5-hydroxytryptophan has been researched along with Colitis, Mucous in 5 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome." | 8.82 | Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders. ( Agazzi, A; Anselmi, L; Candura, SM; Cervio, E; De Giorgio, R; De Ponti, F; Di Nucci, A; Tonini, M, 2003) |
| "To study differences in the visceral sensitivity of the colonic mucosa between patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and those with ulcerative colitis (UC) in remission and to relate these differences with changes in the 5-hydroxytryptophan (5-HT) signaling pathway." | 7.83 | Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis. ( Chi, HG; Huang, SG; Lv, RX; Ye, H; Yu, FY; Zhang, HY; Zheng, XB; Zou, Y, 2016) |
| "In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome." | 4.82 | Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders. ( Agazzi, A; Anselmi, L; Candura, SM; Cervio, E; De Giorgio, R; De Ponti, F; Di Nucci, A; Tonini, M, 2003) |
| "To study differences in the visceral sensitivity of the colonic mucosa between patients with diarrhea-predominant irritable bowel syndrome (IBS-D) and those with ulcerative colitis (UC) in remission and to relate these differences with changes in the 5-hydroxytryptophan (5-HT) signaling pathway." | 3.83 | Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis. ( Chi, HG; Huang, SG; Lv, RX; Ye, H; Yu, FY; Zhang, HY; Zheng, XB; Zou, Y, 2016) |
| "5-HTP induces rectal allodynia in a significant number of healthy controls; IBS patients exhibit lowered pain thresholds in both placebo and 5-HTP conditions." | 2.80 | Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study. ( Buurman, WA; Dekker, J; Jonkers, DM; Keszthelyi, D; Masclee, AA; Troost, FJ; van Eijk, HM, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keszthelyi, D | 2 |
| Troost, FJ | 2 |
| Jonkers, DM | 2 |
| van Eijk, HM | 2 |
| Lindsey, PJ | 1 |
| Dekker, J | 2 |
| Buurman, WA | 2 |
| Masclee, AA | 2 |
| Shao, YY | 1 |
| Huang, J | 1 |
| Ma, YR | 1 |
| Han, M | 1 |
| Ma, K | 1 |
| Qin, HY | 1 |
| Rao, Z | 1 |
| Wu, XA | 1 |
| Yu, FY | 1 |
| Huang, SG | 1 |
| Zhang, HY | 1 |
| Ye, H | 1 |
| Chi, HG | 1 |
| Zou, Y | 1 |
| Lv, RX | 1 |
| Zheng, XB | 1 |
| Agazzi, A | 1 |
| De Ponti, F | 1 |
| De Giorgio, R | 1 |
| Candura, SM | 1 |
| Anselmi, L | 1 |
| Cervio, E | 1 |
| Di Nucci, A | 1 |
| Tonini, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Serotonergic Modulation on Intestinal Permeability and Visceral Hypersensitivity in Healthy Individuals and IBS Patients[NCT00731003] | 60 participants (Actual) | Interventional | 2009-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 5-hydroxytryptophan and Colitis, Mucous
| Article | Year |
|---|---|
Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders.
Topics: 5-Hydroxytryptophan; Depression; Diet; Digestive System; Humans; Irritable Bowel Syndrome; Molecular | 2003 |
2 trials available for 5-hydroxytryptophan and Colitis, Mucous
| Article | Year |
|---|---|
Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Case-Control Studies; Cross-Over Studies; Double-Blind Metho | 2014 |
Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism--a preliminary study.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adult; Double-Blind Method; Female; Humans; Hyperalgesia; | 2015 |
2 other studies available for 5-hydroxytryptophan and Colitis, Mucous
| Article | Year |
|---|---|
Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats.
Topics: 5-Hydroxytryptophan; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding C | 2015 |
Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis.
Topics: 5-Hydroxytryptophan; Abdominal Pain; Adult; Colitis, Ulcerative; Colon; Defecation; Diarrhea; Female | 2016 |