5-hydroxytryptophan has been researched along with Sensitivity and Specificity in 11 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six patients with midgut carcinoid metastases were examined with 11C-5-HTP PET before and 1 h after oral administration of 100 or 200 mg of CD." | 2.72 | Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography. ( Bergström, M; Eriksson, B; Långström, B; Lu, L; Oberg, K; Orlefors, H; Sundin, A, 2006) |
| "MRI detected more liver metastases than 5-HTP PET/CT." | 1.46 | Whole-body MRI including diffusion-weighted MRI compared with 5-HTP PET/CT in the detection of neuroendocrine tumors. ( Ahlström, H; Caballero-Corbalán, J; Carlbom, L; Eriksson, B; Granberg, D; Sörensen, J, 2017) |
| "5-hydroxytryptophan is an important metabolite in the serotonin synthetic pathway, the key pathway in determining somnolence, thus offering a possible link to the eponymous symptoms of "sleeping sickness"." | 1.43 | Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016) |
| "Neopterin is an inflammatory biomarker previously shown in CSF of stage 2 but not stage 1 patients." | 1.43 | Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016) |
| "Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal fluid (CSF))." | 1.43 | Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016) |
| "In all carcinoid patients (18)F-DOPA PET and (11)C-5-HTP PET detected more lesions than SRS (P < ." | 1.35 | Improved staging of patients with carcinoid and islet cell tumors with 18F-dihydroxy-phenyl-alanine and 11C-5-hydroxy-tryptophan positron emission tomography. ( Brouwers, AH; de Vries, EG; Elsinga, PH; Jager, PL; Kema, IP; Koopmans, KP; Neels, OC; Sluiter, WJ; Vanghillewe, K, 2008) |
| "Carcinoid (n = 24) or pancreatic islet cell tumor (n = 23) patients with at least one lesion on conventional imaging including somatostatin receptor scintigraphy (SRS) and computed tomography (CT) scan underwent (11)C-5-hydroxytryptophan ((11)C-5-HTP) PET and 6-[F-18]fluoro-L-dihydroxy-phenylalanine ((18)F-DOPA) PET." | 1.35 | Improved staging of patients with carcinoid and islet cell tumors with 18F-dihydroxy-phenyl-alanine and 11C-5-hydroxy-tryptophan positron emission tomography. ( Brouwers, AH; de Vries, EG; Elsinga, PH; Jager, PL; Kema, IP; Koopmans, KP; Neels, OC; Sluiter, WJ; Vanghillewe, K, 2008) |
| "No melatonin was observed in duodenum under conditions of 2." | 1.29 | Duodenum is not a consistent source of melatonin in rats. ( Brammer, GL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Visser, AK | 1 |
| Ramakrishnan, NK | 1 |
| Willemsen, AT | 1 |
| Di Gialleonardo, V | 1 |
| de Vries, EF | 1 |
| Kema, IP | 3 |
| Dierckx, RA | 1 |
| van Waarde, A | 1 |
| van Asselt, SJ | 1 |
| Brouwers, AH | 2 |
| van Dullemen, HM | 1 |
| van der Jagt, EJ | 1 |
| Bongaerts, AH | 1 |
| Koopmans, KP | 2 |
| Valk, GD | 1 |
| Timmers, HJ | 1 |
| de Herder, WW | 2 |
| Feelders, RA | 2 |
| Fockens, P | 1 |
| Sluiter, WJ | 2 |
| de Vries, EG | 2 |
| Links, TP | 1 |
| Carlbom, L | 1 |
| Caballero-Corbalán, J | 1 |
| Granberg, D | 1 |
| Sörensen, J | 1 |
| Eriksson, B | 2 |
| Ahlström, H | 1 |
| Vincent, IM | 1 |
| Daly, R | 1 |
| Courtioux, B | 1 |
| Cattanach, AM | 1 |
| Biéler, S | 1 |
| Ndung'u, JM | 1 |
| Bisser, S | 1 |
| Barrett, MP | 1 |
| Ureshi, M | 1 |
| Dainobu, M | 1 |
| Sakai, M | 1 |
| Orlefors, H | 1 |
| Sundin, A | 1 |
| Lu, L | 1 |
| Oberg, K | 1 |
| Långström, B | 1 |
| Bergström, M | 1 |
| van Aken, MO | 1 |
| de Jong, FH | 1 |
| Pereira, AM | 1 |
| Lamberts, SW | 1 |
| Neels, OC | 1 |
| Elsinga, PH | 1 |
| Vanghillewe, K | 1 |
| Jager, PL | 1 |
| Brammer, GL | 1 |
| Gostkowski, ML | 1 |
| Wei, J | 1 |
| Shear, JB | 1 |
| Maes, M | 1 |
| D'Hondt, P | 1 |
| Martin, M | 1 |
| Claes, M | 1 |
| Schotte, C | 1 |
| Vandewoude, M | 1 |
| Blockx, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP4 Early Test-of-cure[NCT03112655] | 88 participants (Actual) | Interventional | 2017-02-24 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 5-hydroxytryptophan and Sensitivity and Specificity
| Article | Year |
|---|---|
[Cushing's syndrome. I. New diagnostic developments].
Topics: 5-Hydroxytryptophan; Corticotropin-Releasing Hormone; Cushing Syndrome; Dexamethasone; Diagnosis, Di | 2006 |
1 trial available for 5-hydroxytryptophan and Sensitivity and Specificity
| Article | Year |
|---|---|
Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography.
Topics: 5-Hydroxytryptophan; Carbidopa; Carbon Radioisotopes; Carcinoid Tumor; Female; Humans; Image Enhance | 2006 |
9 other studies available for 5-hydroxytryptophan and Sensitivity and Specificity
| Article | Year |
|---|---|
[(11)C]5-HTP and microPET are not suitable for pharmacodynamic studies in the rodent brain.
Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Carbidopa; Carbon | 2014 |
EUS is superior for detection of pancreatic lesions compared with standard imaging in patients with multiple endocrine neoplasia type 1.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Carbon Radioisotopes; Cross-Sectional Studies; Early D | 2015 |
Whole-body MRI including diffusion-weighted MRI compared with 5-HTP PET/CT in the detection of neuroendocrine tumors.
Topics: 5-Hydroxytryptophan; Adult; Aged; Bone Neoplasms; Contrast Media; Diffusion Magnetic Resonance Imagi | 2017 |
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Biomarkers; Blood-Brain Barrier; Female; Humans; Male; Metab | 2016 |
Serotonin precursor (5-hydroxytryptophan) has a profound effect on the post-copulatory time-fixed sexually refractory stage in the male cricket, Gryllus bimaculatus DeGeer.
Topics: 5-Hydroxytryptophan; Animals; Arousal; Biogenic Amines; Copulation; Ejaculation; Gryllidae; Male; Oc | 2002 |
Improved staging of patients with carcinoid and islet cell tumors with 18F-dihydroxy-phenyl-alanine and 11C-5-hydroxy-tryptophan positron emission tomography.
Topics: 5-Hydroxytryptophan; Adenoma, Islet Cell; Adult; Aged; Carbon Radioisotopes; Carcinoid Tumor; Dihydr | 2008 |
Duodenum is not a consistent source of melatonin in rats.
Topics: 5-Hydroxytryptophan; Animals; Chromatography; Duodenum; In Vitro Techniques; Male; Melatonin; Pineal | 1994 |
Measurements of serotonin and related indoles using capillary electrophoresis with multiphoton-induced hyperluminescence.
Topics: 5-Hydroxytryptophan; Electrophoresis, Capillary; Hydroxyindoleacetic Acid; Indoles; Luminescent Meas | 1998 |
L-5-hydroxytryptophan stimulated cortisol escape from dexamethasone suppression in melancholic patients.
Topics: 5-Hydroxytryptophan; Adult; Aged; Analysis of Variance; Depressive Disorder; Dexamethasone; Female; | 1991 |