5-hydroxytryptophan has been researched along with Trypanosomiasis, African in 1 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-hydroxytryptophan is an important metabolite in the serotonin synthetic pathway, the key pathway in determining somnolence, thus offering a possible link to the eponymous symptoms of "sleeping sickness"." | 1.43 | Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016) |
| "Neopterin is an inflammatory biomarker previously shown in CSF of stage 2 but not stage 1 patients." | 1.43 | Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016) |
| "Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal fluid (CSF))." | 1.43 | Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vincent, IM | 1 |
| Daly, R | 1 |
| Courtioux, B | 1 |
| Cattanach, AM | 1 |
| Biéler, S | 1 |
| Ndung'u, JM | 1 |
| Bisser, S | 1 |
| Barrett, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP4 Early Test-of-cure[NCT03112655] | 88 participants (Actual) | Interventional | 2017-02-24 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for 5-hydroxytryptophan and Trypanosomiasis, African
| Article | Year |
|---|---|
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Biomarkers; Blood-Brain Barrier; Female; Humans; Male; Metab | 2016 |