5-hydroxytryptophan has been researched along with Malignant Carcinoid Syndrome in 31 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Malignant Carcinoid Syndrome: A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Carcinoid tumors with liver metastases, especially those of midgut origin, produce serotonin via the precursors tryptophan and 5-hydroxytryptophan (5-HTP) and this overproduction contributes to the clinical symptoms of the carcinoid syndrome." | 5.07 | Positron emission tomography (PET) in neuroendocrine gastrointestinal tumors. ( Ahlström, H; Bergström, M; Eriksson, B; Långström, B; Lilja, A; Oberg, K, 1993) |
| "Carcinoid tumors with liver metastases, especially those of midgut origin, produce serotonin via the precursors tryptophan and 5-hydroxytryptophan (5-HTP) and this overproduction contributes to the clinical symptoms of the carcinoid syndrome." | 2.67 | Positron emission tomography (PET) in neuroendocrine gastrointestinal tumors. ( Ahlström, H; Bergström, M; Eriksson, B; Långström, B; Lilja, A; Oberg, K, 1993) |
| "None of the twenty-nine patients with carcinoid tumours had clinical or laboratory evidence of the ectopic ACTH syndrome." | 1.26 | Urinary free cortisol excretion in patients with hyperserotoninaemia from the carcinoid syndrome. ( Feldman, JM, 1979) |
| "An atypical case of the malignant carcinoid syndrome, associated with multiple peptic ulcers, is described." | 1.24 | A beta-hydroxytryptophan-secreting carcinoid tumour. ( CAMPBELL, AC; GOWENLOCK, AH; PLATT, DS; SNOW, PJ, 1963) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (90.32) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hallin, ML | 1 |
| Mahmoud, K | 1 |
| Viswanath, A | 1 |
| Gama, R | 1 |
| SANDLER, M | 4 |
| SNOW, PJ | 2 |
| DONALDSON, RM | 1 |
| GRAY, SJ | 1 |
| LETSOU, VG | 1 |
| SJOERDSMA, A | 3 |
| OATES, JA | 2 |
| ZALTZMAN, P | 1 |
| UDENFRIEND, S | 1 |
| PEART, WS | 1 |
| PORTER, KA | 1 |
| ROBERTSON, JI | 1 |
| BALDOCK, E | 1 |
| CAMPBELL, AC | 2 |
| GOWENLOCK, AH | 2 |
| PLATT, DS | 2 |
| WORMSLEY, KG | 1 |
| HALE, JF | 1 |
| LANE-MITCHELL, W | 1 |
| MELMON, KL | 1 |
| GOBERT, JG | 1 |
| SAVEL, J | 1 |
| CRAWFORD, TB | 1 |
| ASHCROFT, GW | 1 |
| ECCLESTON, D | 1 |
| SMITH, AN | 1 |
| LEMONNIER, A | 2 |
| CHARPENTIER, C | 1 |
| LEMONNIER, F | 1 |
| PARAF, A | 1 |
| CLOSE, HG | 1 |
| SCHEUER, PJ | 1 |
| WAT, PJ | 1 |
| Tagari, PC | 1 |
| Boullin, DJ | 1 |
| Davies, CL | 1 |
| Harris, AL | 1 |
| Montgomery, A | 1 |
| Tyce, GM | 1 |
| Creagan, ET | 1 |
| Eriksson, B | 1 |
| Bergström, M | 1 |
| Lilja, A | 1 |
| Ahlström, H | 1 |
| Långström, B | 1 |
| Oberg, K | 1 |
| Mahmood, T | 1 |
| Mudad, R | 1 |
| Feldman, JM | 2 |
| von Studnitz, W | 1 |
| Waldenström, J | 1 |
| Ryss, ES | 1 |
| Porst, H | 1 |
| Naas, W | 1 |
| Renger, F | 1 |
| Dökert, B | 1 |
| Platzbecker, H | 1 |
| Grahame-Smith, DG | 1 |
| Kähler, HJ | 1 |
| Laplante, L | 1 |
| Archambault, A | 1 |
| Thibert, F | 1 |
3 reviews available for 5-hydroxytryptophan and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
Pharmacology of the carcinoid syndrome.
Topics: 5-Hydroxytryptophan; Bradykinin; Diarrhea; Drug Synergism; Humans; Kinins; Malignant Carcinoid Syndr | 1968 |
[Current views on carcinoid and the carcinoid syndrome].
Topics: 1-Propanol; 5-Hydroxytryptophan; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Carcinoi | 1971 |
Progress report: the carcinoid syndrome.
Topics: 5-Hydroxytryptophan; Antineoplastic Agents; Bradykinin; Diarrhea; Heart Valve Diseases; Humans; Hydr | 1970 |
1 trial available for 5-hydroxytryptophan and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
Positron emission tomography (PET) in neuroendocrine gastrointestinal tumors.
Topics: 5-Hydroxytryptophan; Adenoma, Islet Cell; Carbon Radioisotopes; Carcinoid Tumor; Female; Gastrointes | 1993 |
27 other studies available for 5-hydroxytryptophan and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
'Sweet Dreams', 'Happy Days' and elevated 24-h urine 5-hydroxyindoleacetic acid excretion.
Topics: 5-Hydroxytryptophan; Aged; Chromatography, High Pressure Liquid; Chromogranin A; False Positive Reac | 2013 |
An atypical carcinoid tumour secreting 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Carcinoid Tumor; Humans; Malignant Carcinoid Syndrome; Tryptophan | 1958 |
5-Hydroxytryptophan as an intermediate of serotonin biosyntheses in malignant carcinoidosis.
Topics: 5-Hydroxytryptophan; Humans; Malignant Carcinoid Syndrome; Serotonin; Tryptophan | 1959 |
Serotonin synthesis in carcinoid patients. Its inhibition by alpha-methyl-dopa, with measurement of associated increases in urinary 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Carcinoid Tumor; Carcinoma, Neuroendocrine; Dihydroxyphenylalanine; Humans; Mal | 1960 |
Carcinoid syndrome due to pancreatic-duct neoplasm secreting 5-hydroxytryptophan and 5-hydroxytryptamine.
Topics: 5-Hydroxytryptophan; Humans; Malignant Carcinoid Syndrome; Neoplasms; Pancreatic Neoplasms; Serotoni | 1963 |
A beta-hydroxytryptophan-secreting carcinoid tumour.
Topics: 5-Hydroxytryptophan; Carcinoid Tumor; Histamine; Humans; Malignant Carcinoid Syndrome; Neoplasms; Se | 1963 |
OAT-CELL CARCINOMA OF THE BRONCHUS SECRETING 5-HYDROXYTRYPTOPHAN.
Topics: 5-Hydroxytryptophan; Avena; Bronchi; Bronchial Neoplasms; Carcinoma; Colorimetry; Humans; Indoles; M | 1964 |
THE CARCINOID SYNDROME. CASE REPORT AND REVIEW.
Topics: 5-Hydroxytryptophan; Antineoplastic Agents; Appendectomy; Drug Therapy; Humans; Liver Neoplasms; Mal | 1964 |
THE CARCINOID SPECTRUM.
Topics: 5-Hydroxytryptophan; Angiotensins; Antineoplastic Agents; Bronchial Neoplasms; Carcinoid Tumor; Chlo | 1964 |
[SEMI-QUANTITATIVE DETERMINATION OF 5-HYDROXYINDOLIC DERIVATIVES IN THE BLOOD, URINE AND TISSUES].
Topics: 5-Hydroxytryptophan; Biomedical Research; Blood; Bronchial Neoplasms; Chromatography; Histology; Hyd | 1964 |
SOME OBSERVATIONS ON THE METABOLISM OF INDOLES IN TWO PATIENTS WITH THE CARCINOID SYNDROME.
Topics: 5-Hydroxytryptophan; Biochemical Phenomena; Biochemistry; Blood; Cerebrospinal Fluid; Chromatography | 1965 |
[CURRENT DATA ON BIOCHEMISTRY OF THE CARCINOID SYNDROME].
Topics: 5-Hydroxytryptophan; Amino Acids; Biochemistry; Humans; Hydroxyindoleacetic Acid; Malignant Carcinoi | 1965 |
[ATTEMPTS AT MEDICAL TREATMENT OF THE CARCINOID SYNDROME. GENERAL REVIEW AND PERSONAL TRAILS].
Topics: 5-Hydroxytryptophan; Amino Acids; Biochemical Phenomena; Drug Therapy; Humans; Hydroxyindoleacetic A | 1965 |
Biochemical effect of phenylacetic acid in a patient with 5-hydroxytryptophan-secreting carcinoid tumor.
Topics: 5-Hydroxytryptophan; Carcinoid Tumor; Humans; Malignant Carcinoid Syndrome; Phenylacetates | 1959 |
A unique syndrome associated with secretion of 5-hydroxytryptophan by metastatic gastric carcinoids.
Topics: 5-Hydroxytryptophan; Carcinoid Tumor; Humans; Malignant Carcinoid Syndrome; Stomach Neoplasms; Trypt | 1962 |
5-Hydroxytryptophan-secreting bronchial carcinoid tumour.
Topics: 5-Hydroxytryptophan; Bronchi; Bronchial Neoplasms; Malignant Carcinoid Syndrome; Neoplasms; Tryptoph | 1961 |
Simplified determination of serotonin in plasma by liquid chromatography with electrochemical detection.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Catecholamines; Chromatography, High Pressure Liquid; Electr | 1984 |
Orbital carcinoid tumor.
Topics: 5-Hydroxytryptophan; Carcinoid Tumor; Female; Humans; Ileal Neoplasms; Malignant Carcinoid Syndrome; | 1980 |
Measurement of free and bound 5-hydroxytryptophan in plasma by liquid chromatography with electrochemical detection.
Topics: 5-Hydroxytryptophan; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Electrochemistry | 1981 |
Carcinoid syndrome with unknown primary: a case report.
Topics: 5-Hydroxytryptophan; Fatal Outcome; Humans; Hydroxyindoleacetic Acid; Male; Malignant Carcinoid Synd | 1999 |
Urinary free cortisol excretion in patients with hyperserotoninaemia from the carcinoid syndrome.
Topics: 5-Hydroxytryptophan; Adult; Aged; Carcinoid Tumor; Female; Humans; Hydrocortisone; Hydroxyindoleacet | 1979 |
Editorial: Diagnosis of malignant carcinoid syndrome.
Topics: 5-Hydroxytryptophan; Bronchial Neoplasms; Humans; Hydroxyindoleacetic Acid; Malignant Carcinoid Synd | 1975 |
Carcinoid tumors and syndrome.
Topics: 5-Hydroxytryptophan; Carcinoembryonic Antigen; Carcinoid Heart Disease; Carcinoid Tumor; Diagnosis, | 1987 |
[Pharmacological and therapeutic studies (p-chlorphenylalanin) on carcinoid syndrome in 11 cases].
Topics: 5-Hydroxytryptophan; Aged; Blood Pressure; Bradykinin; Epinephrine; Female; Fenclonine; Humans; Hydr | 1971 |
[Carcinoid and carcinoid syndrome].
Topics: 5-Hydroxytryptophan; Bradykinin; Carcinoid Tumor; Female; Gastrointestinal Neoplasms; Hepatomegaly; | 1974 |
[Laboratory findings in the carcinoid syndrome].
Topics: 5-Hydroxytryptophan; Chromatography; Histamine; Humans; Hydroxyindoleacetic Acid; Malignant Carcinoi | 1968 |
[The carcinoid syndrome].
Topics: 5-Hydroxytryptophan; Antineoplastic Agents; Bradykinin; Carcinoid Tumor; Catecholamines; Diet Therap | 1971 |