5-hydroxytryptophan has been researched along with Chronic Insomnia in 17 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the PCPA-pretreated insomniac rats, PGD2 infusion resulted in an immediate increase in slow-wave sleep (SWS) and an increase with a 2-h latency in paradoxical sleep (PS)." | 1.29 | Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine. ( Hayaishi, O; Jouvet, M; Matsumura, H; Nakajima, T; Onoe, H; Sakai, K; Satoh, S, 1994) |
| "We studied the reversibility of this insomnia in physiological slow-wave sleep (SWS) and paradoxical sleep (PS) after 5-hydroxytryptophan (5HTP) and serotonin (5HT) administration." | 1.27 | [Insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin]. ( Buda, C; Janin, M; Jouvet, M; Petitjean, F; Sallanon, M, 1985) |
| "latencies, in insomniac Cats pretreated with P-chlorophenylalanine." | 1.26 | [Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines]. ( Buda, C; Janin, M; Jouvet, M; Petitjean, F; Sallanon, M, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (88.24) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Webb, M | 1 |
| Kirker, JG | 1 |
| Sallanon, M | 4 |
| Buda, C | 3 |
| Janin, M | 3 |
| Jouvet, M | 10 |
| Laguzzi, RF | 1 |
| Adrien, J | 1 |
| Petitjean, F | 3 |
| Satoh, S | 1 |
| Matsumura, H | 1 |
| Nakajima, T | 2 |
| Onoe, H | 1 |
| Sakai, K | 1 |
| Hayaishi, O | 1 |
| Soulairac, A | 1 |
| Lambinet, H | 1 |
| Denoyer, M | 1 |
| Kitahama, K | 1 |
| Aubert, C | 1 |
| Uldry, PA | 1 |
| Regli, F | 1 |
| Touret, M | 1 |
| Wyatt, RJ | 2 |
| Engelman, K | 2 |
| Kupfer, DJ | 1 |
| Fram, DH | 1 |
| Sjoerdsma, A | 2 |
| Snyder, F | 2 |
| Zarcone, V | 1 |
| Dement, WC | 1 |
| Fischer-Perroudon, C | 1 |
| Mouret, J | 1 |
| Pujol, JF | 2 |
| Buguet, A | 1 |
| Froment, JL | 1 |
| Jones, B | 1 |
| Sordet, F | 1 |
| Germain, D | 1 |
2 reviews available for 5-hydroxytryptophan and Chronic Insomnia
| Article | Year |
|---|---|
[Indications for L-5-hydroxytryptophan in neurology].
Topics: 5-Hydroxytryptophan; Down Syndrome; Epilepsy; Humans; Migraine Disorders; Myoclonus; Pain; Parkinson | 1987 |
Biogenic amines and the states of sleep.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Antimetabolites; Brain; Cats; Electromyography; Geniculat | 1969 |
3 trials available for 5-hydroxytryptophan and Chronic Insomnia
| Article | Year |
|---|---|
[Effect of 5-hydroxytryptophan, a serotonin precursor, on sleep disorders].
Topics: 5-Hydroxytryptophan; Adult; Aged; Clinical Trials as Topic; Humans; Male; Middle Aged; Movement; Pla | 1977 |
Effects of L-tryptophan (a natural sedative) on human sleep.
Topics: 5-Hydroxytryptophan; Adult; Age Factors; Aged; Female; Humans; Hydroxyindoleacetic Acid; Male; Middl | 1970 |
Effects of 5-hydroxytryptophan on the sleep of normal human subjects.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Animals; Brain; Cats; Electroencephalo | 1971 |
12 other studies available for 5-hydroxytryptophan and Chronic Insomnia
| Article | Year |
|---|---|
Severe post-traumatic insomnia treated with L-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Adult; Craniocerebral Trauma; Female; Humans; Sleep Initiation and Maintenance | 1981 |
5-HT antagonists suppress sleep and delay its restoration after 5-HTP in p-chlorophenylalanine-pretreated cats.
Topics: 5-Hydroxytryptophan; Animals; Cats; Female; Fenclonine; Humans; Male; Metergoline; Methiothepin; Ser | 1982 |
[Inversion of insomnia produced by para-chlorophenylalanine in the rat. Intraperitoneal and intraventricular administration of 5-hydroxytryptophan].
Topics: 5-Hydroxytryptophan; Animals; Fenclonine; Humans; Injections, Intraperitoneal; Injections, Intravent | 1980 |
[Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines].
Topics: 5-Hydroxytryptophan; Animals; Cats; Female; Fenclonine; Humans; Injections, Intraventricular; Male; | 1980 |
Promotion of sleep by prostaglandin D2 in rats made insomniac by pretreatment with para-chlorophenylalanine.
Topics: 5-Hydroxytryptophan; Animals; Cerebral Ventricles; Diclofenac; Fenclonine; Male; Prostaglandin D2; R | 1994 |
5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Contraindications; Depressive Disorder; Fibromyalgia; Headache; Humans; Obesity | 1998 |
Reversibility of para-chlorophenylalanine-induced insomnia by intrahypothalamic microinjection of L-5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Cats; Female; Fenclonine; Hypothalamus; Hypothalamus | 1989 |
[Indolamines and sleep: 5-HT or 5-HTP?].
Topics: 5-Hydroxytryptophan; Animals; Cats; Fenclonine; Rats; Serotonin; Sleep; Sleep Initiation and Mainten | 1988 |
[Insomnia caused by administration of para-chlorophenylalanine: reversibility by peripheral or central injection of 5-hydroxytryptophan and serotonin].
Topics: 5-Hydroxytryptophan; Animals; Brain; Cats; Chloramphenicol; Electroencephalography; Female; Fencloni | 1985 |
[Case of agrypnia (4 months without sleep) in Morvan's disease. Favorable action of 5-hydroxytryptophan].
Topics: 5-Hydroxytryptophan; Adult; Chorea; Dose-Response Relationship, Drug; Electroconvulsive Therapy; Ele | 1974 |
The central metabolism of serotonin in the cat during insomnia. A neurophysiological and biochemical study after administration of P-chlorophenylalanine or destruction of the Raphé system.
Topics: 5-Hydroxytryptophan; Animals; Cats; Central Nervous System; Cerebral Cortex; Electroencephalography; | 1971 |
[Insomnia and cerebral metabolism of serotonin in cats: study of in vitro synthesis and release of serotonin 18 hours after destruction of the raphe nuclei].
Topics: 5-Hydroxytryptophan; Animals; Cats; Caudate Nucleus; Cerebral Cortex; Humans; Hydroxyindoleacetic Ac | 1972 |