5-hydroxytryptophan has been researched along with Alzheimer Disease in 6 studies
5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serotonin (5-HT), its precursor 5-hydroxytryptophan (5-HTP), and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in the cerebrospinal fluid (CSF) of 14 patients with dementia of the Alzheimer type (DAT) and in nine controls by high-performance liquid chromatography with a novel multisensor coulometric detection system." | 7.67 | Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid. ( Gamache, PH; Langlais, PJ; Mark, KA; Matson, WR; Volicer, L, 1985) |
| "Serotonin (5-HT), its precursor 5-hydroxytryptophan (5-HTP), and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) were measured in the cerebrospinal fluid (CSF) of 14 patients with dementia of the Alzheimer type (DAT) and in nine controls by high-performance liquid chromatography with a novel multisensor coulometric detection system." | 3.67 | Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid. ( Gamache, PH; Langlais, PJ; Mark, KA; Matson, WR; Volicer, L, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borroni, E | 1 |
| Bohrmann, B | 1 |
| Grueninger, F | 1 |
| Prinssen, E | 1 |
| Nave, S | 1 |
| Loetscher, H | 1 |
| Chinta, SJ | 1 |
| Rajagopalan, S | 1 |
| Rane, A | 1 |
| Siddiqui, A | 1 |
| Ellenbroek, B | 1 |
| Messer, J | 1 |
| Pähler, A | 1 |
| Andersen, JK | 1 |
| Wyler, R | 1 |
| Cesura, AM | 1 |
| Klein, C | 1 |
| Roussel, G | 1 |
| Brun, S | 1 |
| Rusu, C | 1 |
| Patte-Mensah, C | 1 |
| Maitre, M | 1 |
| Mensah-Nyagan, AG | 1 |
| Matson, WR | 2 |
| Langlais, P | 1 |
| Volicer, L | 2 |
| Gamache, PH | 2 |
| Bird, E | 1 |
| Mark, KA | 2 |
| Wright, CI | 1 |
| Guela, C | 1 |
| Mesulam, MM | 1 |
| Meyer, JS | 1 |
| Welch, KM | 1 |
| Deshmukh, VD | 1 |
| Perez, FI | 1 |
| Jacob, RH | 1 |
| Haufrect, DB | 1 |
| Mathew, NT | 1 |
| Morrell, RM | 1 |
| Langlais, PJ | 1 |
6 other studies available for 5-hydroxytryptophan and Alzheimer Disease
| Article | Year |
|---|---|
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease.
Topics: 5-Hydroxytryptophan; Acetamides; Alzheimer Disease; Animals; Astrocytes; Gliosis; Humans; Hypertensi | 2017 |
5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease.
Topics: 5-Hydroxytryptophan; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anima | 2018 |
n-Electrode three-dimensional liquid chromatography with electrochemical detection for determination of neurotransmitters.
Topics: 5-Hydroxytryptophan; Alzheimer Disease; Brain Chemistry; Chromatography, Liquid; Electrochemistry; E | 1984 |
Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease.
Topics: 5-Hydroxytryptophan; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Biogenic Monoamines; Brain | 1993 |
Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease.
Topics: 5-Hydroxytryptophan; Aged; Alzheimer Disease; Carbidopa; Dementia; Dopamine; Drug Combinations; Fema | 1977 |
Serotoninergic system in dementia of the Alzheimer type. Abnormal forms of 5-hydroxytryptophan and serotonin in cerebrospinal fluid.
Topics: 5-Hydroxytryptophan; Aged; Alzheimer Disease; Dementia; Humans; Hydroxyindoleacetic Acid; Middle Age | 1985 |