5-hydroxytryptophan has been researched along with Deficiency, Mental in 15 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 7.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency is the most important type of BH4 deficiency related to hyperphenylalaninemia." | 3.73 | Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency. ( Cheng, LY; Chiu, PC; Hsiao, KJ; Lee, NC; Liu, TT; Niu, DM, 2006) |
| "In a patient with the Lesch-Nyhan syndrome we found decreased spinal fluid 5-hydroxyindole acetic acid (5-HIAA), the major metabolite of serotonin, and decreased homovanillic acid (HVA), the major metabolite of dopamine, indicating a decrease in monoamine metabolism." | 3.66 | Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome. ( Castells, S; Chakrabarti, C; Hurwic, M; Nyhan, WL; Perel, JM; Winsberg, BG, 1979) |
| "PAK3-related intellectual disability is caused by mutations in the gene encoding the p21-activated kinase (PAK) protein." | 1.48 | Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome. ( Bartel, T; Blydt-Hansen, I; Connolly, MB; Horvath, GA; Race, S; Ross, CJ; Tarailo-Graovac, M; Van Allen, MI; van Karnebeek, CDM; Wasserman, WW, 2018) |
| "Although phenylketonuria (PKU) is the most common genetic cause of mental retardation, the cellular mechanisms underlying impaired brain function are still unclear." | 1.37 | 5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria. ( Andolina, D; Cabib, S; Conversi, D; Pascucci, T; Puglisi-Allegra, S; Trabalza, A; Ventura, R, 2011) |
| "It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters." | 1.26 | Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horvath, GA | 1 |
| Tarailo-Graovac, M | 1 |
| Bartel, T | 1 |
| Race, S | 1 |
| Van Allen, MI | 1 |
| Blydt-Hansen, I | 1 |
| Ross, CJ | 1 |
| Wasserman, WW | 1 |
| Connolly, MB | 1 |
| van Karnebeek, CDM | 1 |
| Andolina, D | 1 |
| Conversi, D | 1 |
| Cabib, S | 1 |
| Trabalza, A | 1 |
| Ventura, R | 1 |
| Puglisi-Allegra, S | 1 |
| Pascucci, T | 1 |
| PERRY, TL | 1 |
| TISCHLER, B | 1 |
| Lee, NC | 1 |
| Cheng, LY | 1 |
| Liu, TT | 1 |
| Hsiao, KJ | 1 |
| Chiu, PC | 1 |
| Niu, DM | 1 |
| Singh, NN | 1 |
| Koslow, SH | 1 |
| Butler, IJ | 1 |
| Castells, S | 1 |
| Chakrabarti, C | 1 |
| Winsberg, BG | 1 |
| Hurwic, M | 1 |
| Perel, JM | 1 |
| Nyhan, WL | 1 |
| Chazot, G | 1 |
| Guard, O | 1 |
| Setiey, A | 1 |
| Robert, JM | 1 |
| Schott, B | 1 |
| Nomura, Y | 1 |
| Segawa, M | 1 |
| Higurashi, M | 1 |
| Bettschart, W | 1 |
| Broché, JP | 1 |
| Tissot, R | 1 |
| Pare, CM | 1 |
| Partington, MW | 1 |
| MacDonald, MR | 1 |
| Airaksinen, EM | 1 |
| Airaksinen, MM | 1 |
| Pentikäinen, P | 1 |
| Hsia, DY | 1 |
| Woolley, DW | 1 |
| Van der Hoeven, T | 1 |
2 reviews available for 5-hydroxytryptophan and Deficiency, Mental
| Article | Year |
|---|---|
Current trends in the treatment of self-injurious behavior.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Ammonia; Aversive Therapy; Behavior Therapy; Child; Ch | 1981 |
Biochemical factors in mental retardation.
Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Diet Therapy; Female; Guinea Pigs; Haplorhini; Humans | 1967 |
2 trials available for 5-hydroxytryptophan and Deficiency, Mental
| Article | Year |
|---|---|
[Correlation of the clinical and pharmaco-dynamic effects of Niamid in the treatment of severely mentally retarded children].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Child; Clinical Trials as Topic; Down Syndrome; Female; Huma | 1965 |
5-hydroxytryptophan (5-HTP) in Down's syndrome.
Topics: 5-Hydroxytryptophan; Child; Child, Preschool; Clinical Trials as Topic; Down Syndrome; Female; Human | 1971 |
11 other studies available for 5-hydroxytryptophan and Deficiency, Mental
| Article | Year |
|---|---|
Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome.
Topics: 5-Hydroxytryptophan; Adolescent; Brain; Carbidopa; Dopamine; Drug Combinations; Humans; Intellectual | 2018 |
5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Cognition; Cognition Disorders; Critical Period, Psy | 2011 |
5-HYDROXYTRYPTOPHAN ADMINISTRATION IN PHENYLKETONURIA.
Topics: 5-Hydroxytryptophan; Biomedical Research; Brain; Child; Diet; Electroencephalography; Humans; Indole | 1964 |
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Asian People; Biopterins; Child; Child, Preschool; China; Fe | 2006 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea | 1977 |
Effects of L-5-hydroxytryptophan on monoamine and amino acids turnover in the Lesch-Nyhan syndrome.
Topics: 5-Hydroxytryptophan; Amino Acids; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleaceti | 1979 |
[Ramsay-Hunt syndrome and aniridia in 2 monozygotic twins].
Topics: 5-Hydroxytryptophan; Adolescent; Benzodiazepinones; Blood Group Antigens; Cerebellar Ataxia; Disease | 1975 |
Rett syndrome--an early catecholamine and indolamine deficient disorder?
Topics: 5-Hydroxytryptophan; Adolescent; Basal Ganglia; Catecholamines; Child; Child, Preschool; Droxidopa; | 1985 |
5-hydroxyindoles in phenylketonuric and nonphenylketonuric mental defectives.
Topics: 5-Hydroxytryptophan; Animals; Biological Transport; Carboxy-Lyases; Child; Down Syndrome; Humans; Hy | 1968 |
Fate of 14C-labelled tryptophan and 5-hydroxytryptophan in Down's syndrome.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Autoradiography; Blood Platelets; Carb | 1973 |
Serotonin deficiency in infancy as a cause of a mental defect in experimental phenylketonuria.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Chlorpromazine; Electroshock; Female; Humans; In Vit | 1965 |