5-hydroxytryptophan has been researched along with Movement Disorders in 25 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Movement Disorders: Syndromes which feature DYSKINESIAS as a cardinal manifestation of the disease process. Included in this category are degenerative, hereditary, post-infectious, medication-induced, post-inflammatory, and post-traumatic conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, and carbidopa, a peripheral aromatic amino acid decarboxylase inhibitor, were studied in a boy with the Lesch-Nyhan syndrome." | 7.66 | Further observations on the use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. ( Anders, TF; Barchas, JD; Berger, PA; Cann, HM; Ciaranello, RD, 1978) |
| "Severe 6-pyruvoyl-tetrahydrobiopterin synthase deficiency is a tetrahydrobiopterin deficiency disorder that presents in infancy with developmental delay, seizures, and abnormal movements associated with hyperphenylalaninemia usually detectable by neonatal phenylketonuria screening programs." | 3.73 | 6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia. ( Blau, N; Connolly, MB; Demos, MK; Hyland, K; Lillquist, Y; Makhseed, N; Vallance, HD; Waters, PJ, 2005) |
| "The effects of 5-hydroxytryptophan (5-HTP), a serotonin precursor, and carbidopa, a peripheral aromatic amino acid decarboxylase inhibitor, were studied in a boy with the Lesch-Nyhan syndrome." | 3.66 | Further observations on the use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. ( Anders, TF; Barchas, JD; Berger, PA; Cann, HM; Ciaranello, RD, 1978) |
| "Progress in the treatment of action myoclonus is especially noteworthy and has led to the implication of serotonin deficit in the pathophysiology of this syndrome." | 1.26 | New approaches in the management of hyperkinetic movement disorders. ( Fahn, S, 1977) |
| "The syndrome was not seen after thioridazine (3-7 mg/kg)." | 1.26 | Acute dystonia as an idiosyncratic response to neuroleptics in baboons. ( Anlezark, GM; Marsden, CD; Meldrum, BS, 1977) |
| " Although directly related to daily dosage of levodopa, the myoclonus was specifically blocked by the serotonin antagonist, methysergide." | 1.25 | Levodopa-induced myoclonus. ( Bergen, D; Goetz, C; Klawans, HL, 1975) |
| "Levodopa-induced myoclonus may be related to intermittent increases of activity of serotonin in the brain and results from levodopa-induced dysregulation of serotonin activity." | 1.25 | Levodopa-induced myoclonus. ( Bergen, D; Goetz, C; Klawans, HL, 1975) |
| "In monkeys with resting tremor, the administration of DL-5-HTP (5-hydroxytryptophan) or of DL-DOPA (3,4-dihydroxyphenylalanine) relieves the tremor, but the simultaneous administration of DL-5-HTP or DL-DOPA and atropine results in a much more pronounced relief." | 1.25 | The effects of centrally acting drugs on tremor in monkeys with mesencephalic lesions. ( Anagnoste, B; Battista, AF; Goldstein, M; Nakatani, S, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (80.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, Y | 1 |
| Jacob-Vadakot, S | 1 |
| Dugan, EA | 1 |
| McBride, S | 1 |
| Olexa, R | 1 |
| Simansky, K | 1 |
| Murray, M | 1 |
| Shumsky, JS | 1 |
| Dill, P | 1 |
| Wagner, M | 1 |
| Somerville, A | 1 |
| Thöny, B | 1 |
| Blau, N | 2 |
| Weber, P | 1 |
| Indra, B | 1 |
| Tadano, T | 1 |
| Nakagawasai, O | 1 |
| Arai, Y | 1 |
| Yasuhara, H | 1 |
| Ohizumi, Y | 1 |
| Kisara, K | 1 |
| ROOS, BE | 1 |
| STEG, G | 1 |
| Demos, MK | 1 |
| Waters, PJ | 1 |
| Vallance, HD | 1 |
| Lillquist, Y | 1 |
| Makhseed, N | 1 |
| Hyland, K | 1 |
| Connolly, MB | 1 |
| Corral, C | 1 |
| Lissavetzky, J | 1 |
| Manzanares, I | 1 |
| Darias, V | 1 |
| Expósito-Orta, MA | 1 |
| Martïn Conde, JA | 1 |
| Sánchez-Mateo, CC | 1 |
| Fahn, S | 1 |
| Anders, TF | 1 |
| Cann, HM | 1 |
| Ciaranello, RD | 1 |
| Barchas, JD | 1 |
| Berger, PA | 1 |
| Meldrum, BS | 1 |
| Anlezark, GM | 1 |
| Marsden, CD | 1 |
| Klawans, HL | 1 |
| Goetz, C | 1 |
| Bergen, D | 1 |
| Silva, MT | 1 |
| Calil, HM | 1 |
| Pagliusi, SR | 1 |
| Löscher, W | 1 |
| Kitatani, T | 1 |
| Hayashi, S | 1 |
| Sakaguchi, T | 1 |
| Gerber, R | 1 |
| Barbaz, BJ | 1 |
| Martin, LL | 1 |
| Neale, R | 1 |
| Williams, M | 2 |
| Liebman, JM | 1 |
| Bischoff, S | 1 |
| Heinrich, M | 1 |
| Krauss, J | 1 |
| Sills, MA | 1 |
| Vassout, A | 1 |
| Birkmayer, W | 1 |
| Bazelon, M | 1 |
| Barnet, A | 1 |
| Lodge, A | 1 |
| Shelburne, SA | 1 |
| Saïd, G | 1 |
| Selye, H | 1 |
| Kourounakis, P | 1 |
| Szabo, S | 1 |
| Guilleminault, C | 1 |
| Tharp, BR | 1 |
| Cousin, D | 1 |
| Sabouraud, O | 1 |
| Chatel, M | 1 |
| Badiche, A | 1 |
| Chauvel, P | 1 |
| Le Clec'h, G | 1 |
| Goldstein, M | 1 |
| Battista, AF | 1 |
| Nakatani, S | 1 |
| Anagnoste, B | 1 |
| Himwich, WA | 2 |
| Goldstein, SL | 1 |
| Fox, MW | 1 |
| Rovine, BW | 1 |
| Kim, JS | 1 |
| Hassler, R | 1 |
| Kurokawa, M | 1 |
| Bak, IJ | 1 |
| Goldstein, S | 1 |
| Leiner, K | 1 |
| Stout, M | 1 |
25 other studies available for 5-hydroxytryptophan and Movement Disorders
| Article | Year |
|---|---|
5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats.
Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Cervical Vertebrae; Disease Models, Animal; Dose-Response R | 2010 |
Child neurology: paroxysmal stiffening, upward gaze, and hypotonia: hallmarks of sepiapterin reductase deficiency.
Topics: 5-Hydroxytryptophan; Alcohol Oxidoreductases; Behavior; Benserazide; Consanguinity; Developmental Di | 2012 |
Suppressive effect of nantenine, isolated from Nandina domestica Thunberg, on the 5-hydroxy-L-tryptophan plus clorgyline-induced head-twitch response in mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Aporphines; Brain; Clorgyline; | 2002 |
THE EFFECT OF L-3, 4-DIHYDROXYPHENYLALANINE AND DL-5-HYDROXYTRYPTOPHAN ON RIGIDITY AND TREMOR INDUCED BY RESERPINE, CHLORPROMAZINE AND PHENOXYBENZAMINE.
Topics: 5-Hydroxytryptophan; Amino Acids; Chlorpromazine; Dihydroxyphenylalanine; Dopamine; Inulin; Movement | 1964 |
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Cerebral Palsy; Child; Developmental Disabilities; Diagn | 2005 |
Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Apomorphine; Blepharoptosis; Dose-Response Rela | 1999 |
New approaches in the management of hyperkinetic movement disorders.
Topics: 5-Hydroxytryptophan; Carbidopa; Chorea; Dyskinesia, Drug-Induced; Humans; Movement Disorders; Myoclo | 1977 |
Further observations on the use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Carbidopa; Child; Drug Therapy, Combination; Humans; Hydrazines; Lesch-Nyhan Sy | 1978 |
Acute dystonia as an idiosyncratic response to neuroleptics in baboons.
Topics: 5-Hydroxytryptophan; Acute Disease; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; H | 1977 |
Levodopa-induced myoclonus.
Topics: 5-Hydroxytryptophan; Aged; Amantadine; Amphetamine; Animals; Benztropine; Dopamine Antagonists; Dose | 1975 |
Screening hallucinogenic drugs: systematic study of three behavioral tests.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Apomorphine; Arousal; Behavior, Animal; Chlorpromazine; D | 1975 |
Development of tolerance to the wet-dog shake behaviour but not the increase in seizure threshold induced by L-5-hydroxytryptophan during continued treatment in rats.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Body Weight; Brain Chemistry; Carbidopa; Drug Intera | 1985 |
[Effects of pentoxifylline on 5-hydroxytryptamine in the mouse brain].
Topics: 5-Hydroxytryptophan; Animals; Brain; Drug Interactions; Hydroxyindoleacetic Acid; Male; Mice; Mice, | 1985 |
Antagonism of L-5-hydroxytryptophan-induced head twitching in rats by lisuride: a mixed 5-hydroxytryptamine agonist-antagonist?
Topics: 5-Hydroxytryptophan; Animals; Dopamine; Ergolines; Fenfluramine; Lisuride; Lysergic Acid Diethylamid | 1985 |
Interaction of the D1 receptor antagonist SCH 23390 with the central 5-HT system: radioligand binding studies, measurements of biochemical parameters and effects on L-5-HTP syndrome.
Topics: 5-Hydroxytryptophan; Animals; Benzazepines; Binding, Competitive; Corpus Striatum; Dopamine; Frontal | 1988 |
[Experimental findings and new aspects in extrapyramidal diseases].
Topics: 5-Hydroxytryptophan; Blood Pressure; Body Temperature Regulation; Chorea; Dihydroxyphenylalanine; Do | 1966 |
The effect of high doses of 5-hydroxytryptophan on a patient with trisomy 21. Clinical, chemical and EEG correlations.
Topics: 5-Hydroxytryptophan; Age Factors; Central Nervous System; Chromosomes, Human, 21-22 and Y; Down Synd | 1968 |
[Dystonias].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Dihydroxyphenylalanine; Dystonia Musculorum Deformans; Extra | 1972 |
Protection against the neurolathyrism produced by arsanilic acid in the rat.
Topics: 5-Hydroxytryptophan; Animals; Arsenic Poisoning; Biotransformation; Desoxycorticosterone; Female; Ho | 1972 |
HVA and 5HIAA CSF measurements and 5HTP trials in some patients with involuntary movements.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Chorea; Dopamine; Dystonia Musculorum Deformans; Femal | 1973 |
[Observations on the use of 5 HTP in clinical medicine].
Topics: 5-Hydroxytryptophan; Epilepsy; Humans; Male; Mental Disorders; Movement Disorders; Myoclonus; Thinki | 1972 |
The effects of centrally acting drugs on tremor in monkeys with mesencephalic lesions.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Dihydroxyphenylalanine; Disease Models, Animal; Drug Synergi | 1969 |
Psychoactive agents in dogs with bilateral lesions in subcortical structures.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Caudate Nucleus; Dogs; Movement Disorders; Quinoline | 1968 |
Abnormal movements and rigidity induced by harmaline in relation to striatal acetylcholine, serotonin, and dopamine.
Topics: 5-Hydroxytryptophan; Acetylcholine; Alkaloids; Animals; Basal Ganglia; Brain Chemistry; Caudate Nucl | 1970 |
Psychoactive agents in dogs with bilateral lesions in subcortical structures.
Topics: 5-Hydroxytryptophan; Animals; Caudate Nucleus; Chlorpromazine; Dogs; Dopamine; Haloperidol; Hippocam | 1971 |