5-hydroxytryptophan has been researched along with Migraine Disorders in 24 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Interictal serum levels of serotonin and plasma and mononuclear cell concentrations of beta-endorphin were measured in 20 juvenile patients (13 suffering from migraine without aura and 7 from episodic tension-type headache) before and after 3 months of L-5-hydroxytryptophan treatment (5 mg/kg/day) and compared with a control group of 17 headache-free healthy subjects." | 9.08 | beta-endorphin in plasma and monocytes in juvenile headache. ( Battistella, PA; Bordin, A; Broetto, S; Cernetti, R; Corrà, S; Piva, E; Plebani, M, 1996) |
| "L-Tryptophan (L-TP) has been used in migraine and other pain conditions." | 5.27 | Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. Possible implications in migraine prophylaxis. ( Alfonsi, E; Calvani, M; Facchinetti, F; Genazzani, AR; Nappi, G; Rizzo, V; Sances, G; Sandrini, G, 1986) |
| "Interictal serum levels of serotonin and plasma and mononuclear cell concentrations of beta-endorphin were measured in 20 juvenile patients (13 suffering from migraine without aura and 7 from episodic tension-type headache) before and after 3 months of L-5-hydroxytryptophan treatment (5 mg/kg/day) and compared with a control group of 17 headache-free healthy subjects." | 5.08 | beta-endorphin in plasma and monocytes in juvenile headache. ( Battistella, PA; Bordin, A; Broetto, S; Cernetti, R; Corrà, S; Piva, E; Plebani, M, 1996) |
| "In this study fibromyalgia sufferers were randomly administered a combination of monoamine-oxidase inhibitors (MAOIs)-A/B with 5-HTP, 5-HTP alone, MAOIs-A/B alone, or the tricyclic drug amitriptyline in order to compare the efficacy of these treatments." | 5.08 | Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy. ( Nicolodi, M; Sicuteri, F, 1996) |
| "The recently shown high prevalence of migraine in the population of fibromyalgia sufferers, suggests a common ground shared by fibromyalgia and migraine." | 2.68 | Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy. ( Nicolodi, M; Sicuteri, F, 1996) |
| "Migraine has been demonstrated to be characterized by a defect in the serotonergic and adrenergic systems." | 2.68 | Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy. ( Nicolodi, M; Sicuteri, F, 1996) |
| "One hundred and twenty-four migraineurs were treated randomly with 5-hydroxytryptophan (5-HTP) or with methysergide (M)." | 2.66 | 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. ( Alom, J; Codina, A; Dávalos, A; Titus, F, 1986) |
| "Anti-migraine effect of Calotropis gigantea freeze-dried latex by inhibition of dopamine and serotonin receptors (D1 and D2: dopamine receptors; 5-HT: serotonin receptors); yellow color represents serotonergic, and blue color indicates dopaminergic neurons." | 1.72 | Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn. ( Al-Harrasi, A; Aleya, L; Anwer, MK; Behl, T; Bhatia, S; Chigurupati, S; Kabir, MT; Kaushik, D; Kumar, A; Mittal, V; Sehgal, A; Sharma, N; Sharma, PB; Singh, S; Vargas-de-la-Cruz, C, 2022) |
| "To evaluate the analgesic and anti-migraine activities of senkyunolide I from Ligusticum chuanxiong." | 1.37 | Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. ( Feng, Y; He, CY; Hong, YL; Liang, S; Lin, X; Wang, YH; Xu, DS, 2011) |
| "chuanxiong, traditionally used to treat migraine." | 1.37 | Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. ( Feng, Y; He, CY; Hong, YL; Liang, S; Lin, X; Wang, YH; Xu, DS, 2011) |
| "Between attacks, migraineurs had lower plasma 5-HT and higher 5-HIAA levels than did healthy controls and patients with tension headache." | 1.28 | Serotonin metabolism in migraine. ( Bruyn, GW; Ferrari, MD; Odink, J; Pennings, EJ; Tapparelli, C; Van Kempen, GM, 1989) |
| "In thirty patients with common migraine the platelet concentrations of met-enkephalin immunoreactivity (ME) (76 +/- 9 pg/mg protein) were similar to those in 23 healthy volunteers (77 +/- 5), suggesting that there is no alteration in the ME pool in this biochemical compartment in migraine." | 1.27 | Platelet met-enkephalin immunoreactivity and 5-hydroxytryptamine concentrations in migraine patients: effects of 5-hydroxytryptophan, amitriptyline and chlorimipramine treatment. ( Boiardi, A; Bussone, G; Di Giulio, AM; Galva, MD; La Mantia, L; Mantegazza, P; Picotti, GB, 1984) |
| "L-Tryptophan (L-TP) has been used in migraine and other pain conditions." | 1.27 | Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. Possible implications in migraine prophylaxis. ( Alfonsi, E; Calvani, M; Facchinetti, F; Genazzani, AR; Nappi, G; Rizzo, V; Sances, G; Sandrini, G, 1986) |
| "In fourteen untreated migraine patients with a mean age of 40 years platelet sensitivity to 5HT, EN and ADP was investigated during the prodromal phase (three patients), 12-48 h after headache (three patients) and during the headache-free period (eight patients)." | 1.27 | Evidence of enhanced platelet aggregation and platelet sensitivity in migraine patients. ( Fazekas, F; Lechner, H; Ott, E; Pilger, E, 1985) |
| "The vascular mechanism of migraine attacks--intracranial vasoconstriction during the prodromal stage and passive vasodilatation of extracranial arteries during the painful phase--has been confirmed by modern methods." | 1.26 | [Importance of chemical mediators for the pathogenesis and treatment of hemicrania]. ( Berde, B; Fanchamps, A, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (66.67) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Bhatia, S | 1 |
| Al-Harrasi, A | 1 |
| Kumar, A | 1 |
| Behl, T | 1 |
| Sehgal, A | 1 |
| Singh, S | 1 |
| Sharma, N | 1 |
| Anwer, MK | 1 |
| Kaushik, D | 1 |
| Mittal, V | 1 |
| Chigurupati, S | 1 |
| Sharma, PB | 1 |
| Aleya, L | 1 |
| Vargas-de-la-Cruz, C | 1 |
| Kabir, MT | 1 |
| Wang, YH | 1 |
| Liang, S | 1 |
| Xu, DS | 1 |
| Lin, X | 1 |
| He, CY | 1 |
| Feng, Y | 1 |
| Hong, YL | 1 |
| Nagata, E | 1 |
| Shibata, M | 1 |
| Hamada, J | 1 |
| Shimizu, T | 1 |
| Katoh, Y | 1 |
| Gotoh, K | 1 |
| Suzuki, N | 1 |
| Boiardi, A | 2 |
| Crenna, P | 1 |
| Merati, B | 1 |
| Negri, S | 1 |
| Tansini, E | 1 |
| Bussone, G | 2 |
| Picotti, GB | 1 |
| Di Giulio, AM | 1 |
| Galva, MD | 1 |
| La Mantia, L | 1 |
| Mantegazza, P | 1 |
| Bono, G | 1 |
| Criscuoli, M | 1 |
| Martignoni, E | 1 |
| Salmon, S | 1 |
| Nappi, G | 2 |
| Battistella, PA | 1 |
| Bordin, A | 1 |
| Cernetti, R | 1 |
| Broetto, S | 1 |
| Corrà, S | 1 |
| Piva, E | 1 |
| Plebani, M | 1 |
| Nicolodi, M | 2 |
| Sicuteri, F | 4 |
| Lombardi, D | 1 |
| Merusi, I | 1 |
| Bottone, U | 1 |
| Del Bene, E | 1 |
| Fonda, C | 1 |
| Rivas Nuñez, CJ | 1 |
| Fernandez Martin, F | 1 |
| Fanciullacci, M | 1 |
| Franchi, G | 1 |
| Galli, P | 1 |
| Berde, B | 1 |
| Fanchamps, A | 1 |
| Maissen, CP | 1 |
| Ludin, HP | 1 |
| Ferrari, MD | 1 |
| Odink, J | 1 |
| Tapparelli, C | 1 |
| Van Kempen, GM | 1 |
| Pennings, EJ | 1 |
| Bruyn, GW | 1 |
| Welch, KM | 1 |
| Helpern, JA | 1 |
| Ewing, JR | 1 |
| Robertson, WM | 1 |
| D'Andrea, G | 1 |
| Genazzani, AR | 1 |
| Sandrini, G | 1 |
| Facchinetti, F | 1 |
| Rizzo, V | 1 |
| Alfonsi, E | 1 |
| Sances, G | 1 |
| Calvani, M | 1 |
| Uldry, PA | 1 |
| Regli, F | 1 |
| Lechner, H | 1 |
| Ott, E | 1 |
| Fazekas, F | 1 |
| Pilger, E | 1 |
| Curatolo, P | 1 |
| Sciarretta, A | 1 |
| Titus, F | 1 |
| Dávalos, A | 1 |
| Alom, J | 1 |
| Codina, A | 1 |
| Cahen, RL | 1 |
3 reviews available for 5-hydroxytryptophan and Migraine Disorders
| Article | Year |
|---|---|
Sex, migraine and serotonin interrelationships.
Topics: 5-Hydroxytryptophan; Animals; Female; Fenclonine; Headache; Humans; Male; Menstruation; Migraine Dis | 1976 |
[Biochemical aspects of migraine].
Topics: 5-Hydroxytryptophan; Age Factors; Ammonia; Blood Platelet Disorders; Female; Humans; Menstruation; M | 1975 |
[Indications for L-5-hydroxytryptophan in neurology].
Topics: 5-Hydroxytryptophan; Down Syndrome; Epilepsy; Humans; Migraine Disorders; Myoclonus; Pain; Parkinson | 1987 |
6 trials available for 5-hydroxytryptophan and Migraine Disorders
| Article | Year |
|---|---|
Serotonin precursors in migraine prophylaxis.
Topics: 5-Hydroxytryptophan; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Kinetics; | 1982 |
beta-endorphin in plasma and monocytes in juvenile headache.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; beta-Endorphin; Child; Female; Headache; Humans; Male; Migra | 1996 |
Fibromyalgia and migraine, two faces of the same mechanism. Serotonin as the common clue for pathogenesis and therapy.
Topics: 5-Hydroxytryptophan; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety; Drug Therapy, Combina | 1996 |
L-5-hydroxytryptophan can prevent nociceptive disorders in man.
Topics: 5-Hydroxytryptophan; Analgesics; Ascorbic Acid; Child; Child, Preschool; Female; Follow-Up Studies; | 1999 |
[Comparison of the effect of 5-hydroxytryptophan and propranolol in the interval treatment of migraine].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Double-Blind Method; Humans; Middle Aged; Migraine Dis | 1991 |
5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Child; Clinical Trials as Topic; Female; Humans; Male; Methy | 1986 |
15 other studies available for 5-hydroxytryptophan and Migraine Disorders
| Article | Year |
|---|---|
Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn.
Topics: 5-Hydroxytryptophan; Apomorphine; Calotropis; Dizocilpine Maleate; Latex; Migraine Disorders; Phenol | 2022 |
Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong.
Topics: 5-Hydroxytryptophan; Acetates; Analgesics; Animals; Benzofurans; Brain; Dopamine; Drugs, Chinese Her | 2011 |
Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period.
Topics: 5-Hydroxytryptophan; Adult; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyindoleaceti | 2006 |
5-OH-Tryptophane in migraine: clinical and neurophysiological considerations.
Topics: 5-Hydroxytryptophan; Adult; Aspirin; Female; Humans; Male; Middle Aged; Migraine Disorders; Nocicept | 1981 |
Platelet met-enkephalin immunoreactivity and 5-hydroxytryptamine concentrations in migraine patients: effects of 5-hydroxytryptophan, amitriptyline and chlorimipramine treatment.
Topics: 5-Hydroxytryptophan; Adult; Amitriptyline; Blood Platelets; Clomipramine; Enkephalin, Methionine; Fe | 1984 |
[Vertigo in adolescents with hemicrania].
Topics: 5-Hydroxytryptophan; Adolescent; Age Factors; Antidepressive Agents; Female; Flunarizine; Humans; Ma | 2001 |
[Progress of clinical pharmacology in essential headaches].
Topics: 5-Hydroxytryptophan; Brain; Ergotamine; Headache; Humans; Methysergide; Migraine Disorders; Serotoni | 1976 |
[Importance of chemical mediators for the pathogenesis and treatment of hemicrania].
Topics: 5-Hydroxytryptophan; Aminopyrine; Female; Histamine; Humans; Kinins; Lysergic Acid Diethylamide; Men | 1976 |
Serotonin metabolism in migraine.
Topics: 5-Hydroxytryptophan; Headache; Humans; Hydroxyindoleacetic Acid; Migraine Disorders; Monoamine Oxida | 1989 |
Biochemical effects of cerebral ischemia: relevance to migraine.
Topics: 5-Hydroxytryptophan; Brain; Brain Ischemia; Catecholamines; Energy Metabolism; Humans; Magnetic Reso | 1985 |
Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. Possible implications in migraine prophylaxis.
Topics: 5-Hydroxytryptophan; Adult; beta-Endorphin; Carbidopa; Drug Therapy, Combination; Endorphins; Humans | 1986 |
Evidence of enhanced platelet aggregation and platelet sensitivity in migraine patients.
Topics: 5-Hydroxytryptophan; Adenosine Diphosphate; Adolescent; Adult; beta-Thromboglobulin; Epinephrine; Hu | 1985 |
Benign paroxysmal vertigo and migraine.
Topics: 5-Hydroxytryptophan; Child; Child, Preschool; Humans; Migraine Disorders; Vertigo | 1987 |
Emetic effect of biogenic amines.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain; Catecholamines; | 1970 |
The ingestion of serotonin precursors (L-5-hydroxytryptophan and L-tryptophan) improves migraine headache.
Topics: 5-Hydroxytryptophan; Humans; Methysergide; Migraine Disorders; Tryptophan | 1973 |