Page last updated: 2024-10-16

5-hydroxytryptophan and Aging

5-hydroxytryptophan has been researched along with Aging in 54 studies

5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The 5-hydroxytryptophan-induced rise was prevented by the serotonergic antagonist cyproheptadine but not by the dopaminergic antagonist haloperidol."1.26Maturation of central nervous system control of growth hormone secretion in rats. ( Kuhn, CM; Schanberg, SM, 1981)

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-199033 (61.11)18.7374
1990's12 (22.22)18.2507
2000's6 (11.11)29.6817
2010's2 (3.70)24.3611
2020's1 (1.85)2.80

Authors

AuthorsStudies
Ahn, Y1
Hong, KB1
Kim, S1
Suh, HJ1
Jo, K1
Reddy, MY1
Jagota, A1
Esteban, S1
Garau, C1
Aparicio, S1
Moranta, D1
Barceló, P1
Ramis, M1
Tresguerres, JA1
Rial, R1
Kitahama, K1
Jouvet, A1
Fujimiya, M1
Nagatsu, I1
Arai, R1
Turner, BJ1
Lopes, EC1
Cheema, SS1
McDonald, LM1
Moran, PM1
Vythelingum, GN1
Joseph, MH1
Stephenson, JD1
Gray, JA1
Kubera, M1
Kenis, G1
Bosmans, E1
Kajta, M1
Basta-Kaim, A1
Scharpe, S1
Budziszewska, B1
Maes, M1
Shintani, N1
Hashimoto, H1
Tanaka, K1
Kawagishi, N1
Kawaguchi, C1
Hatanaka, M1
Ago, Y1
Matsuda, T1
Baba, A1
Goldman-Rakic, PS1
Brown, RM1
Walker, RF1
Baker, PC1
Goodrich, CA1
Ruckebusch, Y1
Bardon, T1
Goodrich, C3
Wilk, C1
Mellblom, L1
Kuhn, CM2
Schanberg, SM1
Mato, M1
Ookawara, S1
Aikawa, E1
Kawasaki, K1
Ibrahim, MZ1
Koshayan, DS1
Tucker, A1
Greenlees, KJ1
Wright, ML1
Migally, N1
London, ED1
Waller, SB1
Vocci, FJ1
Buterbaugh, GG1
Seki, T1
Kikuyama, S1
Yanaihara, N1
Aguilar, E1
Ranchal, A1
Tena-Sempere, M1
Pinilla, L1
Ling, L1
Bach, KB1
Mitchell, GS1
Saland, LC1
Samora, A1
Sanchez, P1
Chavez, G1
Míguez, JM1
Recio, J1
Sánchez-Barceló, E1
Aldegunde, M1
MohanKumar, PS1
MohanKumar, SM1
Quadri, SK1
Voogt, JL1
Shishkina, GT1
Dygalo, NN1
Sze, PY1
McNamara, MC1
Miller, AT1
Benignus, VA1
Davis, JN1
Breese, GR1
Vogel, RA1
Mueller, RA1
Clineschmidt, BV1
Zacchei, AG1
Totaro, JA1
Pflueger, AB1
McGuffin, JC1
Wishousky, TI1
Tissari, AH2
Raunu, EM1
Kellogg, C1
Mokler, DJ1
Sullivan, SA1
Winterson, BJ1
Montilla, P1
Salcedo, M1
Muñoz, MC1
Montilla, MC1
Vizuete, ML1
Santiago, M2
Herrera, AJ1
Venero, JL2
Machado, A3
Cano, J3
Ben-Harari, RR1
Parent Ermini, A1
Kleinerman, J1
McIntyre, IM1
Oxenkrug, GF1
Koulu, M1
Saavedra, JM1
Bjelogrlic, N1
Niwa, M1
Agren, H1
Linnoila, M1
Reinoso-Suárez, F1
Becú-Villalobos, D1
Lacau-Mengido, IM1
Libertun, C1
Justo, SN1
Rossano, GL1
Szwarcfarb, B1
Rubio, MC1
Moguilevsky, JA1
Lechner, R1
Slone, W1
Johnston, CA1
Negro-Vilar, A1
Bero, LA1
Lucot, JB1
Seiden, LS1
Eble, JP1
Denoroy, L1
Tappaz, ML1
Fety, R1
Vincent, M1
Renaud, B1
Sassard, J1
Engel, JA1
Rydberg, U1
Smith, MD1
Wainwright, SD1
Lloyd, KG1
Hornykiewicz, O1
Hernandez, J1
Illnerová, H1

Reviews

2 reviews available for 5-hydroxytryptophan and Aging

ArticleYear
Glucocorticoid regulation of the serotonergic system of the brain.
    Advances in biochemical psychopharmacology, 1976, Volume: 15

    Topics: 5-Hydroxytryptophan; Adrenalectomy; Aging; Animals; Brain; Carboxy-Lyases; Ethanol; Glucocorticoids;

1976
Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny.
    Medical biology, 1975, Volume: 53, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Biological Transport, Active; Brain; Imiprami

1975

Other Studies

52 other studies available for 5-hydroxytryptophan and Aging

ArticleYear
Changes in Locomotor Activity and Oxidative Stress-Related Factors after the Administration of an Amino Acid Mixture by Generation and Age.
    International journal of molecular sciences, 2021, Sep-10, Volume: 22, Issue:18

    Topics: 5-Hydroxytryptophan; Aging; Amino Acids; Animals; Central Nervous System; Disease Models, Animal; ga

2021
Melatonin has differential effects on age-induced stoichiometric changes in daily chronomics of serotonin metabolism in SCN of male Wistar rats.
    Biogerontology, 2015, Volume: 16, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Chronobiology Phenomena; Circadian Rhythm; Hydroxyindoleacetic

2015
Improving effects of long-term growth hormone treatment on monoaminergic neurotransmission and related behavioral tests in aged rats.
    Rejuvenation research, 2010, Volume: 13, Issue:6

    Topics: 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Aromatic-L-Amino-

2010
5-Hydroxytryptophan (5-HTP) uptake and decarboxylation in the kitten brain.
    Journal of neural transmission (Vienna, Austria : 1996), 2002, Volume: 109, Issue:5-6

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Cats; Decarboxylation; Drug Combinatio

2002
The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis.
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2003, Volume: 4, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Alanine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Body

2003
Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning.
    Psychopharmacology, 2003, Volume: 169, Issue:3-4

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamine; Analysis of Varianc

2003
Stimulatory effect of antidepressants on the production of IL-6.
    International immunopharmacology, 2004, Volume: 4, Issue:2

    Topics: 5-Hydroxytryptophan; Adult; Age Factors; Aging; Antidepressive Agents; Blood Cells; Cyclohexanols; D

2004
Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-).
    Annals of the New York Academy of Sciences, 2006, Volume: 1070

    Topics: 5-Hydroxytryptophan; Aging; Animals; Behavior, Animal; Fluoxetine; Mice; Mice, Knockout; Physical Co

2006
Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys.
    Neuroscience, 1981, Volume: 6, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Animals; Biogenic Amines; Cerebral Cortex; Dopamine; Female; Macaca mula

1981
Reinstatement of LH surges by serotonin neuroleptics in aging, constant estrous rats.
    Neurobiology of aging, 1982,Fall, Volume: 3, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Castration; Estradi

1982
The effects of the specific uptake inhibitor Lu 10-171 (citalopram) upon brain indoleamine stores in the maturing mouse.
    General pharmacology, 1982, Volume: 13, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Brain; Citalopram; Hydrazines; Hydroxyindoleacetic Acid; Mice;

1982
[The motoricity cycle of the small intestine].
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1984, Volume: 298, Issue:14

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Cattle; Electric Conductivity; Female; Fenclo

1984
Temperature preferences and the effect of changes in serotonin in maturing mice.
    Physiology & behavior, 1981, Volume: 26, Issue:6

    Topics: 5-Hydroxytryptophan; Aging; Animals; Choice Behavior; Fenclonine; Mice; Serotonin; Temperature

1981
A quantitative cytochemical study of the growth of individual mast cells.
    Cell and tissue research, 1980, Volume: 208, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Cell Survival; Heparin; Male; Mast Cells; Rats; Serotonin

1980
Maturation of central nervous system control of growth hormone secretion in rats.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Central Nervous System; Clonidine; Female; Growth Hormone; Male

1981
Studies on fluorescent granular perithelium (F.G.P.) of rat cerebral cortex - especially referring to morphological changes in aging.
    Anatomischer Anzeiger, 1981, Volume: 149, Issue:5

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Blood Vessels; Cerebral Cortex; Dioxoles; Lev

1981
The mast cells of the mammalian central nervous system. VIII. Uptake of 35S and 3H-5-hydroxytryptophan inside and outside of CNS.
    Cell and tissue research, 1981, Volume: 220, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Central Nervous System; Glycosaminoglycans; Guinea Pigs; Liver;

1981
Altered vascular responsiveness in isolated perfused lungs from aging rats.
    Experimental lung research, 1982, Volume: 3, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Angiotensin II; Animals; Blood Pressure; Dose-Response Relationship, Dru

1982
Age-dependent reduction in maximum electroshock convulsive threshold associated with decreased concentrations of brain monoamines.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:3

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Biogenic Amines; Brain Chemistry; Elec

1982
In vitro development of Xenopus skin glands producing 5-hydroxytryptamine and caerulein.
    Experientia, 1995, Nov-15, Volume: 51, Issue:11

    Topics: 5-Hydroxytryptophan; Aging; Animals; Cells, Cultured; Ceruletide; Kinetics; Norepinephrine; Sebaceou

1995
Serotoninergic control of prolactin secretion in prepubertal male rats.
    European journal of endocrinology, 1994, Volume: 131, Issue:5

    Topics: 5-Hydroxytryptophan; Aging; Androstane-3,17-diol; Animals; Fluoxetine; Hydroxyindoleacetic Acid; Mal

1994
Phrenic responses to contralateral spinal stimulation in rats: effects of old age or chronic spinal hemisection.
    Neuroscience letters, 1995, Mar-16, Volume: 188, Issue:1

    Topics: 5-Hydroxytryptophan; Age Factors; Aging; Animals; Electric Stimulation; Evoked Potentials; Functiona

1995
Immunocytochemical studies of tryptophan hydroxylase, tyrosine hydroxylase, and serotonin innervation in the aging rat neurointermediate pituitary.
    Experimental neurology, 1993, Volume: 121, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Immunohistochemistry; Male; Pituitary Gland; Rats; Rats, Inbred

1993
Changes with age in daytime and nighttime contents of melatonin, indoleamines, and catecholamines in the pineal gland: a comparative study in rat and Syrian hamster.
    Journal of pineal research, 1998, Volume: 25, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Catecholamines; Circadian Rhyth

1998
Responsiveness of tuberoinfundibular dopaminergic neurons to 5-hydroxytryptophan: effects of aging.
    Endocrine, 1998, Volume: 9, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Arcuate Nucleus of Hypothalamus; Dopamine; Female; Neurons; Ova

1998
Role of the serotoninergic system in the acceleration of sexual maturation in wild Norway rats selected for reduced aggressiveness toward humans.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2000, Volume: 125, Issue:1

    Topics: 5-Hydroxytryptophan; Aggression; Aging; Animals; Epididymis; Female; Fenclonine; Humans; Hypothalamu

2000
Age related changes in the effect of electroconvulsive shock (ECS) on the in vivo hydroxylation of tyrosine and tryptophan in rat brain.
    Brain research, 1977, Aug-12, Volume: 131, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benzyl Alcohols;

1977
Biochemical and behavioral alterations in developing rats treated with 5,7-dihydroxytryptamine.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:3

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Avoidance Learning; Behavior, Animal;

1978
Fenfluramine and brain serotonin.
    Annals of the New York Academy of Sciences, 1978, Jun-12, Volume: 305

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Dealkylation; Dihydroxyphenylalanine;

1978
Subcellular distribution of 5-hydroxytryptamine in rat brain during development: effect of drugs and fasting.
    Journal of neurochemistry, 1975, Volume: 24, Issue:6

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Fasting; Pargyline; Rats; Reserpine; S

1975
Audiogenic seizures: relation to age and mechanisms of monoamine neurotransmission.
    Brain research, 1976, Apr-16, Volume: 106, Issue:1

    Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Aging; Animals; Benserazide; Brain; Catecholamines; Dihyd

1976
Behaviors induced by 5-hydroxytryptophan in neonatal, preweaning, postweaning, and adult Sprague-Dawley rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:3

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Animals,

1992
[Cerebral serotonin and the hypothalamo-hypophyseal-adrenal system of the rat during aging].
    Revista espanola de fisiologia, 1991, Volume: 47, Issue:4

    Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aging; Animals; Brain; Brain Chemistry; Corticoste

1991
Effects of neonatal bilateral eye enucleation on postnatal development of the monoamines in posterior thalamus of the rat.
    Journal of neural transmission. General section, 1991, Volume: 85, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Aromatic Amino Acid Decarboxylase Inhibitors;

1991
Lung concentrations of 5-hydroxytryptamine, tryptophan, 5-hydroxytryptophan and 5-hydroxyindole acetic acid in rats of different ages.
    Pulmonary pharmacology, 1991, Volume: 4, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Hydroxyindoleacetic Acid; Lung; Male; Organ Size; Rats; Rats, I

1991
Age effects on monoamine turnover of the rat substantia nigra.
    Brain research, 1991, Aug-23, Volume: 557, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxyla

1991
Effect of ageing on melatonin synthesis induced by 5-hydroxytryptophan and constant light in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1991, Volume: 15, Issue:4

    Topics: 5-Hydroxytryptophan; Aging; Animals; Light; Male; Melatonin; Pineal Gland; Rats; Rats, Inbred Strain

1991
Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats.
    Brain research, 1986, Aug-06, Volume: 379, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Animals; Hydroxyindoleacetic Acid; Hypertension; Hypothalamus; Kinetics;

1986
Changes in biogenic amines in rat hippocampus during development and aging.
    Life sciences, 1988, Volume: 42, Issue:24

    Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Dopamine; Hippocampus; Homovani

1988
Developmental changes in FSH secretion induced by 5-hydroxytryptophan, naloxone and haloperidol in male and female rats.
    Brain research. Developmental brain research, 1989, Jun-01, Volume: 47, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Animals; Female; Follicle Stimulating Hormone; Haloperidol; Male; Naloxo

1989
Effect of serotoninergic system on FSH secretion in male and female rats: evidence for stimulatory and inhibitory actions.
    Neuroendocrinology, 1989, Volume: 50, Issue:4

    Topics: 5-Hydroxytryptophan; Aging; Animals; Castration; Female; Follicle Stimulating Hormone; Hypothalamus;

1989
Central versus peripheral effects on temperature preference and body temperature following alteration of 5-HT in maturing mice.
    Physiology & behavior, 1989, Volume: 46, Issue:2

    Topics: 5-Hydroxytryptophan; Aging; Amidines; Animals; Behavior, Animal; Body Temperature; Body Temperature

1989
Maturation of the prolactin and proopiomelanocortin-derived peptide responses to ether stress and morphine: neurochemical analysis.
    Endocrinology, 1986, Volume: 118, Issue:2

    Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Aging; Animals; Animals, Newborn; beta-Endorphin;

1986
Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Corticosterone; Cyproheptadine; Fluoxetine; G

1987
Effects of serotonergic agonists and antagonists on the locomotor activity of neonatal rats.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Cinanserin; Female; Methiothepin; Methysergid

1986
The maturational onset of the 5-HT mediated head twitch in mice.
    Physiology & behavior, 1987, Volume: 41, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Carbidopa; Female; Humans; Male; Mice; Motor Activity; Pargylin

1987
Rate of tryptophan hydroxylation in vivo in brain nuclei of genetically hypertensive rats of the Lyon strain.
    Experientia, 1985, Apr-15, Volume: 41, Issue:4

    Topics: 5-Hydroxytryptophan; Aging; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain; Hydrazines

1985
Age-dependent effects of ethanol on central monoamine synthesis in the male rat.
    Acta pharmacologica et toxicologica, 1985, Volume: 57, Issue:5

    Topics: 5-Hydroxytryptophan; Aging; Animals; Biogenic Amines; Brain; Dihydroxyphenylalanine; Ethanol; Male;

1985
5-Hydroxytryptophan decarboxylase (5-HTPD) and monoamine oxidase (MAO) in the maturing mouse eye.
    Comparative and general pharmacology, 1973, Volume: 4, Issue:14

    Topics: 5-Hydroxytryptophan; Aging; Animals; Carbon Radioisotopes; Carboxy-Lyases; Eye; Mice; Mice, Inbred S

1973
Development of hydroxytryptophan decarboxylase activity in the pineal gland, cerebral hemispheres, and cerebellum of the chick embryo and young chick.
    Canadian journal of biochemistry, 1974, Volume: 52, Issue:3

    Topics: 5-Hydroxytryptophan; Aging; Animals; Brain; Carbon Radioisotopes; Cerebellum; Chick Embryo; Chickens

1974
Occurrence and distribution of aromatic L-amino acid (L-DOPA) decarboxylase in the human brain.
    Journal of neurochemistry, 1972, Volume: 19, Issue:6

    Topics: 5-Hydroxytryptophan; Aged; Aging; Animals; Basal Ganglia; Brain; Carbon Isotopes; Cats; Cattle; Caud

1972
5-hydroxytryptophan decarboxylase activity in the rat pineal gland during the first 20 days of postnatal life: effect of light.
    Neuroendocrinology, 1970, Volume: 6, Issue:5

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Carboxy-Lyases; Light; Pineal Gland; Radiatio

1970