5-hydroxytryptophan has been researched along with Benign Infantile Myoclonic Epilepsy in 10 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A patient with Lafora disease reported enough improvement in myoclonus-evoked convulsions to continue chronic use of the drug." | 2.68 | Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan. ( Ashwal, S; Bodensteiner, J; Franz, D; Haas, RH; Huang, Y; Pranzatelli, MR; Tate, E, 1995) |
| "To study the role of serotonin in the ataxia of progressive myoclonus epilepsy, eight patients received oral 5-hydroxy-L-tryptophan (L-5-HTP) or placebo plus carbidopa for 1 month in a controlled, double-blinded, dose-ranging, cross-over, add-on study." | 2.68 | A controlled trial of 5-hydroxy-L-tryptophan for ataxia in progressive myoclonus epilepsy. ( Galvan, I; Pranzatelli, MR; Tate, E; Wheeler, A, 1996) |
| "Ataxia was evaluated using objective and subjective scales." | 2.68 | A controlled trial of 5-hydroxy-L-tryptophan for ataxia in progressive myoclonus epilepsy. ( Galvan, I; Pranzatelli, MR; Tate, E; Wheeler, A, 1996) |
| "Progressive myoclonus epilepsy is a syndrome confused with myoclonic seizures and other epilepsies." | 2.38 | The clinical challenge of progressive myoclonus epilepsy. ( Tate, E, 1993) |
| "The data suggest that this rat cardiac arrest model may be a valuable tool for investigating the pathophysiologic mechanisms of posthypoxic myoclonus and for developing new therapeutic strategies for treating the disorder." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "The auditory-induced myoclonus continues to worsen, reaches a peak about 2 weeks after the arrest, then declines over time to subnormal levels." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "In 18 patients with intention myoclonus due to anoxia or other brain damage, 11 derived more than 50% overall improvement during treatment with L-5HTP and carbidopa." | 1.26 | Long-term therapy of myoclonus and other neurologic disorders with L-5-hydroxytryptophan and carbidopa. ( Bowers, MB; Howieson, J; Rosenbaum, D; Van Woert, MH, 1977) |
| "The neurochemical basis of myoclonus responding to 5HT precursors and clonazepam is discussed." | 1.26 | Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam. ( Chadwick, D; Hallett, M; Harris, R; Jenner, P; Marsden, CD; Reynolds, EH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schutte, RJ | 1 |
| Schutte, SS | 1 |
| Algara, J | 1 |
| Barragan, EV | 1 |
| Gilligan, J | 1 |
| Staber, C | 1 |
| Savva, YA | 1 |
| Smith, MA | 1 |
| Reenan, R | 1 |
| O'Dowd, DK | 1 |
| Pranzatelli, MR | 2 |
| Tate, E | 3 |
| Huang, Y | 1 |
| Haas, RH | 1 |
| Bodensteiner, J | 1 |
| Ashwal, S | 1 |
| Franz, D | 1 |
| Truong, DD | 1 |
| Matsumoto, RR | 1 |
| Schwartz, PH | 1 |
| Hussong, MJ | 1 |
| Wasterlain, CG | 1 |
| Hagan, JJ | 1 |
| Hatcher, JP | 1 |
| Slade, PD | 1 |
| Galvan, I | 1 |
| Wheeler, A | 1 |
| Van Woert, MH | 1 |
| Rosenbaum, D | 1 |
| Howieson, J | 1 |
| Bowers, MB | 1 |
| Chadwick, D | 1 |
| Hallett, M | 1 |
| Harris, R | 1 |
| Jenner, P | 1 |
| Reynolds, EH | 1 |
| Marsden, CD | 1 |
| Seyal, M | 1 |
| Koskiniemi, M | 1 |
| Laakso, J | 1 |
| Kuurne, T | 1 |
| Laipio, M | 1 |
| Härkönen, M | 1 |
1 review available for 5-hydroxytryptophan and Benign Infantile Myoclonic Epilepsy
| Article | Year |
|---|---|
The clinical challenge of progressive myoclonus epilepsy.
Topics: 5-Hydroxytryptophan; Child; Epilepsies, Myoclonic; Female; Humans; Piracetam; Quality of Life | 1993 |
2 trials available for 5-hydroxytryptophan and Benign Infantile Myoclonic Epilepsy
| Article | Year |
|---|---|
Neuropharmacology of progressive myoclonus epilepsy: response to 5-hydroxy-L-tryptophan.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Carbidopa; Cross-Over Studies; Double-Blind Method; Drug The | 1995 |
A controlled trial of 5-hydroxy-L-tryptophan for ataxia in progressive myoclonus epilepsy.
Topics: 5-Hydroxytryptophan; Administration, Oral; Adolescent; Adult; Ataxia; Double-Blind Method; Epilepsie | 1996 |
7 other studies available for 5-hydroxytryptophan and Benign Infantile Myoclonic Epilepsy
| Article | Year |
|---|---|
Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current.
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Brain; Drosophila; Epilepsies, Myoclonic; GABAergic | 2014 |
Novel rat cardiac arrest model of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Ani | 1994 |
The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; CHO Cells; Cricetinae; Epileps | 1995 |
Long-term therapy of myoclonus and other neurologic disorders with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Brain; Carbidopa; Drug Therapy, Combination; Epilepsie | 1977 |
Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Benzodiazepinones; Carbidopa; Child, Preschool; Clonaz | 1977 |
Cortical reflex myoclonus. A study of the relationship between giant somatosensory evoked potentials and motor excitability.
Topics: 5-Hydroxytryptophan; Adult; Cerebral Cortex; Electric Stimulation; Electromyography; Epilepsies, Myo | 1991 |
Indole levels in human lumbar and ventricular cerebrospinal fluid and the effect of L-tryptophan administration.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Anticonvulsants; Child; Chromatography, High Pressure | 1985 |