5-hydroxytryptophan has been researched along with Panic Disorder in 5 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Panic Disorder: A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Salivary cortisol levels were measured in 24 panic disorder patients and 24 healthy volunteers, following ingestion of 200 mg L-5-hydroxytryptophan or placebo." | 9.10 | L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers. ( Griez, E; Nicolson, N; Schruers, K; van Diest, R, 2002) |
| "The results show that L-5-hydroxytryptophan stimulated salivary cortisol is a useful probe of serotonin function in healthy volunteers as well as panic disorder patients, and provide some evidence against a serotonin receptor hypersensitivity in panic disorder." | 9.10 | L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers. ( Griez, E; Nicolson, N; Schruers, K; van Diest, R, 2002) |
| " In order to evaluate the influence of 5-HT-related gene variants on the vulnerability to panic attacks, we genotyped 32 healthy volunteers who participated in the study of the effect of 5-hydroxytryptophan on panic attacks induced with cholecystokinin tetrapeptide (CCK-4)." | 7.72 | Association between serotonin-related genetic polymorphisms and CCK-4-induced panic attacks with or without 5-hydroxytryptophan pretreatment in healthy volunteers. ( Lang, A; Maron, E; Shlik, J; Tasa, G; Tõru, I; Vasar, V, 2004) |
| "L-5-Hydroxytryptophan acts to inhibit panic, which supports a modulatory role of serotonin in panic disorder." | 6.70 | Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. ( Griez, E; Overbeek, T; Schruers, K; van Diest, R, 2002) |
| "Salivary cortisol levels were measured in 24 panic disorder patients and 24 healthy volunteers, following ingestion of 200 mg L-5-hydroxytryptophan or placebo." | 5.10 | L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers. ( Griez, E; Nicolson, N; Schruers, K; van Diest, R, 2002) |
| "The results show that L-5-hydroxytryptophan stimulated salivary cortisol is a useful probe of serotonin function in healthy volunteers as well as panic disorder patients, and provide some evidence against a serotonin receptor hypersensitivity in panic disorder." | 5.10 | L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers. ( Griez, E; Nicolson, N; Schruers, K; van Diest, R, 2002) |
| "To investigate the role of serotonin (5-HT) in the pathophysiology of panic disorder (PD) a challenge test with L-5-hydroxytryptophan (5-HTP) was conducted." | 5.08 | Behavioral, neuroendocrine and biochemical effects of different doses of 5-HTP in panic disorder. ( Den Boer, JA; Slaap, BR; van Vliet, IM; Westenberg, HG, 1996) |
| " In order to evaluate the influence of 5-HT-related gene variants on the vulnerability to panic attacks, we genotyped 32 healthy volunteers who participated in the study of the effect of 5-hydroxytryptophan on panic attacks induced with cholecystokinin tetrapeptide (CCK-4)." | 3.72 | Association between serotonin-related genetic polymorphisms and CCK-4-induced panic attacks with or without 5-hydroxytryptophan pretreatment in healthy volunteers. ( Lang, A; Maron, E; Shlik, J; Tasa, G; Tõru, I; Vasar, V, 2004) |
| "L-5-Hydroxytryptophan acts to inhibit panic, which supports a modulatory role of serotonin in panic disorder." | 2.70 | Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. ( Griez, E; Overbeek, T; Schruers, K; van Diest, R, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schruers, K | 2 |
| van Diest, R | 2 |
| Overbeek, T | 1 |
| Griez, E | 2 |
| Maron, E | 2 |
| Tõru, I | 2 |
| Vasar, V | 2 |
| Shlik, J | 2 |
| Tasa, G | 1 |
| Lang, A | 1 |
| van Vliet, IM | 1 |
| Slaap, BR | 1 |
| Westenberg, HG | 1 |
| Den Boer, JA | 1 |
| Nicolson, N | 1 |
4 trials available for 5-hydroxytryptophan and Panic Disorder
| Article | Year |
|---|---|
Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Brain; Carbon Dioxide; Double-Blind Method; Drug Admin | 2002 |
The effect of 5-hydroxytryptophan on cholecystokinin-4-induced panic attacks in healthy volunteers.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Capsules; Cognition Disorders; Double- | 2004 |
Behavioral, neuroendocrine and biochemical effects of different doses of 5-HTP in panic disorder.
Topics: 5-Hydroxytryptophan; Adult; Affect; Dose-Response Relationship, Drug; Double-Blind Method; Female; H | 1996 |
L-5-hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers.
Topics: 5-Hydroxytryptophan; Adult; Analysis of Variance; Double-Blind Method; Female; Humans; Hydrocortison | 2002 |
1 other study available for 5-hydroxytryptophan and Panic Disorder
| Article | Year |
|---|---|
Association between serotonin-related genetic polymorphisms and CCK-4-induced panic attacks with or without 5-hydroxytryptophan pretreatment in healthy volunteers.
Topics: 5-Hydroxytryptophan; Alleles; DNA Primers; Female; Genotype; Humans; Male; Membrane Glycoproteins; M | 2004 |