5-hydroxytryptophan has been researched along with Down Syndrome in 20 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A review of drug treatment for Down's syndrome individuals was presented." | 1.26 | Review of drug treatment for Down's syndrome persons. ( Share, JB, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cullen, SM | 1 |
| Cronk, CE | 1 |
| Pueschel, SM | 1 |
| Schnell, RR | 1 |
| Reed, RB | 1 |
| Share, JB | 1 |
| Griffiths, MI | 1 |
| Coleman, M | 2 |
| Pollack, MA | 1 |
| Golden, GS | 1 |
| Schmidt, R | 1 |
| Davis, JA | 1 |
| Leeds, N | 1 |
| Petre-Quadens, O | 1 |
| De Lee, C | 1 |
| Uldry, PA | 1 |
| Regli, F | 1 |
| Bazelon, M | 2 |
| Paine, RS | 1 |
| Coeiw, VA | 1 |
| Hunt, P | 1 |
| Houck, JC | 1 |
| Mahanand, D | 1 |
| Lee, JC | 1 |
| Ornitz, EM | 1 |
| Tanguay, PE | 1 |
| Ritvo, ER | 1 |
| Bettschart, W | 1 |
| Broché, JP | 1 |
| Tissot, R | 1 |
| Pare, CM | 1 |
| Oura, T | 1 |
| Uemura, I | 1 |
| Simonsson, H | 1 |
| Partington, MW | 1 |
| MacDonald, MR | 1 |
| Boullin, DJ | 1 |
| O'Brien, RA | 1 |
| Airaksinen, EM | 1 |
| Airaksinen, MM | 1 |
| Pentikäinen, P | 1 |
| Weise, P | 1 |
| Koch, R | 1 |
| Shaw, KN | 1 |
| Rosenfeld, MJ | 1 |
| Chase, TN | 1 |
| Barnet, A | 1 |
| Lodge, A | 1 |
| Shelburne, SA | 1 |
3 reviews available for 5-hydroxytryptophan and Down Syndrome
| Article | Year |
|---|---|
[Indications for L-5-hydroxytryptophan in neurology].
Topics: 5-Hydroxytryptophan; Down Syndrome; Epilepsy; Humans; Migraine Disorders; Myoclonus; Pain; Parkinson | 1987 |
[Down's syndrome and serotonin].
Topics: 5-Hydroxytryptophan; Down Syndrome; Humans; Infant, Newborn; Serotonin | 1968 |
Serotonergic mechanisms and extrapyramidal function in man.
Topics: 5-Hydroxytryptophan; Carbidopa; Cerebellar Diseases; Creutzfeldt-Jakob Syndrome; Down Syndrome; Extr | 1974 |
2 trials available for 5-hydroxytryptophan and Down Syndrome
| Article | Year |
|---|---|
[Correlation of the clinical and pharmaco-dynamic effects of Niamid in the treatment of severely mentally retarded children].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Child; Clinical Trials as Topic; Down Syndrome; Female; Huma | 1965 |
5-hydroxytryptophan (5-HTP) in Down's syndrome.
Topics: 5-Hydroxytryptophan; Child; Child, Preschool; Clinical Trials as Topic; Down Syndrome; Female; Human | 1971 |
15 other studies available for 5-hydroxytryptophan and Down Syndrome
| Article | Year |
|---|---|
Social development and feeding milestones of young Down syndrome children.
Topics: 5-Hydroxytryptophan; Child; Down Syndrome; Feeding Behavior; Female; Heart Defects, Congenital; Huma | 1981 |
Review of drug treatment for Down's syndrome persons.
Topics: 5-Hydroxytryptophan; Amphetamines; Antipsychotic Agents; Behavior; Cell Transplantation; Cognition; | 1976 |
Medicinal treatment for relief of hypotonia in Down's Syndrome.
Topics: 5-Hydroxytryptophan; Down Syndrome; Humans; Muscle Tonus; Muscular Diseases | 1976 |
Myoclonus in the young after 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Age Factors; Down Syndrome; Humans; Infant; Spasms, Infantile | 1977 |
Infantile spasms in Down syndrome: a report of 5 cases and review of the literature.
Topics: 5-Hydroxytryptophan; Brain; Down Syndrome; Electroencephalography; Female; Humans; Infant; Male; Spa | 1978 |
5-Hydroxytryptophan and sleep in Down's syndrome.
Topics: 5-Hydroxytryptophan; Age Factors; Down Syndrome; Humans; Infant; Serotonin; Sleep, REM | 1975 |
Reversal of hypotonia in infants with Down's syndrome by administration of 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Biochemical Phenomena; Biochemistry; Down Syndrome; Female; Humans; Infant, New | 1967 |
Sleep EEG patterns in a case of Down's syndrome--before and after 5-HTP.
Topics: 5-Hydroxytryptophan; Down Syndrome; Electroencephalography; Evoked Potentials; Humans; Infant; Infan | 1969 |
5-hydroxyindoles in phenylketonuric and nonphenylketonuric mental defectives.
Topics: 5-Hydroxytryptophan; Animals; Biological Transport; Carboxy-Lyases; Child; Down Syndrome; Humans; Hy | 1968 |
[Therapy with 5-hydroxytryptophan of Down's disease].
Topics: 5-Hydroxytryptophan; Age Factors; Down Syndrome; Female; Humans; Infant; Infant, Newborn; Male; Musc | 1969 |
The metabolism of 5-hydroxytryptamine by blood platelets from children with mongolism.
Topics: 5-Hydroxytryptophan; Blood Platelets; Child; Child, Preschool; Chromatography, Paper; Down Syndrome; | 1973 |
Fate of 14C-labelled tryptophan and 5-hydroxytryptophan in Down's syndrome.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Autoradiography; Blood Platelets; Carb | 1973 |
The use of 5-HTP in the treatment of Down's syndrome.
Topics: 5-Hydroxytryptophan; Administration, Oral; Age Factors; Child Development; Child, Preschool; Chromat | 1974 |
The effect of high doses of 5-hydroxytryptophan on a patient with trisomy 21. Clinical, chemical and EEG correlations.
Topics: 5-Hydroxytryptophan; Age Factors; Central Nervous System; Chromosomes, Human, 21-22 and Y; Down Synd | 1968 |
Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down's syndrome.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Brain; Down Syndrome; Electroencephalography; Huma | 1971 |