5-hydroxytryptophan has been researched along with Idiopathic Parkinson Disease in 44 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study provides evidence that 5-HTP is safe and effective in improving sleep stability in PD, contributing to ameliorate patients' global sleep quality." | 7.11 | Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease. ( Cannas, A; Carta, M; Defazio, G; Figorilli, M; Meloni, M; Puligheddu, M; Sanna, F; Tamburrino, L, 2022) |
| "This study provides evidence that 5-HTP is safe and effective in improving sleep stability in PD, contributing to ameliorate patients' global sleep quality." | 3.11 | Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease. ( Cannas, A; Carta, M; Defazio, G; Figorilli, M; Meloni, M; Puligheddu, M; Sanna, F; Tamburrino, L, 2022) |
| "Demented patients with Parkinson's disease, particularly those with concurrent depression, had the lowest values of 5-HIAA." | 2.66 | The relationship of serotonin to depression in Parkinson's disease. ( Cote, LJ; Mayeux, R; Sano, M; Stern, Y; Williams, JB, 1988) |
| "We studied 6 patients with myoclonus elicited by flash stimulation (1-15 Hz)." | 1.29 | The pathophysiology and pharmacology of photic cortical reflex myoclonus. ( Artieda, J; Obeso, JA, 1993) |
| " Although directly related to daily dosage of levodopa, the myoclonus was specifically blocked by the serotonin antagonist, methysergide." | 1.25 | Levodopa-induced myoclonus. ( Bergen, D; Goetz, C; Klawans, HL, 1975) |
| "Levodopa-induced myoclonus may be related to intermittent increases of activity of serotonin in the brain and results from levodopa-induced dysregulation of serotonin activity." | 1.25 | Levodopa-induced myoclonus. ( Bergen, D; Goetz, C; Klawans, HL, 1975) |
| "Two cases of idiopathic orthostatic hypotension are reported, one associated with striato-nigral degeneration (case 1) and the other with Lewy body parkinsonism (case 2)." | 1.25 | Idiopathic orthostatic hypotension. Biochemical and pathologic observations in 2 cases. ( Forno, LS; Langston, JW; Schober, R, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (75.00) | 18.7374 |
| 1990's | 6 (13.64) | 18.2507 |
| 2000's | 2 (4.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (6.82) | 2.80 |
| Authors | Studies |
|---|---|
| Meloni, M | 3 |
| Puligheddu, M | 3 |
| Carta, M | 3 |
| Cannas, A | 3 |
| Figorilli, M | 3 |
| Defazio, G | 3 |
| Sanna, F | 2 |
| Farris, R | 1 |
| Tronci, E | 1 |
| Tamburrino, L | 1 |
| Young, SN | 2 |
| Gauthier, S | 2 |
| Chouinard, G | 1 |
| Anderson, GM | 1 |
| Purdy, WC | 1 |
| Birkmayer, W | 2 |
| Riederer, P | 1 |
| Youdim, MB | 1 |
| Sternberg, EM | 1 |
| Van Woert, MH | 2 |
| Magnussen, I | 1 |
| Baker, H | 1 |
| Osterland, CK | 1 |
| Tohgi, H | 1 |
| Abe, T | 1 |
| Takahashi, S | 1 |
| Takahashi, J | 1 |
| Hamato, H | 1 |
| Artieda, J | 1 |
| Obeso, JA | 1 |
| Nakajima, T | 1 |
| Iacono, RP | 1 |
| Kuniyoshi, SM | 1 |
| Ahlman, JR | 1 |
| Zimmerman, GJ | 1 |
| Maeda, G | 1 |
| Pearlstein, RD | 1 |
| Soares-da-Silva, P | 1 |
| Parada, A | 1 |
| Serrão, P | 1 |
| Burkhard, P | 1 |
| Dominici, P | 1 |
| Borri-Voltattorni, C | 1 |
| Jansonius, JN | 1 |
| Malashkevich, VN | 1 |
| Nagatsu, T | 1 |
| Carlsson, A | 1 |
| Bastard, J | 1 |
| Truelle, JL | 1 |
| Emile, J | 1 |
| Klawans, HL | 3 |
| Goetz, C | 1 |
| Bergen, D | 1 |
| Schober, R | 1 |
| Langston, JW | 1 |
| Forno, LS | 1 |
| Joly, P | 1 |
| Lampert, A | 1 |
| Thomine, E | 1 |
| Lauret, P | 1 |
| Sandyk, R | 1 |
| van Praag, HM | 2 |
| Mayeux, R | 1 |
| Stern, Y | 1 |
| Sano, M | 1 |
| Williams, JB | 1 |
| Cote, LJ | 1 |
| Uldry, PA | 1 |
| Regli, F | 1 |
| Carvey, PM | 1 |
| Tanner, CM | 1 |
| Goetz, CG | 2 |
| Klein, P | 1 |
| Lees, A | 1 |
| Stern, G | 1 |
| Chase, TN | 4 |
| Hassler, R | 1 |
| Saïd, G | 1 |
| Goldstein, M | 1 |
| Anagnoste, B | 1 |
| Battista, AF | 1 |
| Nakatani, S | 1 |
| Ogawa, M | 1 |
| Sano, I | 1 |
| Taniguchi, K | 1 |
| Ng, LK | 1 |
| Watanabe, AM | 1 |
| Benesová, O | 1 |
| Presthus, J | 1 |
| Teitel, S | 1 |
| Brossi, A | 1 |
| Cotzias, GC | 1 |
| Papavasiliou, PS | 1 |
| Gellene, R | 1 |
| Aronson, RB | 1 |
| Bell, EA | 1 |
| Janzen, DH | 1 |
| Casati, C | 1 |
| Vogel, WH | 1 |
| Bowers, MB | 1 |
| Tyce, GM | 1 |
| Muenter, MD | 1 |
| Owen, CA | 1 |
10 reviews available for 5-hydroxytryptophan and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Amine precursor amino acid therapy: from neurochemical basis to clinical aspects.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Depressive Disorder; Droxidopa; Histidine; Humans; Levodo | 1996 |
Monoamine precursors and analogues.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Dr | 1975 |
Affective disorders and aggression disorders: evidence for a common biological mechanism.
Topics: 5-Hydroxytryptophan; Aggression; Blood Platelets; Carrier Proteins; Celiac Disease; Depressive Disor | 1986 |
[Indications for L-5-hydroxytryptophan in neurology].
Topics: 5-Hydroxytryptophan; Down Syndrome; Epilepsy; Humans; Migraine Disorders; Myoclonus; Pain; Parkinson | 1987 |
Indoleamines in depression and suicide.
Topics: 5-Hydroxytryptophan; Brain; Celiac Disease; Depression; Humans; Parkinson Disease; Serotonin; Suicid | 1986 |
Serotonergic mechanisms and extrapyramidal function in man.
Topics: 5-Hydroxytryptophan; Carbidopa; Cerebellar Diseases; Creutzfeldt-Jakob Syndrome; Down Syndrome; Extr | 1974 |
[Review of current pharmacotherapy of Parkinsonism. Comprehensive review].
Topics: 5-Hydroxytryptophan; Amantadine; Anticonvulsants; Apomorphine; Benztropine; Carboxy-Lyases; Chemical | 1973 |
[Other trials with drug therapy in parkinsonism].
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Dr | 1973 |
Alkaloids in the mammalian system.
Topics: 5-Hydroxytryptophan; Acetaldehyde; Alkaloids; Animals; Aporphines; Biogenic Amines; Catalysis; Cells | 1974 |
[Parkinson's disease: current therapeutic aspects].
Topics: 5-Hydroxytryptophan; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Humans; M | 1971 |
8 trials available for 5-hydroxytryptophan and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Efficacy and safety of 5-hydroxytryptophan on depression and apathy in Parkinson's disease: a preliminary finding.
Topics: 5-Hydroxytryptophan; Aged; Apathy; Cross-Over Studies; Depression; Double-Blind Method; Female; Huma | 2020 |
Efficacy and safety of 5-Hydroxytryptophan on levodopa-induced motor complications in Parkinson's disease: A preliminary finding.
Topics: 5-Hydroxytryptophan; Animals; Antiparkinson Agents; Cross-Over Studies; Dose-Response Relationship, | 2020 |
Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease.
Topics: 5-Hydroxytryptophan; Cross-Over Studies; Humans; Parkinson Disease; Polysomnography; REM Sleep Behav | 2022 |
Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Carbidopa; Clinical Trials as Topic; Drug Therapy, Com | 1980 |
[Effectiveness of 5 hydroxy-tryptophan in Parkinson's disease].
Topics: 5-Hydroxytryptophan; Aged; Antiparkinson Agents; Clinical Trials as Topic; Drug Therapy, Combination | 1976 |
The relationship of serotonin to depression in Parkinson's disease.
Topics: 5-Hydroxytryptophan; Aged; Clinical Trials as Topic; Dementia; Depressive Disorder; Female; Humans; | 1988 |
Parkinson's disease. Modification by 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Adult; Aged; Brain; Carboxy-Lyases; Clinical Trials as Topic; Drug Synergism; E | 1972 |
Parkinsonism and DOPA.
Topics: 5-Hydroxytryptophan; Clinical Trials as Topic; Dihydroxyphenylalanine; Dopamine; Humans; Male; Manga | 1968 |
26 other studies available for 5-hydroxytryptophan and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.
Topics: 5-Hydroxytryptophan; Adult; Benserazide; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Humans; | 1982 |
(-)Deprenyl in the treatment of Parkinson's disease.
Topics: 5-Hydroxytryptophan; Brain; Dopamine; Drug Synergism; Drug Therapy, Combination; Humans; Levodopa; L | 1982 |
Concentrations of serotonin and its related substances in the cerebrospinal fluid of parkinsonian patients and their relations to the severity of symptoms.
Topics: 5-Hydroxytryptophan; Humans; Hydroxyindoleacetic Acid; Kynurenine; Middle Aged; Parkinson Disease; R | 1993 |
The pathophysiology and pharmacology of photic cortical reflex myoclonus.
Topics: 5-Hydroxytryptophan; Aged; Aged, 80 and over; Ataxia; Cerebral Cortex; Dopamine Agents; Electroencep | 1993 |
Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders.
Topics: 5-Hydroxytryptophan; Aged; Biogenic Amines; Cerebral Ventricles; Gait; Homovanillic Acid; Humans; Hy | 1997 |
The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Brain; Cells, Cultu | 2000 |
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Be | 2001 |
[Tyrosine hydroxylase (author's transl)].
Topics: 5-Hydroxytryptophan; Adrenal Glands; Brain; Catecholamines; Chemical Phenomena; Chemistry; Coenzymes | 1976 |
Levodopa-induced myoclonus.
Topics: 5-Hydroxytryptophan; Aged; Amantadine; Amphetamine; Animals; Benztropine; Dopamine Antagonists; Dose | 1975 |
Idiopathic orthostatic hypotension. Biochemical and pathologic observations in 2 cases.
Topics: 5-Hydroxytryptophan; Aged; Amines; Brain Diseases; Female; Ganglia, Autonomic; Humans; Hydroxyindole | 1975 |
Development of pseudobullous morphea and scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Aged; Carbidopa; Chronic Disease; Depression; Drug Therapy, Combination; Eosino | 1991 |
Pineal melatonin functions and the depression of Parkinson's disease: a hypothesis.
Topics: 5-Hydroxytryptophan; Animals; Depression; Dopamine; Humans; Melatonin; Models, Neurological; Parkins | 1990 |
Drug-induced myoclonus.
Topics: 5-Hydroxytryptophan; Anesthetics; Animals; Anti-Bacterial Agents; Antidepressive Agents; Bismuth; Ca | 1986 |
Consequences of chronic 5-hydroxy-tryptophan in parkinsonian instability of gait and balance and in other neurological disorders.
Topics: 5-Hydroxytryptophan; Adult; Aged; Benserazide; Cerebellar Ataxia; Drug Therapy, Combination; Female; | 1987 |
5-hydroxytryptophan in parkinsonism.
Topics: 5-Hydroxytryptophan; Aged; Female; Humans; Male; Middle Aged; Parkinson Disease; Tremor | 1970 |
Letter: Myoclonus, methysergide, and serotonin.
Topics: 5-Hydroxytryptophan; Animals; Dihydroxyphenylalanine; Drug Antagonism; Guinea Pigs; Humans; Methyser | 1974 |
[Experimental findings and new aspects in extrapyramidal diseases].
Topics: 5-Hydroxytryptophan; Blood Pressure; Body Temperature Regulation; Chorea; Dihydroxyphenylalanine; Do | 1966 |
[Correlations between chemical mediators (dopamine, serotonin, acetylcholine and gaba), muscular tone and rapidity of movement].
Topics: 5-Hydroxytryptophan; Acetylcholine; Alkaloids; Aminobutyrates; Animals; Dihydroxyphenylalanine; Dopa | 1972 |
[Dystonias].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Dihydroxyphenylalanine; Dystonia Musculorum Deformans; Extra | 1972 |
Biochemical aspects of experimentally induced parkinsonism.
Topics: 5-Hydroxytryptophan; Amines; Amino Acids; Animals; Antiparkinson Agents; Apomorphine; Basal Ganglia; | 1972 |
[L-5-hydroxytryptophan(L-5-HTP) therapy of Parkinson's disease. 2].
Topics: 5-Hydroxytryptophan; Adult; Aged; Depression; Dihydroxyphenylalanine; Female; Humans; Male; Middle A | 1972 |
Medical and ecological considerations of L-dopa and 5-HTP in seeds.
Topics: 5-Hydroxytryptophan; Carboxy-Lyases; Colombia; Costa Rica; Dihydroxyphenylalanine; Ecology; Insecta; | 1971 |
Non-enzymatic decarboxylation of dihydroxypheylalanine.
Topics: 5-Hydroxytryptophan; Carbon Dioxide; Carbon Isotopes; Chemical Phenomena; Chemistry; Copper; Dihydro | 1969 |
The effect of L-dopa on monoamine metabolites in Parkinson's disease.
Topics: 5-Hydroxytryptophan; Aged; Dihydroxyphenylalanine; Dopamine; Humans; Hydroxyindoleacetic Acid; Middl | 1970 |
Metabolism of L-dihydroxyphenylalanine by patients with Parkinson's disease.
Topics: 5-Hydroxytryptophan; Adult; Aged; Dihydroxyphenylalanine; Dopa Decarboxylase; Dopamine; Female; Huma | 1970 |
Cerebrospinal fluid monoamine metabolites and peripheral decarboxylase inhibitors in parkinsonism.
Topics: 5-Hydroxytryptophan; Adult; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Dr | 1970 |