5-hydroxytryptophan has been researched along with Seizures in 76 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice." | 7.68 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| "Convulsive responsiveness of O'Grady mice, inbred for susceptibility to audiogenic seizures, was decreased following treatment with the serotonin precursor, 5-hydroxytryptophan, or serotonin depletor, p-chlorophenylalanine." | 7.65 | Additive effect of 5-hydroxytryptophan and p-chloro-phenylalanine in preventing audiogenic seizures in inbred mice. ( Alexander, GJ; Kopeloff, LM, 1976) |
| "However, DOPS significantly potentiated seizures induced by imipramine in disulfiram-pretreated animals." | 5.29 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| "In the work reported here, audiogenic seizure susceptibility and brain tryptophan and serotonin concentrations were measured in DBA/2J mice after administration of three doses of L-tryptophan or p-chlorophenylalanine." | 5.27 | Audiogenic seizures and brain serotonin after L-tryptophan and p-chlorophenylalanine. ( Lack, DB; Peters, RI, 1985) |
| " Changes in breathing and cardiac electrical activity in DBA/1 and C57BL/6J mice that incurred sudden death during generalized seizures evoked by pentylenetetrazole (PTZ) were studied by plethysmography and electrocardiography." | 3.83 | 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. ( Cotten, JF; Feng, HJ; Xue, Q; Yang, X; Zhang, H; Zhao, H, 2016) |
| "Severe 6-pyruvoyl-tetrahydrobiopterin synthase deficiency is a tetrahydrobiopterin deficiency disorder that presents in infancy with developmental delay, seizures, and abnormal movements associated with hyperphenylalaninemia usually detectable by neonatal phenylketonuria screening programs." | 3.73 | 6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia. ( Blau, N; Connolly, MB; Demos, MK; Hyland, K; Lillquist, Y; Makhseed, N; Vallance, HD; Waters, PJ, 2005) |
| "6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency is the most important type of BH4 deficiency related to hyperphenylalaninemia." | 3.73 | Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency. ( Cheng, LY; Chiu, PC; Hsiao, KJ; Lee, NC; Liu, TT; Niu, DM, 2006) |
| "The aim of our study was to analyse the possible implication of the serotoninergic system in the pathophysiology and the lethality of audiogenic seizures induced by magnesium deficiency, either by decreasing cerebral serotonin (5-HT) levels (p-chlorophenylalanine) or by increasing 5-HT levels in the brain (5-hydroxytryptophan, L-tryptophan, nialamide, fluoxetine)." | 3.69 | Effect of various serotoninergically induced manipulations on audiogenic seizures in magnesium-deficient mice. ( Bac, P; Binet, P; Dewulf, C; Durlach, J; Herrenknecht, C; Pages, N, 1994) |
| "The influence of some noradrenergic, 5-hydroxytryptaminergic and cholinergic agents on imipramine-induced seizures were investigated in mice." | 3.68 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| "To clarify the role of the serotonergic system in limbic and thalamic epileptic activity, we examined the effects of 5-hydroxytryptophan (5-HTP, 20 and 40 mg/kg) on fully kindled seizures from the hippocampus and lateral geniculate nucleus." | 3.68 | Serotonergic inhibition of limbic and thalamic seizures in cats. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1992) |
| " The present experiments studied anticonvulsant effects of a serotonin precursor, L-5-hydroxytryptophan (5-HTP), on photosensitivity in the LGN-kindled cat under D,L-allylglycine and on LGN-kindled seizures." | 3.68 | Suppressive effects of L-5-hydroxytryptophan in a feline model of photosensitive epilepsy. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1991) |
| " Catecholamines, to a lesser extent the indolamine, serotonin, and the inhibitory transmitter gamma-aminobutyric acid all alter seizures as do less well understood intrinsic hormones and pentapeptides." | 3.67 | Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon. ( Killam, EK; Killam, KF, 1984) |
| " The pharmacological tests were L-5-hydroxytryptophan syndrome in mice and tryptamine-induced clonic seizures in rats." | 3.67 | Zetidoline, a specific dopamine antagonist devoid of antiserotonergic activity in rodent brain. ( Barone, D; Peruzzi, M; Pugnetti, P; Restelli, A, 1985) |
| " The administration of 5-hydroxytryptophan with MK486 markedly depressed the incidence of seizures in the E1 mouse." | 3.66 | Brain monoamine levels and E1 mouse convulsions. ( Hiramatsu, M, 1981) |
| "Convulsive responsiveness of O'Grady mice, inbred for susceptibility to audiogenic seizures, was decreased following treatment with the serotonin precursor, 5-hydroxytryptophan, or serotonin depletor, p-chlorophenylalanine." | 3.65 | Additive effect of 5-hydroxytryptophan and p-chloro-phenylalanine in preventing audiogenic seizures in inbred mice. ( Alexander, GJ; Kopeloff, LM, 1976) |
| "A myoclonic syndrome consisting of tremor, myoclonus, and seizures was produced following the systemic administration of 5-hydroxytryptophan to adult rats previously given intracisternal injections of 5,7-dihydroxytryptamine and systemic desmethylimipramine, but not in their controls." | 3.65 | Myoclonus after 5-hydroxytryptophan in rats with lesions of indoleamine neurons in the central nervous system. ( Baldessarini, RJ; Cancian, D; Growdon, JH; Stewart, RM, 1976) |
| "The effect of 5-HTP administration on seizure-induced mortality evoked by acoustic stimulation or by PTZ was investigated in DBA/1 mice." | 1.43 | 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. ( Cotten, JF; Feng, HJ; Xue, Q; Yang, X; Zhang, H; Zhao, H, 2016) |
| "Insulin produces seizures in healthy and diabetic animals." | 1.32 | Investigation of central mechanism of insulin induced hypoglycemic convulsions in mice. ( Anuradha, K; Hota, D; Pandhi, P, 2004) |
| "Convulsions were induced in Swiss male albino mice with graded doses of insulin." | 1.32 | Investigation of central mechanism of insulin induced hypoglycemic convulsions in mice. ( Anuradha, K; Hota, D; Pandhi, P, 2004) |
| "However, DOPS significantly potentiated seizures induced by imipramine in disulfiram-pretreated animals." | 1.29 | The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice. ( Amabeoku, GJ, 1993) |
| "Photically-induced seizures were completely blocked 1." | 1.28 | Suppressive effects of L-5-hydroxytryptophan in a feline model of photosensitive epilepsy. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1991) |
| "Ro 15-1788 completely blocked type B myoclonus without decreasing the level of vigilance in the two types of baboons, and reversed the antiepileptic action of the BZs in the photosensitive ones, permitting the reappearance of myoclonus following EEG paroxysmal discharges (type A)." | 1.27 | Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio. ( Bryere, P; Kaijima, M; Naquet, R; Valin, A, 1983) |
| "In the work reported here, audiogenic seizure susceptibility and brain tryptophan and serotonin concentrations were measured in DBA/2J mice after administration of three doses of L-tryptophan or p-chlorophenylalanine." | 1.27 | Audiogenic seizures and brain serotonin after L-tryptophan and p-chlorophenylalanine. ( Lack, DB; Peters, RI, 1985) |
| " Chronic administration of 5-HTP 25 mg/kg and femoxetine 15 mg/kg prolonged the duration of behavioral seizures." | 1.26 | Serotonergic mechanism in seizures kindled from the rabbit amygdala. ( Kacz, D; Lazarova, MB; Stach, R, 1981) |
| " In the present study we determined the time-course and dose-response effects of 6-MeO-THbetaC for blockade of AGS." | 1.26 | Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice. ( Buckholtz, NS; Sparks, DL, 1980) |
| "It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters." | 1.26 | Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977) |
| "Correlation between the kindled seizure susceptibility and brain monoamine levels was investigated in the hippocampal and amygdaloid kindled cats." | 1.26 | [Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation]. ( Mitsunobu, K; Nakashima, T; Otsuki, S; Sato, M, 1976) |
| "Amitriptyline (AMI) was studied in rats snd mice in order to find out whether it had a central antiserotonin activity, previously demonstrated for doxepin - a compound chemically related to AMI." | 1.26 | Central antiserotonin action of amitriptyline. ( Lewandowska, A; Maj, J; Rawtów, A, 1979) |
| "Experiments with pentylenetetrazol convulsion model in albino mice--80 mg/kg subcutaneously--have revealed the following." | 1.26 | On some relationships between dopaminergic and serotoninergic mechanisms in pentylenetetrazol convulsions in albino mice. ( Lazarova, M; Roussinov, K, 1979) |
| "Generalised seizures were seen 15-30 min after imipramine or chlorimipramine (20 mg/kg), and these two drugs showed no difference in their epileptogenicity." | 1.26 | Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms. ( Anlezark, G; Meldrum, B; Trimble, M, 1977) |
| "Reserpine enhanced the incidence of seizures, and the effect was reversed by 5-hydroxytryptophan but not by dihydroxyphenylalanine." | 1.25 | Effects of aminergic drugs and glutamic acid on audiogenic seizures induced by early exposure to ethanol. ( Ginsburg, BE; Sze, PY; Yanai, J, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (82.89) | 18.7374 |
| 1990's | 5 (6.58) | 18.2507 |
| 2000's | 6 (7.89) | 29.6817 |
| 2010's | 1 (1.32) | 24.3611 |
| 2020's | 1 (1.32) | 2.80 |
| Authors | Studies |
|---|---|
| Nash, E | 1 |
| Jamshidi, N | 1 |
| Zhang, H | 1 |
| Zhao, H | 1 |
| Yang, X | 1 |
| Xue, Q | 1 |
| Cotten, JF | 1 |
| Feng, HJ | 1 |
| Matosiuk, D | 1 |
| Fidecka, S | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Lipkowski, J | 1 |
| Dybala, I | 1 |
| Koziol, AE | 1 |
| Pericić, D | 1 |
| LESSIN, AW | 1 |
| PARKES, MW | 1 |
| CAHN, J | 1 |
| HEROLD, M | 1 |
| BARRE, N | 1 |
| KURIHARA, M | 1 |
| Anuradha, K | 1 |
| Hota, D | 1 |
| Pandhi, P | 1 |
| Expósito-Orta, MA | 1 |
| Albertos, LM | 1 |
| Darias, V | 1 |
| Sánchez-Mateo, CC | 1 |
| Demos, MK | 1 |
| Waters, PJ | 1 |
| Vallance, HD | 1 |
| Lillquist, Y | 1 |
| Makhseed, N | 1 |
| Hyland, K | 1 |
| Blau, N | 1 |
| Connolly, MB | 1 |
| Lee, NC | 1 |
| Cheng, LY | 1 |
| Liu, TT | 1 |
| Hsiao, KJ | 1 |
| Chiu, PC | 1 |
| Niu, DM | 1 |
| Lazarova, M | 2 |
| Roussinov, K | 2 |
| Valin, A | 1 |
| Kaijima, M | 1 |
| Bryere, P | 1 |
| Naquet, R | 1 |
| Killam, EK | 1 |
| Killam, KF | 1 |
| Hiramatsu, M | 1 |
| Munkenbeck, KE | 1 |
| Schwark, WS | 1 |
| Stach, R | 1 |
| Lazarova, MB | 1 |
| Kacz, D | 1 |
| Cavalheiro, EA | 1 |
| Elisabetsky, E | 1 |
| Campos, CJ | 1 |
| Sparks, DL | 1 |
| Buckholtz, NS | 1 |
| Ashton, D | 1 |
| Leysen, JE | 1 |
| Wauquier, A | 1 |
| Philo, R | 1 |
| Reiter, RJ | 1 |
| London, ED | 2 |
| Waller, SB | 1 |
| Vocci, FJ | 1 |
| Buterbaugh, GG | 2 |
| Bac, P | 1 |
| Pages, N | 1 |
| Herrenknecht, C | 1 |
| Dewulf, C | 1 |
| Binet, P | 1 |
| Durlach, J | 1 |
| Amabeoku, GJ | 1 |
| Endo, K | 1 |
| Morita, K | 1 |
| Uchiyama, Y | 1 |
| Takada, K | 1 |
| Tsujimoto, A | 1 |
| Dohi, T | 1 |
| Koslow, SH | 1 |
| Butler, IJ | 1 |
| Yanai, J | 1 |
| Sze, PY | 1 |
| Ginsburg, BE | 1 |
| Avakian, RM | 1 |
| Alexander, GJ | 2 |
| Kopeloff, LM | 2 |
| Georgiev, VP | 1 |
| Petkova, BP | 1 |
| Sato, M | 1 |
| Nakashima, T | 1 |
| Mitsunobu, K | 1 |
| Otsuki, S | 1 |
| Thut, PD | 1 |
| Myslinski, NR | 1 |
| Kumashiro, H | 1 |
| Aono, T | 1 |
| Watanabe, K | 1 |
| Koizumi, S | 1 |
| Nakanishi, S | 1 |
| Kaneko, Y | 1 |
| Ohno, E | 1 |
| Uemura, S | 1 |
| Calderini, G | 1 |
| Carlsson, A | 1 |
| Nordström, CH | 1 |
| Maj, J | 1 |
| Lewandowska, A | 1 |
| Rawtów, A | 1 |
| Trimble, M | 1 |
| Anlezark, G | 1 |
| Meldrum, B | 1 |
| Arushanian, EB | 1 |
| Klawans, HL | 2 |
| D'Amico, DJ | 1 |
| Patel, BC | 1 |
| Kellogg, C | 1 |
| Stewart, RM | 1 |
| Growdon, JH | 1 |
| Cancian, D | 1 |
| Baldessarini, RJ | 1 |
| Wada, Y | 2 |
| Hasegawa, H | 2 |
| Nakamura, M | 2 |
| Yamaguchi, N | 2 |
| Pagliusi, SR | 1 |
| Löscher, W | 1 |
| Leadbetter, MI | 1 |
| Parmar, SS | 1 |
| Pugnetti, P | 1 |
| Barone, D | 1 |
| Peruzzi, M | 1 |
| Restelli, A | 1 |
| Peters, RI | 1 |
| Lack, DB | 1 |
| Ueki, S | 1 |
| Watanabe, S | 1 |
| Yamamoto, T | 1 |
| Kataoka, Y | 1 |
| Shibata, S | 1 |
| Shibata, K | 1 |
| Ohta, H | 1 |
| Shimazoe, T | 1 |
| Kawamoto, H | 1 |
| Nagai, Y | 1 |
| Narumi, S | 1 |
| Saji, Y | 1 |
| Nagawa, Y | 1 |
| Wenger, GR | 1 |
| Stitzel, RE | 1 |
| Craig, CR | 1 |
| Opitz, K | 1 |
| De la Torre, JC | 1 |
| Kawanaga, HM | 1 |
| Mullan, S | 1 |
| Jobe, PC | 2 |
| Picchioni, AL | 1 |
| Chin, L | 1 |
| De Oliveira, LF | 2 |
| Bretas, AD | 1 |
| Diaz, PM | 1 |
| Bennett, JM | 1 |
| Coleman, M | 1 |
| Schlesinger, K | 3 |
| Boggan, WO | 4 |
| Freedman, DX | 1 |
| Wada, JA | 2 |
| Terao, A | 1 |
| Scholtmeyer, H | 1 |
| Trapp, WG | 1 |
| Seiden, LS | 1 |
| Prakh'e, IB | 1 |
| Heavner, JE | 1 |
| de Jong, RH | 1 |
| Clineschmidt, BV | 1 |
| Lotti, VJ | 1 |
| Stull, RE | 1 |
| Geiger, PF | 1 |
| Westheimer, R | 1 |
| Feldstein, A | 1 |
| Sidel, CM | 1 |
| Ferrini, R | 1 |
| Glässer, A | 1 |
| Weissman, A | 1 |
| Koe, BK | 1 |
| Ikeda, H | 1 |
| McGeer, EG | 1 |
| Yamamoto, I | 1 |
| Inoki, R | 1 |
| Tamari, Y | 1 |
| Iwatsubo, K | 1 |
| Griek, BJ | 1 |
| Gusel', VA | 1 |
| Aschkenasy-Lelu, P | 1 |
| Spach, C | 1 |
1 review available for 5-hydroxytryptophan and Seizures
| Article | Year |
|---|---|
[Central monoaminergic mechanisms and generalized convulsions (review)].
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Biogenic Amines; Brain; Cerebral Cortex; | 1976 |
75 other studies available for 5-hydroxytryptophan and Seizures
| Article | Year |
|---|---|
Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report.
Topics: 5-Hydroxytryptophan; Adult; Hippocampus; Humans; Ischemia; Male; Seizures; Serotonin | 2022 |
5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Brain Stem; Disease Models, Animal; Dose-Respons | 2016 |
Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine: part 2. Synthesis and pharmacological activity of 1,6-diaryl-5,7(1H)dioxo-2,3-dihydroimidazo[1,2-a][1,3,5]triazines.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Behavior, Animal; Binding, Competitive; Body Tempe | 2002 |
Swim stress inhibits 5-HT2A receptor-mediated head twitch behaviour in mice.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-2 Receptor Antagonists; Animals; Anticonvulsants; Brain; Diaze | 2003 |
The effects of reserpine and other agents upon leptazol convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Dihydroxyphenylalanine; Iproniazid; Mice; Pentylenetetrazole; R | 1959 |
[Action of different inhibitors of L-DOPA 5 HTP decarboxylase on insulin hypoglycemia in the rat].
Topics: 5-Hydroxytryptophan; Animals; Antihypertensive Agents; Antimetabolites; Cinnamates; Dopa Decarboxyla | 1963 |
[SOME PHARMACOLOGICAL EXPERIMENTS ON ANTIDEPRESSANTS--IN REFERENCE TO CEREBRAL MONOAMINES].
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Bemegride; Dihydroxyphenylalanine; Eyelids; Fever; Imipr | 1963 |
Investigation of central mechanism of insulin induced hypoglycemic convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Antihypertensive Agents; Blood Glucose; Dopamine; Dop | 2004 |
Behavioural effects of thieno and pyrazolo [2,1] benzothiazepine derivatives in mice.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Apomorphi | 2004 |
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Cerebral Palsy; Child; Developmental Disabilities; Diagn | 2005 |
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Asian People; Biopterins; Child; Child, Preschool; China; Fe | 2006 |
Role of the relationships between the neurotransmitter systems in the convulsive-seizure reactions.
Topics: 5-Hydroxytryptophan; Amantadine; Amphetamine; Animals; Dopamine; Electroshock; gamma-Aminobutyric Ac | 1982 |
Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Flumazenil; g | 1983 |
Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon.
Topics: 5-Hydroxytryptophan; Acetylcholine; Amphetamine; Animals; Brain; Disease Models, Animal; Dopamine; E | 1984 |
Brain monoamine levels and E1 mouse convulsions.
Topics: 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Brain; Dioxoles; Dopamine; Evoked Potentials; Fu | 1981 |
Serotonergic mechanisms in amygdaloid-kindled seizures in the rat.
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain; Female; Fenclonine; Hydroxyindoleacetic Acid; Kindlin | 1982 |
Serotonergic mechanism in seizures kindled from the rabbit amygdala.
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Fenclonine; Male; Rabbits; Receptors, Serotonin; Seizures | 1981 |
Effect of brain serotonin level on induced hippocampal paroxysmal activity in rats.
Topics: 5-Hydroxytryptophan; Animals; Brain; Electric Stimulation; Electroencephalography; Fenclonine; Hippo | 1981 |
Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Benzofurans; Carbolines; Citalopram; Clomipramin | 1980 |
Neurotransmitters and receptor binding in amygdaloid kindled rats: serotonergic and noradrenergic modulatory effects.
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain; Clonidine; Dexetimide; Electric Stimulation; Male; Mi | 1980 |
The involvement of brain amines in pinealectomy-induced convulsions in the gerbil: I. Serotonin.
Topics: 5-Hydroxytryptophan; Animals; Brain; Dopamine; Evoked Potentials; Gerbillinae; Male; Norepinephrine; | 1981 |
Age-dependent reduction in maximum electroshock convulsive threshold associated with decreased concentrations of brain monoamines.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Biogenic Amines; Brain Chemistry; Elec | 1982 |
Effect of various serotoninergically induced manipulations on audiogenic seizures in magnesium-deficient mice.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Analysis of Variance; Animals; Brain; Fenclonine; Fluoxet | 1994 |
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.
Topics: 5-Hydroxytryptophan; Acetylcholine; alpha-Methyltyrosine; Animals; Atropine; Clonidine; Dioxanes; Dr | 1993 |
Involvement of brain serotonergic function in lidocaine-induced convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Cerebral Cortex; Electric Stimulation; Lidocaine; Male; Mice; N | 1993 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea | 1977 |
Effects of aminergic drugs and glutamic acid on audiogenic seizures induced by early exposure to ethanol.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug I | 1975 |
[Role of the striatum in the influence of serotoninergic substances on the course of corazole seizures in rats].
Topics: 5-Hydroxytryptophan; Animals; Corpus Striatum; Female; Fenclonine; Male; Pentylenetetrazole; Rats; S | 1976 |
Audiogenic seizures in mice: influence of agents affecting brain serotonin.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Amides; Animals; Behavior, Animal; Brain Chemistry; Fencl | 1976 |
The effect of p-bromomethamphetamine (V-111), a selective serotoninergic amphetamine, on the convulsive seizure excitability threshold in mice.
Topics: 5-Hydroxytryptophan; Animals; Fenclonine; Imipramine; Male; Methamphetamine; Mice; Nialamide; Pentyl | 1976 |
Additive effect of 5-hydroxytryptophan and p-chloro-phenylalanine in preventing audiogenic seizures in inbred mice.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Brain; Drug Synergism; Drug Therapy, Combination | 1976 |
[Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation].
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain Chemistry; Catecholamines; Cats; Dopamine; Electric St | 1976 |
The role of dopamine and serotonin in the prolongation of post-decapitation convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain; Decerebrate State; Ditiocarb; Dopamine; Fenclonine | 1976 |
DC potential shifts associated with convulsive seizures and brain monoamine changes in rabbits.
Topics: 5-Hydroxytryptophan; Adolescent; Animals; Bemegride; Brain Damage, Chronic; Caudate Nucleus; Cerebra | 1977 |
Modification of electroshock convulsive responses and thresholds in neonatal rats after brain monoamine reduction.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Biogenic Amines; Brain; Dru | 1978 |
Monoamine metabolism during bicuculline-induced epileptic seizures in the rat.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Bicuculline; Brain; Catecholamines; Cerebellum; Corpus St | 1978 |
Central antiserotonin action of amitriptyline.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Behavior, Animal; Central Nervous System; Decerebrate S | 1979 |
On some relationships between dopaminergic and serotoninergic mechanisms in pentylenetetrazol convulsions in albino mice.
Topics: 5-Hydroxytryptophan; Amantadine; Amphetamine; Animals; Apomorphine; Dopamine; Levodopa; Male; Mice; | 1979 |
Seizure activity in photosensitive baboons following antidepressant drugs and the role of serotoninergic mechanisms.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Electroencephal | 1977 |
Behavioral supersensitivity to 5-hydroxytryptophan induced by chronic methysergide pretreatment.
Topics: 5-Hydroxytryptophan; Animals; Behavior; Brain Chemistry; Drug Synergism; Guinea Pigs; Humans; Male; | 1975 |
Audiogenic seizures: relation to age and mechanisms of monoamine neurotransmission.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Aging; Animals; Benserazide; Brain; Catecholamines; Dihyd | 1976 |
Myoclonus after 5-hydroxytryptophan in rats with lesions of indoleamine neurons in the central nervous system.
Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain; Dose-Response Relationship, Drug; Drug Interaction | 1976 |
Serotonergic inhibition of limbic and thalamic seizures in cats.
Topics: 5-Hydroxytryptophan; Animals; Cats; Electroencephalography; Female; Geniculate Bodies; Hippocampus; | 1992 |
Suppressive effects of L-5-hydroxytryptophan in a feline model of photosensitive epilepsy.
Topics: 5-Hydroxytryptophan; Allylglycine; Animals; Cats; Electric Stimulation; Electroencephalography; Fema | 1991 |
Development of tolerance to the wet-dog shake behaviour but not the increase in seizure threshold induced by L-5-hydroxytryptophan during continued treatment in rats.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Body Weight; Brain Chemistry; Carbidopa; Drug Intera | 1985 |
Serotonin as a facilitatory neurotransmitter in the anticonvulsant activity of methaqualone.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Fenclonine; | 1989 |
Zetidoline, a specific dopamine antagonist devoid of antiserotonergic activity in rodent brain.
Topics: 5-Hydroxytryptophan; Animals; Antipsychotic Agents; Binding, Competitive; Brain; Chlorpromazine; Dop | 1985 |
Audiogenic seizures and brain serotonin after L-tryptophan and p-chlorophenylalanine.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Brain Chemistry; Female; Fenclonine; Male; Mice; | 1985 |
Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative.
Topics: 5-Hydroxytryptophan; Aggression; Anesthesia; Animals; Azabicyclo Compounds; Behavior, Animal; Confli | 1987 |
[A TRH analog (DN-1417). Anti-reserpine action in electroconvulsive threshold and involvement of serotonergic (5-HT) mechanism in mice].
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Biogenic Amines; Brain Chemistry; Drug Interactions; | 1985 |
The role of biogenic amines in the reserpine-induced alteration of minimal electroshock seizure thresholds in the mouse.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Disulfiram; Dopamine; Drug Interactions; Elect | 1973 |
[Anorexigenic phenylalkylamines and serotonin metabolism].
Topics: 5-Hydroxytryptophan; Animals; Appetite Depressants; Chlorphentermine; Diarrhea; Eating; Feeding and | 1967 |
Seizure susceptibility after manipulation of brain serotonin.
Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Blood-Brain Barrier; Bra | 1970 |
Role of brain 5-hydroxytryptamine in audiogenic seizure in the rat.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Brain; Cold Temperature; Dopamine; Dose-Response | 1973 |
Effects of 5-hydroxytryptophan, iproniazid and p-chlorophenylalanine on lidocaine seizure threshold of mice.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fen | 1974 |
Interaction of pentylenetetrazol and trimethadione on the metabolism of serotonin in brain and its relation to the anticonvulsant action of trimethadione.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Brain; Brain Chemistry; Dose-Response Relationship, D | 1974 |
Relation of dopa and 5-HTP to convulsions induced by strychnine and leptazol.
Topics: 5-Hydroxytryptophan; Animals; Anura; Dihydroxyphenylalanine; Injections, Subcutaneous; Muscle Contra | 1970 |
Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down's syndrome.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Brain; Down Syndrome; Electroencephalography; Huma | 1971 |
Genetics of audiogenic seizures. 3. Time response relationships between drug administration and seizure susceptibility.
Topics: 5-Hydroxytryptophan; Age Factors; Animals; Brain; Brain Chemistry; Female; Hydrazines; Iproniazid; M | 1970 |
Susceptibility to audiogenic stimuli induced by hyperbaric oxygenation and various neuroactive agents.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Brain; Dihydroxyphenylalanine; Fenclonine; Hyperbaric Oxygen | 1971 |
5-Hydroxytryptophan reversal of reserpine enhancement of audiogenic seizure susceptibility in mice.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Be | 1973 |
[Effect of agents, changing the monoamine level, on audiogenic epileptic seizures in rats].
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Brain; Depression, Chemical; Di | 1973 |
5-Hydroxytryptophan intensifies local anesthetic-induced convulsions.
Topics: 5-Hydroxytryptophan; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Drug Synergism | 1974 |
Indoleamine antagonists: relative potencies as inhibitors of tryptamine- and 5-hydroxytryptophan-evoked responses.
Topics: 5-Hydroxytryptophan; Anilides; Animals; Cinnamates; Cyproheptadine; Ergolines; Female; Foot; Head; M | 1974 |
Pharmacological correlates of ECS induced disruption of a passive avoidance task in mice.
Topics: 5-Hydroxytryptophan; Acetates; Animals; Atropine; Avoidance Learning; Electroshock; Female; Levodopa | 1974 |
The relative significance of norepinephrine, dopamine and 5-hydroxytryptamine in electroshock seizure in the rat.
Topics: 5-Hydroxytryptophan; Animals; Benserazide; Brain Chemistry; Dihydroxyphenylalanine; Dopamine; Electr | 1974 |
The role of serotonin in the pathophysiology of myoclonic seizures associated with acute imipramine toxicity.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Brain Chemistry; Drug Synergism; Guinea Pigs; | 1974 |
Phenelzine-induced convulsions and alterations in the conversion of 5-HTP-14C to serotonin-14C in vivo.
Topics: 5-Hydroxytryptophan; Animals; Brain; Carboxy-Lyases; Hydroxyindoleacetic Acid; In Vitro Techniques; | 1966 |
Antagonism of central effects of tryptamine and 5-hydroxytryptophan by 1,6-dimethyl-8beta-carbobenzyloxy-aminomethyl-10alpha-ergoline. Interference with amphetamine and DOPA.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Central Nervous System; Dihydroxyphenylalanine; Fever; Mi | 1965 |
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxid | 1967 |
The susceptibility to audiogenic stimuli of rats treated with methionine sulfoximine and various psychoactive agents.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug Antagonism; Drug Synerg | 1967 |
Effect of reserpine on brain levels of 14C-nicotine in relation to nicotine-induced convulsions.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Carbon Isotopes; Chlorpromazine; Dihydroxyphen | 1967 |
Pharmacogenetic correlates of pentylenetetrazol and electroconvulsive seizure thresholds in mice.
Topics: 5-Hydroxytryptophan; Acetates; Amines; Animals; Brain Chemistry; Electroshock; Female; Genotype; Hyb | 1968 |
[Effect of substances interacting with serotonin reactive systems on the epileptiform discharge in the hippocampus in rabbits].
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Depression, Chemical; Electroencephalography; Hippo | 1971 |
[Relation between peculiarities of behavior and the metabolism of serotonin in a strain of Wistar rats showing the "hairless" mutation].
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Female; Genetics, Behavioral; Hair; Hybridiza | 1971 |