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5-hydroxytryptophan and Cancer of Liver

5-hydroxytryptophan has been researched along with Cancer of Liver in 14 studies

5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.

Research Excerpts

Treatment

ExcerptReference
"MRI detected more liver metastases than 5-HTP PET/CT."( Ahlström, H; Caballero-Corbalán, J; Carlbom, L; Eriksson, B; Granberg, D; Sörensen, J, 2017)
"Six patients with midgut carcinoid metastases were examined with 11C-5-HTP PET before and 1 h after oral administration of 100 or 200 mg of CD."( Bergström, M; Eriksson, B; Långström, B; Lu, L; Oberg, K; Orlefors, H; Sundin, A, 2006)
"Three of 30 patients (10%) with carcinoid tumors metastatic to the liver had large hepatic pseudocysts."( Dent, GA; Feldman, JM, 1984)
"Carcinoid tumors with liver metastases, especially those of midgut origin, produce serotonin via the precursors tryptophan and 5-hydroxytryptophan (5-HTP) and this overproduction contributes to the clinical symptoms of the carcinoid syndrome."( Ahlström, H; Bergström, M; Eriksson, B; Långström, B; Lilja, A; Oberg, K, 1993)
"In three patients with carcinoid liver and/or lymph node metastases, we studied the process of tumor tracer uptake and decarboxylation by means of positron emission tomography (PET) using 5-hydroxy-L-tryptophan (5-HTP) 11C-labeled in the beta-position (HTP) and later the same day with 5-HTP 11C-labeled in the carboxyl group (HTC)."( Bergström, M; Bjurling, P; Eriksson, B; Långström, B; Lindner, KJ; Oberg, K; Sundin, A, 2000)
"Four of the 23 patients with the carcinoid syndrome (15%) had markedly elevated excretion of 5-hydroxytryptophan."( Feldman, JM, 1978)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19908 (57.14)18.7374
1990's2 (14.29)18.2507
2000's2 (14.29)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carlbom, L1
Caballero-Corbalán, J1
Granberg, D1
Sörensen, J1
Eriksson, B5
Ahlström, H3
Norlén, O1
Nilsson, A1
Krause, J1
Stålberg, P1
Hellman, P1
Sundin, A3
BIRKENHAEGER, JC1
GRAHAME-SMITH, DG2
HALE, JF1
LANE-MITCHELL, W1
Orlefors, H1
Lu, L1
Oberg, K4
Långström, B4
Bergström, M4
Dent, GA1
Feldman, JM2
Lilja, A2
Bjurling, P2
Lindner, KJ2
Lipsett, MB1
Porst, H1
Naas, W1
Renger, F1
Dökert, B1
Platzbecker, H1

Reviews

1 review(s) available for 5-hydroxytryptophan and Cancer of Liver

ArticleYear
Progress report: the carcinoid syndrome.
    Gut, 1970, Volume: 11, Issue:2

    Topics: 5-Hydroxytryptophan; Antineoplastic Agents; Bradykinin; Diarrhea; Heart Valve Diseases; Humans; Hydroxyindoleacetic Acid; Kallikreins; Liver Neoplasms; Malignant Carcinoid Syndrome; Methyldopa; Methysergide; Neoplasm Metastasis; Phenoxybenzamine; Phenylalanine; Serotonin

1970

Trials

4 trial(s) available for 5-hydroxytryptophan and Cancer of Liver

ArticleYear
11C-5-hydroxytryptophan positron emission tomography after radiofrequency ablation of neuroendocrine tumor liver metastases.
    Nuclear medicine and biology, 2012, Volume: 39, Issue:6

    Topics: 5-Hydroxytryptophan; Ablation Techniques; Carbon Radioisotopes; Follow-Up Studies; Humans; Liver Neoplasms; Neuroendocrine Tumors; Positron-Emission Tomography; Radio Waves

2012
Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography.
    European journal of nuclear medicine and molecular imaging, 2006, Volume: 33, Issue:1

    Topics: 5-Hydroxytryptophan; Carbidopa; Carbon Radioisotopes; Carcinoid Tumor; Female; Humans; Image Enhancement; Liver Neoplasms; Lymphatic Metastasis; Male; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity

2006
Positron emission tomography (PET) in neuroendocrine gastrointestinal tumors.
    Acta oncologica (Stockholm, Sweden), 1993, Volume: 32, Issue:2

    Topics: 5-Hydroxytryptophan; Adenoma, Islet Cell; Carbon Radioisotopes; Carcinoid Tumor; Female; Gastrointestinal Neoplasms; Humans; Hydroxyindoleacetic Acid; Liver Neoplasms; Lung Neoplasms; Male; Malignant Carcinoid Syndrome; Neoplasms; Neurosecretory Systems; Pancreatic Neoplasms; Serotonin; Tomography, Emission-Computed

1993
Positron-emission tomography as a radiological technique in neuroendocrine gastrointestinal tumors.
    Annals of the New York Academy of Sciences, 1994, Sep-15, Volume: 733

    Topics: 5-Hydroxytryptophan; Carbon Radioisotopes; Carcinoid Tumor; Gastrointestinal Neoplasms; Humans; Interferon-alpha; Liver Neoplasms; Lymphatic Metastasis; Neuroendocrine Tumors; Octreotide; Pancreatic Neoplasms; Tomography, Emission-Computed

1994

Other Studies

9 other study(ies) available for 5-hydroxytryptophan and Cancer of Liver

ArticleYear
Whole-body MRI including diffusion-weighted MRI compared with 5-HTP PET/CT in the detection of neuroendocrine tumors.
    Upsala journal of medical sciences, 2017, Volume: 122, Issue:1

    Topics: 5-Hydroxytryptophan; Adult; Aged; Bone Neoplasms; Contrast Media; Diffusion Magnetic Resonance Imaging; Female; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neuroendocrine Tumors; Positron Emission Tomography Computed Tomography; Sensitivity and Specificity; Whole Body Imaging

2017
METASTASIZING NEUROBLASTOMA WITH EXCRETION OF 5-HYDROXYINDOLEACETIC ACID, SEROTONIN AND 5-HYDROXYTRYPTOPHAN.
    Acta medica Scandinavica, 1963, Volume: 174

    Topics: 5-Hydroxytryptophan; Abdominal Neoplasms; Chromatography; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Liver Neoplasms; Neoplasm Metastasis; Neuroblastoma; Pathology; Serotonin; Tryptophan; Urine

1963
TRYPTOPHAN HYDROXYLATION IN CARCINOID TUMOURS.
    Biochimica et biophysica acta, 1964, Apr-04, Volume: 86

    Topics: 5-Hydroxytryptophan; Amines; Autoradiography; Carbon Isotopes; Carboxy-Lyases; Carcinoid Tumor; Chromatography; Hydroxylation; Indoles; Liver Neoplasms; Metabolism; Monoamine Oxidase; Neoplasm Metastasis; Pharmacology; Research; Serotonin; Tryptophan

1964
THE CARCINOID SYNDROME. CASE REPORT AND REVIEW.
    The Central African journal of medicine, 1964, Volume: 10

    Topics: 5-Hydroxytryptophan; Antineoplastic Agents; Appendectomy; Drug Therapy; Humans; Liver Neoplasms; Malignant Carcinoid Syndrome; Neoplasm Metastasis; Neoplasms; Zimbabwe

1964
Pseudocystic liver metastases in patients with carcinoid tumors: report of three cases.
    American journal of clinical pathology, 1984, Volume: 82, Issue:3

    Topics: 5-Hydroxytryptophan; Adenocarcinoma; Adrenocorticotropic Hormone; Adult; Aged; Blood Platelets; Carcinoid Tumor; Cysts; Female; Humans; Liver Neoplasms; Male; Middle Aged; Serotonin; Tomography, X-Ray Computed; Ultrasonography

1984
Demonstration of [11C] 5-hydroxy-L-tryptophan uptake and decarboxylation in carcinoid tumors by specific positioning labeling in positron emission tomography.
    Nuclear medicine and biology, 2000, Volume: 27, Issue:1

    Topics: 5-Hydroxytryptophan; Antineoplastic Agents; Carbon Radioisotopes; Carcinoid Tumor; Decarboxylation; Female; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Regression Analysis; Tomography, Emission-Computed

2000
Serotonin metabolism in patients with carcinoid tumors: incidence of 5-hydroxytryptophan-secreting tumors.
    Gastroenterology, 1978, Volume: 75, Issue:6

    Topics: 5-Hydroxytryptophan; Adult; Aged; Carcinoid Tumor; Female; Gastrointestinal Neoplasms; Humans; Hydroxyindoleacetic Acid; Liver Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Serotonin; Tryptamines; Tyramine

1978
Humoral syndromes associated with cancer.
    Cancer research, 1965, Volume: 25, Issue:7

    Topics: 5-Hydroxytryptophan; Carcinoid Tumor; Carcinoma, Hepatocellular; Carotid Body Tumor; Catecholamines; Cushing Syndrome; Endocrine System Diseases; Female; Fibrosarcoma; Humans; Hyperthyroidism; Hypoglycemia; Hyponatremia; Liver Neoplasms; Lung Neoplasms; Male; Neoplasms; Polycythemia Vera; Puberty, Precocious; Vasopressins

1965
[Carcinoid and carcinoid syndrome].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1974, Aug-01, Volume: 29, Issue:15

    Topics: 5-Hydroxytryptophan; Bradykinin; Carcinoid Tumor; Female; Gastrointestinal Neoplasms; Hepatomegaly; Humans; Kallikreins; Liver Neoplasms; Malignant Carcinoid Syndrome; Middle Aged; Neoplasm Metastasis; Prostaglandins; Radiography; Serotonin; Skin Manifestations; Tryptophan

1974