.
    Journal of photochemistry and photobiology. B, Biology, 1990, Volume: 7, Issue:2-4

    Topics: 5-Methoxypsoralen; Animals; Carcinogens; Disease Models, Animal; Female; Humans; Methoxsalen; Mice;

1990
Modification of 5-methoxypsoralen phototumorigenesis by UVB sunscreens: a statistical and histologic study in the hairless albino mouse.
    The Journal of investigative dermatology, 1987, Volume: 89, Issue:6

    Topics: 5-Methoxypsoralen; Animals; Female; Methoxsalen; Mice; Mice, Hairless; Neoplasms, Radiation-Induced;

1987