5-hydroxytryptophan has been researched along with BH4 Deficiency in 50 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Severe 6-pyruvoyl-tetrahydrobiopterin synthase deficiency is a tetrahydrobiopterin deficiency disorder that presents in infancy with developmental delay, seizures, and abnormal movements associated with hyperphenylalaninemia usually detectable by neonatal phenylketonuria screening programs." | 3.73 | 6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia. ( Blau, N; Connolly, MB; Demos, MK; Hyland, K; Lillquist, Y; Makhseed, N; Vallance, HD; Waters, PJ, 2005) |
| "6-Pyruvoyl-tetrahydropterin synthase (PTPS) deficiency is the most important type of BH4 deficiency related to hyperphenylalaninemia." | 3.73 | Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency. ( Cheng, LY; Chiu, PC; Hsiao, KJ; Lee, NC; Liu, TT; Niu, DM, 2006) |
| "A total of 38 cases were diagnosed as BH4 deficiency, all of them were revealed as 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency from the extremely decreased urine biopterin, normal DHPR activities and drop down of blood phenylalanine level to normal range within 4 to 8 hours after BH4 loading." | 3.73 | [Study on tetrahydrobiopterin deficiency in Northern Chinese population]. ( Chang, M; Fu, GX; He, C; Hsiao, KJ; Li, XW; Liu, TT; Shen, M; Shen, S; Wang, L; Yu, WM; Zhao, SP, 2006) |
| " Dietary restriction of phenylalanine and oral administration of amine precursors, L-dopa and 5-hydroxytryptophan had poor efficiency on epilepsy and psychomotor delay." | 3.70 | [Progressive convulsive encephalopathy: considering a abnormality of biopterin metabolism]. ( Dhondt, JL; Mikaeloff, Y; Pinton, F; Ponsot, G; Sevin, C, 1999) |
| " All patients received tetrahydrobiopterin replacement in a daily dosage between approximately 2 and 4 mg/kg." | 2.73 | Long-term follow-up of Taiwanese Chinese patients treated early for 6-pyruvoyl-tetrahydropterin synthase deficiency. ( Cheng, LY; Hsiao, KJ; Lee, NC; Liu, KM; Liu, TT; Niu, DM, 2008) |
| "The patients with BH4 deficiency were treated with BH4 and neurotransmitter after diagnosis." | 1.42 | Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China. ( Cao, Z; Han, B; Liu, Y; Zhu, W; Zou, H, 2015) |
| "40 cases with BH4 deficiency were identified and all classified as PTPS deficiency between 2004 and 2012 in Shandong province, China." | 1.42 | Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China. ( Cao, Z; Han, B; Liu, Y; Zhu, W; Zou, H, 2015) |
| "Our study emphasized that screening for BH4 deficiency should be carried out in all patients with HPA in order to minimize misdiagnosis." | 1.42 | Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China. ( Cao, Z; Han, B; Liu, Y; Zhu, W; Zou, H, 2015) |
| "Although phenylketonuria (PKU) is the most common genetic cause of mental retardation, the cellular mechanisms underlying impaired brain function are still unclear." | 1.37 | 5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria. ( Andolina, D; Cabib, S; Conversi, D; Pascucci, T; Puglisi-Allegra, S; Trabalza, A; Ventura, R, 2011) |
| " This report suggests that serum prolactin levels can be a good biomarker for optimal dosage of hydroxylated precursors in long-term treatment monitoring." | 1.35 | Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients. ( Concolino, D; Moricca, MT; Muzzi, G; Pascale, MG; Rapsomaniki, M; Strisciuglio, P, 2008) |
| "Hyperphenylalaninaemias with tetrahydrobiopterin deficiency make up about 1-3% of all hyperphenylalaninaemias." | 1.35 | Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients. ( Concolino, D; Moricca, MT; Muzzi, G; Pascale, MG; Rapsomaniki, M; Strisciuglio, P, 2008) |
| "A total of 38 cases were diagnosed as BH4 deficiency, all of them were revealed as 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency from the extremely decreased urine biopterin, normal DHPR activities and drop down of blood phenylalanine level to normal range within 4 to 8 hours after BH4 loading." | 1.33 | [Study on tetrahydrobiopterin deficiency in Northern Chinese population]. ( Chang, M; Fu, GX; He, C; Hsiao, KJ; Li, XW; Liu, TT; Shen, M; Shen, S; Wang, L; Yu, WM; Zhao, SP, 2006) |
| "The differential diagnosis for BH4 deficiency should be carried out in all patients with HPA." | 1.33 | [Study on tetrahydrobiopterin deficiency in Northern Chinese population]. ( Chang, M; Fu, GX; He, C; Hsiao, KJ; Li, XW; Liu, TT; Shen, M; Shen, S; Wang, L; Yu, WM; Zhao, SP, 2006) |
| "The most common forms of BH4 deficiency are 6-pyruvoyl-tetrahydropterin synthase (PTPS) deficiency (MIM 261640) and dihydropteridine reductase (DHPR) deficiency (MIM 261630), which require a different treatment from classical HPA." | 1.31 | Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese. ( Chiang, SH; Hsiao, KJ; Liu, TT; Wu, SJ, 2001) |
| "The high incidence of BH4 deficiency in the Taiwanese population may be explained by a founder effect, since all of the patients revealed 6-pyruvoyltetrahydropterin synthase gene mutations, and grouping N52S and P87S mutations together constituted 88." | 1.31 | Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations. ( Chiang, SC; Chien, YH; Chiu, YN; Chou, SP; Chu, SY; Huang, A; Hwu, WL; Lin, JM; Wang, TR, 2001) |
| "We report a child in whom dihydropteridine reductase deficiency was diagnosed prenatally because of an affected sibling and who was treated from birth with apparent good response." | 1.28 | Successful treatment of dihydropteridine reductase deficiency, with an interesting effect of 5-hydroxytryptophan deficiency on sleep patterns. ( Cotton, RG; Earl, JW; Lipson, AH; O'Halloran, M; Wilcken, B; Yu, JS, 1991) |
| "The mechanism of folinic acid action in DHPR deficiency may be to increase indirectly the synthesis of 5-methyltetrahydrofolate." | 1.27 | Folinic acid therapy in treatment of dihydropteridine reductase deficiency. ( Butler, IJ; Irons, M; Kaufman, S; Langlais, PJ; Levy, HL; Milstien, S; O'Flynn, ME; Stack, CV, 1987) |
| "It is postulated that the seizures and neurological deterioration of the patient were related to a deficiency in the synthesis of biogenic amine neurotransmitters." | 1.26 | Biogenic amine synthesis defect in dihydropteridine reductase deficiency. ( Butler, IJ; Koslow, SH, 1977) |
| "A child with phenylketonuria had normal phenylalanine hydroxylase activity in vitro." | 1.26 | Atypical phenylketonuria with normal phenylalanine hydroxylase and dihydropteridine reductase activity in vitro. ( Bartholomé, K; Byrd, DJ; Kaufman, S; Milstien, S, 1977) |
| "An experimental phenylketonuria-like syndrome was produced in rats by oral administration of 1-phenylalanine (Phe, 500 mg/kg) and dl-p-chloro-phenylalanine (pCPA, 100-125 mg/kg) daily from the 2nd-3rd day of life to the age of 42 days." | 1.25 | Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats. ( Airaksinen, MM; MacDonald, EJ; Marvola, M; Turakka, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (62.00) | 18.7374 |
| 1990's | 4 (8.00) | 18.2507 |
| 2000's | 12 (24.00) | 29.6817 |
| 2010's | 3 (6.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Han, B | 2 |
| Zou, H | 1 |
| Zhu, W | 1 |
| Cao, Z | 1 |
| Liu, Y | 1 |
| Pascucci, T | 3 |
| Andolina, D | 2 |
| Mela, IL | 1 |
| Conversi, D | 2 |
| Latagliata, C | 1 |
| Ventura, R | 3 |
| Puglisi-Allegra, S | 3 |
| Cabib, S | 3 |
| Trabalza, A | 1 |
| Dill, P | 1 |
| Wagner, M | 1 |
| Somerville, A | 1 |
| Thöny, B | 1 |
| Blau, N | 4 |
| Weber, P | 1 |
| HSIA, DY | 3 |
| NISHIMURA, K | 1 |
| BRENCHLEY, Y | 1 |
| PERRY, TL | 2 |
| TISCHLER, B | 1 |
| WOOLLEY, DW | 2 |
| VANDERHOEVEN, T | 1 |
| JUSTICE, P | 1 |
| YUWILER, A | 1 |
| GELLER, E | 1 |
| SLATER, GG | 1 |
| LING, GM | 1 |
| HANSEN, S | 1 |
| MACDOUGALL, L | 1 |
| Peng, SS | 1 |
| Tseng, WY | 1 |
| Chien, YH | 2 |
| Hwu, WL | 2 |
| Liu, HM | 1 |
| Capistrano-Estrada, SB | 1 |
| Nyhan, WL | 1 |
| Demos, MK | 1 |
| Waters, PJ | 1 |
| Vallance, HD | 1 |
| Lillquist, Y | 1 |
| Makhseed, N | 1 |
| Hyland, K | 1 |
| Connolly, MB | 1 |
| Lee, NC | 2 |
| Cheng, LY | 2 |
| Liu, TT | 4 |
| Hsiao, KJ | 4 |
| Chiu, PC | 1 |
| Niu, DM | 2 |
| Wang, L | 1 |
| Yu, WM | 1 |
| Li, XW | 1 |
| He, C | 1 |
| Chang, M | 1 |
| Shen, M | 1 |
| Zhao, SP | 1 |
| Fu, GX | 1 |
| Shen, S | 1 |
| Sedel, F | 1 |
| Ribeiro, MJ | 1 |
| Remy, P | 1 |
| Saudubray, JM | 1 |
| Agid, Y | 1 |
| Liu, KM | 1 |
| Concolino, D | 1 |
| Muzzi, G | 1 |
| Rapsomaniki, M | 1 |
| Moricca, MT | 1 |
| Pascale, MG | 1 |
| Strisciuglio, P | 1 |
| Beck, B | 1 |
| Brandt, NJ | 1 |
| Christensen, E | 1 |
| Niederwieser, A | 3 |
| Pedersen, PS | 1 |
| Endres, W | 1 |
| Curtius, HC | 1 |
| Wang, M | 1 |
| Ohrt, B | 1 |
| Schaub, J | 1 |
| Salomon, F | 1 |
| Fagioli, I | 1 |
| Rey, F | 1 |
| Salzarulo, P | 1 |
| Piel, N | 1 |
| Lane, JD | 1 |
| Hüther, G | 1 |
| Neuhoff, V | 4 |
| Tsukada, Y | 2 |
| Takamatsu, K | 1 |
| Goldstein, DS | 1 |
| Hahn, SH | 1 |
| Holmes, C | 1 |
| Tifft, C | 1 |
| Harvey-White, J | 1 |
| Milstien, S | 4 |
| Kaufman, S | 5 |
| Dhondt, JL | 2 |
| Mikaeloff, Y | 1 |
| Pinton, F | 1 |
| Sevin, C | 1 |
| Ponsot, G | 1 |
| Chiang, SH | 1 |
| Wu, SJ | 1 |
| Chiang, SC | 1 |
| Huang, A | 1 |
| Lin, JM | 1 |
| Chiu, YN | 1 |
| Chou, SP | 1 |
| Chu, SY | 1 |
| Wang, TR | 1 |
| Koslow, SH | 2 |
| Butler, IJ | 3 |
| Krumholz, A | 1 |
| Holtzman, NA | 1 |
| Bartholomé, K | 2 |
| Byrd, DJ | 2 |
| Airaksinen, MM | 1 |
| Turakka, H | 1 |
| Marvola, M | 1 |
| MacDonald, EJ | 1 |
| Luchins, D | 1 |
| Brewster, TG | 1 |
| Moskowitz, MA | 1 |
| Breslow, JL | 1 |
| Abroms, IF | 1 |
| Kohsaka, S | 1 |
| Schafer, EW | 1 |
| McKean, CM | 1 |
| Lipson, AH | 1 |
| Earl, JW | 1 |
| Wilcken, B | 1 |
| Yu, JS | 1 |
| O'Halloran, M | 1 |
| Cotton, RG | 1 |
| Ponzone, A | 1 |
| Guardamagna, O | 1 |
| Ferraris, S | 1 |
| Biasetti, S | 1 |
| Bracco, G | 1 |
| Irons, M | 1 |
| Levy, HL | 1 |
| O'Flynn, ME | 1 |
| Stack, CV | 1 |
| Langlais, PJ | 1 |
| Cohen, BE | 1 |
| Szeinberg, A | 1 |
| Quint, J | 1 |
| Normand, M | 1 |
| Blonder, J | 1 |
| Peled, I | 1 |
| Pare, CM | 1 |
| Costil, J | 1 |
| Galli, J | 1 |
| Richardet, JM | 1 |
| Brissaud, HE | 1 |
| Quentin, CD | 3 |
| Behbehani, AW | 2 |
| Schulte, FJ | 2 |
| Loo, YH | 1 |
| Behbehani, A | 1 |
| Prinz, H | 1 |
| Van der Hoeven, T | 1 |
3 reviews available for 5-hydroxytryptophan and BH4 Deficiency
| Article | Year |
|---|---|
[Correlation between monoamine content in the brain and discriminative learning ability (author's transl)].
Topics: 5-Hydroxytryptophan; Animals; Biogenic Amines; Brain; Discrimination Learning; Humans; Macaca mulatt | 1981 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
Biochemical factors in mental retardation.
Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Diet Therapy; Female; Guinea Pigs; Haplorhini; Humans | 1967 |
3 trials available for 5-hydroxytryptophan and BH4 Deficiency
| Article | Year |
|---|---|
Long-term follow-up of Taiwanese Chinese patients treated early for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Asian People; Child; Child, Preschool; Female; Humans; Infan | 2008 |
Atypical phenylketonuria due to biopterin deficiency. Early treatment with tetrahydrobiopterin and neurotransmitter precursors, trials of monotherapy.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Clinical Trials as Topic; Humans; Infant; Levodopa; Male | 1982 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
45 other studies available for 5-hydroxytryptophan and BH4 Deficiency
| Article | Year |
|---|---|
Diagnosis, treatment and follow-up of patients with tetrahydrobiopterin deficiency in Shandong province, China.
Topics: 5-Hydroxytryptophan; Biopterins; Child, Preschool; China; Follow-Up Studies; Genotype; Humans; Infan | 2015 |
5-Hydroxytryptophan rescues serotonin response to stress in prefrontal cortex of hyperphenylalaninaemic mice.
Topics: 5-Hydroxytryptophan; Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Diet, | 2009 |
5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Cognition; Cognition Disorders; Critical Period, Psy | 2011 |
Child neurology: paroxysmal stiffening, upward gaze, and hypotonia: hallmarks of sepiapterin reductase deficiency.
Topics: 5-Hydroxytryptophan; Alcohol Oxidoreductases; Behavior; Benserazide; Consanguinity; Developmental Di | 2012 |
Deficits in brain serotonin synthesis in a genetic mouse model of phenylketonuria.
Topics: 5-Hydroxytryptophan; Animals; Blood-Brain Barrier; Brain; Disease Models, Animal; Female; Genotype; | 2002 |
MECHANISMS FOR THE DECREASE OF BRAIN SEROTONIN.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Blood Chemical Analysis; Brain; Carboxy-Lyases; Diet | 1963 |
5-HYDROXYTRYPTOPHAN ADMINISTRATION IN PHENYLKETONURIA.
Topics: 5-Hydroxytryptophan; Biomedical Research; Brain; Child; Diet; Electroencephalography; Humans; Indole | 1964 |
PREVENTION OF A MENTAL DEFECT OF PHENYLKETONURIA WITH SEROTONIN CONGENERS SUCH AS MELATONIN OR HYDROXYTRYPTOPHAN.
Topics: 5-Hydroxytryptophan; Animals; Biomedical Research; Indoles; Learning; Melatonin; Mice; Pharmacology; | 1964 |
STUDIES ON INHIBITION OF BRAIN 5-HYDROXYTRYPTOPHAN DECARBOXYLASE BY PHENYLALANINE METABOLITES.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Antimetabolites; Aromatic-L-Amino-Acid Decarboxylases; Br | 1965 |
ON THE MECHANISM OF THE BRAIN SEROTONIN DEPLETION IN EXPERIMENTAL PHENYLKETONURIA.
Topics: 5-Hydroxytryptophan; Adrenal Glands; Ascorbic Acid; Blood; Brain; Brain Chemistry; Carboxy-Lyases; C | 1965 |
UNIMPAIRED LEARNING ABILITY OF RATS MADE ARTIFICIALLY PHENYLKETONURIC DURING FETAL OR NEONATAL LIFE.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Brain Chemistry; Diet; Discrimination Learning; Fetu | 1965 |
Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment.
Topics: 5-Hydroxytryptophan; Axons; Biopterins; Brain Damage, Chronic; Cerebral Cortex; Child; Child, Presch | 2004 |
6-pyruvoyl tetrahydropterin synthase deficiency: a case report.
Topics: 5-Hydroxytryptophan; Biopterins; Dihydroxyphenylalanine; Female; Humans; Infant, Newborn; Neonatal S | 2003 |
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Cerebral Palsy; Child; Developmental Disabilities; Diagn | 2005 |
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Asian People; Biopterins; Child; Child, Preschool; China; Fe | 2006 |
[Study on tetrahydrobiopterin deficiency in Northern Chinese population].
Topics: 5-Hydroxytryptophan; Asian People; Biopterins; Child, Preschool; China; Dihydropteridine Reductase; | 2006 |
Dihydropteridine reductase deficiency: levodopa's long-term effectiveness without dyskinesia.
Topics: 5-Hydroxytryptophan; Adult; Antidepressive Agents, Second-Generation; Dopamine Agents; Drug Combinat | 2006 |
Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients.
Topics: 5-Hydroxytryptophan; Aromatic Amino Acid Decarboxylase Inhibitors; Biomarkers; Carbidopa; Child, Pre | 2008 |
Diagnostic and therapeutic aspects of dihydrobiopterin deficiency.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Chromatography, High Pressure Liquid; Dihydroxyphenylala | 1983 |
Sleep patterns in the "new variant" phenylketonuria.
Topics: 5-Hydroxytryptophan; Dopamine; Humans; Infant; NADH, NADPH Oxidoreductases; Phenylketonurias; Sleep | 1981 |
Impaired permeability of the blood-cerebrospinal fluid barrier in hyperphenylalaninaemia.
Topics: 5-Hydroxytryptophan; Animals; Biological Transport, Active; Blood-Brain Barrier; Brain Chemistry; Ca | 1982 |
Monoaminergic effects of folinic acid, L-DOPA, and 5-hydroxytryptophan in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Monoamines; Humans; Infant; Leucovorin; Levodopa; Male; Phenylketonuri | 1995 |
Tetrahydrobiopterin deficiency and an international database of patients.
Topics: 5-Hydroxytryptophan; Alcohol Oxidoreductases; Biomarkers; Biopterins; Carbidopa; Child; Dihydropteri | 1993 |
[Progressive convulsive encephalopathy: considering a abnormality of biopterin metabolism].
Topics: 5-Hydroxytryptophan; Algeria; Anticonvulsants; Biopterins; Brain; Child, Preschool; Consanguinity; D | 1999 |
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
Topics: 5-Hydroxytryptophan; Biopterins; Diagnosis, Differential; Dihydropteridine Reductase; Female; Geneti | 2001 |
Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations.
Topics: 5-Hydroxytryptophan; Base Sequence; Biopterins; DNA Mutational Analysis; Founder Effect; Humans; Inf | 2001 |
Biogenic amine synthesis defect in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Carbidopa; Dopamine; Homovanillic Acid; Humans; Hydroxyindolea | 1977 |
A disorder of biogenic amines in dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Biogenic Amines; Brain; Child, Preschool; Homovanillic Acid; Humans; Hydroxyind | 1978 |
Letter: L-dopa and 5-hydroxytryptophan therapy in phenylketonuria with normal phenylalanine-hydroxylase activity.
Topics: 5-Hydroxytryptophan; Carbidopa; Drug Therapy, Combination; Humans; Infant; Levodopa; Phenylalanine H | 1975 |
Protective effect of tryptophan and 5-hydroxytryptophan on experimental phenylketonuria induced with phenylalanine+ p-cholorophenylalanine in rats.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Body Weight; Brain; Female; Fenclonine; Humans; Hydr | 1975 |
Atypical phenylketonuria with normal phenylalanine hydroxylase and dihydropteridine reductase activity in vitro.
Topics: 5-Hydroxytryptophan; Dihydropteridine Reductase; Humans; Infant, Newborn; Levodopa; Liver; Male; NAD | 1977 |
Dihydropteridine reductase deficiency associated with severe neurologic disease and mild hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Ascorbic Acid; Consanguinity; Dopamine; Humans; Infant; Levodopa; Liver; Male; | 1979 |
Neurochemical and behavioral studies on the experimental phenylketonuric rats.
Topics: 5-Hydroxytryptophan; Animals; Brain Chemistry; Discrimination Learning; DNA; Humans; Hydroxyindoleac | 1979 |
Evidence that monoamines influence human evoked potentials.
Topics: 5-Hydroxytryptophan; Adolescent; Biogenic Amines; Dihydroxyphenylalanine; Evoked Potentials; Female; | 1975 |
Successful treatment of dihydropteridine reductase deficiency, with an interesting effect of 5-hydroxytryptophan deficiency on sleep patterns.
Topics: 5-Hydroxytryptophan; Female; Humans; Levodopa; Male; Phenylketonurias; Pregnancy; Prenatal Diagnosis | 1991 |
Neurotransmitter therapy and diet in malignant phenylketonuria.
Topics: 5-Hydroxytryptophan; Carbidopa; Combined Modality Therapy; Female; Homovanillic Acid; Humans; Hydrox | 1987 |
Folinic acid therapy in treatment of dihydropteridine reductase deficiency.
Topics: 5-Hydroxytryptophan; Brain; Carbidopa; Drug Therapy, Combination; Female; Folic Acid; Humans; Infant | 1987 |
Malignant phenylketonuria due to defective synthesis of dihydrobiopterin.
Topics: 5-Hydroxytryptophan; Biopterins; Carbidopa; Drug Combinations; Female; Humans; Infant, Newborn; Levo | 1985 |
5-hydroxyindoles in phenylketonuric and nonphenylketonuric mental defectives.
Topics: 5-Hydroxytryptophan; Animals; Biological Transport; Carboxy-Lyases; Child; Down Syndrome; Humans; Hy | 1968 |
[Urinary excretion of 5-hydroxyindoleacetic acid. II. In children with phenylketonuria, effects of 5-hydroxytryptophan].
Topics: 5-Hydroxytryptophan; Administration, Oral; Child, Preschool; Female; Humans; Hydroxyindoleacetic Aci | 1973 |
Microanalysis with 14C-dansyl chloride of amino acids and amines in the cerebrospinal fluid of patients with phenylketonuria. I. Analysis in untreated phenylketonuria.
Topics: 5-Hydroxytryptophan; Amines; Amino Acids; Autoradiography; Carbon Radioisotopes; Chlorides; Chromato | 1974 |
Serotonin deficiency in experimental hyperphenylalaninemia.
Topics: 5-Hydroxytryptophan; Animals; Biphenyl Compounds; Brain; Carbon Radioisotopes; Carboxy-Lyases; Dopa | 1974 |
Identification of 5-hydroxytryptophan by dansylation in the cerebrospinal fluid of children with phenylketonuria.
Topics: 5-Hydroxytryptophan; Child; Chromatography, Thin Layer; Dansyl Compounds; Humans; Phenylketonurias; | 1974 |
Microanalysis with 14-C-dansyl chloride of amino acids and amines in the cerebrospinal fluid of patients with phenylketonuria. II. Determination of 5-hydroxyindole derivatives after loading with L-phenylalanine.
Topics: 5-Hydroxytryptophan; Amines; Amino Acids; Autoradiography; Carbon Radioisotopes; Child; Child, Presc | 1974 |
Serotonin deficiency in infancy as a cause of a mental defect in experimental phenylketonuria.
Topics: 5-Hydroxytryptophan; Animals; Animals, Newborn; Chlorpromazine; Electroshock; Female; Humans; In Vit | 1965 |