5-hydroxymethylfurfural and Leukemia--Basophilic--Acute

5-hydroxymethylfurfural has been researched along with Leukemia--Basophilic--Acute* in 1 studies

Other Studies

1 other study(ies) available for 5-hydroxymethylfurfural and Leukemia--Basophilic--Acute

Article	Year
Isolation of 5-(hydroxymethyl)furfural from Lycium chinense and its inhibitory effect on the chemical mediator release by basophilic cells. Planta medica, 2011, Volume: 77, Issue:5 The effect of hot water extracts of LYCIUM CHINENSE fruits (LCF) on the β-hexosaminidase (β-hexo) release by IgE sensitized BSA stimulated rat basophilic leukemia (RBL-2H3) cells was investigated. The ethylacetate (EtOAc) layer of the extract has shown an inhibitory effect on β-hexo release from RBL-2H3 cells at the antigen antibody binding stage. The water (H₂O) fraction (EFW) of the chloroform (CHCl₃) extract from the EtOAc layer also inhibited β-hexo release at the same stage in a dose-dependent manner. With column chromatography preparation, proton and carbon nuclear magnetic resonance (¹H and ¹³C NMR) spectra, electron ionization mass spectrometer (EI-MS) spectra, and high-performance liquid chromatography (HPLC) analysis, the active component was determined to be 5-(hydroxymethyl)furfural (5-HMF). Thus, the 5-HMF showed an inhibitory effect on β-hexo release at the antigen-antibody binding stage and the antibody-receptor binding stage. Furthermore, 5-HMF suppressed [Ca²+] I influx in the IgE-sensitized BSA-stimulated RBL-2H3 cells. Our results show that 5-HMF may be useful for the treatment or prevention of type I allergic diseases. Topics: Animals; Anti-Allergic Agents; Antigen-Antibody Reactions; Basophils; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Dose-Response Relationship, Drug; Fruit; Furaldehyde; Immunoglobulin E; Leukemia, Basophilic, Acute; Lycium; Nuclear Magnetic Resonance, Biomolecular; Plant Extracts; Rats	2011

Article

Year

Isolation of 5-(hydroxymethyl)furfural from Lycium chinense and its inhibitory effect on the chemical mediator release by basophilic cells.

Planta medica, 2011, Volume: 77, Issue:5

The effect of hot water extracts of LYCIUM CHINENSE fruits (LCF) on the β-hexosaminidase (β-hexo) release by IgE sensitized BSA stimulated rat basophilic leukemia (RBL-2H3) cells was investigated. The ethylacetate (EtOAc) layer of the extract has shown an inhibitory effect on β-hexo release from RBL-2H3 cells at the antigen antibody binding stage. The water (H₂O) fraction (EFW) of the chloroform (CHCl₃) extract from the EtOAc layer also inhibited β-hexo release at the same stage in a dose-dependent manner. With column chromatography preparation, proton and carbon nuclear magnetic resonance (¹H and ¹³C NMR) spectra, electron ionization mass spectrometer (EI-MS) spectra, and high-performance liquid chromatography (HPLC) analysis, the active component was determined to be 5-(hydroxymethyl)furfural (5-HMF). Thus, the 5-HMF showed an inhibitory effect on β-hexo release at the antigen-antibody binding stage and the antibody-receptor binding stage. Furthermore, 5-HMF suppressed [Ca²+] I influx in the IgE-sensitized BSA-stimulated RBL-2H3 cells. Our results show that 5-HMF may be useful for the treatment or prevention of type I allergic diseases.

Topics: Animals; Anti-Allergic Agents; Antigen-Antibody Reactions; Basophils; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Dose-Response Relationship, Drug; Fruit; Furaldehyde; Immunoglobulin E; Leukemia, Basophilic, Acute; Lycium; Nuclear Magnetic Resonance, Biomolecular; Plant Extracts; Rats

2011