Page last updated: 2024-10-16

5-hydroxytryptophan and Depression

5-hydroxytryptophan has been researched along with Depression in 97 studies

5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"Fifty elderly patients (mean age, 68 years) affected by depression were treated with a combination (P3007) containing 3 mg of dihydroergocristine and 100 mg of levo-5-hydroxytryptophan or placebo for 60 days in a double-blind trial."9.06Effects of a levo-5-hydroxytryptophan-dihydroergocristine combination on depression and neuropsychic performance: a double-blind placebo-controlled clinical trial in elderly patients. ( Rousseau, JJ, 1987)
"Through a controlled double-blind study in 30 hospitalized patients affected with endogenous depression, the antidepressant action of the combination of nialamide+l-5-HTP has been evaluated and compared with a control group which only received nialamide (+ placebo)."9.045-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study. ( Aliño, JJ; Gutierrez, JL; Iglesias, ML, 1976)
"A double-blind evaluation of the antidepressant efficacy of treatment with a combination of orally administered L-tryptophan (L-TP) and electroconvulsive therapy (ECT) was made in patients suffering from endogenous depression."9.04Evaluation of the combination of tryptophan and ECT in the treatment of depression. I. Clinical analysis. ( D'Elia, G; Lehmann, J; Raotma, H, 1977)
"In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome."8.82Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders. ( Agazzi, A; Anselmi, L; Candura, SM; Cervio, E; De Giorgio, R; De Ponti, F; Di Nucci, A; Tonini, M, 2003)
"5 Hydroxytryptophan (5-HTP) and tryptophan are so-called natural alternatives to traditional antidepressants, used to treat unipolar depression and dysthymia."8.81Tryptophan and 5-hydroxytryptophan for depression. ( Del Mar, C; Shaw, K; Turner, J, 2002)
"Trials were included if they were randomized, included patients with unipolar depression or dysthymia, compared preparations of 5-HTP or tryptophan with placebo, and included clinical outcomes assessed by scales assessing depressive symptoms."8.81Tryptophan and 5-hydroxytryptophan for depression. ( Del Mar, C; Shaw, K; Turner, J, 2001)
"5 Hydroxytryptophan (5-HTP) and tryptophan are so-called natural alternatives to traditional antidepressants, used to treat unipolar depression and dysthymia."8.81Tryptophan and 5-hydroxytryptophan for depression. ( Del Mar, C; Shaw, K; Turner, J, 2001)
"Trials were included if they were randomized, included patients with unipolar depression or dysthymia, compared preparations of 5-HTP or tryptophan with placebo, and included clinical outcomes assessed by scales assessing depressive symptoms."8.81Tryptophan and 5-hydroxytryptophan for depression. ( Del Mar, C; Shaw, K; Turner, J, 2002)
"), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats."7.77Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011)
"Until recently, all drugs used to treat depression appeared to enhance neurotransmission in one or both of these systems, which was used to explain their antidepressant actions (Gelenberg and Klerman, 1978)."7.75Tyrosine for the treatment of depression. ( Gelenberg, AJ; Gibson, CJ, 1984)
" To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied."7.69Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994)
"To test the hypothesis that a new potent and selective 5-HT2 receptor antagonist would be an excellent blocker of D,L-5-hydroxytryptophan (5-HTP)-induced response suppression in an animal model of depression, we administered LY53857 60 min prior to 5-HTP injections into rats working on an operant schedule for milk reinforcement."7.67Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857). ( Aprison, MH; Fuller, RW; Hingtgen, JN; Mason, NR, 1985)
"Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule."7.67Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984)
"The treatment with nialamide + l-5-HTP proved to have a shorter delay of onset."6.645-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study. ( Aliño, JJ; Gutierrez, JL; Iglesias, ML, 1976)
"Mood disorders and constipation are often comorbid, yet their shared etiologies have rarely been explored."5.51Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression. ( Bunnett, NW; Caron, MG; Carson, W; Del Colle, A; Israelyan, N; Jacobsen, JPR; Jensen, DD; Latorre, R; Law, K; Li, Z; Luna, RA; Madra, M; Margolis, KG; Park, Y; Rahim, R; Saurman, V; Xing, A, 2019)
" It is the immediate precursor of serotonin and is widely available as a dietary supplement, which is well absorbed after an oral dose."5.335-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. ( Blackwell, AD; Turner, EH, 2005)
"Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy."5.335-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. ( Blackwell, AD; Turner, EH, 2005)
" Chronic administration of trazodone (2 mg/kg trazodone/day) also resulted in a significant blockade of the 5-HTP effect (75%)."5.27Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984)
"Pretreatment with desipramine (2."5.27Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857). ( Aprison, MH; Fuller, RW; Hingtgen, JN; Mason, NR, 1985)
"Fifty elderly patients (mean age, 68 years) affected by depression were treated with a combination (P3007) containing 3 mg of dihydroergocristine and 100 mg of levo-5-hydroxytryptophan or placebo for 60 days in a double-blind trial."5.06Effects of a levo-5-hydroxytryptophan-dihydroergocristine combination on depression and neuropsychic performance: a double-blind placebo-controlled clinical trial in elderly patients. ( Rousseau, JJ, 1987)
"A double-blind evaluation of the antidepressant efficacy of treatment with a combination of orally administered L-tryptophan (L-TP) and electroconvulsive therapy (ECT) was made in patients suffering from endogenous depression."5.04Evaluation of the combination of tryptophan and ECT in the treatment of depression. I. Clinical analysis. ( D'Elia, G; Lehmann, J; Raotma, H, 1977)
"Through a controlled double-blind study in 30 hospitalized patients affected with endogenous depression, the antidepressant action of the combination of nialamide+l-5-HTP has been evaluated and compared with a control group which only received nialamide (+ placebo)."5.045-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study. ( Aliño, JJ; Gutierrez, JL; Iglesias, ML, 1976)
"This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP) for the treatment of depression."4.83Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. ( Blackwell, AD; Loftis, JM; Turner, EH, 2006)
"In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome."4.82Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders. ( Agazzi, A; Anselmi, L; Candura, SM; Cervio, E; De Giorgio, R; De Ponti, F; Di Nucci, A; Tonini, M, 2003)
"Increasing evidence indicates that tryptophan (Trp) metabolism disturbance controls hippocampal 5-hydroxytryptamine (5-HT) and thereby affecting depression-like behavior, in which the gut microbiota (GM) might be involved."4.31Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor. ( Chen, Y; Guo, M; He, J; Li, Z; Liu, Y; Maitiniyazi, G; Tao, W; Xia, S, 2023)
"21]) were associated with higher odds of antepartum depression and 4 metabolites (betaine [OR = =0."3.96Metabolomic markers of antepartum depression and suicidal ideation. ( Clish, C; Gelaye, B; Larrabure-Torrealva, GT; Mitro, SD; Molsberry, SA; Sanchez, SE; Williams, MA, 2020)
" A possible mechanism was explored in the tests of antagonism of reserpine-induced ptosis and hypothermia, and 5-HTP induced head twitch response in mice."3.79Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. ( Cui, YL; Ding, SL; Mao, HP; Qi, XJ; Wang, QS, 2013)
"5mg/kg), which could antagonize reserpine-induced ptosis and hypothermia, moreover, both of them could elevate the contents of NE, 5-HT in hippocampus as well as NE, 5-HT, DA in striatum significantly."3.79Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. ( Cui, YL; Ding, SL; Mao, HP; Qi, XJ; Wang, QS, 2013)
"), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats."3.77Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011)
"Until recently, all drugs used to treat depression appeared to enhance neurotransmission in one or both of these systems, which was used to explain their antidepressant actions (Gelenberg and Klerman, 1978)."3.75Tyrosine for the treatment of depression. ( Gelenberg, AJ; Gibson, CJ, 1984)
" To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied."3.69Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994)
"Acute pretreatment with clinically equivalent doses of antidepressive drugs has been observed to block D,L-5-hydroxytryptophan (5-HTP) induced behavioral depression in rats working on a food-reinforced operant schedule."3.67Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984)
"Since reserpine precipitates depression in some hypertensive patients, we tested this drug on our animal model of depression."3.67Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. ( Aprison, MH; Brugge, KL; Hingtgen, JN, 1987)
"To test the hypothesis that a new potent and selective 5-HT2 receptor antagonist would be an excellent blocker of D,L-5-hydroxytryptophan (5-HTP)-induced response suppression in an animal model of depression, we administered LY53857 60 min prior to 5-HTP injections into rats working on an operant schedule for milk reinforcement."3.67Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857). ( Aprison, MH; Fuller, RW; Hingtgen, JN; Mason, NR, 1985)
"To further test the new hypersensitive postsynaptic serotonin (5-HT) receptor theory of depression bases on or animal model, it was necessary to demonstrate that some of the currently used antidepressive drugs can block D,L-5-hydroxytryptophan (5-HTP) induced depression acting through postsynaptic rather than presynaptic mechanisms."3.66Postsynaptic action by four antidepressive drugs in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1981)
"Rats working on a food-reinforced operant schedule and exhibiting behavioral depression following administration of D,L-5-hydroxytryptophan (5-HTP) were pretreated with one of three drugs: methysergide, fluoxetine, or amitriptyline."3.66Pre- and postsynaptic serotonergic manipulations in an animal model of depression. ( Aprison, MH; Hingtgen, JN; Nagayama, H, 1980)
"The treatment with nialamide + l-5-HTP proved to have a shorter delay of onset."2.645-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study. ( Aliño, JJ; Gutierrez, JL; Iglesias, ML, 1976)
"Depression is a psychiatric disorder with limited therapy options."1.72β-carboline-independent antidepressant-like effect of the standardized extract of the barks of ( Amariz, IA; Brys, I; Damasceno, TA; Duarte-Filho, LAMS; Massaranduba, ABR; Menezes, PMN; Nishimura, RHV; Ribeiro, LAA; Rolim, LA; Silva, FS, 2022)
"Treatment with 5-hydroxytryptophan restores the levels of 5-HT and its precursors in the HpC, improves HpC neurogenesis, and alleviates despair-like symptoms."1.56Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine. ( Bigot, M; Chevalier, G; Eberl, G; Katsimpardi, L; Lledo, PM; Moigneu, C; Saha, S; Siopi, E, 2020)
"Mood disorders and constipation are often comorbid, yet their shared etiologies have rarely been explored."1.51Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression. ( Bunnett, NW; Caron, MG; Carson, W; Del Colle, A; Israelyan, N; Jacobsen, JPR; Jensen, DD; Latorre, R; Law, K; Li, Z; Luna, RA; Madra, M; Margolis, KG; Park, Y; Rahim, R; Saurman, V; Xing, A, 2019)
" It is the immediate precursor of serotonin and is widely available as a dietary supplement, which is well absorbed after an oral dose."1.335-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. ( Blackwell, AD; Turner, EH, 2005)
"Unfortunately, depression is a common side effect of IFN therapy, affecting approximately a third of HCV patients receiving IFN therapy."1.335-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin. ( Blackwell, AD; Turner, EH, 2005)
"Thus amperozide is a potent antagonist of muricidal behaviour (ED50 = 0."1.28Amperozide and emotional behaviour. ( Christensson, E; Gustafsson, B, 1990)
"Pretreatment with desipramine (2."1.27Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857). ( Aprison, MH; Fuller, RW; Hingtgen, JN; Mason, NR, 1985)
" However, possible toxic effects of high and long term use render its clinical use doubtful."1.27[Serotonin precursors as antidepressive agents: a review]. ( Beckmann, H; Kasper, S, 1983)
" Chronic administration of trazodone (2 mg/kg trazodone/day) also resulted in a significant blockade of the 5-HTP effect (75%)."1.27Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression. ( Aprison, MH; Hendrie, HC; Hingtgen, JN, 1984)
" The drug effects on 5-HTP (25 mg/kg) induced behavioral depression were tested by chronic administration using methysergide which is a postsynaptic blocker of 5-HT, or by comparable clinical doses of antidepressant drugs."1.27Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression. ( Akiyoshi, J; Nagayama, H; Tobo, M, 1986)

Research

Studies (97)

TimeframeStudies, this research(%)All Research%
pre-199064 (65.98)18.7374
1990's6 (6.19)18.2507
2000's9 (9.28)29.6817
2010's11 (11.34)24.3611
2020's7 (7.22)2.80

Authors

AuthorsStudies
Duarte-Filho, LAMS1
Amariz, IA1
Nishimura, RHV1
Massaranduba, ABR1
Menezes, PMN1
Damasceno, TA1
Brys, I1
Rolim, LA1
Silva, FS1
Ribeiro, LAA1
Hermanns, T2
Graf-Boxhorn, S1
Poeck, B2
Strauss, R2
Xia, S1
Maitiniyazi, G1
Liu, Y1
Chen, Y1
Guo, M1
He, J1
Tao, W1
Li, Z2
Javelle, F1
Lampit, A1
Bloch, W1
Häussermann, P1
Johnson, SL1
Zimmer, P1
Mitro, SD1
Larrabure-Torrealva, GT1
Sanchez, SE1
Molsberry, SA1
Williams, MA1
Clish, C1
Gelaye, B1
Meloni, M1
Puligheddu, M1
Carta, M1
Cannas, A1
Figorilli, M1
Defazio, G1
Siopi, E1
Chevalier, G1
Katsimpardi, L1
Saha, S1
Bigot, M1
Moigneu, C1
Eberl, G1
Lledo, PM1
Ries, AS1
Tian, P1
Wang, G1
Zhao, J1
Zhang, H1
Chen, W1
Israelyan, N1
Del Colle, A1
Park, Y1
Xing, A1
Jacobsen, JPR1
Luna, RA1
Jensen, DD1
Madra, M1
Saurman, V1
Rahim, R1
Latorre, R1
Law, K1
Carson, W1
Bunnett, NW1
Caron, MG1
Margolis, KG1
Wang, QS1
Ding, SL1
Mao, HP1
Cui, YL1
Qi, XJ1
Xie, C1
Peng, Z1
Zhao, SL1
Pan, CY1
Guan, LP1
Sun, XY1
Ostabal Artigas, MI1
Fukuda, K1
Rajkumar, R1
Pandey, DK1
Mahesh, R2
Radha, R1
Diaz, SL1
Maroteaux, L1
Iezhitsa, IN1
Spasov, AA1
Kharitonova, MV1
Kravchenko, MS1
Jindal, A1
Gautam, B1
Bhatt, S1
Pandey, D1
KLINE, NS2
SACKS, W3
SIMPSON, GM1
COPPEN, A1
SHAW, DM1
MALLESON, A1
Agazzi, A1
De Ponti, F1
De Giorgio, R1
Candura, SM1
Anselmi, L1
Cervio, E1
Di Nucci, A1
Tonini, M1
Young, SN1
Turner, EH2
Blackwell, AD2
Loftis, JM1
Hughes, ZA1
Liu, F1
Platt, BJ1
Dwyer, JM1
Pulicicchio, CM1
Zhang, G1
Schechter, LE1
Rosenzweig-Lipson, S1
Day, M1
van Praag, HM11
de Haan, S1
van Praag, H1
de Hann, S1
Meltzer, HY1
Bono, G1
Micieli, G1
Sances, G1
Calvani, M1
Nappi, G1
Gelenberg, AJ1
Gibson, CJ1
Beckmann, H1
Kasper, S1
Hingtgen, JN5
Hendrie, HC1
Aprison, MH5
Westenberg, HG1
Thijssen, JH1
de Jong, JT1
van Hiele, LJ1
Nagayama, H5
Lôo, H1
Zarifian, E1
Wirth, JF1
Deniker, P1
Kline, N1
Akiyoshi, J2
Tsuchiyama, K1
Mizobe, Y1
Nakamura, M1
Kuranaga, H1
Meyers, S1
Shaw, K2
Turner, J2
Del Mar, C2
Trimble, M1
Chadwick, D1
Reynolds, EH1
Marsden, CD1
Benkert, O1
Luchins, D1
Tachiki, KH1
Takagi, A1
Tateishi, T1
Kido, A1
Nishiwaki, K1
Nakamura, E1
Takahashi, R3
Praag, HM1
Wirz-Justice, A3
Nakajima, T1
Konishi, H1
Zarcone, VP1
Berger, PA1
Brodie, KH1
Sack, R1
Barchas, JD1
D'Elia, G2
Lehmann, J1
Raotma, H2
Angst, J1
Woggon, B1
Schoepf, J1
Hanson, L1
Kirkegaard, C1
Bjørum, N1
Cohn, D1
Faber, J1
Lauridsen, UB1
Nekup, J1
Mitsunobu, K1
Aliño, JJ1
Gutierrez, JL1
Iglesias, ML1
Roos, BE2
Takahashi, S4
Kondo, H1
Kato, N1
Clark, JA1
Clark, MS1
Palfreyman, ES1
Palfreyman, MG1
Korf, J5
Masumura, I2
Miike, A2
Joly, P1
Lampert, A1
Thomine, E1
Lauret, P1
Bovier, P1
Dick, P1
Asnis, GM1
Kahn, RS1
Brown, SL1
Korn, M1
Friedman, JM1
Wetzler, S1
Sandyk, R1
Gustafsson, B1
Christensson, E1
Rousseau, JJ1
Tobo, M1
Brugge, KL1
Fuller, RW1
Mason, NR1
Persson, T1
Fujiwara, J1
Otsuki, S1
Spooner, CE1
Mandell, AJ1
Winters, WD1
Sabbot, IM1
Cruikshank, MK1
Sano, I5
Taniguchi, K1
Leeton, J1
van den Burg, W1
Bos, ER1
Dols, LC2
Schut, T1
Lapin, IP1
Airaksinen, MM1
McIsaac, WM1
van Woudenberg, F1
Coppen, AJ1
Robie, TR1
Dewhurst, WG1

Reviews

18 reviews available for 5-hydroxytryptophan and Depression

ArticleYear
Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis.
    Nutrition reviews, 2020, 01-01, Volume: 78, Issue:1

    Topics: 5-Hydroxytryptophan; Antidepressive Agents; Clinical Trials as Topic; Cohort Studies; Cross-Sectiona

2020
In brief: 5-HTP for depression.
    The Medical letter on drugs and therapeutics, 2012, Feb-20, Volume: 54, Issue:1384

    Topics: 5-Hydroxytryptophan; Animals; Depression; Humans; Treatment Outcome

2012
Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35, Issue:8

    Topics: 5-Hydroxytryptophan; Depression; Diet; Digestive System; Humans; Irritable Bowel Syndrome; Molecular

2003
Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.
    Pharmacology & therapeutics, 2006, Volume: 109, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Depression; Humans; Randomized Controlled Trial

2006
Central serotonin deficiency--a factor which increases depression vulnerability?
    Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280

    Topics: 5-Hydroxytryptophan; Adult; Biogenic Amines; Brain Chemistry; Clomipramine; Depression; Female; Huma

1980
Serotonergic function in the affective disorders: the effect of antidepressants and lithium on the 5-hydroxytryptophan-induced increase in serum cortisol.
    Annals of the New York Academy of Sciences, 1984, Volume: 430

    Topics: 5-Hydroxytryptophan; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depr

1984
Tyrosine for the treatment of depression.
    Nutrition and health, 1984, Volume: 3, Issue:3

    Topics: 5-Hydroxytryptophan; Adult; Animals; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; D

1984
Treatment of depression with an mao inhibitor followed by 5-HTP--an unfinished research project.
    Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280

    Topics: 5-Hydroxytryptophan; Carboxy-Lyases; Clinical Trials as Topic; Depression; Double-Blind Method; Drug

1980
Use of neurotransmitter precursors for treatment of depression.
    Alternative medicine review : a journal of clinical therapeutic, 2000, Volume: 5, Issue:1

    Topics: 5-Hydroxytryptophan; Depression; Humans; Phenylalanine; Tryptophan; Tyrosine

2000
Tryptophan and 5-hydroxytryptophan for depression.
    The Cochrane database of systematic reviews, 2001, Issue:3

    Topics: 5-Hydroxytryptophan; Antidepressive Agents, Second-Generation; Depression; Humans; Randomized Contro

2001
Tryptophan and 5-hydroxytryptophan for depression.
    The Cochrane database of systematic reviews, 2002, Issue:1

    Topics: 5-Hydroxytryptophan; Antidepressive Agents, Second-Generation; Depression; Humans; Randomized Contro

2002
Biogenic amines and affective disorders. A critical analysis.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:3

    Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar

1976
Theoretical and therapeutic potential of indoleamine precursors. (5).
    Nihon rinsho. Japanese journal of clinical medicine, 1977, Apr-10, Volume: 35, Issue:4

    Topics: 5-Hydroxytryptophan; Depression; Female; Humans; Serotonin; Tryptamines; Tryptophan

1977
[Depression and serotonin metabolism].
    Nihon rinsho. Japanese journal of clinical medicine, 1978, Volume: 36, Issue:1

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Female; Humans; L

1978
Nosological tunnel vision in biological psychiatry. A plea for a functional psychopathology.
    Annals of the New York Academy of Sciences, 1990, Volume: 600

    Topics: 5-Hydroxytryptophan; Aggression; Biology; Depression; Depressive Disorder; Humans; Mental Disorders;

1990
Indoleamines in depression and suicide.
    Progress in brain research, 1986, Volume: 65

    Topics: 5-Hydroxytryptophan; Brain; Celiac Disease; Depression; Humans; Parkinson Disease; Serotonin; Suicid

1986
Kynurenines as probable participants of depression.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1973, Volume: 6, Issue:6

    Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Behavior; Blood Pressure; Body Temperature; Depression; D

1973
Indolealkylamines and behavior.
    Annales medicinae experimentalis et biologiae Fenniae, 1968, Volume: 46, Issue:3

    Topics: 5-Hydroxytryptophan; Alkaloids; Amines; Animals; Behavior; Brain; Brain Chemistry; Cats; Chemical Ph

1968

Trials

17 trials available for 5-hydroxytryptophan and Depression

ArticleYear
Efficacy and safety of 5-hydroxytryptophan on depression and apathy in Parkinson's disease: a preliminary finding.
    European journal of neurology, 2020, Volume: 27, Issue:5

    Topics: 5-Hydroxytryptophan; Aged; Apathy; Cross-Over Studies; Depression; Double-Blind Method; Female; Huma

2020
L-5HTP treatment in primary headaches: an attempt at clinical identification of responsive patients.
    Cephalalgia : an international journal of headache, 1984, Volume: 4, Issue:3

    Topics: 5-Hydroxytryptophan; Adult; Anxiety; Chronic Disease; Clinical Trials as Topic; Depression; Female;

1984
Tyrosine for the treatment of depression.
    Nutrition and health, 1984, Volume: 3, Issue:3

    Topics: 5-Hydroxytryptophan; Adult; Animals; Clinical Trials as Topic; Depression; Dihydroxyphenylalanine; D

1984
Treatment of depression with an mao inhibitor followed by 5-HTP--an unfinished research project.
    Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280

    Topics: 5-Hydroxytryptophan; Carboxy-Lyases; Clinical Trials as Topic; Depression; Double-Blind Method; Drug

1980
Studies on pituitary hormones and releasing hormones in depression and sexual impotence.
    Progress in brain research, 1975, Volume: 42

    Topics: 5-Hydroxytryptophan; Benserazide; Bipolar Disorder; Clinical Trials as Topic; Depression; Erectile D

1975
Biogenic amines and affective disorders. A critical analysis.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:3

    Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar

1976
The indoleamine hypothesis of depression: an overview and pilot study.
    Diseases of the nervous system, 1977, Volume: 38, Issue:8

    Topics: 5-Hydroxytryptophan; Adult; Aged; Carbidopa; Clinical Trials as Topic; Depression; Female; Homovanil

1977
Evaluation of the combination of tryptophan and ECT in the treatment of depression. I. Clinical analysis.
    Acta psychiatrica Scandinavica, 1977, Volume: 56, Issue:4

    Topics: 5-Hydroxytryptophan; Administration, Oral; Adult; Antidepressive Agents, Tricyclic; Clinical Trials

1977
The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study.
    Archiv fur Psychiatrie und Nervenkrankheiten, 1977, Oct-11, Volume: 224, Issue:2

    Topics: 5-Hydroxytryptophan; Adult; Clinical Trials as Topic; Depression; Double-Blind Method; Drug Synergis

1977
L-tryptophan and 5-hydroxytryptophan in the treatment of depression. A review.
    Acta psychiatrica Scandinavica, 1978, Volume: 57, Issue:3

    Topics: 5-Hydroxytryptophan; Antidepressive Agents; Clinical Trials as Topic; Depression; Drug Evaluation; H

1978
5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:1

    Topics: 5-Hydroxytryptophan; Adult; Clinical Trials as Topic; Depression; Drug Therapy, Combination; Female;

1976
Tryptophan, 5-hydroxytryptophan and tricyclic antidepressants in the treatment of depression.
    Monographs in neural sciences, 1976, Volume: 3

    Topics: 5-Hydroxytryptophan; Catecholamines; Clinical Trials as Topic; Clomipramine; Depression; Depression,

1976
Effects of a levo-5-hydroxytryptophan-dihydroergocristine combination on depression and neuropsychic performance: a double-blind placebo-controlled clinical trial in elderly patients.
    Clinical therapeutics, 1987, Volume: 9, Issue:3

    Topics: 5-Hydroxytryptophan; Aged; Clinical Trials as Topic; Depression; Dihydroergotoxine; Double-Blind Met

1987
A pilot study of the predictive value of the probenecid test in application of 5-hydroxytryptophan as antidepressant.
    Psychopharmacologia, 1972, Volume: 25, Issue:1

    Topics: 5-Hydroxytryptophan; Brain; Clinical Trials as Topic; Depression; Humans; Placebos; Probenecid; Sero

1972
5-Hydroxytrytophan as an antidepressant. The predictive value of the probenecid test.
    The Journal of nervous and mental disease, 1974, Volume: 158, Issue:5

    Topics: 5-Hydroxytryptophan; Biological Transport; Brain; Brain Chemistry; Clinical Trials as Topic; Depress

1974
Serotonin metabolism in depression: clinical application of the probenecid test.
    International pharmacopsychiatry, 1974, Volume: 9, Issue:1

    Topics: 5-Hydroxytryptophan; Adjustment Disorders; Administration, Oral; Clinical Trials as Topic; Depressio

1974
Investigation into the possible influence of chlorinated amphetamine derivatives on 5-hydroxytryptamine synthesis in man.
    Psychopharmacologia, 1970, Volume: 18, Issue:4

    Topics: 5-Hydroxytryptophan; Amphetamine; Antidepressive Agents; Brain; Carbon Isotopes; Clinical Trials as

1970

Other Studies

65 other studies available for 5-hydroxytryptophan and Depression

ArticleYear
β-carboline-independent antidepressant-like effect of the standardized extract of the barks of
    Journal of psychopharmacology (Oxford, England), 2022, Volume: 36, Issue:7

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Carbolines; Depression; Harmine; Humans; Mice;

2022
Octopamine mediates sugar relief from a chronic-stress-induced depression-like state in Drosophila.
    Current biology : CB, 2022, 09-26, Volume: 32, Issue:18

    Topics: 5-Hydroxytryptophan; Animals; Depression; Depressive Disorder, Major; Dopaminergic Neurons; Drosophi

2022
Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor.
    Food research international (Ottawa, Ont.), 2023, Volume: 169

    Topics: 5-Hydroxytryptophan; Animals; Depression; Female; Kynurenine; Mice; Serotonin; Tryptophan; Whey Prot

2023
Metabolomic markers of antepartum depression and suicidal ideation.
    Journal of affective disorders, 2020, 02-01, Volume: 262

    Topics: 5-Hydroxytryptophan; Adult; Betaine; Biomarkers; Carnitine; Citrulline; Cross-Sectional Studies; Dep

2020
Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine.
    Cell reports, 2020, 03-17, Volume: 30, Issue:11

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Cell Differentiation; Chronic Disease; Depressi

2020
Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment.
    Nature communications, 2017, 06-06, Volume: 8

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Brain; Cyclic AMP; Depression; Drosophila melan

2017
Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis.
    The Journal of nutritional biochemistry, 2019, Volume: 66

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Bifidobacterium; Butyrates; Depression; Dysbiosis; F

2019
Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.
    Gastroenterology, 2019, Volume: 157, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Constipation; Delayed-Action Preparations; Depression; Disease Models,

2019
Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice.
    Journal of ethnopharmacology, 2013, Jul-09, Volume: 148, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Coptis; Corpus Striatum; Depr

2013
Synthesis of 2´-hydroxy-4´-isoprenyloxychalcone derivatives with potential antidepressant-like activity.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2014, Volume: 10, Issue:8

    Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Antidepressive Agents; Chalcones; Depression; Ex

2014
[Serotoninergic syndrome due to interaction between linezolid and 5-hydroxytryptophan].
    Medicina clinica, 2015, Dec-21, Volume: 145, Issue:12

    Topics: 5-Hydroxytryptophan; Anti-Bacterial Agents; Antidepressive Agents, Second-Generation; Depression; Di

2015
Integrated theory to unify status among schizophrenia and manic depressive illness.
    Medical hypotheses, 2015, Volume: 85, Issue:4

    Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biopterins; Bipolar Dis

2015
1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay.
    European journal of pharmacology, 2009, Apr-17, Volume: 608, Issue:1-3

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behav

2009
Implication of 5-HT(2B) receptors in the serotonin syndrome.
    Neuropharmacology, 2011, Volume: 61, Issue:3

    Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Depression; Dose-Response Relationship, Drug; Explor

2011
Effect of magnesium chloride on psychomotor activity, emotional status, and acute behavioural responses to clonidine, d-amphetamine, arecoline, nicotine, apomorphine, and L-5-hydroxytryptophan.
    Nutritional neuroscience, 2011, Volume: 14, Issue:1

    Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anxiety; Apomorphine; Arecoline; Clonidine; Depression; D

2011
Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression.
    Biochemical and biophysical research communications, 2011, Jun-17, Volume: 409, Issue:4

    Topics: 5-Hydroxytryptophan; Acetamides; Animals; Antidepressive Agents; Behavior; Depression; Disease Model

2011
Relief of depression within one day using an M.A.O. inhibitor and intravenous 5-HTP.
    The American journal of psychiatry, 1963, Volume: 120

    Topics: 5-Hydroxytryptophan; Depression; Depressive Disorder; Humans; Indoles; Monoamine Oxidase Inhibitors

1963
FURTHER STUDIES ON: ONE DAY TREATMENT OF DEPRESSION WITH 5-HTP.
    The American journal of psychiatry, 1964, Volume: 121

    Topics: 5-Hydroxytryptophan; Biomedical Research; Depression; Depressive Disorder; Drug Therapy; Geriatrics;

1964
CHANGES IN 5-HYDROXYTRYPTOPHAN METABOLISM IN DEPRESSION.
    The British journal of psychiatry : the journal of mental science, 1965, Volume: 111

    Topics: 5-Hydroxytryptophan; Amino Acids; Depression; Depressive Disorder; Humans

1965
Are SAMe and 5-HTP safe and effective treatments for depression?
    Journal of psychiatry & neuroscience : JPN, 2003, Volume: 28, Issue:6

    Topics: 5-Hydroxytryptophan; Anti-Inflammatory Agents; Antidepressive Agents; Depression; Humans; Male; Midd

2003
5-Hydroxytryptophan plus SSRIs for interferon-induced depression: synergistic mechanisms for normalizing synaptic serotonin.
    Medical hypotheses, 2005, Volume: 65, Issue:1

    Topics: 5-Hydroxytryptophan; Antiviral Agents; Brain Chemistry; Depression; Drug Synergism; Drug Therapy, Co

2005
WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent.
    Neuropharmacology, 2008, Volume: 54, Issue:7

    Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal;

2008
Depression vulnerability and 5-hydroxytryptophan prophylaxis.
    Psychiatry research, 1980, Volume: 3, Issue:1

    Topics: 5-Hydroxytryptophan; Adult; Brain; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl

1980
[Serotonin precursors as antidepressive agents: a review].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:5

    Topics: 5-Hydroxytryptophan; Climacteric; Depression; Depressive Disorder; Female; Humans; Tryptophan

1983
Postsynaptic serotonergic blockade following chronic antidepressive treatment with trazodone in an animal model of depression.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 20, Issue:3

    Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Humans; Male; Methy

1984
Hormone response to 5-HTP: a reply.
    Psychiatry research, 1984, Volume: 11, Issue:1

    Topics: 5-Hydroxytryptophan; Depression; Growth Hormone; Humans; Hydrocortisone; Prolactin

1984
[Central serotonin metabolism in depression].
    Nederlands tijdschrift voor geneeskunde, 1980, Jun-14, Volume: 124, Issue:24

    Topics: 5-Hydroxytryptophan; Affect; Brain; Depression; Humans; Longitudinal Studies; Probenecid; Serotonin;

1980
l-5-Hydroxytryptophan in depression: the first substitution therapy in psychiatry? The treatment of 99 out-patients with 'therapy-resistant' depressions.
    Neuropsychobiology, 1980, Volume: 6, Issue:4

    Topics: 5-Hydroxytryptophan; Adult; Age Factors; Aged; Antidepressive Agents; Carbidopa; Depression; Drug Re

1980
Pre- and postsynaptic serotonergic manipulations in an animal model of depression.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 13, Issue:4

    Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Depression; Disease Models, Animal; Drug Synergism; Flu

1980
[Open study of L-5-H.T.P. in melancholic depressed patients over 50 years of age (author's transl)].
    L'Encephale, 1980, Volume: 6, Issue:3

    Topics: 5-Hydroxytryptophan; Aged; Depression; Drug Evaluation; Female; Humans; Male; Middle Aged

1980
Postsynaptic action by four antidepressive drugs in an animal model of depression.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 15, Issue:1

    Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Di

1981
Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model.
    Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:1

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Cerebral Cort

1994
Letter: L 5-Hydroxytryptophan and mood.
    Lancet (London, England), 1975, Mar-08, Volume: 1, Issue:7906

    Topics: 5-Hydroxytryptophan; Affective Symptoms; Aggression; Brain Neoplasms; Depression; Dose-Response Rela

1975
Animal model of depression. III. Mechanism of action of tetrabenazine.
    Biological psychiatry, 1978, Volume: 13, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Depression; Disease Models, Animal; Dopamine;

1978
The Harold E. Himwich Memorial Lecture. Significance of biochemical parameters in the diagnosis, treatment, and prevention of depressive disorders.
    Biological psychiatry, 1977, Volume: 12, Issue:1

    Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Autopsy; Bipolar Disorder; Brain Chemistry; C

1977
Theoretical and therapeutic potential of indolamine precursors in affective disorders.
    Neuropsychobiology, 1977, Volume: 3, Issue:4

    Topics: 5-Hydroxytryptophan; Amino Acids; Bipolar Disorder; Depression; Emotions; Female; Humans; Levodopa;

1977
[L-5-hydroxytryptophan treatment of depression].
    Nihon rinsho. Japanese journal of clinical medicine, 1978, Volume: Suppl

    Topics: 5-Hydroxytryptophan; Depression; Humans

1978
Studies on the influence of biogenic amines and psychoactive drugs on the prognostic value of the TRH stimulation test in endogenous depression.
    Psychoneuroendocrinology, 1977, Volume: 2, Issue:2

    Topics: 5-Hydroxytryptophan; Aged; Biogenic Amines; Depression; Female; Humans; Isoproterenol; Male; Middle

1977
Effect of l-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients.
    Journal of psychiatric research, 1975, Volume: 12, Issue:3

    Topics: 5-Hydroxytryptophan; Adjustment Disorders; Adult; Aged; Blood Platelets; Brain; Depression; Female;

1975
The effect of tryptophan and a tryptophan/5-hydroxytryptophan combination on indoles in the brains of rats fed a tryptophan deficient diet.
    Psychopharmacologia, 1975, Dec-31, Volume: 45, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; 5-Hydroxytryptophan; Animals; Brain; Depression; Diet; Drug Synergism; Hu

1975
Central monoamine deficiency in depressions: causative of secondary phenomenon?
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1975, Volume: 8, Issue:5

    Topics: 5-Hydroxytryptophan; Clomipramine; Depression; Dopamine; Homovanillic Acid; Humans; Serotonin

1975
Theoretical and therapeutic potential of indoleamine precursors. (1). Introduction.
    Nihon rinsho. Japanese journal of clinical medicine, 1976, Sep-10, Volume: 34, Issue:9

    Topics: 5-Hydroxytryptophan; Affective Symptoms; Animals; Biogenic Amines; Depression; Diagnosis, Differenti

1976
Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Folia psychiatrica et neurologica japonica, 1976, Volume: 30, Issue:4

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Depression; Female; Humans; Hydroxyindoleacetic Acid; Male;

1976
Reduction of blood platelet serotonin levels in manic and depressed patients.
    Folia psychiatrica et neurologica japonica, 1976, Volume: 30, Issue:4

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Bipolar Disorder; Blood Platelets; Depression; Female;

1976
Measurement of 5-hydroxyindole compounds during L-5-HTP treatment in depressed patients.
    Folia psychiatrica et neurologica japonica, 1976, Volume: 30, Issue:4

    Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Depression; Female; Humans; Hydroxyind

1976
Development of pseudobullous morphea and scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
    Journal of the American Academy of Dermatology, 1991, Volume: 25, Issue:2 Pt 1

    Topics: 5-Hydroxytryptophan; Aged; Carbidopa; Chronic Disease; Depression; Drug Therapy, Combination; Eosino

1991
[Current status, perspectives and limitations of serotonin precursors].
    Revue medicale de la Suisse romande, 1990, Volume: 110, Issue:10

    Topics: 5-Hydroxytryptophan; Central Nervous System; Depression; Humans; Serotonin; Sleep; Tryptophan

1990
Pineal melatonin functions and the depression of Parkinson's disease: a hypothesis.
    The International journal of neuroscience, 1990, Volume: 51, Issue:1-2

    Topics: 5-Hydroxytryptophan; Animals; Depression; Dopamine; Humans; Melatonin; Models, Neurological; Parkins

1990
Amperozide and emotional behaviour.
    Pharmacology & toxicology, 1990, Volume: 66 Suppl 1

    Topics: 5-Hydroxytryptophan; Aggression; Animals; Behavior, Animal; Blepharoptosis; Conflict, Psychological;

1990
Action of chronically administered antidepressants on the serotonergic postsynapse in a model of depression.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 25, Issue:4

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Conditioning, Operant; Depression; Male; Rats;

1986
Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Depression; Disease Models, Animal; Drug Synergism; Male; Rats; Rats,

1987
Blockade of a 5-hydroxytryptophan-induced animal model of depression with a potent and selective 5-HT2 receptor antagonist (LY53857).
    Biological psychiatry, 1985, Volume: 20, Issue:6

    Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Conditioning, Operant; Depression; Desipramine; Disea

1985
5-hydroxytryptophan for depression.
    Lancet (London, England), 1967, Nov-04, Volume: 2, Issue:7523

    Topics: 5-Hydroxytryptophan; Amitriptyline; Depression; Dihydroxyphenylalanine; Electroconvulsive Therapy; H

1967
Subtype of affective psychoses classified by response on amineprecursors and monoamine metabolism.
    Folia psychiatrica et neurologica japonica, 1974, Volume: 28, Issue:2

    Topics: 5-Hydroxytryptophan; Amines; Depression; Dihydroxyphenylalanine; Female; Humans; Hydroxyindoleacetic

1974
Pharmacological and biochemical correlates of 5-hydroxytryptamine entry into the central nervous system during maturation.
    Proceedings of the Western Pharmacology Society, 1968, Volume: 11

    Topics: 5-Hydroxytryptophan; Age Factors; Animals; Brain Chemistry; Cerebellum; Chickens; Depression; Dience

1968
[L-5-hydroxytryptophan-(L-5-HTP) therapy].
    Folia psychiatrica et neurologica japonica, 1972, Volume: 26, Issue:1

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Antidepressive Agents; Child; Depression; Female; Huma

1972
[L-5-hydroxytryptophan(L-5-HTP) therapy in endogenous depression. 1].
    Munchener medizinische Wochenschrift (1950), 1972, Oct-06, Volume: 114, Issue:40

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Benzoates; Bipolar Disorder; Child; Depression; Female

1972
[L-5-hydroxytryptophan(L-5-HTP) therapy of Parkinson's disease. 2].
    Munchener medizinische Wochenschrift (1950), 1972, Oct-06, Volume: 114, Issue:40

    Topics: 5-Hydroxytryptophan; Adult; Aged; Depression; Dihydroxyphenylalanine; Female; Humans; Male; Middle A

1972
[Treatment of endogenous depression with L-hydroxy-tryptophan (L-5-HTP)].
    Nihon rinsho. Japanese journal of clinical medicine, 1973, Volume: 31, Issue:1

    Topics: 5-Hydroxytryptophan; Aged; Depression; Humans; Isomerism; Male; Middle Aged

1973
Depression induced by oral contraception and the role of vitamin B6 in its management.
    The Australian and New Zealand journal of psychiatry, 1974, Volume: 8, Issue:2

    Topics: 5-Hydroxytryptophan; Contraceptives, Oral; Depression; Female; Humans; Pyridoxine; Serotonin; Trypto

1974
5-hydroxytryptophan in combination with clomipramine in "therapy-resistant" depressions.
    Psychopharmacologia, 1974, Volume: 38, Issue:3

    Topics: 5-Hydroxytryptophan; Adult; Antidepressive Agents; Carboxy-Lyases; Depression; Dibenzazepines; Drug

1974
Depressed states and indolealkylamines.
    Advances in pharmacology, 1968, Volume: 6, Issue:Pt B

    Topics: 5-Hydroxytryptophan; Carbon Isotopes; Catecholamines; Depression; Humans; Indoles; Middle Aged; Mono

1968
Crash treatment for melancholia. Resistant to other recently developed methods.
    The Journal of the Medical Society of New Jersey, 1970, Volume: 67, Issue:8

    Topics: 5-Hydroxytryptophan; Adult; Aged; Antidepressive Agents; Blood Pressure Determination; Depression; D

1970
Tryptophan pyrrolase and depressive illness.
    The British journal of psychiatry : the journal of mental science, 1970, Volume: 117, Issue:537

    Topics: 5-Hydroxytryptophan; Depression; Humans; Hydroxyindoleacetic Acid; Psychiatric Status Rating Scales;

1970
["Precursor therapy" with active amines. I. Treatment of depression by L-5-HTP (L-5-hydroxytryptophan)].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1971, Volume: 73, Issue:10

    Topics: 5-Hydroxytryptophan; Adult; Aged; Depression; Female; Gastrointestinal Diseases; Humans; Male; Middl

1971