Page last updated: 2024-08-25

5-hydroxymethylcytosine and Disease Models, Animal

5-hydroxymethylcytosine has been researched along with Disease Models, Animal in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's27 (69.23)24.3611
2020's12 (30.77)2.80

Authors

AuthorsStudies
Bhagat, T; Jacobs, WR; Levine, M; Luchtel, RA; Pradhan, K; Shenoy, N; Verma, A1
Li, L; Li, W; Liu, Z; Miao, M; Qiu, Y; Wang, Q; Zhu, Y1
Chen, JL; Chen, TJ; Chen, YJ; Feng, Y; Li, Q; Li, X; Liu, T; Liu, Y; Wu, TT; Wu, YC; Zhu, XY1
Cao, D; Jiang, D; Li, J; Yu, H; Zhou, D1
Bao, B; Boerner, JL; Bollig-Fischer, A; Dyson, G; Mitrea, C; Teslow, EA1
Chow, HM; Herrup, K; Li, J; Li, L; Ma, Z; Xu, K; Zhang, Y; Zhang, Z1
Cao, S; Hu, J; Li, L; Wang, D; Wang, L; Wu, Q; Zhang, Z1
Green, SJ; Hyde, MV; Maienschein-Cline, M; McLachlan, A; Oropeza, CE; Shalaby, RE; Taha, TY; Tarnow, G1
Chen, J; Cheng, X; Gao, H; Li, X; Liu, N; Qu, W; Shu, Q; Tao, H; Xu, GL; Xu, W; Zhang, J1
Allen, EG; Barwick, BG; Castellino, RC; Chen, J; Chen, L; Conneely, KN; Jin, P; Johnson, ND; Kang, Y; Kenney, AM; Kim, H; Li, J; Li, Y; Liao, X; Lin, L; McSwain, L; Robinson, MH; Shu, Q; Van Meir, EG; Vertino, PM; Yuan, X; Zhang, Z; Zhao, J; Zhu, D1
Allen, EG; Cao, Y; Gu, L; Jin, P; Li, R; Li, Y; Li, Z; Meng, C; Zhu, D1
Lunnon, K; Smith, RG1
Chen, XL; Cuevas-Nunez, MC; Gomes, CBF; Lian, CG; Murphy, GF; Ramsey, MR; Woo, SB; Xu, S; Xu, T; Zhan, Q1
Chen, D; Chen, L; Cheng, Y; Huang, L; Jin, P; Li, Y; Tang, B; Wang, Z; Wu, H; Yao, B; Zhang, W1
Dinulescu, DM; Getchell, CR; Gupta, M; Hasselblatt, KT; Hirsch, MS; Kaplan, SJ; Ko, JY; Lee, JJ; Li, W; Lian, CG; Liu, JF; MacDonald, LA; Malik, A; Matulonis, UA; McCarthy, ET; Medina, JE; Murphy, GF; Ohman, AW; Sasamoto, N; Shafrir, A; Terry, KL; Tucker, DW; Xu, S; Zhang, H1
Bogo, MR; Crippa, JAS; da Silva, VK; de Freitas, BS; Dornelles, VC; Hallak, JE; Kist, LW; Schröder, N; Silva, MC; Streck, EL; Zuardi, AW1
Chen, H; Duan, X; Gan, L; Jaypaul, H; Liu, N; Liu, X; Makamure, JT; Ming, Z; Wang, X; Zhang, S; Zhu, K1
Huang, Y; Jin, L; Lin, S; Ren, A; Wang, L1
Akiyama, N; Kojima, H; Yamamoto-Fukuda, T; Yoshikawa, M1
Guo, C; Han, C; Liao, YQ; Lin, X; Luo, HR; Sun, Q; Tang, TS; Wang, D; Wang, F; Wang, JQ; Wu, YS; Xie, W; Yang, Y; Yang, YG; Zhu, S1
Galloway, JN; Jin, P; Lin, L; Nelson, DL; Street, RC; Wu, H; Yao, B; Zalewski, ZA1
Cowley, AW; Liang, M; Liu, P; Liu, Y; Yang, C1
Arias, C; Bermúdez-Rattoni, F; Cadena-del-Castillo, C; Carmona-Aldana, F; Recillas-Targa, F; Valdes-Quezada, C1
De Sousa, PA; Gliddon, C; Horsburgh, K; Ruzov, A; Tsenkina, Y1
Alisch, RS; Barrett-Wilt, GA; Cengiz, P; Kintner, DB; Li, S; Papale, LA; Sabat, G1
Alisch, RS; Chen, K; Keleş, S; Li, S; Papale, LA; Zhang, Q1
Cao, JL; Ding, HL; Hao, LY; Li, GF; Li, YQ; Ma, T; Pan, Z; Xue, ZY; Zhang, M; Zhu, LJ1
Bao, H; Bernstein, AI; Dai, Q; Duan, R; Gearing, M; He, C; Jin, P; Lah, JJ; Levey, AI; Lin, L; Lin, Y; Mullé, JG; Nelson, PT; Street, RC; Yu, L1
Huang, L; Jin, P; Li, L; Li, X; Lin, L; Shen, H; Shu, L; Sun, W; Xie, P; Xu, Q; Xu, Z1
Alisch, RS; Chen, L; Chopra, P; Jin, P; Keleş, S; Li, S; Madrid, A; Papale, LA; Zhang, Q1
Jiang, ZS; Li, AF; Li, GH; Li, RQ; Liu, LS; Peng, J; Ren, Z; Tang, XQ; Tang, ZH; Wang, Z; Wei, DH; Yang, Q; Zheng, XL1
Li, H; Luan, P; Peng, W; Wang, K; Xu, Y; Zhang, P; Zhuang, J1
Chang, Q; Cheng, X; Dai, Q; Gearing, M; Godley, LA; He, C; Irier, H; Jin, P; Levey, AI; Li, X; Li, Y; Song, CX; Szulwach, KE; Upadhyay, AK; Vasanthakumar, A; Wu, H1
Chang, Q; Chestnut, BA; Lesuisse, C; Martin, LJ; Price, A; Wong, M1
Chouliaras, L; Rutten, BP; van den Hove, DL1
Chen, H; Dzitoyeva, S; Manev, H1
Cang, J; Huang, N; Tan, L; Wang, H; Xue, Z1
Chouliaras, L; Delbroek, L; Prickaerts, J; Rostamian, S; Rutten, BP; Sierksma, AS; Steinbusch, HW; van den Hove, DL1
Albasanz, JL; Barrachina, M; Blanch, M; Ferrer, I; Martín, M; Pereira-Veiga, T; Pérez-Navarro, E; Tyebji, S; Villar-Menéndez, I1

Reviews

1 review(s) available for 5-hydroxymethylcytosine and Disease Models, Animal

ArticleYear
DNA Modifications and Alzheimer's Disease.
    Advances in experimental medicine and biology, 2017, Volume: 978

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Causality; Disease Models, Animal; DNA Methylation; DNA-Cytosine Methylases; Epigenesis, Genetic; Forecasting; Gene Expression Regulation; Genome-Wide Association Study; Humans; Mice; Mice, Transgenic; Nerve Tissue Proteins; Tissue Array Analysis

2017

Other Studies

38 other study(ies) available for 5-hydroxymethylcytosine and Disease Models, Animal

ArticleYear
High-dose ascorbic acid synergizes with anti-PD1 in a lymphoma mouse model.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 01-21, Volume: 117, Issue:3

    Topics: 5-Methylcytosine; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Ascorbic Acid; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Drug Synergism; Female; Granzymes; Immunotherapy; Lymphoma; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Tumor Microenvironment

2020
Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.
    Human molecular genetics, 2020, 07-21, Volume: 29, Issue:11

    Topics: 5-Methylcytosine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cell Differentiation; Cognitive Dysfunction; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Gene Expression Regulation; Hippocampus; Histone Deacetylase 1; Humans; Learning; Mice; Mice, Transgenic; Neural Stem Cells; Proto-Oncogene Proteins; RNA-Seq

2020
TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson's disease.
    Human molecular genetics, 2020, 05-28, Volume: 29, Issue:8

    Topics: 5-Methylcytosine; Animals; Cyclin-Dependent Kinase Inhibitor p16; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Dopaminergic Neurons; Epigenesis, Genetic; Humans; Male; Mesencephalon; Mice; Parkinson Disease; Proto-Oncogene Proteins

2020
A Comparative Study on 5hmC Targeting Regulation of Neurons in AD Mice by Several Natural Compounds.
    BioMed research international, 2020, Volume: 2020

    Topics: 5-Methylcytosine; Alzheimer Disease; Animals; Cell Line, Tumor; Deoxyadenosines; Disease Models, Animal; Humans; Mice; Mice, Mutant Strains; Neurons; Resveratrol

2020
Role of TET1 and 5hmC in an Obesity-Linked Pathway Driving Cancer Stem Cells in Triple-Negative Breast Cancer.
    Molecular cancer research : MCR, 2020, Volume: 18, Issue:12

    Topics: 5-Methylcytosine; Animals; Cell Line, Tumor; Diet, High-Fat; Disease Models, Animal; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Mice; Mixed Function Oxygenases; Neoplastic Stem Cells; Obesity; Proto-Oncogene Proteins; Serine-Arginine Splicing Factors; Triple Negative Breast Neoplasms

2020
Selective loss of 5hmC promotes neurodegeneration in the mouse model of Alzheimer's disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:12

    Topics: 5-Methylcytosine; Alzheimer Disease; Animals; Astrocytes; Brain; Cell Line; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epigenomics; Genome; HEK293 Cells; Humans; Mice; Neurodegenerative Diseases; Neurons

2020
Effects of caffeic acid on epigenetics in the brain of rats with chronic unpredictable mild stress.
    Molecular medicine reports, 2020, Volume: 22, Issue:6

    Topics: 5-Methylcytosine; Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Caffeic Acids; Catechol O-Methyltransferase; Depression; Depressive Disorder, Major; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Epigenomics; Hippocampus; Male; Prefrontal Cortex; Rats; Rats, Wistar; Stress, Psychological

2020
Relative DNA Methylation and Demethylation Efficiencies during Postnatal Liver Development Regulate Hepatitis B Virus Biosynthesis.
    Journal of virology, 2021, 02-24, Volume: 95, Issue:6

    Topics: 5-Methylcytosine; Animals; Animals, Newborn; Demethylation; Dioxygenases; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Replication; DNA, Viral; Gene Expression Regulation, Developmental; Gene Expression Regulation, Viral; Hepatitis B virus; Hepatitis B, Chronic; Hepatocyte Nuclear Factors; Liver; Mice; Mice, Transgenic; RNA, Viral; Virus Replication

2021
Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.
    Human molecular genetics, 2021, 05-29, Volume: 30, Issue:10

    Topics: 5-Methylcytosine; Animals; Cardiomegaly; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Fibrosis; Gene Expression Regulation; Heart; HSP70 Heat-Shock Proteins; Humans; MAP Kinase Signaling System; Mice; Myocytes, Cardiac; Phosphorylation; Transcriptome

2021
Ten-eleven translocation protein 1 modulates medulloblastoma progression.
    Genome biology, 2021, 04-29, Volume: 22, Issue:1

    Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Computational Biology; CpG Islands; Databases, Nucleic Acid; Disease Models, Animal; Disease Progression; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Medulloblastoma; Mice; Mice, Transgenic; Mixed Function Oxygenases; Nucleotide Motifs; Prognosis; Proto-Oncogene Proteins

2021
Ten-eleven translocation 2 modulates allergic inflammation by 5-hydroxymethylcytosine remodeling of immunologic pathways.
    Human molecular genetics, 2021, 10-13, Volume: 30, Issue:21

    Topics: 5-Methylcytosine; Animals; Biomarkers; Dioxygenases; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Gene Expression Regulation; Hypersensitivity; Immunomodulation; Mice; Mice, Knockout; Proto-Oncogene Proteins; Signal Transduction

2021
Biological significance of 5-hydroxymethylcytosine in oral epithelial dysplasia and oral squamous cell carcinoma.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2018, Volume: 125, Issue:1

    Topics: 5-Methylcytosine; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cells, Cultured; Disease Models, Animal; DNA Methylation; Early Diagnosis; Fibroma; Humans; Immunoblotting; Immunoenzyme Techniques; Keratinocytes; Lichen Planus, Oral; Mice; Mouth Neoplasms; Precancerous Conditions; Prognosis

2018
DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress.
    Nature communications, 2017, 10-24, Volume: 8, Issue:1

    Topics: 5-Methylcytosine; Adenine; Animals; Brain; Computational Biology; Depression; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genome; Humans; Long Interspersed Nucleotide Elements; Male; Mental Disorders; Mice; Mice, Inbred C57BL; Neurons; Prefrontal Cortex; Stress, Physiological; Swimming; Transcriptome

2017
Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2018, 03-15, Volume: 24, Issue:6

    Topics: 5-Methylcytosine; Animals; Cell Survival; Cellular Reprogramming; Combined Modality Therapy; Cystadenocarcinoma, Serous; Dioxygenases; Disease Models, Animal; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Grading; Ovarian Neoplasms; Prognosis; Proto-Oncogene Proteins; Recurrence; Survival Analysis; Xenograft Model Antitumor Assays

2018
Novel insights into mitochondrial molecular targets of iron-induced neurodegeneration: Reversal by cannabidiol.
    Brain research bulletin, 2018, Volume: 139

    Topics: 5-Methylcytosine; Animals; Animals, Newborn; Cannabidiol; Creatine Kinase; Disease Models, Animal; DNA Methylation; DNA, Mitochondrial; Female; Gene Expression Regulation; Hippocampus; Iron Carbonyl Compounds; Male; Mitochondria; Mitochondrial Proteins; Muscle Proteins; NADH Dehydrogenase; Neurodegenerative Diseases; Pregnancy; Rats; Rats, Wistar

2018
Ten-eleven Translocation-2 Regulates DNA Hydroxymethylation Status and Psoriasiform Dermatitis Progression in Mice.
    Acta dermato-venereologica, 2018, Jun-08, Volume: 98, Issue:6

    Topics: 5-Methylcytosine; Aminoquinolines; Animals; Case-Control Studies; Cell Differentiation; Cell Proliferation; Chemokine CXCL1; Dioxygenases; Disease Models, Animal; Disease Progression; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Humans; Imiquimod; Interferon-gamma; Interleukin-17; Mice, Inbred BALB C; Proto-Oncogene Proteins; Psoriasis; Skin; Time Factors

2018
Decreased global DNA hydroxymethylation in neural tube defects: Association with polycyclic aromatic hydrocarbons.
    Epigenetics, 2019, Volume: 14, Issue:10

    Topics: 5-Methylcytosine; Animals; Case-Control Studies; Disease Models, Animal; Embryo Culture Techniques; Female; Humans; Linear Models; Liver; Male; Maternal Exposure; Mice; Neural Tube Defects; Polycyclic Aromatic Hydrocarbons; Pregnancy; Superoxide Dismutase

2019
Regulation of DNA methylation levels in the process of oral mucosal regeneration in a rat oral ulcer model.
    Histology and histopathology, 2020, Volume: 35, Issue:3

    Topics: 5-Methylcytosine; Animals; Cell Proliferation; Disease Models, Animal; DNA Methylation; Epithelial Cells; Gene Expression Regulation; Immunohistochemistry; Ligands; Male; Mouth Mucosa; Oral Ulcer; Rats; Rats, Wistar; Regeneration; Wnt-5a Protein

2020
Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.
    Human molecular genetics, 2013, Sep-15, Volume: 22, Issue:18

    Topics: 5-Methylcytosine; Animals; Brain; Corpus Striatum; Cytosine; Disease Models, Animal; DNA Methylation; Epigenomics; Humans; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Sequence Alignment; Sequence Analysis, DNA

2013
Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome.
    Human molecular genetics, 2014, Feb-15, Volume: 23, Issue:4

    Topics: 5-Methylcytosine; Animals; Ataxia; Base Sequence; Cerebellum; Consensus Sequence; Cytosine; Disease Models, Animal; DNA Methylation; Fragile X Syndrome; Humans; Mice; Mice, Transgenic; Terminator Regions, Genetic; Transcription Initiation Site; Tremor

2014
Base-resolution maps of 5-methylcytosine and 5-hydroxymethylcytosine in Dahl S rats: effect of salt and genomic sequence.
    Hypertension (Dallas, Tex. : 1979), 2014, Volume: 63, Issue:4

    Topics: 5-Methylcytosine; Animals; Base Sequence; CpG Islands; Cytosine; Disease Models, Animal; Epigenomics; Genome-Wide Association Study; Hypertension; Kidney Medulla; Male; Phenotype; Rats; Rats, Inbred Dahl; RNA, Messenger; Sodium Chloride, Dietary; Transcriptome

2014
Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:3

    Topics: 5-Methylcytosine; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Cytosine; Disease Models, Animal; Gene Expression Regulation; Genotype; Humans; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1; tau Proteins

2014
White matter tract and glial-associated changes in 5-hydroxymethylcytosine following chronic cerebral hypoperfusion.
    Brain research, 2014, Dec-10, Volume: 1592

    Topics: 5-Methylcytosine; Animals; Autophagy-Related Proteins; Calcium-Binding Proteins; Cerebrovascular Disorders; Chronic Disease; Corpus Callosum; Cytosine; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Gray Matter; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Mice, Inbred C57BL; Microfilament Proteins; Neural Stem Cells; Neuroglia; Oxidative Stress; Pilot Projects; Proto-Oncogene Proteins; Random Allocation; White Matter

2014
Hippocampal increase of 5-hmC in the glucocorticoid receptor gene following acute stress.
    Behavioural brain research, 2015, Jun-01, Volume: 286

    Topics: 3' Untranslated Regions; 5-Methylcytosine; Acute Disease; Animals; Cytosine; Disease Models, Animal; Hippocampus; Mice; Neurons; Random Allocation; Receptors, Glucocorticoid; Restraint, Physical; Stress, Psychological

2015
Genome-wide disruption of 5-hydroxymethylcytosine in a mouse model of autism.
    Human molecular genetics, 2015, Dec-15, Volume: 24, Issue:24

    Topics: 5-Methylcytosine; Animals; Autistic Disorder; Corpus Striatum; Cytosine; Disease Models, Animal; DNA; DNA Methylation; Epigenesis, Genetic; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Annotation; Nerve Tissue Proteins; Reelin Protein

2015
Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Mar-02, Volume: 36, Issue:9

    Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Down-Regulation; Epigenesis, Genetic; Formaldehyde; Gene Expression Regulation; HEK293 Cells; Humans; Male; Mice; Mice, Inbred Strains; MicroRNAs; Pain; Phosphopyruvate Hydratase; Promoter Regions, Genetic; Proto-Oncogene Proteins; Spinal Cord; Time Factors

2016
5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity.
    Human molecular genetics, 2016, 06-15, Volume: 25, Issue:12

    Topics: 5-Methylcytosine; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Autopsy; Disease Models, Animal; DNA Methylation; Drosophila melanogaster; Epigenesis, Genetic; Female; Gene Expression Regulation; Genome, Human; Humans; Male; Neurogenesis; Neurons; Polymorphism, Single Nucleotide; Prefrontal Cortex; Protein Interaction Mapping; tau Proteins

2016
Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease.
    BMC genomics, 2016, 05-20, Volume: 17

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Genome-Wide Association Study; Humans; Mice; Mice, Transgenic

2016
Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress.
    Neurobiology of disease, 2016, Volume: 96

    Topics: 5-Methylcytosine; Animals; Chromatin Immunoprecipitation; Disease Models, Animal; Epigenesis, Genetic; Female; Gene Ontology; Hippocampus; Male; Methylation; Mice; Mice, Inbred C57BL; Sex Factors; Stress, Psychological

2016
Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice.
    Oncotarget, 2016, 11-22, Volume: 7, Issue:47

    Topics: 5-Methylcytosine; Animals; Apolipoproteins E; Atherosclerosis; Autophagy; Cytokines; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Gene Expression; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Immunohistochemistry; Inflammation Mediators; Lipoproteins, LDL; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic; Proto-Oncogene Proteins

2016
The Yin-Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling.
    Arteriosclerosis, thrombosis, and vascular biology, 2017, Volume: 37, Issue:1

    Topics: 5-Methylcytosine; Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Azacitidine; Cell Dedifferentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Decitabine; Diet, High-Fat; Dioxygenases; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme Inhibitors; Epigenesis, Genetic; Genetic Predisposition to Disease; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Promoter Regions, Genetic; Proto-Oncogene Proteins; Rats; Signal Transduction; Time Factors; Trans-Activators; Vascular Remodeling

2017
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
    Nature neuroscience, 2011, Oct-30, Volume: 14, Issue:12

    Topics: 5-Methylcytosine; Aging; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Chromosome Deletion; Chromosome Mapping; Cytosine; Disease Models, Animal; DNA Methylation; Epigenomics; Gene Expression Regulation, Developmental; Hippocampus; Humans; Immunoprecipitation; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Organ Specificity; Phosphopyruvate Hydratase; Rett Syndrome; X Chromosome

2011
Epigenetic regulation of motor neuron cell death through DNA methylation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46

    Topics: 5-Methylcytosine; Age Factors; Amyloid Precursor Protein Secretases; Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Aspartic Acid Endopeptidases; Camptothecin; Caspase 3; Cell Line, Transformed; Central Nervous System; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Enzyme Inhibitors; Epigenomics; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Humans; Indoles; Mice; Mice, Transgenic; Motor Neurons; Mutation; Phthalimides; Propionates; RNA, Small Interfering; Sciatic Neuropathy; Superoxide Dismutase; Transfection; Tryptophan; Up-Regulation

2011
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
    Current Alzheimer research, 2012, Volume: 9, Issue:5

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Humans; Translocation, Genetic

2012
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
    Restorative neurology and neuroscience, 2012, Volume: 30, Issue:3

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Arachidonate 5-Lipoxygenase; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Hippocampus; Male; Mice; Mice, Inbred C57BL; Up-Regulation

2012
Reduction of DNA hydroxymethylation in the mouse kidney insulted by ischemia reperfusion.
    Biochemical and biophysical research communications, 2012, Jun-15, Volume: 422, Issue:4

    Topics: 5-Methylcytosine; Animals; Chemokine CXCL10; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Kidney; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins; Receptors, Interferon; Reperfusion Injury

2012
Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice.
    Neurobiology of aging, 2013, Volume: 34, Issue:1

    Topics: 5-Methylcytosine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavioral Symptoms; Benzofurans; Cognition Disorders; Cytosine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Female; Hippocampus; Humans; Male; Memory Disorders; Mice; Mice, Transgenic; Pregnancy; Prenatal Exposure Delayed Effects; Presenilin-1; Quinolines; Space Perception; Stress, Psychological

2013
Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease.
    Neuromolecular medicine, 2013, Volume: 15, Issue:2

    Topics: 5-Methylcytosine; 5' Untranslated Regions; Adult; Aged; Aged, 80 and over; Animals; Corpus Striatum; Cytosine; Disease Models, Animal; Disease Progression; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation; Humans; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Transgenic; Middle Aged; Nerve Tissue Proteins; Putamen; Receptor, Adenosine A2A

2013