Compounds > 5-hydroxymethylcytosine
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5-hydroxymethylcytosine and Aging

5-hydroxymethylcytosine has been researched along with Aging in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's25 (92.59)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Borkowska, J; Buyanovskaya, O; Charzewski, L; Domaszewska-Szostek, A; Kołodziej, P; Noszczyk, B; Połosak, J; Puzianowska-Kuznicka, M; Stańczyk, M; Wicik, Z1
Andreou, AZ; Kouidou, S; Malousi, A1
Fernández, AF; Fraga, MF; López, V1
Lunnon, K; Smith, RG1
Bacalini, MG; Breusing, N; Bürkle, A; Caiafa, P; Calabrese, R; Capri, M; Ciccarone, F; Franceschi, C; Grune, T; Guastafierro, T; Malavolta, M; Moreno-Villanueva, M; Reale, A; Valentini, E; Zampieri, M1
Bieri, G; Gontier, G; Iyer, M; Ramalho-Santos, M; Shea, JM; Villeda, SA; Wheatley, EG1
Cavalcante, RG; Dolinoy, DC; Kochmanski, J; Marchlewicz, EH; Sartor, MA1
Aston, KI; Cairns, BR; Carrell, DT; Jenkins, TG1
De Jonge, CJ1
Arias, C; Bermúdez-Rattoni, F; Cadena-del-Castillo, C; Carmona-Aldana, F; Recillas-Targa, F; Valdes-Quezada, C1
Cai, C; Cheng, Y; Dave, R; Davis, TH; Irier, H; Jin, P; Lin, L; Street, RC; Yao, B1
Li, X; Shu, Q; Sun, W; Zang, L1
Guibourt, V; Kraus, TF; Kretzschmar, HA1
Chan, WY; Chung, JP; Kong, GW; Lee, TL; Qian, Y; Tang, NL; Tu, J1
Bachman, M; Balasubramanian, S; Burgess, HE; Iurlaro, M; Murrell, A; Reik, W; Uribe-Lewis, S; Yang, X1
Iatrou, A; Kenis, G; Lardenoije, R; Meuwissen, KPV; Rutten, BPF; Schmitz, C; Steinbusch, HWM; Vaessen, TSJ; van den Hove, DLA; van Hagen, BTJ1
Guibourt, V; Kilinc, S; Kraus, TF; Kretzschmar, HA; Steinmaurer, M; Stieglitz, M1
Huang, L; Jin, P; Li, L; Li, X; Lin, L; Shen, H; Shu, L; Sun, W; Xie, P; Xu, Q; Xu, Z1
Bayón, GF; Belmonte, T; Carella, A; Cubillo, I; Del Real, Á; Delgado-Calle, J; Fernández, AF; Fraga, MF; García, MG; García-Castro, J; Pérez-Campo, FM; Riancho, JA; Sierra, MI; Toraño, EG; Urdinguio, RG1
De Jager, PL; Klein, HU1
Chen, YF; Hsu, MT; Lin, IH1
Chang, Q; Cheng, X; Dai, Q; Gearing, M; Godley, LA; He, C; Irier, H; Jin, P; Levey, AI; Li, X; Li, Y; Song, CX; Szulwach, KE; Upadhyay, AK; Vasanthakumar, A; Wu, H1
Flax, JD; Soloway, PD1
Chouliaras, L; Rutten, BP; van den Hove, DL1
Irier, HA; Jin, P1
Chen, H; Dzitoyeva, S; Manev, H2

Reviews

5 review(s) available for 5-hydroxymethylcytosine and Aging

ArticleYear
The role of 5-hydroxymethylcytosine in development, aging and age-related diseases.
    Ageing research reviews, 2017, Volume: 37

    Topics: 5-Methylcytosine; Aging; Animals; Cell Differentiation; Cytosine; DNA Methylation; Epigenesis, Genetic; Humans; Neoplasms; Oxidation-Reduction

2017
DNA Modifications and Alzheimer's Disease.
    Advances in experimental medicine and biology, 2017, Volume: 978

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Causality; Disease Models, Animal; DNA Methylation; DNA-Cytosine Methylases; Epigenesis, Genetic; Forecasting; Gene Expression Regulation; Genome-Wide Association Study; Humans; Mice; Mice, Transgenic; Nerve Tissue Proteins; Tissue Array Analysis

2017
From development to diseases: the role of 5hmC in brain.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Humans; Nervous System Diseases; Neurons

2014
Uncovering the Role of the Methylome in Dementia and Neurodegeneration.
    Trends in molecular medicine, 2016, Volume: 22, Issue:8

    Topics: 5-Methylcytosine; Aging; Animals; Brain; Dementia; DNA Methylation; Epigenesis, Genetic; Epigenomics; Humans; Neurodegenerative Diseases

2016
Dynamics of DNA methylation in aging and Alzheimer's disease.
    DNA and cell biology, 2012, Volume: 31 Suppl 1

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; DNA; DNA Methylation; Humans; Neurodegenerative Diseases

2012

Other Studies

22 other study(ies) available for 5-hydroxymethylcytosine and Aging

ArticleYear
Alterations in 5hmC level and genomic distribution in aging-related epigenetic drift in human adipose stem cells.
    Epigenomics, 2020, Volume: 12, Issue:5

    Topics: 5-Methylcytosine; Adipose Tissue; Aging; Binding Sites; Cellular Senescence; Dioxygenases; DNA Methylation; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation; Genetic Drift; Humans; Protein Binding; Stem Cells

2020
In silico structural analysis of sequences containing 5-hydroxymethylcytosine reveals its potential as binding regulator for development, ageing and cancer-related transcription factors.
    Epigenetics, 2021, Volume: 16, Issue:5

    Topics: 5-Methylcytosine; Aging; DNA Methylation; G-Quadruplexes; Humans; Neoplasms; Transcription Factors

2021
DNA Hydroxymethylation Levels Are Altered in Blood Cells From Down Syndrome Persons Enrolled in the MARK-AGE Project.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2018, 05-09, Volume: 73, Issue:6

    Topics: 5-Methylcytosine; Adult; Aged; Aging; Cross-Sectional Studies; DNA Methylation; Down Syndrome; Epigenesis, Genetic; Europe; Female; Humans; Immunoblotting; Italy; Leukocytes, Mononuclear; Male; Middle Aged; Mixed Function Oxygenases; Proto-Oncogene Proteins; RNA, Messenger

2018
Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.
    Cell reports, 2018, 02-20, Volume: 22, Issue:8

    Topics: 5-Methylcytosine; Aging; Animals; Brain; Cognition; Dentate Gyrus; Dioxygenases; DNA-Binding Proteins; Male; Mice, Inbred C57BL; Models, Animal; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Parabiosis; Proto-Oncogene Proteins

2018
Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood.
    Epigenetics, 2018, Volume: 13, Issue:7

    Topics: 5-Methylcytosine; Aging; Animals; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Gene Expression Regulation; Genome; Male; Mice

2018
Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.
    Fertility and sterility, 2013, Volume: 100, Issue:4

    Topics: 5-Methylcytosine; Adult; Age Factors; Aging; Cytosine; DNA; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Humans; Male; Middle Aged; Paternal Age; Prospective Studies; Risk Factors; Spermatozoa; Up-Regulation

2013
Paternal age and sperm methylation status.
    Fertility and sterility, 2013, Volume: 100, Issue:4

    Topics: 5-Methylcytosine; Aging; Cytosine; DNA; DNA Methylation; Humans; Male; Paternal Age; Spermatozoa

2013
Age-dependent increment of hydroxymethylation in the brain cortex in the triple-transgenic mouse model of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:3

    Topics: 5-Methylcytosine; Age Factors; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Cytosine; Disease Models, Animal; Gene Expression Regulation; Genotype; Humans; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1; tau Proteins

2014
Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.
    Genomics, 2014, Volume: 104, Issue:5

    Topics: 5-Methylcytosine; Aging; Animals; Cytosine; DNA Methylation; Gene Expression Regulation; Gene-Environment Interaction; Hippocampus; Learning; Mice

2014
5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.
    Journal of neural transmission (Vienna, Austria : 1996), 2015, Volume: 122, Issue:7

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cytosine; Female; Fetus; Gestational Age; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Phosphopyruvate Hydratase; Young Adult

2015
Dynamic changes of DNA epigenetic marks in mouse oocytes during natural and accelerated aging.
    The international journal of biochemistry & cell biology, 2015, Volume: 67

    Topics: 5-Methylcytosine; Aging; Animals; Cellular Senescence; Cyclohexenes; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Female; Histones; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Oocytes; Ovary; Protein Isoforms; Proto-Oncogene Proteins; Thymine DNA Glycosylase; Vinyl Compounds

2015
5-Formylcytosine can be a stable DNA modification in mammals.
    Nature chemical biology, 2015, Volume: 11, Issue:8

    Topics: 5-Methylcytosine; Aging; Animals; Animals, Newborn; Brain; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation, Developmental; Half-Life; Liver; Mice; Mice, Inbred C57BL; Myocardium

2015
Epigenetic modifications in mouse cerebellar Purkinje cells: effects of aging, caloric restriction, and overexpression of superoxide dismutase 1 on 5-methylcytosine and 5-hydroxymethylcytosine.
    Neurobiology of aging, 2015, Volume: 36, Issue:11

    Topics: 5-Methylcytosine; Aging; Animals; Caloric Restriction; Cytosine; DNA Methylation; Epigenesis, Genetic; Gene Expression; Immunohistochemistry; Mice, Inbred C57BL; Purkinje Cells; Superoxide Dismutase; Superoxide Dismutase-1

2015
Profiling of methylation and demethylation pathways during brain development and ageing.
    Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:3

    Topics: 5-Methylcytosine; Aging; Animals; Brain; Cytosine; DNA Methylation; Epigenesis, Genetic; Female; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Transcriptome

2016
Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease.
    BMC genomics, 2016, 05-20, Volume: 17

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Genome-Wide Association Study; Humans; Mice; Mice, Transgenic

2016
Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells.
    Journal of translational medicine, 2016, 07-08, Volume: 14, Issue:1

    Topics: 5-Methylcytosine; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Bone Marrow Cells; Child; Child, Preschool; Chromatin; CpG Islands; DNA Methylation; Genome, Human; Genomics; Humans; Mesenchymal Stem Cells; Middle Aged; Young Adult

2016
Correlated 5-Hydroxymethylcytosine (5hmC) and Gene Expression Profiles Underpin Gene and Organ-Specific Epigenetic Regulation in Adult Mouse Brain and Liver.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cerebral Cortex; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Essential; Genome; Hippocampus; Hypothalamus; Liver; Male; Mice; Mitochondrial Proteins; Organ Specificity; Ribosomal Proteins; Sequence Analysis, RNA; Sex Chromosomes; Thalamus; Transcriptome

2017
5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
    Nature neuroscience, 2011, Oct-30, Volume: 14, Issue:12

    Topics: 5-Methylcytosine; Aging; Analysis of Variance; Animals; Animals, Newborn; Cerebellum; Chromosome Deletion; Chromosome Mapping; Cytosine; Disease Models, Animal; DNA Methylation; Epigenomics; Gene Expression Regulation, Developmental; Hippocampus; Humans; Immunoprecipitation; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Organ Specificity; Phosphopyruvate Hydratase; Rett Syndrome; X Chromosome

2011
Methylation on the mind.
    Nature neuroscience, 2011, Nov-23, Volume: 14, Issue:12

    Topics: 5-Methylcytosine; Aging; Animals; Cerebellum; Cytosine; Epigenomics; Gene Expression Regulation, Developmental; Hippocampus; Humans

2011
The role of 5-hydroxymethylcytosine in aging and Alzheimer's disease: current status and prospects for future studies.
    Current Alzheimer research, 2012, Volume: 9, Issue:5

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Humans; Translocation, Genetic

2012
Effect of aging on 5-hydroxymethylcytosine in the mouse hippocampus.
    Restorative neurology and neuroscience, 2012, Volume: 30, Issue:3

    Topics: 5-Methylcytosine; Aging; Alzheimer Disease; Animals; Arachidonate 5-Lipoxygenase; Cytosine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Hippocampus; Male; Mice; Mice, Inbred C57BL; Up-Regulation

2012
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.
    Neurobiology of aging, 2012, Volume: 33, Issue:12

    Topics: 5-Methylcytosine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Brain; Cells, Cultured; Cytosine; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; DNA, Mitochondrial; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Developmental; Laser Capture Microdissection; Male; Methyltransferases; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Proto-Oncogene Proteins

2012