5-hydroxytryptophan has been researched along with Parkinson Disease in 44 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study provides evidence that 5-HTP is safe and effective in improving sleep stability in PD, contributing to ameliorate patients' global sleep quality." | 7.11 | Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease. ( Cannas, A; Carta, M; Defazio, G; Figorilli, M; Meloni, M; Puligheddu, M; Sanna, F; Tamburrino, L, 2022) |
| "This study provides evidence that 5-HTP is safe and effective in improving sleep stability in PD, contributing to ameliorate patients' global sleep quality." | 3.11 | Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease. ( Cannas, A; Carta, M; Defazio, G; Figorilli, M; Meloni, M; Puligheddu, M; Sanna, F; Tamburrino, L, 2022) |
| "Demented patients with Parkinson's disease, particularly those with concurrent depression, had the lowest values of 5-HIAA." | 2.66 | The relationship of serotonin to depression in Parkinson's disease. ( Cote, LJ; Mayeux, R; Sano, M; Stern, Y; Williams, JB, 1988) |
| "We studied 6 patients with myoclonus elicited by flash stimulation (1-15 Hz)." | 1.29 | The pathophysiology and pharmacology of photic cortical reflex myoclonus. ( Artieda, J; Obeso, JA, 1993) |
| " Although directly related to daily dosage of levodopa, the myoclonus was specifically blocked by the serotonin antagonist, methysergide." | 1.25 | Levodopa-induced myoclonus. ( Bergen, D; Goetz, C; Klawans, HL, 1975) |
| "Levodopa-induced myoclonus may be related to intermittent increases of activity of serotonin in the brain and results from levodopa-induced dysregulation of serotonin activity." | 1.25 | Levodopa-induced myoclonus. ( Bergen, D; Goetz, C; Klawans, HL, 1975) |
| "Two cases of idiopathic orthostatic hypotension are reported, one associated with striato-nigral degeneration (case 1) and the other with Lewy body parkinsonism (case 2)." | 1.25 | Idiopathic orthostatic hypotension. Biochemical and pathologic observations in 2 cases. ( Forno, LS; Langston, JW; Schober, R, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (75.00) | 18.7374 |
| 1990's | 6 (13.64) | 18.2507 |
| 2000's | 2 (4.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| Meloni, M | 3 |
| Puligheddu, M | 3 |
| Carta, M | 3 |
| Cannas, A | 3 |
| Figorilli, M | 3 |
| Defazio, G | 3 |
| Sanna, F | 2 |
| Farris, R | 1 |
| Tronci, E | 1 |
| Tamburrino, L | 1 |
| Young, SN | 2 |
| Gauthier, S | 2 |
| Chouinard, G | 1 |
| Anderson, GM | 1 |
| Purdy, WC | 1 |
| Birkmayer, W | 2 |
| Riederer, P | 1 |
| Youdim, MB | 1 |
| Sternberg, EM | 1 |
| Van Woert, MH | 2 |
| Magnussen, I | 1 |
| Baker, H | 1 |
| Osterland, CK | 1 |
| Tohgi, H | 1 |
| Abe, T | 1 |
| Takahashi, S | 1 |
| Takahashi, J | 1 |
| Hamato, H | 1 |
| Artieda, J | 1 |
| Obeso, JA | 1 |
| Nakajima, T | 1 |
| Iacono, RP | 1 |
| Kuniyoshi, SM | 1 |
| Ahlman, JR | 1 |
| Zimmerman, GJ | 1 |
| Maeda, G | 1 |
| Pearlstein, RD | 1 |
| Soares-da-Silva, P | 1 |
| Parada, A | 1 |
| Serrão, P | 1 |
| Burkhard, P | 1 |
| Dominici, P | 1 |
| Borri-Voltattorni, C | 1 |
| Jansonius, JN | 1 |
| Malashkevich, VN | 1 |
| Nagatsu, T | 1 |
| Carlsson, A | 1 |
| Bastard, J | 1 |
| Truelle, JL | 1 |
| Emile, J | 1 |
| Klawans, HL | 3 |
| Goetz, C | 1 |
| Bergen, D | 1 |
| Schober, R | 1 |
| Langston, JW | 1 |
| Forno, LS | 1 |
| Joly, P | 1 |
| Lampert, A | 1 |
| Thomine, E | 1 |
| Lauret, P | 1 |
| Sandyk, R | 1 |
| van Praag, HM | 2 |
| Mayeux, R | 1 |
| Stern, Y | 1 |
| Sano, M | 1 |
| Williams, JB | 1 |
| Cote, LJ | 1 |
| Uldry, PA | 1 |
| Regli, F | 1 |
| Carvey, PM | 1 |
| Tanner, CM | 1 |
| Goetz, CG | 2 |
| Klein, P | 1 |
| Lees, A | 1 |
| Stern, G | 1 |
| Chase, TN | 4 |
| Hassler, R | 1 |
| Saïd, G | 1 |
| Goldstein, M | 1 |
| Anagnoste, B | 1 |
| Battista, AF | 1 |
| Nakatani, S | 1 |
| Ogawa, M | 1 |
| Sano, I | 1 |
| Taniguchi, K | 1 |
| Ng, LK | 1 |
| Watanabe, AM | 1 |
| Benesová, O | 1 |
| Presthus, J | 1 |
| Teitel, S | 1 |
| Brossi, A | 1 |
| Cotzias, GC | 1 |
| Papavasiliou, PS | 1 |
| Gellene, R | 1 |
| Aronson, RB | 1 |
| Bell, EA | 1 |
| Janzen, DH | 1 |
| Casati, C | 1 |
| Vogel, WH | 1 |
| Bowers, MB | 1 |
| Tyce, GM | 1 |
| Muenter, MD | 1 |
| Owen, CA | 1 |
10 reviews available for 5-hydroxytryptophan and Parkinson Disease
| Article | Year |
|---|---|
Amine precursor amino acid therapy: from neurochemical basis to clinical aspects.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Depressive Disorder; Droxidopa; Histidine; Humans; Levodo | 1996 |
Monoamine precursors and analogues.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Dr | 1975 |
Affective disorders and aggression disorders: evidence for a common biological mechanism.
Topics: 5-Hydroxytryptophan; Aggression; Blood Platelets; Carrier Proteins; Celiac Disease; Depressive Disor | 1986 |
[Indications for L-5-hydroxytryptophan in neurology].
Topics: 5-Hydroxytryptophan; Down Syndrome; Epilepsy; Humans; Migraine Disorders; Myoclonus; Pain; Parkinson | 1987 |
Indoleamines in depression and suicide.
Topics: 5-Hydroxytryptophan; Brain; Celiac Disease; Depression; Humans; Parkinson Disease; Serotonin; Suicid | 1986 |
Serotonergic mechanisms and extrapyramidal function in man.
Topics: 5-Hydroxytryptophan; Carbidopa; Cerebellar Diseases; Creutzfeldt-Jakob Syndrome; Down Syndrome; Extr | 1974 |
[Review of current pharmacotherapy of Parkinsonism. Comprehensive review].
Topics: 5-Hydroxytryptophan; Amantadine; Anticonvulsants; Apomorphine; Benztropine; Carboxy-Lyases; Chemical | 1973 |
[Other trials with drug therapy in parkinsonism].
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Dr | 1973 |
Alkaloids in the mammalian system.
Topics: 5-Hydroxytryptophan; Acetaldehyde; Alkaloids; Animals; Aporphines; Biogenic Amines; Catalysis; Cells | 1974 |
[Parkinson's disease: current therapeutic aspects].
Topics: 5-Hydroxytryptophan; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Humans; M | 1971 |
8 trials available for 5-hydroxytryptophan and Parkinson Disease
| Article | Year |
|---|---|
Efficacy and safety of 5-hydroxytryptophan on depression and apathy in Parkinson's disease: a preliminary finding.
Topics: 5-Hydroxytryptophan; Aged; Apathy; Cross-Over Studies; Depression; Double-Blind Method; Female; Huma | 2020 |
Efficacy and safety of 5-Hydroxytryptophan on levodopa-induced motor complications in Parkinson's disease: A preliminary finding.
Topics: 5-Hydroxytryptophan; Animals; Antiparkinson Agents; Cross-Over Studies; Dose-Response Relationship, | 2020 |
Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease.
Topics: 5-Hydroxytryptophan; Cross-Over Studies; Humans; Parkinson Disease; Polysomnography; REM Sleep Behav | 2022 |
Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Carbidopa; Clinical Trials as Topic; Drug Therapy, Com | 1980 |
[Effectiveness of 5 hydroxy-tryptophan in Parkinson's disease].
Topics: 5-Hydroxytryptophan; Aged; Antiparkinson Agents; Clinical Trials as Topic; Drug Therapy, Combination | 1976 |
The relationship of serotonin to depression in Parkinson's disease.
Topics: 5-Hydroxytryptophan; Aged; Clinical Trials as Topic; Dementia; Depressive Disorder; Female; Humans; | 1988 |
Parkinson's disease. Modification by 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Adult; Aged; Brain; Carboxy-Lyases; Clinical Trials as Topic; Drug Synergism; E | 1972 |
Parkinsonism and DOPA.
Topics: 5-Hydroxytryptophan; Clinical Trials as Topic; Dihydroxyphenylalanine; Dopamine; Humans; Male; Manga | 1968 |
26 other studies available for 5-hydroxytryptophan and Parkinson Disease
| Article | Year |
|---|---|
The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.
Topics: 5-Hydroxytryptophan; Adult; Benserazide; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Humans; | 1982 |
(-)Deprenyl in the treatment of Parkinson's disease.
Topics: 5-Hydroxytryptophan; Brain; Dopamine; Drug Synergism; Drug Therapy, Combination; Humans; Levodopa; L | 1982 |
Concentrations of serotonin and its related substances in the cerebrospinal fluid of parkinsonian patients and their relations to the severity of symptoms.
Topics: 5-Hydroxytryptophan; Humans; Hydroxyindoleacetic Acid; Kynurenine; Middle Aged; Parkinson Disease; R | 1993 |
The pathophysiology and pharmacology of photic cortical reflex myoclonus.
Topics: 5-Hydroxytryptophan; Aged; Aged, 80 and over; Ataxia; Cerebral Cortex; Dopamine Agents; Electroencep | 1993 |
Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders.
Topics: 5-Hydroxytryptophan; Aged; Biogenic Amines; Cerebral Ventricles; Gait; Homovanillic Acid; Humans; Hy | 1997 |
The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Cells, Cultu | 2000 |
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Be | 2001 |
[Tyrosine hydroxylase (author's transl)].
Topics: 5-Hydroxytryptophan; Adrenal Glands; Brain; Catecholamines; Chemical Phenomena; Chemistry; Coenzymes | 1976 |
Levodopa-induced myoclonus.
Topics: 5-Hydroxytryptophan; Aged; Amantadine; Amphetamine; Animals; Benztropine; Dopamine Antagonists; Dose | 1975 |
Idiopathic orthostatic hypotension. Biochemical and pathologic observations in 2 cases.
Topics: 5-Hydroxytryptophan; Aged; Amines; Brain Diseases; Female; Ganglia, Autonomic; Humans; Hydroxyindole | 1975 |
Development of pseudobullous morphea and scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Aged; Carbidopa; Chronic Disease; Depression; Drug Therapy, Combination; Eosino | 1991 |
Pineal melatonin functions and the depression of Parkinson's disease: a hypothesis.
Topics: 5-Hydroxytryptophan; Animals; Depression; Dopamine; Humans; Melatonin; Models, Neurological; Parkins | 1990 |
Drug-induced myoclonus.
Topics: 5-Hydroxytryptophan; Anesthetics; Animals; Anti-Bacterial Agents; Antidepressive Agents; Bismuth; Ca | 1986 |
Consequences of chronic 5-hydroxy-tryptophan in parkinsonian instability of gait and balance and in other neurological disorders.
Topics: 5-Hydroxytryptophan; Adult; Aged; Benserazide; Cerebellar Ataxia; Drug Therapy, Combination; Female; | 1987 |
5-hydroxytryptophan in parkinsonism.
Topics: 5-Hydroxytryptophan; Aged; Female; Humans; Male; Middle Aged; Parkinson Disease; Tremor | 1970 |
Letter: Myoclonus, methysergide, and serotonin.
Topics: 5-Hydroxytryptophan; Animals; Dihydroxyphenylalanine; Drug Antagonism; Guinea Pigs; Humans; Methyser | 1974 |
[Experimental findings and new aspects in extrapyramidal diseases].
Topics: 5-Hydroxytryptophan; Blood Pressure; Body Temperature Regulation; Chorea; Dihydroxyphenylalanine; Do | 1966 |
[Correlations between chemical mediators (dopamine, serotonin, acetylcholine and gaba), muscular tone and rapidity of movement].
Topics: 5-Hydroxytryptophan; Acetylcholine; Alkaloids; Aminobutyrates; Animals; Dihydroxyphenylalanine; Dopa | 1972 |
[Dystonias].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Dihydroxyphenylalanine; Dystonia Musculorum Deformans; Extra | 1972 |
Biochemical aspects of experimentally induced parkinsonism.
Topics: 5-Hydroxytryptophan; Amines; Amino Acids; Animals; Antiparkinson Agents; Apomorphine; Basal Ganglia; | 1972 |
[L-5-hydroxytryptophan(L-5-HTP) therapy of Parkinson's disease. 2].
Topics: 5-Hydroxytryptophan; Adult; Aged; Depression; Dihydroxyphenylalanine; Female; Humans; Male; Middle A | 1972 |
Medical and ecological considerations of L-dopa and 5-HTP in seeds.
Topics: 5-Hydroxytryptophan; Carboxy-Lyases; Colombia; Costa Rica; Dihydroxyphenylalanine; Ecology; Insecta; | 1971 |
Non-enzymatic decarboxylation of dihydroxypheylalanine.
Topics: 5-Hydroxytryptophan; Carbon Dioxide; Carbon Isotopes; Chemical Phenomena; Chemistry; Copper; Dihydro | 1969 |
The effect of L-dopa on monoamine metabolites in Parkinson's disease.
Topics: 5-Hydroxytryptophan; Aged; Dihydroxyphenylalanine; Dopamine; Humans; Hydroxyindoleacetic Acid; Middl | 1970 |
Metabolism of L-dihydroxyphenylalanine by patients with Parkinson's disease.
Topics: 5-Hydroxytryptophan; Adult; Aged; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Female; Huma | 1970 |
Cerebrospinal fluid monoamine metabolites and peripheral decarboxylase inhibitors in parkinsonism.
Topics: 5-Hydroxytryptophan; Adult; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Dr | 1970 |