5-hydroxytryptophan has been researched along with Chronic Illness in 12 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite a significant increase in serum 5-hydroxytryptophan and serotonin levels, oral 5-hydroxytryptophan did not modulate IBD-related fatigue better than placebo." | 9.51 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "A parallel, randomized, double-blind trial is reported, in which 78 patients with chronic tension-type headaches were treated with L-5-hydroxytryptophan (5-HTP) (n = 43) or placebo (n = 35) for 8 weeks, after a washout period of 2 weeks and with a follow-up period of a further 2 weeks." | 9.09 | L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. For the Portuguese Head Society. ( Ribeiro, CA, 2000) |
| "Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD), and only limited treatment options are available." | 7.11 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "Despite a significant increase in serum 5-hydroxytryptophan and serotonin levels, oral 5-hydroxytryptophan did not modulate IBD-related fatigue better than placebo." | 5.51 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "A parallel, randomized, double-blind trial is reported, in which 78 patients with chronic tension-type headaches were treated with L-5-hydroxytryptophan (5-HTP) (n = 43) or placebo (n = 35) for 8 weeks, after a washout period of 2 weeks and with a follow-up period of a further 2 weeks." | 5.09 | L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. For the Portuguese Head Society. ( Ribeiro, CA, 2000) |
| "Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD), and only limited treatment options are available." | 3.11 | Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial. ( Bos, S; Bossuyt, P; Cremer, A; De Vos, M; Dewint, P; Dewit, O; Ferrante, M; Gonzales, GB; Holvoet, T; Lambrecht, G; Laukens, D; Lobatón, T; Louis, E; Muls, V; Peeters, A; Peeters, H; Pouillon, L; Rahier, JF; Truyens, M; Vandermeulen, L; Vermeire, S, 2022) |
| "Treatment with 5-hydroxytryptophan restores the levels of 5-HT and its precursors in the HpC, improves HpC neurogenesis, and alleviates despair-like symptoms." | 1.56 | Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine. ( Bigot, M; Chevalier, G; Eberl, G; Katsimpardi, L; Lledo, PM; Moigneu, C; Saha, S; Siopi, E, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Truyens, M | 1 |
| Lobatón, T | 1 |
| Ferrante, M | 1 |
| Bossuyt, P | 1 |
| Vermeire, S | 1 |
| Pouillon, L | 1 |
| Dewint, P | 1 |
| Cremer, A | 1 |
| Peeters, H | 1 |
| Lambrecht, G | 1 |
| Louis, E | 1 |
| Rahier, JF | 1 |
| Dewit, O | 1 |
| Muls, V | 1 |
| Holvoet, T | 1 |
| Vandermeulen, L | 1 |
| Peeters, A | 1 |
| Gonzales, GB | 1 |
| Bos, S | 1 |
| Laukens, D | 1 |
| De Vos, M | 1 |
| Siopi, E | 1 |
| Chevalier, G | 1 |
| Katsimpardi, L | 1 |
| Saha, S | 1 |
| Bigot, M | 1 |
| Moigneu, C | 1 |
| Eberl, G | 1 |
| Lledo, PM | 1 |
| Azam, B | 1 |
| Wienecke, J | 1 |
| Jensen, DB | 1 |
| Azam, A | 1 |
| Zhang, M | 1 |
| Bono, G | 1 |
| Micieli, G | 1 |
| Sances, G | 1 |
| Calvani, M | 1 |
| Nappi, G | 1 |
| al Mardini, H | 1 |
| Harrison, EJ | 1 |
| Ince, PG | 1 |
| Bartlett, K | 1 |
| Record, CO | 1 |
| Ribeiro, CA | 1 |
| Esteban, S | 1 |
| Moranta, D | 1 |
| Sastre-Coll, A | 1 |
| Miralles, A | 1 |
| García-Sevilla, JA | 1 |
| Bigelow, LB | 1 |
| Walls, P | 1 |
| Gillin, JC | 1 |
| Wyatt, RJ | 2 |
| Joly, P | 1 |
| Lampert, A | 1 |
| Thomine, E | 1 |
| Lauret, P | 1 |
| Grollman, A | 1 |
| Krishnamurty, VS | 1 |
| Kaplan, J | 1 |
| Vaughan, T | 1 |
| Mena, I | 1 |
| Court, J | 1 |
| Fuenzalida, S | 1 |
| Papavasiliou, PS | 1 |
| Cotzias, GC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicentric, Double-blind, Placebo Controlled Clinical Trial With 5-hydroxytryptophan (5-HTP) in Patients With Inflammatory Bowel Disease in Clinical and Biologic Remission: Effect on Fatigue Scores[NCT03574948] | Phase 2 | 175 participants (Actual) | Interventional | 2018-12-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for 5-hydroxytryptophan and Chronic Illness
| Article | Year |
|---|---|
Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial.
Topics: 5-Hydroxytryptophan; Chronic Disease; Fatigue; Humans; Inflammatory Bowel Diseases; Serotonin; Trypt | 2022 |
L-5HTP treatment in primary headaches: an attempt at clinical identification of responsive patients.
Topics: 5-Hydroxytryptophan; Adult; Anxiety; Chronic Disease; Clinical Trials as Topic; Depression; Female; | 1984 |
L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. For the Portuguese Head Society.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Chronic Disease; Double-Blind Method; Female; Humans; Incide | 2000 |
Clinical effects of L-5-hydroxytryptophan administration in chronic schizophrenic patients.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Chlorpromazine; Chronic Disease; Clinical Trials | 1979 |
Tolerance and dependence to serotonin. A speculation.
Topics: 5-Hydroxytryptophan; Adult; Animals; Brain Chemistry; Cats; Chronic Disease; Clinical Trials as Topi | 1973 |
Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Chronic Disease; Dihydroxyphenylalanine; Humans; Male; Manga | 1970 |
6 other studies available for 5-hydroxytryptophan and Chronic Illness
| Article | Year |
|---|---|
Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Cell Differentiation; Chronic Disease; Depressi | 2020 |
Spinal Cord Hemisection Facilitates Aromatic L-Amino Acid Decarboxylase Cells to Produce Serotonin in the Subchronic but Not the Chronic Phase.
Topics: 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Carbidopa; Chronic Disease; Hind | 2015 |
Brain indoles in human hepatic encephalopathy.
Topics: 5-Hydroxytryptophan; Adult; Aged; Brain; Chronic Disease; Female; Hepatic Encephalopathy; Humans; Hy | 1993 |
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Cerebral Cor | 2002 |
Development of pseudobullous morphea and scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Aged; Carbidopa; Chronic Disease; Depression; Drug Therapy, Combination; Eosino | 1991 |
Contractile response of the aorta of the normotensive and acute and chronic hypertensive rat.
Topics: 5-Hydroxytryptophan; Acute Disease; Animals; Aorta; Blood Pressure; Calcium; Chronic Disease; Dose-R | 1973 |