5-hydroxytryptophan has been researched along with Muscle Contraction in 37 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " L-5-hydroxytryptophan plus carbidopa was administered to eight patients with this disorder or other syndromes in which myoclonus is prominent." | 7.65 | L-5-hydroxytryptophan in treatment of several different syndromes in which myoclonus is prominent. ( Growdon, JH; Shahani, BT; Young, RR, 1976) |
| " L-5-hydroxytryptophan plus carbidopa was administered to eight patients with this disorder or other syndromes in which myoclonus is prominent." | 3.65 | L-5-hydroxytryptophan in treatment of several different syndromes in which myoclonus is prominent. ( Growdon, JH; Shahani, BT; Young, RR, 1976) |
| "The data suggest that this rat cardiac arrest model may be a valuable tool for investigating the pathophysiologic mechanisms of posthypoxic myoclonus and for developing new therapeutic strategies for treating the disorder." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "The auditory-induced myoclonus continues to worsen, reaches a peak about 2 weeks after the arrest, then declines over time to subnormal levels." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "Between attacks, migraineurs had lower plasma 5-HT and higher 5-HIAA levels than did healthy controls and patients with tension headache." | 1.28 | Serotonin metabolism in migraine. ( Bruyn, GW; Ferrari, MD; Odink, J; Pennings, EJ; Tapparelli, C; Van Kempen, GM, 1989) |
| " Long-term administration of lithium decreased the number of not only 5-HT2 receptors in the frontal cortex but also 5-HT1 and 5-HT2 receptors in the hippocampus in rats." | 1.27 | Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain. ( Hotta, I; Segawa, T; Yamawaki, S, 1986) |
| "A patient with post-hypoxic myoclonus, sensitive to therapy with 5-hydroxytryptophan and clonazepam, was subjected to detailed electrophysiological investigation." | 1.26 | Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. ( Adam, J; Chadwick, D; Hallett, M; Marsden, CD, 1977) |
| " This behavioral syndrome, characterized by tremor and muscle twitches (myoclonus), showed a clear dose-response relationship with 5,7-DHT as well as with 5-HTP." | 1.26 | Inhibition of 5,7-dihydroxytryptamine-induced supersensitivity to 5-hydroxytryptophan in mice by treatment with cycloheximide. ( Baldessarini, RJ; Campbell, A; Sperk, G; Stewart, RM, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (83.78) | 18.7374 |
| 1990's | 4 (10.81) | 18.2507 |
| 2000's | 1 (2.70) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dickson, EJ | 1 |
| Heredia, DJ | 1 |
| Smith, TK | 1 |
| Pascual, D | 1 |
| Girón, R | 1 |
| Alsasua, A | 1 |
| Benhamú, B | 1 |
| López-Rodríguez, ML | 1 |
| Martín, MI | 1 |
| Colpaert, FC | 1 |
| Janssen, PA | 1 |
| Sunohara, N | 1 |
| Mukoyama, M | 1 |
| Mano, Y | 1 |
| Satoyoshi, E | 1 |
| Thiele, K | 1 |
| Jahn, U | 1 |
| Geissmann, F | 1 |
| Zirngibl, L | 1 |
| Barbeau, H | 2 |
| Bédard, P | 2 |
| Truong, DD | 1 |
| Matsumoto, RR | 1 |
| Schwartz, PH | 1 |
| Hussong, MJ | 1 |
| Wasterlain, CG | 1 |
| Delini-Stula, A | 1 |
| Radeke, E | 1 |
| Vassout, A | 1 |
| Magnussen, I | 1 |
| Dupont, E | 1 |
| Prange-Hansen, A | 1 |
| de Fine Olivarius, B | 1 |
| Hallett, M | 1 |
| Chadwick, D | 2 |
| Adam, J | 1 |
| Marsden, CD | 2 |
| Hallet, M | 1 |
| Jenner, P | 1 |
| Sperk, G | 1 |
| Stewart, RM | 1 |
| Campbell, A | 1 |
| Baldessarini, RJ | 1 |
| Barbeau, G | 1 |
| Filion, M | 1 |
| Muneoka, Y | 1 |
| Shiba, Y | 1 |
| Kanno, Y | 1 |
| Handley, SL | 1 |
| Miskin, RC | 1 |
| Maj, J | 1 |
| Palider, W | 1 |
| Baran, L | 1 |
| Growdon, JH | 1 |
| Young, RR | 1 |
| Shahani, BT | 1 |
| Wand, P | 1 |
| Kuemmerle, JF | 1 |
| Martin, DC | 1 |
| Murthy, KS | 1 |
| Kellum, JM | 1 |
| Grider, JR | 1 |
| Makhlouf, GM | 1 |
| Nakayama, K | 1 |
| Hata, S | 1 |
| Ishiro, H | 1 |
| Tanaka, Y | 1 |
| Ishii, K | 1 |
| Rawlow, A | 1 |
| King, RG | 1 |
| Ferrari, MD | 1 |
| Odink, J | 1 |
| Tapparelli, C | 1 |
| Van Kempen, GM | 1 |
| Pennings, EJ | 1 |
| Bruyn, GW | 1 |
| Gunning, SJ | 1 |
| Bradbury, AJ | 1 |
| Costall, B | 1 |
| Naylor, RJ | 1 |
| Crone, C | 1 |
| Hultborn, H | 2 |
| Kiehn, O | 2 |
| Mazieres, L | 1 |
| Wigström, H | 1 |
| Hounsgaard, J | 1 |
| Jespersen, B | 1 |
| Wulschke, S | 1 |
| Ehrlein, HJ | 1 |
| Tsiamitas, C | 1 |
| Hotta, I | 1 |
| Yamawaki, S | 1 |
| Segawa, T | 1 |
| Hashimoto, T | 1 |
| Hirata, M | 1 |
| Ito, Y | 1 |
| Bennett, JM | 1 |
| Grollman, A | 1 |
| Krishnamurty, VS | 1 |
| Ellaway, PH | 1 |
| Trott, JR | 1 |
| Birtley, RD | 1 |
| Baines, MW | 1 |
| Bieger, D | 1 |
| Larochelle, L | 1 |
| Hornykiewicz, O | 1 |
| Reinke, DA | 1 |
| Rosenbaum, AH | 1 |
| Bennett, DR | 1 |
| Ludwick, JR | 1 |
| Wiley, JN | 1 |
| Bass, P | 1 |
| Salánki, J | 1 |
| Zs-Nagy, I | 1 |
| Hiripi, L | 1 |
| Takagi, K | 1 |
| Takayanagi, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury[NCT04807764] | 45 participants (Anticipated) | Interventional | 2021-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
37 other studies available for 5-hydroxytryptophan and Muscle Contraction
| Article | Year |
|---|---|
Critical role of 5-HT1A, 5-HT3, and 5-HT7 receptor subtypes in the initiation, generation, and propagation of the murine colonic migrating motor complex.
Topics: 5-Hydroxytryptophan; Animals; Colon; Electric Stimulation; Excitatory Postsynaptic Potentials; In Vi | 2010 |
New benzimidazole derivatives: selective and orally active 5-HT3 receptor antagonists.
Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Aza Compounds; Behavior, Animal; Benzimidazoles; | 2003 |
The head-twitch response to intraperitoneal injection of 5-hydroxytryptophan in the rat: antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, an LSD antagonist.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Male; Muscle Contr | 1983 |
Action-induced rhythmic dystonia: an autopsy case.
Topics: 5-Hydroxytryptophan; Cerebral Infarction; Clonazepam; Dystonia; Electroencephalography; Electromyogr | 1984 |
[New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline].
Topics: 5-Hydroxytryptophan; Animals; Anti-Inflammatory Agents; Blood Pressure; Bronchi; Chemical Phenomena; | 1984 |
Denervation supersensitivity to 5-hydroxytryptophan in rats following spinal transection and 5,7-dihydroxytryptamine injection.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Denervation; Dihydroxytryptamines; Electromyo | 1981 |
Novel rat cardiac arrest model of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Ani | 1994 |
Some aspects of the psychopharmacological activity of maprotiline (Ludiomil): effects of single and repeated treatments.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Anthracenes; Behavior, Animal; Body Temperature; Clomip | 1978 |
Palatal myoclonus treated with 5-hydroxytryptophan and a decarboxylase-inhibitor.
Topics: 5-Hydroxytryptophan; Adult; Carbidopa; Drug Combinations; Humans; Hydrazines; Male; Muscle Contracti | 1977 |
Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Clonazepam; Electroencephalography; Evoked Potentials; Humans; Hypoxia; Male; M | 1977 |
5-Hydroxytryptophan-induced behaviour in guinea-pigs: its relevance to human myoclonus [proceedings].
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Electromyography; Guinea Pigs; Humans; Muscle Contra | 1977 |
Inhibition of 5,7-dihydroxytryptamine-induced supersensitivity to 5-hydroxytryptophan in mice by treatment with cycloheximide.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Animals; Brain; Cycloheximide; Desipramine; Dihydroxyt | 1978 |
Progressive increase of motor activity induced by 5-HTP in the rat below a complete secretion of the spinal cord.
Topics: 5-Hydroxytryptophan; Animals; Electromyography; Female; Hindlimb; Motor Activity; Motor Neurons; Mov | 1979 |
Relaxation of Mytilus smooth muscle by 5-hydroxytryptophan and dopa.
Topics: 5-Hydroxytryptophan; Animals; Bivalvia; In Vitro Techniques; Levodopa; Muscle Contraction; Muscle Re | 1979 |
The interaction of some kynurenine pathway metabolites with 5-hydroxytryptophan and 5-hydroxytryptamine.
Topics: 5-Hydroxytryptophan; Animals; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Hydr | 1977 |
The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anthracenes; Clonidine; Cyproheptadine; Decerebrate State | 1976 |
L-5-hydroxytryptophan in treatment of several different syndromes in which myoclonus is prominent.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Child, Preschool; Drug Evaluation; Female; Humans | 1976 |
The response of alpha-motoneurons of different size to stretch and vibration of extensor muscles after injection of 5-hydroxytryptophan in spinal cats.
Topics: 5-Hydroxytryptophan; Animals; Cats; Female; Male; Motor Neurons; Muscle Contraction; Muscles; Reflex | 1976 |
Coexistence of contractile and relaxant 5-hydroxytryptamine receptors coupled to distinct signaling pathways in intestinal muscle cells: convergence of the pathways on Ca2+ mobilization.
Topics: 5-Hydroxytryptophan; Animals; Calcium; Cells, Cultured; Cyclic AMP; Guinea Pigs; Intestinal Mucosa; | 1992 |
Potentiation by endothelin-1 of 5-hydroxytryptamine-induced contraction in coronary artery of the pig.
Topics: 5-Hydroxytryptophan; Animals; Coronary Vessels; Endothelins; In Vitro Techniques; Isometric Contract | 1992 |
A novel in vivo test for drugs affecting central serotonergic and adrenergic systems.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Albuterol; Animals; Cl | 1990 |
Serotonin metabolism in migraine.
Topics: 5-Hydroxytryptophan; Headache; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Monoamine Oxida | 1989 |
Evidence that 5-hydroxytryptamine may exert both facilitatory and inhibitory control of electrical field stimulation-evoked contractions in longitudinal muscle taken from the body of guinea-pig stomach.
Topics: 5-Hydroxytryptophan; Animals; Electric Stimulation; Fenclonine; Guinea Pigs; In Vitro Techniques; Ma | 1986 |
Maintained changes in motoneuronal excitability by short-lasting synaptic inputs in the decerebrate cat.
Topics: 5-Hydroxytryptophan; Animals; Cats; Decerebrate State; Electromyography; Hindlimb; Methysergide; Mot | 1988 |
Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Cats; Decerebrate State; Hindlimb; Membrane Potenti | 1988 |
The control mechanisms of gastric emptying are not overridden by motor stimulants.
Topics: 5-Hydroxytryptophan; Animals; Cisapride; Dogs; Duodenum; Gastric Emptying; Gastrointestinal Motility | 1986 |
Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Brain; Frontal Lobe; Head; Hippocampus; In Vitro Techniques; Ketanseri | 1986 |
A role for inositol 1,4,5-trisphosphate in the initiation of agonist-induced contractions of dog tracheal smooth muscle.
Topics: 5-Hydroxytryptophan; Acetylcholine; Animals; Calcium; Cimetidine; Dinoprost; Dogs; Female; Histamine | 1985 |
Relation of dopa and 5-HTP to convulsions induced by strychnine and leptazol.
Topics: 5-Hydroxytryptophan; Animals; Anura; Dihydroxyphenylalanine; Injections, Subcutaneous; Muscle Contra | 1970 |
Contractile response of the aorta of the normotensive and acute and chronic hypertensive rat.
Topics: 5-Hydroxytryptophan; Acute Disease; Animals; Aorta; Blood Pressure; Calcium; Chronic Disease; Dose-R | 1973 |
Proceedings: Participation of gamma motoneurones in the stretch reflex produced by 5-HTP in the spinal cat.
Topics: 5-Hydroxytryptophan; Animals; Cats; Cerebral Decortication; Electric Stimulation; Motor Neurons; Mus | 1974 |
The effects of metoclopramide on some isolated intestinal preparations.
Topics: 5-Hydroxytryptophan; Acetylcholine; Anesthesia, Local; Animals; Dose-Response Relationship, Drug; Fe | 1973 |
A model for the quantitative study of central dopaminergic and serotoninergic activity.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Caudate Nucleus; Chlorpromazine; Dihydroxyphenylalanine; | 1972 |
Patterns of dog gastrointestinal contractile activity monitored in vivo with extraluminal force transducers.
Topics: 5-Hydroxytryptophan; Animals; Colon; Digestion; Dogs; Duodenum; Electrophysiology; Fasting; Female; | 1967 |
Experimental contractile force and electrical activity of reversed canine duodenum.
Topics: 5-Hydroxytryptophan; Animals; Autonomic Nervous System; Digestion; Dogs; Duodenum; Electrophysiology | 1968 |
Nissl-substance and serotonin level in the ganglia of the fresh-water mussel (Anodonta cygnea L.) after treatment with actinomycin-D, in relation to activity regulation.
Topics: 5-Hydroxytryptophan; Animals; Dactinomycin; Ganglia; Mollusca; Motor Activity; Muscle Contraction; N | 1968 |
Mode of action of partial agonists on the taenia caecum of the guinea pig and drug-receptor theory.
Topics: 5-Hydroxytryptophan; Acetylcholine; Animals; Atropine; Calcium; Choline; Colon; Dibenzylchlorethamin | 1969 |