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5-hydroxytryptophan and African Sleeping Sickness

5-hydroxytryptophan has been researched along with African Sleeping Sickness in 1 studies

5-Hydroxytryptophan: The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
5-hydroxytryptophan : A tryptophan derivative that is tryptophan substituted by a hydroxy group at position 5.

Research Excerpts

ExcerptRelevanceReference
"5-hydroxytryptophan is an important metabolite in the serotonin synthetic pathway, the key pathway in determining somnolence, thus offering a possible link to the eponymous symptoms of "sleeping sickness"."1.43Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016)
"Neopterin is an inflammatory biomarker previously shown in CSF of stage 2 but not stage 1 patients."1.43Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016)
"Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the blood-brain barrier in the cerebrospinal fluid (CSF))."1.43Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis. ( Barrett, MP; Biéler, S; Bisser, S; Cattanach, AM; Courtioux, B; Daly, R; Ndung'u, JM; Vincent, IM, 2016)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vincent, IM1
Daly, R1
Courtioux, B1
Cattanach, AM1
Biéler, S1
Ndung'u, JM1
Bisser, S1
Barrett, MP1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP4 Early Test-of-cure[NCT03112655]88 participants (Actual)Interventional2017-02-24Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

1 other study available for 5-hydroxytryptophan and African Sleeping Sickness

ArticleYear
Metabolomics Identifies Multiple Candidate Biomarkers to Diagnose and Stage Human African Trypanosomiasis.
    PLoS neglected tropical diseases, 2016, Volume: 10, Issue:12

    Topics: 5-Hydroxytryptophan; Adolescent; Adult; Biomarkers; Blood-Brain Barrier; Female; Humans; Male; Metab

2016