5-hydroxytryptophan has been researched along with Epilepsies, Myoclonic in 10 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Epilepsies, Myoclonic: A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A patient with Lafora disease reported enough improvement in myoclonus-evoked convulsions to continue chronic use of the drug." | 2.68 | Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan. ( Ashwal, S; Bodensteiner, J; Franz, D; Haas, RH; Huang, Y; Pranzatelli, MR; Tate, E, 1995) |
| "To study the role of serotonin in the ataxia of progressive myoclonus epilepsy, eight patients received oral 5-hydroxy-L-tryptophan (L-5-HTP) or placebo plus carbidopa for 1 month in a controlled, double-blinded, dose-ranging, cross-over, add-on study." | 2.68 | A controlled trial of 5-hydroxy-L-tryptophan for ataxia in progressive myoclonus epilepsy. ( Galvan, I; Pranzatelli, MR; Tate, E; Wheeler, A, 1996) |
| "Ataxia was evaluated using objective and subjective scales." | 2.68 | A controlled trial of 5-hydroxy-L-tryptophan for ataxia in progressive myoclonus epilepsy. ( Galvan, I; Pranzatelli, MR; Tate, E; Wheeler, A, 1996) |
| "Progressive myoclonus epilepsy is a syndrome confused with myoclonic seizures and other epilepsies." | 2.38 | The clinical challenge of progressive myoclonus epilepsy. ( Tate, E, 1993) |
| "The data suggest that this rat cardiac arrest model may be a valuable tool for investigating the pathophysiologic mechanisms of posthypoxic myoclonus and for developing new therapeutic strategies for treating the disorder." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "The auditory-induced myoclonus continues to worsen, reaches a peak about 2 weeks after the arrest, then declines over time to subnormal levels." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "In 18 patients with intention myoclonus due to anoxia or other brain damage, 11 derived more than 50% overall improvement during treatment with L-5HTP and carbidopa." | 1.26 | Long-term therapy of myoclonus and other neurologic disorders with L-5-hydroxytryptophan and carbidopa. ( Bowers, MB; Howieson, J; Rosenbaum, D; Van Woert, MH, 1977) |
| "The neurochemical basis of myoclonus responding to 5HT precursors and clonazepam is discussed." | 1.26 | Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam. ( Chadwick, D; Hallett, M; Harris, R; Jenner, P; Marsden, CD; Reynolds, EH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schutte, RJ | 1 |
| Schutte, SS | 1 |
| Algara, J | 1 |
| Barragan, EV | 1 |
| Gilligan, J | 1 |
| Staber, C | 1 |
| Savva, YA | 1 |
| Smith, MA | 1 |
| Reenan, R | 1 |
| O'Dowd, DK | 1 |
| Pranzatelli, MR | 2 |
| Tate, E | 3 |
| Huang, Y | 1 |
| Haas, RH | 1 |
| Bodensteiner, J | 1 |
| Ashwal, S | 1 |
| Franz, D | 1 |
| Truong, DD | 1 |
| Matsumoto, RR | 1 |
| Schwartz, PH | 1 |
| Hussong, MJ | 1 |
| Wasterlain, CG | 1 |
| Hagan, JJ | 1 |
| Hatcher, JP | 1 |
| Slade, PD | 1 |
| Galvan, I | 1 |
| Wheeler, A | 1 |
| Van Woert, MH | 1 |
| Rosenbaum, D | 1 |
| Howieson, J | 1 |
| Bowers, MB | 1 |
| Chadwick, D | 1 |
| Hallett, M | 1 |
| Harris, R | 1 |
| Jenner, P | 1 |
| Reynolds, EH | 1 |
| Marsden, CD | 1 |
| Seyal, M | 1 |
| Koskiniemi, M | 1 |
| Laakso, J | 1 |
| Kuurne, T | 1 |
| Laipio, M | 1 |
| Härkönen, M | 1 |
1 review available for 5-hydroxytryptophan and Epilepsies, Myoclonic
| Article | Year |
|---|---|
The clinical challenge of progressive myoclonus epilepsy.
Topics: 5-Hydroxytryptophan; Child; Epilepsies, Myoclonic; Female; Humans; Piracetam; Quality of Life | 1993 |
2 trials available for 5-hydroxytryptophan and Epilepsies, Myoclonic
| Article | Year |
|---|---|
Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Cross-Over Studies; Double-Blind Method; Drug The | 1995 |
A controlled trial of 5-hydroxy-L-tryptophan for ataxia in progressive myoclonus epilepsy.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Ataxia; Double-Blind Method; Epilepsie | 1996 |
7 other studies available for 5-hydroxytryptophan and Epilepsies, Myoclonic
| Article | Year |
|---|---|
Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current.
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Brain; Drosophila; Epilepsies, Myoclonic; GABAergic | 2014 |
Novel rat cardiac arrest model of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Ani | 1994 |
The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; Epileps | 1995 |
Long-term therapy of myoclonus and other neurologic disorders with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Brain; Carbidopa; Drug Therapy, Combination; Epilepsie | 1977 |
Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Benzodiazepinones; Carbidopa; Child, Preschool; Clonaz | 1977 |
Cortical reflex myoclonus. A study of the relationship between giant somatosensory evoked potentials and motor excitability.
Topics: 5-Hydroxytryptophan; Adult; Cerebral Cortex; Electric Stimulation; Electromyography; Epilepsies, Myo | 1991 |
Indole levels in human lumbar and ventricular cerebrospinal fluid and the effect of L-tryptophan administration.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Anticonvulsants; Child; Chromatography, High Pressure | 1985 |