5-hydroxytryptophan has been researched along with Drug Withdrawal Symptoms in 27 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The tremors induced by harmine, LON-954 (N-carbamoyl-2-(2,6-dichlorophenyl)acetamidine hydrochloride) and 5-hydroxytryptophan (5-HTP) were studied in control rats and in rats withdrawn for 16-48 hrs from 6 to 9 days' ethanol administration." | 7.67 | Harmine-, LON-954- and 5-hydroxytryptophan-induced tremors in rats withdrawn from ethanol. ( Gothóni, P, 1985) |
| "The tremors induced by harmine, LON-954 (N-carbamoyl-2-(2,6-dichlorophenyl)acetamidine hydrochloride) and 5-hydroxytryptophan (5-HTP) were studied in control rats and in rats withdrawn for 16-48 hrs from 6 to 9 days' ethanol administration." | 3.67 | Harmine-, LON-954- and 5-hydroxytryptophan-induced tremors in rats withdrawn from ethanol. ( Gothóni, P, 1985) |
| "20 patients suffering from alcohol addictions starting a detoxification therapy have been included in a prospective, randomized, double blind study." | 2.76 | The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms. ( Boben-Bardutzky, D; Hafner, M; Ihan, A; Jukić, T; Rojc, B, 2011) |
| "Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms." | 1.37 | 5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawal. ( Domino, EF; Jutkiewicz, EM; Ohmura, Y; Yoshioka, M, 2011) |
| "In summary, we conclude that morphine addiction is associated with supersensitivity of 5-HT1A serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) that modulate the synthesis of monoamines in brain." | 1.31 | Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats. ( Esteban, S; García-Sevilla, JA; Sastre-Coll, A, 2002) |
| " 5-HTP alone (200 mg/kg) increased wet dog shakes epissodes, whereas TP alone in the same dosage practically did not have any influence on the wet dog shakes in morphine-dependent rats." | 1.27 | The role of central serotoninergic neurotransmission in the morphine abstinence syndrome in rats. ( Kruszewska, A; Langwiński, R, 1983) |
| "It has been shown that depakin, a GABA-ergic agonist, and alpha-methyl-DOPA that inhibits catecholamine synthesis are capable of removing the withdrawal syndrome (disturbed pavlovian behavior pattern and aggressiveness) occurring after discontinuance of long-term administration (30 days) of phenazepam to rats in a dose of 2 mg/kg." | 1.26 | [Role of GABA-ergic and dopaminergic mechanisms in the withdrawal syndrome after discontinuation of long-term phenazepam administration]. ( Garibova, TL; Voronina, TA, 1980) |
| "After chronic administration of ethanol to mice by the intragastric route head twitches occur as part of the ethanol withdrawal syndrome." | 1.25 | Biogenic amines and head twitches in mice during ethanol withdrawal. ( Collier, HO; Hammond, MD; Schneider, C, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (62.96) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moranta, D | 2 |
| Esteban, S | 3 |
| García-Sevilla, JA | 3 |
| Ohmura, Y | 1 |
| Jutkiewicz, EM | 1 |
| Yoshioka, M | 1 |
| Domino, EF | 1 |
| Jukić, T | 1 |
| Rojc, B | 1 |
| Boben-Bardutzky, D | 1 |
| Hafner, M | 1 |
| Ihan, A | 1 |
| Kruszewska, A | 2 |
| Langwiński, R | 2 |
| Voronina, TA | 1 |
| Garibova, TL | 1 |
| Berge, OG | 1 |
| Hole, K | 1 |
| Bonnafous, C | 1 |
| Lefevre, P | 1 |
| Bueno, L | 1 |
| Darmani, NA | 1 |
| Shaddy, J | 1 |
| Elder, EL | 1 |
| Baumann, MH | 1 |
| Rothman, RB | 1 |
| Harris, GC | 2 |
| Aston-Jones, G | 2 |
| Altomare, K | 1 |
| Sastre-Coll, A | 2 |
| Miralles, A | 1 |
| Mogilnicka, E | 1 |
| Klimek, V | 1 |
| Zarcone, VP | 1 |
| Hoddes, E | 1 |
| Wyatt, RJ | 2 |
| Gillin, JC | 1 |
| Vetulani, J | 1 |
| Bednarczyk, B | 1 |
| Reichenberg, K | 1 |
| Contreras, E | 1 |
| Tamayo, L | 1 |
| Quijada, L | 1 |
| Ritzmann, RF | 1 |
| Tabakoff, B | 1 |
| Kleven, MS | 1 |
| Sparber, SB | 1 |
| Gothóni, P | 1 |
| Goldstein, DB | 1 |
| Collier, HO | 3 |
| Hammond, MD | 1 |
| Schneider, C | 2 |
| Francis, DL | 1 |
| Henderson, G | 1 |
| Kaplan, J | 1 |
| Vaughan, T | 1 |
2 trials available for 5-hydroxytryptophan and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms.
Topics: 5-Hydroxytryptophan; Alcoholism; Bilirubin; CD4-Positive T-Lymphocytes; Dietary Supplements; Double- | 2011 |
Tolerance and dependence to serotonin. A speculation.
Topics: 5-Hydroxytryptophan; Adult; Animals; Brain Chemistry; Cats; Chronic Disease; Clinical Trials as Topi | 1973 |
25 other studies available for 5-hydroxytryptophan and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Benzoxazines; B | 2009 |
5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawal.
Topics: 5-Hydroxytryptophan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Behavior, Animal; Hydraz | 2011 |
The role of central serotoninergic neurotransmission in the morphine abstinence syndrome in rats.
Topics: 5-Hydroxytryptophan; Animals; Brain; Fenclonine; Humans; Male; Metergoline; Morphine; Rats; Rats, In | 1983 |
[Role of GABA-ergic and dopaminergic mechanisms in the withdrawal syndrome after discontinuation of long-term phenazepam administration].
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Dihydr | 1980 |
Tolerance to the antinociceptive effect of morphine in the spinal rat.
Topics: 5-Hydroxytryptophan; Analgesics; Animals; Drug Tolerance; Humans; Male; Morphine; Naloxone; Rats; Se | 1981 |
Benzodiazepine-withdrawal-induced gastric emptying disturbances in rats: evidence for serotonin receptor involvement.
Topics: 5-Hydroxytryptophan; Animals; Diazepam; Gastric Emptying; Male; Rats; Rats, Wistar; Receptors, Serot | 1995 |
Prolonged deficits in presynaptic serotonin function following withdrawal from chronic cocaine exposure as revealed by 5-HTP-induced head-twitch response in mice.
Topics: 5-Hydroxytryptophan; Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; | 1997 |
Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal | 1998 |
Augmented accumbal serotonin levels decrease the preference for a morphine associated environment during withdrawal.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Conditioning, Psychological; Drug Administration Schedule; En | 2001 |
Preference for a cocaine-associated environment is attenuated by augmented accumbal serotonin in cocaine withdrawn rats.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Addictive; Cocaine; Conditioning, Psychological; Dopamine Up | 2001 |
Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Biogenic Monoam | 2002 |
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Cerebral Cor | 2002 |
Mianserin, danitracen and amitriptyline withdrawal increases the behavioural responses of rats to L-5-HTP.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Behavior, Animal; Dibenzazepines; Humans; Male; Mianser | 1979 |
Effects of 5-hydroxytryptophan on fragmentation of REM sleep in alcoholics.
Topics: 5-Hydroxytryptophan; Adult; Ethanol; Humans; Middle Aged; Sleep, REM; Substance Withdrawal Syndrome | 1975 |
Development to tolerance of and dependence on endogenous neurotransmitters.
Topics: 5-Hydroxytryptophan; Acetylcholine; Adult; Animals; Antipsychotic Agents; Brain Chemistry; Catechola | 1975 |
Inhibition of "wet shakes" during morphine abstinence by an antagonist of opiate analgesia.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Drug Interactions; Humans; Lysergic Acid Diethylamid | 1978 |
Partial inhibition of the abstinence syndrome in morphine tolerant-dependent mice following pharmacological denervation.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Behavior, Animal; Denervation; Drug Tolerance; Humans; Methy | 1978 |
[The effect of reserpine on the morphine abstinence syndrome in mice (author's transl)].
Topics: 5-Hydroxytryptophan; Animals; Drug Antagonism; Humans; Levodopa; Male; Mice; Morphine Dependence; Re | 1979 |
Ethanol, serotonin metabolism, and body temperature.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Central Nervous System; Dose-Response Relationship, | 1976 |
Modification of quasi-morphine withdrawal with serotonin agonists and antagonists: evidence for a role of serotonin in the expression of opiate withdrawal.
Topics: 1-Methyl-3-isobutylxanthine; 5-Hydroxytryptophan; Animals; Fluoxetine; Male; Methysergide; Mianserin | 1989 |
Harmine-, LON-954- and 5-hydroxytryptophan-induced tremors in rats withdrawn from ethanol.
Topics: 5-Hydroxytryptophan; Alkaloids; Animals; Ethanol; Harmine; Male; Physostigmine; Rats; Rats, Inbred S | 1985 |
Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.
Topics: 5-Hydroxytryptophan; Acetates; Aminobutyrates; Animals; Atropine; Ethanol; Fenclonine; Humans; Male; | 1973 |
Biogenic amines and head twitches in mice during ethanol withdrawal.
Topics: 5-Hydroxytryptophan; Amphetamine; Amphetamines; Animals; Behavior, Animal; Biogenic Amines; Cerebral | 1974 |
The concept of the quasi-abstinence effect and its use in the investigation of dependence mechanisms.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Hormones; Humans; Naloxone; Phosphodiesterase | 1974 |
Quasi morphine-abstinence syndrome.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Delayed-Action Preparations; Disease Models, Animal; | 1974 |