5-hydroxytryptophan has been researched along with Epilepsy in 21 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 7.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "We aimed to demonstrate the biochemical characteristics of vitamin B6-dependent epilepsy, with a particular focus on pyridoxal 5'-phosphate and pyridoxal in the cerebrospinal fluid." | 7.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "We identified seven patients with pyridoxine-dependent epilepsy caused by an ALDH7A1 gene abnormality, two patients with pyridoxal 5'-phosphate homeostasis protein deficiency, and 28 patients with other epilepsies with low cerebrospinal fluid pyridoxal 5'-phosphate concentrations." | 7.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "Low cerebrospinal fluid pyridoxal concentrations may be a better indicator of pyridoxal 5'-phosphate deficiency in the brain in vitamin B6-dependent epilepsy than low cerebrospinal fluid pyridoxal 5'-phosphate concentrations." | 7.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats." | 7.69 | Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. ( Cheong, JH; Dailey, JW; Jobe, PC; Ko, KH; Yan, QS, 1994) |
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 3.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "We aimed to demonstrate the biochemical characteristics of vitamin B6-dependent epilepsy, with a particular focus on pyridoxal 5'-phosphate and pyridoxal in the cerebrospinal fluid." | 3.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "We identified seven patients with pyridoxine-dependent epilepsy caused by an ALDH7A1 gene abnormality, two patients with pyridoxal 5'-phosphate homeostasis protein deficiency, and 28 patients with other epilepsies with low cerebrospinal fluid pyridoxal 5'-phosphate concentrations." | 3.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "Low cerebrospinal fluid pyridoxal concentrations may be a better indicator of pyridoxal 5'-phosphate deficiency in the brain in vitamin B6-dependent epilepsy than low cerebrospinal fluid pyridoxal 5'-phosphate concentrations." | 3.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| " Dietary restriction of phenylalanine and oral administration of amine precursors, L-dopa and 5-hydroxytryptophan had poor efficiency on epilepsy and psychomotor delay." | 3.70 | [Progressive convulsive encephalopathy: considering a abnormality of biopterin metabolism]. ( Dhondt, JL; Mikaeloff, Y; Pinton, F; Ponsot, G; Sevin, C, 1999) |
| "This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats." | 3.69 | Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats. ( Cheong, JH; Dailey, JW; Jobe, PC; Ko, KH; Yan, QS, 1994) |
| "In 6 patients with intention myoclonus, the cerebrospinal fluid concentration of 5-hydroxyindoleacetic acid, a metabolite of serotonin was found to be significantly decreased." | 2.64 | Serotonin and myoclonus. ( Bowers, MB; Jutkowitz, R; Rosenbaum, D; Van Woert, MH, 1976) |
| "The 5-hydroxytryptophan content was much higher in both El groups." | 1.28 | Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice. ( Mori, A; Suzuki, S, 1992) |
| "The kynurenine content was remarkably high in the El mice." | 1.28 | Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice. ( Mori, A; Suzuki, S, 1992) |
| "Correlation between the kindled seizure susceptibility and brain monoamine levels was investigated in the hippocampal and amygdaloid kindled cats." | 1.26 | [Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation]. ( Mitsunobu, K; Nakashima, T; Otsuki, S; Sato, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (61.90) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Kayacan, Y | 1 |
| Ghojebeigloo, BE | 1 |
| Çerit, G | 1 |
| Kocacan, SE | 1 |
| Ayyıldız, M | 1 |
| Akiyama, T | 1 |
| Hyodo, Y | 1 |
| Hasegawa, K | 1 |
| Oboshi, T | 1 |
| Imai, K | 1 |
| Ishihara, N | 1 |
| Dowa, Y | 1 |
| Koike, T | 1 |
| Yamamoto, T | 1 |
| Shibasaki, J | 1 |
| Shimbo, H | 1 |
| Fukuyama, T | 1 |
| Takano, K | 1 |
| Shiraku, H | 1 |
| Takeshita, S | 1 |
| Okanishi, T | 1 |
| Baba, S | 1 |
| Kubota, M | 1 |
| Hamano, SI | 1 |
| Kobayashi, K | 1 |
| WADA, JA | 2 |
| García-Cazorla, A | 1 |
| Serrano, M | 1 |
| Pérez-Dueñas, B | 1 |
| González, V | 1 |
| Ormazábal, A | 1 |
| Pineda, M | 1 |
| Fernández-Alvarez, E | 1 |
| Campistol, JM | 1 |
| Artuch, RM | 1 |
| Sellinger, OZ | 1 |
| Dietz, DD | 1 |
| Yan, QS | 2 |
| Jobe, PC | 2 |
| Cheong, JH | 1 |
| Ko, KH | 1 |
| Dailey, JW | 2 |
| Mikaeloff, Y | 1 |
| Pinton, F | 1 |
| Sevin, C | 1 |
| Dhondt, JL | 1 |
| Ponsot, G | 1 |
| Sato, M | 1 |
| Nakashima, T | 1 |
| Mitsunobu, K | 1 |
| Otsuki, S | 1 |
| Kumashiro, H | 1 |
| Aono, T | 1 |
| Watanabe, K | 1 |
| Koizumi, S | 1 |
| Nakanishi, S | 1 |
| Kaneko, Y | 1 |
| Ohno, E | 1 |
| Uemura, S | 1 |
| Van Woert, MH | 1 |
| Jutkowitz, R | 1 |
| Rosenbaum, D | 1 |
| Bowers, MB | 1 |
| Chazot, G | 1 |
| Guard, O | 1 |
| Setiey, A | 1 |
| Robert, JM | 1 |
| Schott, B | 1 |
| Suzuki, S | 1 |
| Mori, A | 1 |
| Nakamura, M | 1 |
| Wada, Y | 1 |
| Hasegawa, H | 1 |
| Yamaguchi, N | 1 |
| Neuman, RS | 1 |
| Uldry, PA | 1 |
| Regli, F | 1 |
| Balzamo, E | 2 |
| Meldrum, BS | 2 |
| Naquet, R | 1 |
| Rohmer, F | 1 |
| Warter, JM | 1 |
| Coquillat, G | 1 |
| Maitrot, D | 1 |
| Kurtz, D | 1 |
| Micheletti, G | 1 |
| Mack, G | 1 |
| Mandel, P | 1 |
| Vuillon-Cacciuttolo, G | 1 |
| Sabouraud, O | 1 |
| Chatel, M | 1 |
| Badiche, A | 1 |
| Chauvel, P | 1 |
| Le Clec'h, G | 1 |
| Kolpakov, VG | 1 |
1 review available for 5-hydroxytryptophan and Epilepsy
| Article | Year |
|---|---|
[Indications for L-5-hydroxytryptophan in neurology].
Topics: 5-Hydroxytryptophan; Down Syndrome; Epilepsy; Humans; Migraine Disorders; Myoclonus; Pain; Parkinson | 1987 |
2 trials available for 5-hydroxytryptophan and Epilepsy
| Article | Year |
|---|---|
Serotonin and myoclonus.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Clinical Trials as Topic; Epilepsy; Female; Homov | 1976 |
[Pharmacological and biochemical approach to a syndrome of action and intention myoclonus in the course of degenerative disease of the nervous system].
Topics: 5-Hydroxytryptophan; Adult; Benzazepines; Cerebellar Ataxia; Clinical Trials as Topic; Diagnosis, Di | 1973 |
18 other studies available for 5-hydroxytryptophan and Epilepsy
| Article | Year |
|---|---|
Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.
Topics: 5-Hydroxytryptophan; Animals; Epilepsy; Male; Penicillins; Quality of Life; Rats; Serotonin | 2020 |
Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate.
Topics: 5-Hydroxytryptophan; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, | 2020 |
Epileptogenic cerebral electrical activity and serotonin levels.
Topics: 5-Hydroxytryptophan; Animals; Biochemical Phenomena; Brain; Cats; Epilepsy; Nervous System Physiolog | 1961 |
Secondary abnormalities of neurotransmitters in infants with neurological disorders.
Topics: 5-Hydroxytryptophan; Atrophy; Brain; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Hu | 2007 |
The metabolism of 5-hydroxytryptamine in the methionine sulfoximine epileptogenic rat brain.
Topics: 5-Hydroxytryptophan; Animals; Brain; Epilepsy; Hydroxyindoleacetic Acid; Male; Methionine Sulfoximin | 1981 |
Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Epilepsy; Female; Fenclonine; Fluoxetine; Hydroxyindo | 1994 |
Evidence that a serotonergic mechanism is involved in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Epilepsy; Fem | 1994 |
[Progressive convulsive encephalopathy: considering a abnormality of biopterin metabolism].
Topics: 5-Hydroxytryptophan; Algeria; Anticonvulsants; Biopterins; Brain; Child, Preschool; Consanguinity; D | 1999 |
[Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation].
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain Chemistry; Catecholamines; Cats; Dopamine; Electric St | 1976 |
DC potential shifts associated with convulsive seizures and brain monoamine changes in rabbits.
Topics: 5-Hydroxytryptophan; Adolescent; Animals; Bemegride; Brain Damage, Chronic; Caudate Nucleus; Cerebra | 1977 |
[Ramsay-Hunt syndrome and aniridia in 2 monozygotic twins].
Topics: 5-Hydroxytryptophan; Adolescent; Benzodiazepinones; Blood Group Antigens; Cerebellar Ataxia; Disease | 1975 |
Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine | 1992 |
Serotonergic mechanism in hippocampal kindled seizures.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Cats; | 1992 |
Suppression of penicillin-induced epileptiform activity by noxious stimulation: mediation by 5-hydroxytryptamine.
Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Epilepsy; Fenclonine; Locus Coeruleus; Male; Membrane | 1986 |
Behavioural and electrographic effects of L-5-hydroxytryptophan and D, L-parachlorophenyl-alanine on epileptic Senegalese baboon (Papio papio).
Topics: 5-Hydroxytryptophan; Animals; Brain; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Fenc | 1972 |
Electroretinogram and afferent visual transmission in the epileptic baboon Papio papio. Effects of drugs influencing monoaminergic systems.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Dihydroxyphenylalanine; Electroretinography; Epilepsy | 1973 |
[Observations on the use of 5 HTP in clinical medicine].
Topics: 5-Hydroxytryptophan; Epilepsy; Humans; Male; Mental Disorders; Movement Disorders; Myoclonus; Thinki | 1972 |
[On the probable pathogenetic mechanisms of epilepsy].
Topics: 5-Hydroxytryptophan; Alanine; Ammonia; Animals; Asparagine; Carboxy-Lyases; Epilepsy; Glutamates; Li | 1967 |