5-hydroxytryptophan has been researched along with Hypoxia in 26 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of cinepazide, a vasodilator, on the content, biosynthesis and turnover of noradrenaline (NA), dopamine (DA) and 5-hydroxytryptamine (5-HT) in the rat brain were examined under room air and hypoxia (10% O2, 90% N2)." | 7.67 | The effects of cinepazide on the content, biosynthesis and turnover of noradrenaline, dopamine and 5-hydroxytryptamine in the rat brain under room air and hypoxia. ( Fujiwara, M; Lee, K; Miwa, S, 1986) |
| "In view of the fact that diazepam has been shown to prevent an increase in catecholamine synthesis and/or turnover rates in stressful situations, and to modify the cerebral metabolic (and circulatory) response to hypoxia and hypercapnia, the influence of the drug on synthesis rates of DOPA and 5-HTP in three regions of the rat brain were studied under normoxic-normocapnic conditions, as well as in hypoxia and hypercapnia." | 7.66 | Effect of diazepam on cerebral monoamine synthesis during hypoxia and hypercapnia in the rat. ( Carlsson, A; Dahlgren, N; Sakabe, T; Siesjö, BK, 1982) |
| "The influence of long-term hypoxia (10% O2, 14 days) on in vivo activity of tryptophan hydroxylase and on 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentration in discrete brain regions of rats was assessed." | 3.69 | Activity of tryptophan hydroxylase and content of indolamines in discrete brain regions after a long-term hypoxic exposure in the rat. ( Dalmaz, Y; Denoroy, L; Pequignot, JM; Poncet, L, 1997) |
| "The effects of cinepazide, a vasodilator, on the content, biosynthesis and turnover of noradrenaline (NA), dopamine (DA) and 5-hydroxytryptamine (5-HT) in the rat brain were examined under room air and hypoxia (10% O2, 90% N2)." | 3.67 | The effects of cinepazide on the content, biosynthesis and turnover of noradrenaline, dopamine and 5-hydroxytryptamine in the rat brain under room air and hypoxia. ( Fujiwara, M; Lee, K; Miwa, S, 1986) |
| "In view of the fact that diazepam has been shown to prevent an increase in catecholamine synthesis and/or turnover rates in stressful situations, and to modify the cerebral metabolic (and circulatory) response to hypoxia and hypercapnia, the influence of the drug on synthesis rates of DOPA and 5-HTP in three regions of the rat brain were studied under normoxic-normocapnic conditions, as well as in hypoxia and hypercapnia." | 3.66 | Effect of diazepam on cerebral monoamine synthesis during hypoxia and hypercapnia in the rat. ( Carlsson, A; Dahlgren, N; Sakabe, T; Siesjö, BK, 1982) |
| " During asphyxia and subsequent recovery the endogenous levels of tryptophan and 5-hydroxytryptamine (5-HT, serotonin) were measured." | 3.66 | Serotonin metabolism in neonatal rat brain during asphyxia and recovery. ( Hedner, T; Lundborg, P, 1980) |
| "Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor." | 3.65 | Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486. ( Sethy, VH; Van Woert, MH, 1975) |
| "Posthypoxic action myoclonus is usually associated with impaired serotonin (5-HT) neurotransmission but in some patients 5-HT precursors aggravate and 5-HT blockers improve action myoclonus." | 1.27 | Clinical, biochemical, and pharmacological observation in a patient with postasphyxic myoclonus: association to serotonin hyperactivity. ( De Yebenes, JG; Giménez-Roldán, S; Mateo, D; Muradas, V, 1988) |
| "Postanoxic myoclonus was first accepted as being related to a dysfunction of the ventrolateral thalamic nucleus." | 1.26 | Postanoxic myoclonus. Treatment of a case with 5-hydroxytryptophane and a decarboxylase inhibitor. ( Beretta, E; de Crousaz, G; Regli, F; Steck, AJ, 1981) |
| "A patient with post-hypoxic myoclonus, sensitive to therapy with 5-hydroxytryptophan and clonazepam, was subjected to detailed electrophysiological investigation." | 1.26 | Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. ( Adam, J; Chadwick, D; Hallett, M; Marsden, CD, 1977) |
| "Post-hypoxic intention myoclonus successfully treated by long-term administration of the combination of 5-hydroxytryptophan and carbidopa is described." | 1.26 | Post-hypoxic intention myoclonus treated with 5-hydroxy-tryptophan and an extracerebral decarboxylase inhibitor. ( de Fine Olivarius, B; Dupont, E; Engbaek, F; Magnussen, I, 1978) |
| "In two patients with postanoxic action myoclonus, L-tryptophan or a monoamine oxidase inhibitor induced a moderate improvement, but L-5-hydroxytryptophan had greater therapeutic effect." | 1.26 | Beneficial effects of serotonin precursors in postanoxic action myoclonus. ( De Léan, J; Hornykiewicz, O; Richardson, JC, 1976) |
| "Three patients with postanoxic intention myoclonus, two patients with intention tremor, and one patient with cerebral palsy were administered L-5-hydroxytryptophan (L-5HTP), the precursor of serotonin, in combination with MK 486, a peripheral amino acid decarboxylase inhibitor." | 1.25 | Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486. ( Sethy, VH; Van Woert, MH, 1975) |
| "4." | 1.25 | Effect of hypobaric stress on enzymes of tryptophan metabolism. ( Inamdar, AR; Kurup, CK; Ramasarma, T, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (88.46) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beretta, E | 1 |
| Regli, F | 1 |
| de Crousaz, G | 1 |
| Steck, AJ | 1 |
| Sakabe, T | 1 |
| Dahlgren, N | 1 |
| Carlsson, A | 5 |
| Siesjö, BK | 2 |
| Hedner, T | 4 |
| Lundborg, P | 4 |
| Poncet, L | 1 |
| Denoroy, L | 1 |
| Dalmaz, Y | 1 |
| Pequignot, JM | 1 |
| Frucht, SJ | 1 |
| Engel, J | 2 |
| Brown, RM | 2 |
| Kehr, W | 1 |
| Davis, JN | 3 |
| Hallett, M | 2 |
| Chadwick, D | 2 |
| Adam, J | 1 |
| Marsden, CD | 2 |
| Magnussen, I | 1 |
| Dupont, E | 1 |
| Engbaek, F | 1 |
| de Fine Olivarius, B | 1 |
| Van Woert, MH | 3 |
| Sethy, VH | 2 |
| De Léan, J | 2 |
| Richardson, JC | 2 |
| Hornykiewicz, O | 1 |
| Nilsson, GE | 1 |
| Rosenbaum, D | 1 |
| Chung, EY | 1 |
| Jenner, P | 1 |
| Rewcastle, NB | 1 |
| Miwa, S | 1 |
| Fujiwara, M | 2 |
| Lee, K | 1 |
| Giménez-Roldán, S | 1 |
| Mateo, D | 1 |
| Muradas, V | 1 |
| De Yebenes, JG | 1 |
| Inamdar, AR | 1 |
| Kurup, CK | 1 |
| Ramasarma, T | 1 |
| MacMillan, V | 1 |
| Snider, SR | 1 |
| Lowy, PH | 1 |
| Keighley, G | 1 |
| Cohen, NS | 1 |
26 other studies available for 5-hydroxytryptophan and Hypoxia
| Article | Year |
|---|---|
Postanoxic myoclonus. Treatment of a case with 5-hydroxytryptophane and a decarboxylase inhibitor.
Topics: 5-Hydroxytryptophan; Benserazide; Humans; Hydrazines; Hydroxyindoleacetic Acid; Hypoxia; Male; Middl | 1981 |
Effect of diazepam on cerebral monoamine synthesis during hypoxia and hypercapnia in the rat.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Brain; Cerebrovascular Circulation; Diazepam; Dihydroxyph | 1982 |
Serotonin metabolism in neonatal rat brain during asphyxia and recovery.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Asphyxia; Brain; Brain Stem; Diencephalon; Hippocamp | 1980 |
Survival of neonatal rats during hypoxia after monoamine stimulating agents.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Apomorphine; Biogenic Amines; Carbidopa; Female; Hyp | 1982 |
Activity of tryptophan hydroxylase and content of indolamines in discrete brain regions after a long-term hypoxic exposure in the rat.
Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Brain Chemistry; | 1997 |
The clinical challenge of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Anticonvulsants; Clonazepam; Humans; Hypoxia; Levetiracetam; Myoclonus; Neuropr | 2002 |
Effect of hypoxia on monoamine synthesis in brains of developing rats.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Benzyl Compounds; Brain; Carboxy-Lyases; Dihydroxyph | 1977 |
Effect of hypoxia on monoamine synthesis in brains of developing rats. III. Various O2 levels.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Brain; Dihydroxyphenylalanine; Female; Hypoxia; Nore | 1978 |
Functional and biochemical aspects of catecholamine metabolism in brain under hypoxia.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Brain; Catecholamin | 1975 |
Adaptation of brain monoamine synthesis to hypoxia in the rat.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Brain Chemistry; Chromatography, Ion Exchange; | 1975 |
Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Clonazepam; Electroencephalography; Evoked Potentials; Humans; Hypoxia; Male; M | 1977 |
Post-hypoxic intention myoclonus treated with 5-hydroxy-tryptophan and an extracerebral decarboxylase inhibitor.
Topics: 5-Hydroxytryptophan; Adult; Carbidopa; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrazine | 1978 |
Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aromatic Amino Acid Decarboxylase Inhibitors; Carbidopa; Cer | 1975 |
Beneficial effects of serotonin precursors in postanoxic action myoclonus.
Topics: 5-Hydroxytryptophan; Aged; Carbidopa; Female; Humans; Hydroxyindoleacetic Acid; Hypoxia; Levodopa; M | 1976 |
Turnover of serotonin in brain of an anoxia-tolerant vertebrate, the crucian carp.
Topics: 5-Hydroxytryptophan; Animals; Brain; Carps; Cyprinidae; Hydrazines; Hydroxyindoleacetic Acid; Hypoxi | 1990 |
Biochemistry and therapeutics of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aspartic Acid; Benzodiazepines; Carbidopa; Electro | 1986 |
Treatment of posthypoxic action myoclonus: implications for the pathophysiology of the disorder.
Topics: 5-Hydroxytryptophan; Benzodiazepines; Clonazepam; Female; Fenclonine; Humans; Hydroxyindoleacetic Ac | 1986 |
Pathological findings in a case of hypoxic myoclonus treated with 5-hydroxytryptophan and a decarboxylase inhibitor.
Topics: 5-Hydroxytryptophan; Aged; Brain; Carbidopa; Diazepam; Electroencephalography; Female; Fenclonine; H | 1986 |
The effects of cinepazide on the content, biosynthesis and turnover of noradrenaline, dopamine and 5-hydroxytryptamine in the rat brain under room air and hypoxia.
Topics: 5-Hydroxytryptophan; Animals; Brain; Dihydroxyphenylalanine; Dopamine; Hydroxyindoleacetic Acid; Hyd | 1986 |
Clinical, biochemical, and pharmacological observation in a patient with postasphyxic myoclonus: association to serotonin hyperactivity.
Topics: 5-Hydroxytryptophan; Aged; Humans; Hydroxyindoleacetic Acid; Hypoxia; Male; Methysergide; Myoclonus; | 1988 |
Letter: Treatment of post-anoxic intention myoclonus.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Drug Evaluation; Drug Synergism; Drug Therapy, Co | 1974 |
The effect of hypoxia on monoamine synthesis, levels and metabolism in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Dihydroxyphenylalanine; Dopamine; Fluorometry; | 1973 |
Effect of hypobaric stress on enzymes of tryptophan metabolism.
Topics: 5-Hydroxytryptophan; Animals; Atmospheric Pressure; Cycloheximide; Hydrocortisone; Hypoxia; Liver; M | 1972 |
Brain tryptophan hydroxylation: dependence on arterial oxygen tension.
Topics: 5-Hydroxytryptophan; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals | 1973 |
Changes in biogenic amine synthesis and turnover induced by hypoxia and/or foot shock stress. II. The central nervous system.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Brain Stem; Corpus Striatum; Depression, Chemi | 1974 |
Stimulation by serotonin of erythropoietin-dependent erythropoiesis in mice.
Topics: 5-Hydroxytryptophan; Animals; Epinephrine; Erythropoiesis; Erythropoietin; Female; Hematocrit; Hemog | 1970 |