5-hydroxytryptophan has been researched along with Dementia in 4 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serotonin (5-HT), its precursor 5-hydroxytryptophan (5-HTP), and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in the cerebrospinal fluid (CSF) of 14 patients with dementia of the Alzheimer type (DAT) and in nine controls by high-performance liquid chromatography with a novel multisensor coulometric detection system." | 7.67 | Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid. ( Gamache, PH; Langlais, PJ; Mark, KA; Matson, WR; Volicer, L, 1985) |
| "Twenty-four senile dementia patients in the age range 65-85 years were subjected to a new sensitive tryptophan loading test: Dopa-Tryptophan loading ("Dop-Try loading") in order to determine whether Try malabsorption occurs in senile dementia and if so how frequent this is." | 7.66 | Tryptophan malabsorption in dementia. Improvement in certain cases after tryptophan therapy as indicated by mental behaviour and blood analysis. ( Lehmann, J; Persson, S; Wålinder, J; Wallin, L, 1981) |
| "Serotonin (5-HT), its precursor 5-hydroxytryptophan (5-HTP), and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in the cerebrospinal fluid (CSF) of 14 patients with dementia of the Alzheimer type (DAT) and in nine controls by high-performance liquid chromatography with a novel multisensor coulometric detection system." | 3.67 | Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid. ( Gamache, PH; Langlais, PJ; Mark, KA; Matson, WR; Volicer, L, 1985) |
| "Twenty-four senile dementia patients in the age range 65-85 years were subjected to a new sensitive tryptophan loading test: Dopa-Tryptophan loading ("Dop-Try loading") in order to determine whether Try malabsorption occurs in senile dementia and if so how frequent this is." | 3.66 | Tryptophan malabsorption in dementia. Improvement in certain cases after tryptophan therapy as indicated by mental behaviour and blood analysis. ( Lehmann, J; Persson, S; Wålinder, J; Wallin, L, 1981) |
| "Demented patients with Parkinson's disease, particularly those with concurrent depression, had the lowest values of 5-HIAA." | 2.66 | The relationship of serotonin to depression in Parkinson's disease. ( Cote, LJ; Mayeux, R; Sano, M; Stern, Y; Williams, JB, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lehmann, J | 1 |
| Persson, S | 1 |
| Wålinder, J | 1 |
| Wallin, L | 1 |
| Meyer, JS | 1 |
| Welch, KM | 1 |
| Deshmukh, VD | 1 |
| Perez, FI | 1 |
| Jacob, RH | 1 |
| Haufrect, DB | 1 |
| Mathew, NT | 1 |
| Morrell, RM | 1 |
| Volicer, L | 1 |
| Langlais, PJ | 1 |
| Matson, WR | 1 |
| Mark, KA | 1 |
| Gamache, PH | 1 |
| Mayeux, R | 1 |
| Stern, Y | 1 |
| Sano, M | 1 |
| Williams, JB | 1 |
| Cote, LJ | 1 |
1 trial available for 5-hydroxytryptophan and Dementia
| Article | Year |
|---|---|
The relationship of serotonin to depression in Parkinson's disease.
Topics: 5-Hydroxytryptophan; Aged; Clinical Trials as Topic; Dementia; Depressive Disorder; Female; Humans; | 1988 |
3 other studies available for 5-hydroxytryptophan and Dementia
| Article | Year |
|---|---|
Tryptophan malabsorption in dementia. Improvement in certain cases after tryptophan therapy as indicated by mental behaviour and blood analysis.
Topics: 5-Hydroxytryptophan; Brain Chemistry; Dementia; Dopamine; Humans; Hydroxyindoleacetic Acid; Intestin | 1981 |
Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease.
Topics: 5-Hydroxytryptophan; Aged; Alzheimer Disease; Carbidopa; Dementia; Dopamine; Drug Combinations; Fema | 1977 |
Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid.
Topics: 5-Hydroxytryptophan; Aged; Alzheimer Disease; Dementia; Humans; Hydroxyindoleacetic Acid; Middle Age | 1985 |