5-hydroxytryptophan has been researched along with Bipolar Disorder in 30 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serum cortisol levels were significantly increased following administration of 5-hydroxytryptophan (5-HTP), 200 mg orally, to patients with affective disorders." | 9.05 | Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate. ( Goodnick, P; Lowy, M; Meltzer, HY; Perline, R; Robertson, A, 1984) |
| "Serum cortisol levels were significantly higher after administration of 5-hydroxytryptophan (5-HTP), 200 mg orally, in unmedicated patients with affective disorders than in controls." | 9.05 | Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. II. Relation to suicide, psychosis, and depressive symptoms. ( Lowy, M; Meltzer, HY; Perline, R; Robertson, A; Tricou, BJ, 1984) |
| "Serum cortisol levels were significantly increased following administration of 5-hydroxytryptophan (5-HTP), 200 mg orally, to patients with affective disorders." | 5.05 | Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate. ( Goodnick, P; Lowy, M; Meltzer, HY; Perline, R; Robertson, A, 1984) |
| "Serum cortisol levels were significantly higher after administration of 5-hydroxytryptophan (5-HTP), 200 mg orally, in unmedicated patients with affective disorders than in controls." | 5.05 | Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. II. Relation to suicide, psychosis, and depressive symptoms. ( Lowy, M; Meltzer, HY; Perline, R; Robertson, A; Tricou, BJ, 1984) |
| "In an open study 25 depressed patients were treated with L-5-hydroxytryptophan (L-5-HTP) either alone or in combination with a peripheral decarboxylase inhibitor." | 1.27 | L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression. ( Battegay, R; Gastpar, M; Zmilacher, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (93.33) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuda, K | 1 |
| Meltzer, HY | 6 |
| van Praag, HM | 2 |
| Lowy, M | 3 |
| Robertson, A | 3 |
| Goodnick, P | 1 |
| Perline, R | 3 |
| Mendlewicz, J | 1 |
| Youdim, MB | 1 |
| Umberkoman-Wiita, B | 1 |
| Tricou, BJ | 2 |
| Westenberg, HG | 1 |
| de Jong, JT | 1 |
| Thijssen, JH | 1 |
| Maes, M | 1 |
| Calabrese, J | 1 |
| Jayathilake, K | 1 |
| Poitou, P | 1 |
| Boulu, R | 1 |
| Bohuon, C | 1 |
| Benkert, O | 1 |
| Luchins, D | 1 |
| Murphy, DL | 1 |
| Campbell, IC | 1 |
| Costa, JL | 1 |
| Praag, HM | 1 |
| Wirz-Justice, A | 1 |
| Nakajima, T | 1 |
| Kudo, Y | 1 |
| Kaneko, Z | 1 |
| Kaneko, M | 1 |
| Kumashiro, H | 1 |
| Takahashi, Y | 1 |
| Hoshino, Y | 1 |
| Tissot, R | 2 |
| Mikhalenko, IN | 1 |
| Kiseleva, LP | 1 |
| Lapin, IP | 1 |
| Takahashi, S | 2 |
| Amamoto, T | 1 |
| Sarai, K | 1 |
| López-Ibor, JJ | 1 |
| Saiz-Ruiz, J | 1 |
| Pérez de los Cobos, JC | 1 |
| Riederer, P | 1 |
| Beckmann, H | 1 |
| Brücke, T | 1 |
| Metz, JT | 1 |
| Holcomb, HH | 1 |
| Zmilacher, K | 1 |
| Battegay, R | 1 |
| Gastpar, M | 1 |
| Goodnick, PJ | 1 |
| Fieve, RR | 1 |
| Schlegel, A | 1 |
| Williams, RH | 1 |
| Sano, I | 1 |
| Kondo, H | 1 |
| Yoshimura, M | 1 |
| Ochi, Y | 1 |
| Yoshimi, T | 1 |
4 reviews available for 5-hydroxytryptophan and Bipolar Disorder
| Article | Year |
|---|---|
Serotonergic function in the affective disorders: the effect of antidepressants and lithium on the 5-hydroxytryptophan-induced increase in serum cortisol.
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depr | 1984 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
The brain serotonergic system in the affective disorders.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Animals; Bipolar Disorder; Brain; Brain Chemistry; Fencloni | 1978 |
The common pathophysiology of monaminergic psychoses: a new hypothesis.
Topics: 5-Hydroxytryptophan; Amino Acids; Biological Transport, Active; Bipolar Disorder; Blood-Brain Barrie | 1975 |
6 trials available for 5-hydroxytryptophan and Bipolar Disorder
| Article | Year |
|---|---|
In search of the mode of action of antidepressants: 5-HTP/tyrosine mixtures in depression.
Topics: 5-Hydroxytryptophan; Adult; Antidepressive Agents; Biogenic Amines; Bipolar Disorder; Clinical Trial | 1984 |
Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. III. Effect of antidepressants and lithium carbonate.
Topics: 5-Hydroxytryptophan; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depr | 1984 |
Antidepressant potentiation of 5-hydroxytryptophan by L-deprenil in affective illness.
Topics: 5-Hydroxytryptophan; Adult; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Drug Therapy | 1980 |
Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. II. Relation to suicide, psychosis, and depressive symptoms.
Topics: 5-Hydroxytryptophan; Bipolar Disorder; Depressive Disorder; Humans; Hydrocortisone; Mood Disorders; | 1984 |
Studies on pituitary hormones and releasing hormones in depression and sexual impotence.
Topics: 5-Hydroxytryptophan; Benserazide; Bipolar Disorder; Clinical Trials as Topic; Depression; Erectile D | 1975 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
21 other studies available for 5-hydroxytryptophan and Bipolar Disorder
| Article | Year |
|---|---|
Integrated theory to unify status among schizophrenia and manic depressive illness.
Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biopterins; Bipolar Dis | 2015 |
Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders. I. Enhanced response in depression and mania.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adult; Bipolar Disorder; Brain Chemistry; Depressive Diso | 1984 |
Postsynaptic serotonergic activity in depressive patients: evaluation of the neuroendocrine strategy.
Topics: 5-Hydroxytryptophan; Adult; Bipolar Disorder; Blood Glucose; Depressive Disorder; Female; Growth Hor | 1982 |
Effects of subchronic treatment with valproate on L-5-HTP-induced cortisol responses in mania: evidence for increased central serotonergic neurotransmission.
Topics: 5-Hydroxytryptophan; Adult; Animals; Bipolar Disorder; Dose-Response Relationship, Drug; Female; Hum | 1997 |
Effect of lithium and other drugs on the amphetamine chlordiazeposice hyperactivity in mice.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Bipolar Disorder; Brain Chemistry; Chlordiazepoxide; Dise | 1975 |
The Harold E. Himwich Memorial Lecture. Significance of biochemical parameters in the diagnosis, treatment, and prevention of depressive disorders.
Topics: 5-Hydroxytryptophan; Antidepressive Agents, Tricyclic; Autopsy; Bipolar Disorder; Brain Chemistry; C | 1977 |
Theoretical and therapeutic potential of indolamine precursors in affective disorders.
Topics: 5-Hydroxytryptophan; Amino Acids; Bipolar Disorder; Depression; Emotions; Female; Humans; Levodopa; | 1977 |
Clinical evaluation of 5-hydroxy-L-tryptophan as an antidepressant drug.
Topics: 5-Hydroxytryptophan; Adjustment Disorders; Adult; Aged; Antidepressive Agents; Bipolar Disorder; Dru | 1978 |
L-5HTP treatment and serum 5-HT level after L-5-HTP loading on depressed patients.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Bipolar Disorder; Female; Humans; Male; Middle Aged; Seroton | 1979 |
[Hypothetical concept: the physiopathological entity of monoaminergic psychoses].
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Behavior, Animal; Bipolar Disorder; Blood-Brain Barrier; | 1975 |
[Absecence of the antidepressant action of lithium under clinical and experimental conditions].
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Drug Interaction | 1976 |
Reduction of blood platelet serotonin levels in manic and depressed patients.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Bipolar Disorder; Blood Platelets; Depression; Female; | 1976 |
On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adult; Bipolar Disorder; Female; Humans; Hydroxyindoleace | 1976 |
Biological correlations of suicide and aggressivity in major depressions (with melancholia): 5-hydroxyindoleacetic acid and cortisol in cerebral spinal fluid, dexamethasone suppression test and therapeutic response to 5-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Adult; Aggression; Bipolar Disorder; Carbidopa; Depressive Disorder; Dexamethas | 1985 |
[Current biochemical hypotheses of endogenous depression].
Topics: 5-Hydroxytryptophan; Amitriptyline; Autopsy; Biogenic Amines; Bipolar Disorder; Brain; Depressive Di | 1985 |
Effect of 5-hydroxytryptophan on H-reflex recovery curves in normal subjects and patients with affective disorders.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Antidepressive Agents; Arousal; Bipolar Disorder; Brain; Dep | 1988 |
L-5-hydroxytryptophan alone and in combination with a peripheral decarboxylase inhibitor in the treatment of depression.
Topics: 5-Hydroxytryptophan; Adult; Aged; Benserazide; Bipolar Disorder; Depressive Disorder; Dose-Response | 1988 |
Lithium discontinuation, serum cortisol, and 5-HTP.
Topics: 5-Hydroxytryptophan; Adult; Bipolar Disorder; Brain; Female; Humans; Hydrocortisone; Lithium; Male; | 1987 |
Metabolism and mentation.
Topics: 5-Hydroxytryptophan; Acetylcholine; Amino Acid Metabolism, Inborn Errors; Aminobutyrates; Basal Gang | 1970 |
[L-5-hydroxytryptophan(L-5-HTP) therapy in endogenous depression. 1].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Benzoates; Bipolar Disorder; Child; Depression; Female | 1972 |
Growth hormone responses to administration of L-5-hydroxytryptophan (L-5-HTP) in manic-depressive psychoses.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Bipolar Disorder; Blood Glucose; Femal | 1973 |