5-hydroxytryptophan has been researched along with Nausea in 7 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A recently developed oral serotonergic challenge test consisting of 5-Hydroxytryptophane (5-HTP, 200 mg) combined with carbidopa (CBD, 100 mg + 50 mg) exhibited dose-related neuroendocrine responsiveness and predictable pharmacokinetics." | 2.75 | Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron. ( de Kam, ML; Derijk, RH; Jacobs, GE; Kamerling, IM; van Gerven, JM; van Pelt, J; Zitman, FG, 2010) |
| "5-hydroxytryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor used to assess central serotonergic function." | 2.73 | Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa. ( de Kam, ML; de Rijk, R; Gijsman, HJ; Hoeberechts-Lefrandt, DH; Jacobs, GE; Schoemaker, RC; Smarius, LJ; van der Post, JP; van Gerven, JM; van Pelt, J; Zitman, FG, 2008) |
| " By combining 5-HTP with carbidopa (CBD), increased bioavailability for brain penetration and decreased peripheral side effects would be expected, due to reduced peripheral decarboxylation of 5-HTP to 5-HT." | 2.73 | Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa. ( de Kam, ML; de Rijk, R; Gijsman, HJ; Hoeberechts-Lefrandt, DH; Jacobs, GE; Schoemaker, RC; Smarius, LJ; van der Post, JP; van Gerven, JM; van Pelt, J; Zitman, FG, 2008) |
| " A double-blind, placebo-controlled, single rising dose, four-way crossover trial with placebo randomisation was performed in 15 healthy male volunteers to investigate the neuroendocrine dose-response relationship at various 5-HTP levels; the tolerability and subjective effects of oral 5-HTP at 100, 200 and 300 mg combined with CBD and the pharmacokinetic properties of the 5-HTP/CBD-challenge." | 2.73 | Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa. ( de Kam, ML; de Rijk, R; Gijsman, HJ; Hoeberechts-Lefrandt, DH; Jacobs, GE; Schoemaker, RC; Smarius, LJ; van der Post, JP; van Gerven, JM; van Pelt, J; Zitman, FG, 2008) |
| "Six patients with myoclonus of varying cause were treated with L-5-hydroxytryptophan (L-5-HTP) and carbidopa." | 1.26 | Treatment of myoclonus with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemical observations. ( Katzman, R; Sharpless, NS; Thal, LJ; Wolfson, L, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haruki, H | 1 |
| Pedersen, MG | 1 |
| Gorska, KI | 1 |
| Pojer, F | 1 |
| Johnsson, K | 1 |
| Jacobs, GE | 2 |
| Kamerling, IM | 1 |
| de Kam, ML | 2 |
| Derijk, RH | 1 |
| van Pelt, J | 2 |
| Zitman, FG | 2 |
| van Gerven, JM | 2 |
| Smarius, LJ | 1 |
| Hoeberechts-Lefrandt, DH | 1 |
| van der Post, JP | 1 |
| de Rijk, R | 1 |
| Schoemaker, RC | 1 |
| Gijsman, HJ | 1 |
| Thal, LJ | 1 |
| Sharpless, NS | 1 |
| Wolfson, L | 1 |
| Katzman, R | 1 |
| Takahashi, S | 1 |
| Kondo, H | 1 |
| Kato, N | 1 |
| Cangiano, C | 1 |
| Ceci, F | 1 |
| Cairella, M | 1 |
| Cascino, A | 1 |
| Del Ben, M | 1 |
| Laviano, A | 1 |
| Muscaritoli, M | 1 |
| Rossi-Fanelli, F | 1 |
| Sano, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Daily Supplementation of 5-HTP on Body Composition, a Randomized Investigation[NCT05216406] | 65 participants (Actual) | Interventional | 2021-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for 5-hydroxytryptophan and Nausea
| Article | Year |
|---|---|
Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Antidepressive Agents, Second-Generation; Antiemetics; Area | 2010 |
Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adrenocorticotropic Hormone; Adult; Affect; Antidepressiv | 2008 |
Effects of 5-hydroxytryptophan on eating behavior and adherence to dietary prescriptions in obese adult subjects.
Topics: 5-Hydroxytryptophan; Adult; Anorexia; Diet, Reducing; Dietary Carbohydrates; Feeding Behavior; Femal | 1991 |
4 other studies available for 5-hydroxytryptophan and Nausea
| Article | Year |
|---|---|
Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
Topics: 5-Hydroxytryptophan; Adult; Alcohol Oxidoreductases; Anti-Infective Agents; Biopterins; Cell Line; C | 2013 |
Treatment of myoclonus with L-5-hydroxytryptophan and carbidopa: clinical, electrophysiological, and biochemical observations.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Clonazepam; Diarrhea; Drug Therapy, Combination; | 1980 |
Effect of l-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients.
Topics: 5-Hydroxytryptophan; Adjustment Disorders; Adult; Aged; Blood Platelets; Brain; Depression; Female; | 1975 |
[L-5-hydroxytryptophan(L-5-HTP) therapy in endogenous depression. 1].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Benzoates; Bipolar Disorder; Child; Depression; Female | 1972 |