5-hydroxytryptophan has been researched along with Obsessive-Compulsive Disorder in 6 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "On the basis of numerous previous studies, the serotonergic system plays a role in the pathogenesis of obsessive-compulsive disorder (OCD) and effective agents in this pathway, such as 5-hydroxytryptophan, can potentially contribute to treatment of patients with this disorder." | 9.34 | 5-Hydroxytryptophan as adjuvant therapy in treatment of moderate to severe obsessive-compulsive disorder: a double-blind randomized trial with placebo control. ( Akhondzadeh, S; Alikhani, R; Aqamolaei, A; Ghaffari, S; Jalilevand, S; Mortazavi, SH; Mortezaei, A; Mousavi, SB; Naderi, S; Sadri, A; Sahebolzamani, E; Shalbafan, MR; Shamabadi, A; Yousefzadeh, F, 2020) |
| "A double-blind placebo-controlled study of 5-HTP and clomipramine was carried out on 45 patients suffering from anxiety disorders (DSM-III)." | 9.06 | Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo. ( Gispen-de Wied, CC; Kahn, RS; Kamerbeek, WD; Verhoeven, WM; Westenberg, HG, 1987) |
| "Clomipramine has shown to be effective in that it induced significant improvement on all rating scales as compared to placebo." | 6.66 | Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo. ( Gispen-de Wied, CC; Kahn, RS; Kamerbeek, WD; Verhoeven, WM; Westenberg, HG, 1987) |
| "On the basis of numerous previous studies, the serotonergic system plays a role in the pathogenesis of obsessive-compulsive disorder (OCD) and effective agents in this pathway, such as 5-hydroxytryptophan, can potentially contribute to treatment of patients with this disorder." | 5.34 | 5-Hydroxytryptophan as adjuvant therapy in treatment of moderate to severe obsessive-compulsive disorder: a double-blind randomized trial with placebo control. ( Akhondzadeh, S; Alikhani, R; Aqamolaei, A; Ghaffari, S; Jalilevand, S; Mortazavi, SH; Mortezaei, A; Mousavi, SB; Naderi, S; Sadri, A; Sahebolzamani, E; Shalbafan, MR; Shamabadi, A; Yousefzadeh, F, 2020) |
| "A double-blind placebo-controlled study of 5-HTP and clomipramine was carried out on 45 patients suffering from anxiety disorders (DSM-III)." | 5.06 | Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo. ( Gispen-de Wied, CC; Kahn, RS; Kamerbeek, WD; Verhoeven, WM; Westenberg, HG, 1987) |
| "Clomipramine has shown to be effective in that it induced significant improvement on all rating scales as compared to placebo." | 2.66 | Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo. ( Gispen-de Wied, CC; Kahn, RS; Kamerbeek, WD; Verhoeven, WM; Westenberg, HG, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yousefzadeh, F | 1 |
| Sahebolzamani, E | 1 |
| Sadri, A | 1 |
| Mortezaei, A | 1 |
| Aqamolaei, A | 1 |
| Mortazavi, SH | 1 |
| Shalbafan, MR | 1 |
| Ghaffari, S | 1 |
| Alikhani, R | 1 |
| Mousavi, SB | 1 |
| Naderi, S | 1 |
| Shamabadi, A | 1 |
| Jalilevand, S | 1 |
| Akhondzadeh, S | 1 |
| Camfield, DA | 1 |
| Sarris, J | 1 |
| Berk, M | 1 |
| Rojas-Corrales, MO | 1 |
| Gibert-Rahola, J | 1 |
| Mico, JA | 1 |
| Meltzer, H | 1 |
| Bastani, B | 1 |
| Jayathilake, K | 1 |
| Maes, M | 1 |
| Kahn, RS | 2 |
| van Praag, HM | 1 |
| Wetzler, S | 1 |
| Asnis, GM | 1 |
| Barr, G | 1 |
| Westenberg, HG | 1 |
| Verhoeven, WM | 1 |
| Gispen-de Wied, CC | 1 |
| Kamerbeek, WD | 1 |
2 reviews available for 5-hydroxytryptophan and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence.
Topics: 5-Hydroxytryptophan; Acetylcysteine; Dietary Supplements; Glycine; Humans; Hypericum; Inositol; Obse | 2011 |
Serotonin and anxiety revisited.
Topics: 5-Hydroxytryptophan; Animals; Anxiety Disorders; Benzodiazepines; Brain; Humans; Obsessive-Compulsiv | 1988 |
3 trials available for 5-hydroxytryptophan and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
5-Hydroxytryptophan as adjuvant therapy in treatment of moderate to severe obsessive-compulsive disorder: a double-blind randomized trial with placebo control.
Topics: 5-Hydroxytryptophan; Adult; Double-Blind Method; Drug Therapy, Combination; Female; Fluvoxamine; Hum | 2020 |
Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder.
Topics: 5-Hydroxytryptophan; Adult; Age Factors; Antidepressive Agents, Second-Generation; Antidepressive Ag | 1997 |
Effect of a serotonin precursor and uptake inhibitor in anxiety disorders; a double-blind comparison of 5-hydroxytryptophan, clomipramine and placebo.
Topics: 5-Hydroxytryptophan; Adult; Agoraphobia; Anxiety Disorders; Clinical Trials as Topic; Clomipramine; | 1987 |
1 other study available for 5-hydroxytryptophan and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Do | 2007 |