5-hydroxytryptophan has been researched along with Hypothermia in 25 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats." | 7.77 | Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011) |
| "Depressing functional serotonin or depleting serotonin levels in rat brains with either p-chlorophenylalanine, 5,6-dihydroxytryptamine or raphe lesions greatly enhanced hypothermia induced by chloropromazine (CPZ)." | 7.66 | Effects of brain serotonin alterations on hypothermia produced by chlorpromazine in rats. ( Chern, YF; Chow, CF; Li, YP; Lin, MT, 1979) |
| " A possible mechanism was explored in the tests of antagonism of reserpine-induced ptosis and hypothermia, and 5-HTP induced head twitch response in mice." | 3.79 | Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. ( Cui, YL; Ding, SL; Mao, HP; Qi, XJ; Wang, QS, 2013) |
| "5mg/kg), which could antagonize reserpine-induced ptosis and hypothermia, moreover, both of them could elevate the contents of NE, 5-HT in hippocampus as well as NE, 5-HT, DA in striatum significantly." | 3.79 | Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. ( Cui, YL; Ding, SL; Mao, HP; Qi, XJ; Wang, QS, 2013) |
| "), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats." | 3.77 | Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011) |
| " The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only." | 3.74 | Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. ( Fox, MA; French, HT; Huang, SJ; Jensen, CL; Murphy, DL; Stein, AR; Tolliver, TJ, 2008) |
| "In order to better define the role of 5-HT(1A) receptors in the modulation of extrapyramidal motor functions, we investigated the effect of 5-HT(1A) agonists on tacrine-induced tremulous jaw movements (TJM) in rats, a putative model of parkinsonian tremor." | 3.73 | In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties. ( Artaiz, I; Castro, E; Del Olmo, E; Innerárity, A; Labeaga, L; Orjales, A; Pazos, A; Zazpe, A, 2006) |
| " In vivo, NAE-086 induced all the typical effects of a 5-HT(1A) receptor agonist in rats: it decreased 5-HT synthesis (5-HTP accumulation) and 5-HT turnover (measured as the ratio of 5-hydroxyindoleacetic acid/5-HT), increased corticosterone secretion, induced the 5-HT(1A) syndrome (flat body posture and forepaw treading), inhibited the cage-leaving response, and caused hypothermia." | 3.71 | The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist. ( Evenden, JL; Fowler, CJ; Jerning, E; Kelder, D; Lake-Bakaar, D; Larsson, LG; Mohell, N; Rënyi, L; Ross, SB; Sällemark, M, 2001) |
| ") does not antagonize the reserpine hypothermia in mice and does not potentiate the 5-hydroxytryptophan head twitches in rats." | 3.70 | Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation. ( Maj, J; Margas, W; Rogóz, Z; Skuza, G, 1998) |
| " In substantiation of selective blockade of serotonin uptake, sertraline potentiated various symptoms of 5-hydroxytryptophan but did not reverse reserpine-induced hypothermia." | 3.66 | Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. ( Browne, RG; Koe, BK; Weissman, A; Welch, WM, 1983) |
| "Depressing functional serotonin or depleting serotonin levels in rat brains with either p-chlorophenylalanine, 5,6-dihydroxytryptamine or raphe lesions greatly enhanced hypothermia induced by chloropromazine (CPZ)." | 3.66 | Effects of brain serotonin alterations on hypothermia produced by chlorpromazine in rats. ( Chern, YF; Chow, CF; Li, YP; Lin, MT, 1979) |
| "Alcoholism is a complex disorder involving, among others, the serotoninergic (5-HT) system, mainly regulated by 5-HT(1A) autoreceptors in the dorsal raphe nucleus." | 1.35 | Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice. ( Chouchana, L; Hamon, M; Hanoun, N; Kelaï, S; Lanfumey, L; Renoir, T; Saurini, F, 2008) |
| "In conclusion, hypothermia is a highly specific and sensitive response to activation of postsynaptic 5-HT1A receptors." | 1.29 | Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. ( Canton, H; Gobert, A; Le Marouille-Girardon, S; Millan, MJ; Rivet, JM, 1993) |
| "Sumatriptan failed to produce either of these effects due to a poor brain penetration." | 1.29 | 5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates. ( Barf, TA; de Boer, P; Ennis, MD; Ghazal, NB; McGuire, JC; Peroutka, SJ; Smith, MW; Swensson, K; Wikström, H, 1996) |
| "Flunarizine is considered to be a calcium channel antagonist; therefore this study was aimed at investigating the effect of flunarizine (given in single doses of 5, 10 and 20 mg/kg p." | 1.28 | Some central pharmacological effects of the calcium channel antagonist flunarizine. ( Czyrak, A; Maj, J; Mogilnicka, E, 1991) |
| "Sertraline was a very weak inhibitor of [3H]quinuclidinyl benzilate binding to rat brain membranes in vitro and did not produce anticholinergic effects in mice in vivo." | 1.27 | Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. ( Browne, RG; Koe, BK; Weissman, A; Welch, WM, 1983) |
| " Acute and repeated dosing of sertraline decreased serotonin content of whole blood." | 1.27 | Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. ( Browne, RG; Koe, BK; Weissman, A; Welch, WM, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (36.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 7 (28.00) | 29.6817 |
| 2010's | 3 (12.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, GL | 1 |
| He, ZM | 1 |
| Zhu, HY | 1 |
| Gao, YG | 1 |
| Zhao, Y | 1 |
| Yang, H | 1 |
| Zhang, LX | 1 |
| Wang, QS | 1 |
| Ding, SL | 1 |
| Mao, HP | 1 |
| Cui, YL | 1 |
| Qi, XJ | 1 |
| Fox, MA | 1 |
| Jensen, CL | 1 |
| French, HT | 1 |
| Stein, AR | 1 |
| Huang, SJ | 1 |
| Tolliver, TJ | 1 |
| Murphy, DL | 1 |
| Kelaï, S | 1 |
| Renoir, T | 1 |
| Chouchana, L | 1 |
| Saurini, F | 1 |
| Hanoun, N | 1 |
| Hamon, M | 1 |
| Lanfumey, L | 1 |
| Mahesh, R | 1 |
| Jindal, A | 1 |
| Gautam, B | 1 |
| Bhatt, S | 1 |
| Pandey, D | 1 |
| Sánchez-Mateo, CC | 3 |
| Darias, V | 3 |
| Expósito-Orta, MA | 3 |
| Albertos, LM | 2 |
| ASKEW, BM | 1 |
| NAKAJIMA, H | 1 |
| GRANDJEAN, JL | 1 |
| LHUILLIER, J | 1 |
| THUILLIER, J | 1 |
| Imeri, L | 1 |
| Bianchi, S | 1 |
| Opp, MR | 1 |
| Zazpe, A | 1 |
| Artaiz, I | 1 |
| Innerárity, A | 1 |
| Del Olmo, E | 1 |
| Castro, E | 1 |
| Labeaga, L | 1 |
| Pazos, A | 1 |
| Orjales, A | 1 |
| Koe, BK | 1 |
| Weissman, A | 1 |
| Welch, WM | 1 |
| Browne, RG | 1 |
| Rubat, C | 1 |
| Coudert, P | 1 |
| Bastide, P | 1 |
| Tronche, P | 1 |
| Millan, MJ | 1 |
| Rivet, JM | 1 |
| Canton, H | 1 |
| Le Marouille-Girardon, S | 1 |
| Gobert, A | 1 |
| Barf, TA | 1 |
| de Boer, P | 1 |
| Wikström, H | 1 |
| Peroutka, SJ | 1 |
| Swensson, K | 1 |
| Ennis, MD | 1 |
| Ghazal, NB | 1 |
| McGuire, JC | 1 |
| Smith, MW | 1 |
| Maj, J | 2 |
| Rogóz, Z | 1 |
| Skuza, G | 1 |
| Margas, W | 1 |
| Corral, C | 1 |
| Lissavetzky, J | 1 |
| Manzanares, I | 1 |
| Martïn Conde, JA | 1 |
| Rënyi, L | 1 |
| Evenden, JL | 1 |
| Fowler, CJ | 1 |
| Jerning, E | 1 |
| Kelder, D | 1 |
| Lake-Bakaar, D | 1 |
| Larsson, LG | 1 |
| Mohell, N | 1 |
| Sällemark, M | 1 |
| Ross, SB | 1 |
| Lin, MT | 1 |
| Chern, YF | 1 |
| Chow, CF | 1 |
| Li, YP | 1 |
| Metys, J | 1 |
| Metysová, J | 1 |
| Valchár, M | 1 |
| Dlabac, A | 1 |
| Popova, NK | 1 |
| Czyrak, A | 1 |
| Mogilnicka, E | 1 |
| Fahim, I | 1 |
| Ismail, M | 1 |
| Osman, OH | 1 |
| Sasame, HA | 1 |
| Perez-Cruet, J | 1 |
| Di Chiara, G | 1 |
| Tagliamonte, A | 1 |
| Tagliamonte, P | 1 |
| Gessa, GL | 1 |
| Barofsky, I | 1 |
| Feldstein, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder - Fear of Harm Phenotype[NCT05209217] | 20 participants (Anticipated) | Observational | 2019-06-04 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
25 other studies available for 5-hydroxytryptophan and Hypothermia
| Article | Year |
|---|---|
Involvement of serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like effect of ginsenoside Rb1, a major active ingredient of Panax ginseng C.A. Meyer.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Brain; Dopamine; Ginsenosides | 2017 |
Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Coptis; Corpus Striatum; Depr | 2013 |
Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Chemistry; Catech | 2008 |
Chronic voluntary ethanol intake hypersensitizes 5-HT(1A) autoreceptors in C57BL/6J mice.
Topics: 5-Hydroxytryptophan; Action Potentials; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Bod | 2008 |
Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression.
Topics: 5-Hydroxytryptophan; Acetamides; Animals; Antidepressive Agents; Behavior; Depression; Disease Model | 2011 |
Neuropharmacological study of hetero[2,1]benzothiazepine derivatives analogues of tianeptine.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Drug Synergism; Female; Hypot | 2003 |
A SIMPLE SCREENING PROCEDURE FOR IMIPRAMINE-LIKE ANTIDEPRESSANT AGENTS.
Topics: 5-Hydroxytryptophan; Amitriptyline; Amphetamine; Amphetamines; Antidepressive Agents; Atropine; Beme | 1963 |
[EXPERIMENTAL ANTAGONISM OF CHLORPROMAZINE AND THIORIDAZINE IN RELATION TO CERTAIN EFFECTS OF LYSERGIDE].
Topics: 5-Hydroxytryptophan; Catalepsy; Chlorpromazine; Dihydroxyphenylalanine; Humans; Hypothermia; Lysergi | 1964 |
Behavioural effects of thieno and pyrazolo [2,1] benzothiazepine derivatives in mice.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Apomorphi | 2004 |
Antagonism of corticotropin-releasing hormone alters serotonergic-induced changes in brain temperature, but not sleep, of rats.
Topics: 5-Hydroxytryptophan; Animals; Brain; Corticotropin-Releasing Hormone; Dose-Response Relationship, Dr | 2005 |
In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties.
Topics: 5-Hydroxytryptophan; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Avoidance Lea | 2006 |
Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.
Topics: 1-Naphthylamine; 5-Hydroxytryptophan; Animals; Behavior, Animal; Blood Pressure; Brain Chemistry; Do | 1983 |
Behavioural profile of two potential antidepressant pyridazine derivatives including arylpiperazinyl moieties in their structure, in mice.
Topics: 5-Hydroxytryptophan; Analgesia; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Bleph | 1995 |
Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body | 1993 |
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.
Topics: 5-Hydroxytryptophan; Acrylamides; Animals; Brain; CHO Cells; Cricetinae; Cyclic AMP; Ethylamines; Gu | 1996 |
Repeated trimipramine induces dopamine D2/D3 and alpha1-adrenergic up-regulation.
Topics: 5-Hydroxytryptophan; Aggression; Animals; Antidepressive Agents, Tricyclic; Dopamine Agonists; Explo | 1998 |
Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Apomorphine; Blepharoptosis; Dose-Response Rela | 1999 |
The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Benzopyrans; Corticosterone; Cyclic AMP; Dihydroxyph | 2001 |
Effects of brain serotonin alterations on hypothermia produced by chlorpromazine in rats.
Topics: 5-Hydroxytryptophan; 5,6-Dihydroxytryptamine; Animals; Body Temperature Regulation; Brain; Chlorprom | 1979 |
Comparative studies of a new anti-migraine drugs. II. To the mode of their central action.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents, Tricyclic; Benzothiepins; Cyproheptadine; Hypot | 1979 |
[Effect of serotonin on the awakening from winter hibernation].
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Hibernation; Hypothermia; Male; Sciuridae; Serotonin | 1975 |
Some central pharmacological effects of the calcium channel antagonist flunarizine.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Body Temperature Regulation; Dopamine; Dopamine Antagonis | 1991 |
Role of 5-hydroxytryptamine in ketamine-induced hypothermia in the rat.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Dose-Response Relationship, Drug; Ergotamine; | 1973 |
Evidence that methadone blocks dopamine receptors in the brain.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Basal Ganglia; Brain; Brain Chemistry; Butyrophenones; Ca | 1972 |
Serotonin and its metabolites: their respective roles in the production of hypothermia in the mouse.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Ethanol; Hydroxyindoleacetic Acid; Hypothermia; Indo | 1970 |